A Short Travel for Neutrinos in Large Extra Dimensions

Neutrino oscillations successfully explain the flavor transitions observed in neutrinos produced in natural sources like the center of the sun and the earth atmosphere, and also from man-made sources like reactors and accelerators. These oscillations are driven by two mass-squared differences, solar and atmospheric, at the sub-eV scale. However, longstanding anomalies at short-baselines might imply the existence of new oscillation frequencies at the eV-scale and the possibility of this sterile state(s) to mix with the three active neutrinos. One of the many future neutrino programs that are expected to provide a final word on this issue is the Short-Baseline Neutrino Program (SBN) at FERMILAB. In this letter, we consider a specific model of Large Extra Dimensions (LED) which provides interesting signatures of oscillation of extra sterile states. We started re-creating sensitivity analyses for sterile neutrinos in the 3+1 scenario, previously done by the SBN collaboration, by simulating neutrino events in the three SBN detectors from both muon neutrino disappearance and electron neutrino appearance. Then, we implemented neutrino oscillations as predicted in the LED model and also we have performed sensitivity analysis to the LED parameters. Finally, we studied the SBN power of discriminating between the two models, the 3+1 and the LED. We have found that SBN is sensitive to the oscillations predicted in the LED model and have the potential to constrain the LED parameter space better than any other oscillation experiment, for $m_{1}^D<0.1\,\text{eV}$. In case SBN observes a departure from the three active neutrino framework, it also has the power of discriminating between sterile oscillations predicted in the 3+1 framework and the LED ones.Comment: 21 pages, 6 figures, 2 table

Physics with Beam Tau-Neutrino Appearance at DUNE

We explore the capabilities of the upcoming Deep Underground Neutrino Experiment (DUNE) to measure $\nu_\tau$ charged-current interactions and the associated oscillation probability $P(\nu_\mu \to \nu_\tau)$ at its far detector, concentrating on how such results can be used to probe neutrino properties and interactions. DUNE has the potential to identify significantly more $\nu_\tau$ events than all existing experiments and can use this data sample to nontrivially test the three-massive-neutrinos paradigm by providing complementary measurements to those from the $\nu_e$ appearance and $\nu_\mu$ disappearance channels. We further discuss the sensitivity of the $\nu_\tau$ appearance channel to several hypotheses for the physics that may lurk beyond the three-massive-neutrinos paradigm: a non-unitary lepton mixing matrix, the $3+1$ light neutrinos hypothesis, and the existence of non-standard neutral-current neutrino interactions. Throughout, we also consider the relative benefits of the proposed high-energy tune of the Long-Baseline Neutrino Facility (LBNF) beam-line.Comment: 23 pages, 14 figures, 2 appendice

A short travel for neutrinos in large extra dimensions

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICONeutrino oscillations successfully explain the flavor transitions observed in neutrinos produced in natural sources like the center of the sun and the earth atmosphere, and also from man-made sources like reactors and accelerators. These oscillations are driven by two mass-squared differences, solar and atmospheric, at the sub-eV scale. However, longstanding anomalies at short-baselines might imply the existence of new oscillation frequencies at the eV-scale and the possibility of this sterile state(s) to mix with the three active neutrinos. One of the many future neutrino programs that are expected to provide a final word on this issue is the Short-Baseline Neutrino Program (SBN) at FERMILAB. In this letter, we consider a specific model of Large Extra Dimensions (LED) which provides interesting signatures of oscillation of extra sterile states. We started re-creating sensitivity analyses for sterile neutrinos in the 3+1 scenario, previously done by the SBN collaboration, by simulating neutrino events in the three SBN detectors from both muon neutrino disappearance and electron neutrino appearance. Then, we implemented neutrino oscillations as predicted in the LED model and also we have performed sensitivity analysis to the LED parameters. Finally, we studied the SBN power of discriminating between the two models, the 3+1 and the LED. We have found that SBN is sensitive to the oscillations predicted in the LED model and have the potential to constrain the LED parameter space better than any other oscillation experiment for m1 D < 0.1 eV. In case SBN observes a departure from the three active neutrino framework, it also has the power of discriminating between sterile oscillations predicted in the 3+1 framework and the LED ones.11121FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO2014/19164-62016/00272-92016/08308-22017/12904-22017/01749-6307269/2013-2304715/2016-

On The Decaying-Sterile Neutrino Solution to the Electron (Anti)Neutrino Appearance Anomalies

We explore the hypothesis that the unexplained data from LSND and MiniBooNE are evidence for a new, heavy neutrino mass-eigenstate that mixes with the muon-type neutrino and decays into an electron-type neutrino and a new, very light scalar particle. We consider two different decay scenarios, one with Majorana neutrinos, one with Dirac neutrinos; both fit the data equally well. We find a reasonable, albeit not excellent, fit to the data of MiniBooNE and LSND. The decaying-sterile-neutrino hypothesis, however, cleanly evades constraints from disappearance searches and precision measurements of leptonic meson decays, as long as $1~{\rm MeV}\gtrsim m_4\gtrsim 10$~keV. The SBN program at Fermilab should be able to definitively test the decaying-sterile-neutrino hypothesis.Comment: This version v2 has been accepted for publication in JHEP. The changes from previous version are: inclusion of the data from KARMEN in the analysis, a new subsection about the sensitivity of SBN to nonzero decay effects, an new appendix describing the details of MiniBooNE analysis, additional references and some other minor change

Patterns of male-specific inter-population divergence in Europe, West Asia and North Africa

We typed 1801 males from 55 locations for the Y-specific binary markers YAP! DYZ3, SRY10831 and the (CA)n microsatellites YCAII and DYS413. Phylogenetic relationships of chromosomes with the same binary haplotype were condensed in seven large one-step networks! which accounted for 95% of all chromosomes. Their coalescence ages were estimated based on microsatellite diversity. The three largest and oldest networks undergo sharp frequency changes in three areas. The more recent network; 3.1A clearly discriminates between Western and Eastern European populations. Pairwise Pst showed an overall increment with increasing geographic distance but with a slope greatly reduced when compared to previous reports. BI sectioning the entire data set according to geographic and linguistic criteria, we found higher Fst-on-distance slopes within Europe than in West Asia or across the tno continents

Uniparental markers of contemporary Italian population reveals details on its pre-Roman heritage.

BACKGROUND: According to archaeological records and historical documentation, Italy has been a melting point for populations of different geographical and ethnic matrices. Although Italy has been a favorite subject for numerous population genetic studies, genetic patterns have never been analyzed comprehensively, including uniparental and autosomal markers throughout the country. METHODS/PRINCIPAL FINDINGS: A total of 583 individuals were sampled from across the Italian Peninsula, from ten distant (if homogeneous by language) ethnic communities--and from two linguistic isolates (Ladins, Grecani Salentini). All samples were first typed for the mitochondrial DNA (mtDNA) control region and selected coding region SNPs (mtSNPs). This data was pooled for analysis with 3,778 mtDNA control-region profiles collected from the literature. Secondly, a set of Y-chromosome SNPs and STRs were also analyzed in 479 individuals together with a panel of autosomal ancestry informative markers (AIMs) from 441 samples. The resulting genetic record reveals clines of genetic frequencies laid according to the latitude slant along continental Italy--probably generated by demographical events dating back to the Neolithic. The Ladins showed distinctive, if more recent structure. The Neolithic contribution was estimated for the Y-chromosome as 14.5% and for mtDNA as 10.5%. Y-chromosome data showed larger differentiation between North, Center and South than mtDNA. AIMs detected a minor sub-Saharan component; this is however higher than for other European non-Mediterranean populations. The same signal of sub-Saharan heritage was also evident in uniparental markers. CONCLUSIONS/SIGNIFICANCE: Italy shows patterns of molecular variation mirroring other European countries, although some heterogeneity exists based on different analysis and molecular markers. From North to South, Italy shows clinal patterns that were most likely modulated during Neolithic times

Ashkenazi Jewish Centenarians Do Not Demonstrate Enrichment in Mitochondrial Haplogroup J

BACKGROUND: Association of mitochondrial haplogroup J with longevity has been reported in several population subgroups. While studies from northern Italy and Finland, have described a higher frequency of haplogroup J among centenarians in comparison to non-centenarian, several other studies could not replicate these results and suggested various explanations for the discrepancy. METHODOLOGY/PRINCIPAL FINDINGS: We have evaluated haplogroup frequencies among Ashkenazi Jewish centenarians using two different sets of matched controls. No difference was observed in the haplogroup J frequencies between the centenarians or either matched control group, despite adequate statistical power to detect such a difference. Furthermore, the lack of association was robust to population substructure in the Ashkenazi Jewish population. Given this discrepancy with the previous reported associations in the northern Italian and the Finnish populations, we conducted re-analysis of these previously published data, which supported one of several possible explanations: i) inadequate matching of cases and controls; ii) inadequate adjustment for multiple comparison testing; iii) cryptic population stratification. CONCLUSIONS/SIGNIFICANCE: There does not exist a universal association of mitochondrial haplogroup J with longevity across all population groups. Reported associations in specialized populations may reflect genetic or other interactions specific to those populations or else cryptic confounding influences, such as inadequate matching attributable to population substructure, which are of general relevance to all studies of the possible association of mitochondrial DNA haplogroups with common complex phenotypes

A Universal Trend of Reduced mRNA Stability near the Translation-Initiation Site in Prokaryotes and Eukaryotes

Recent studies have suggested that the thermodynamic stability of mRNA secondary structure near the start codon can regulate translation efficiency in Escherichia coli, and that translation is more efficient the less stable the secondary structure. We survey the complete genomes of 340 species for signals of reduced mRNA secondary structure near the start codon. Our analysis includes bacteria, archaea, fungi, plants, insects, fishes, birds, and mammals. We find that nearly all species show evidence for reduced mRNA stability near the start codon. The reduction in stability generally increases with increasing genomic GC content. In prokaryotes, the reduction also increases with decreasing optimal growth temperature. Within genomes, there is variation in the stability among genes, and this variation correlates with gene GC content, codon bias, and gene expression level. For birds and mammals, however, we do not find a genome-wide trend of reduced mRNA stability near the start codon. Yet the most GC rich genes in these organisms do show such a signal. We conclude that reduced stability of the mRNA secondary structure near the start codon is a universal feature of all cellular life. We suggest that the origin of this reduction is selection for efficient recognition of the start codon by initiator-tRNA

The rapid spread of SARS-COV-2 Omicron variant in Italy reflected early through wastewater surveillance

The SARS-CoV-2 Omicron variant emerged in South Africa in November 2021, and has later been identified worldwide, raising serious concerns. A real-time RT-PCR assay was designed for the rapid screening of the Omicron variant, targeting characteristic mutations of the spike gene. The assay was used to test 737 sewage samples collected throughout Italy (19/21 Regions) between 11 November and 25 December 2021, with the aim of assessing the spread of the Omicron variant in the country. Positive samples were also tested with a real-time RT-PCR developed by the European Commission, Joint Research Centre (JRC), and through nested RT-PCR followed by Sanger sequencing. Overall, 115 samples tested positive for Omicron SARS-CoV-2 variant. The first occurrence was detected on 7 December, in Veneto, North Italy. Later on, the variant spread extremely fast in three weeks, with prevalence of positive wastewater samples rising from 1.0% (1/104 samples) in the week 5–11 December, to 17.5% (25/143 samples) in the week 12–18, to 65.9% (89/135 samples) in the week 19–25, in line with the increase in cases of infection with the Omicron variant observed during December in Italy. Similarly, the number of Regions/Autonomous Provinces in which the variant was detected increased from one in the first week, to 11 in the second, and to 17 in the last one. The presence of the Omicron variant was confirmed by the JRC real-time RT-PCR in 79.1% (91/115) of the positive samples, and by Sanger sequencing in 66% (64/97) of PCR amplicons. In conclusion, we designed an RT-qPCR assay capable to detect the Omicron variant, which can be successfully used for the purpose of wastewater-based epidemiology. We also described the history of the introduction and diffusion of the Omicron variant in the Italian population and territory, confirming the effectiveness of sewage monitoring as a powerful surveillance tool