A Synthesis of International Rural Education Issues and Responses

This article synthesizes problems impacting rural primary and secondary schools and describes how schools and relevant organizations have responded to the challenges. Given the context of a globally-compressed world, the focus of the literature review is on international rural education research and strategies. The exploration took the path of topical rather than regional or methodological investigation of rural education for the purpose of thematic understanding of issues. The paper opens with a discussion of the ambiguity of the definition of “rural” to reinforce an epistemological challenge with rural education research. An adaptation of Bronfenbrenner’s ecological theory is used as a framework for the literature review; rural education challenges are synthesized into macro-, mezzo-, and micro-systemic level issues. The paper culminates by positing that rural education issues require inter-sectoral and collaborative responses

Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease

Little is known about airway inflammatory markers in chronic obstructive pulmonary disease (COPD). The objective of the present study was to identify and try to correlate pulmonary and peripheral blood inflammatory markers in COPD. In a cross-sectional study on patients with stable COPD, induced sputum and blood samples were collected for the determination of C-reactive protein, eosinophilic cationic protein, serum amyloid A protein, a-1 antitrypsin (a-1AT), and neutrophil elastase. Twenty-two patients were divided into two groups according to post-bronchodilator forced expiratory volume in the first second (%FEV1): group 1 (N = 12, FEV1 <40%) and group 2 (N = 10, FEV1 ³40%). An increase in serum elastase, eosinophilic cationic protein and a-1AT was observed in serum markers in both groups. Cytology revealed the same total number of cells in groups 1 and 2. There was a significantly higher number of neutrophils in group 1 compared to group 2 (P < 0.05). No difference in eosinophils or macrophages was observed between groups. Serum elastase was positively correlated with serum a-1AT (group 1, r = 0.81, P < 0.002 and group 2, r = 0.83, P < 0.17) and negatively correlated with FEV1 (r = -0.85, P < 0.03 and -0.14, P < 0.85, respectively). The results indicate the presence of chronic and persistent pulmonary inflammation in stable patients with COPD. Induced sputum permitted the demonstration of the existence of a subpopulation of cells in which neutrophils predominated. The serum concentration of all inflammatory markers did not correlate with the pulmonary functional impairment

An investment case analysis for the prevention and treatment of adolescent mental disorders and suicide in England

BackgroundAdolescent mental health (AMH) needs in England have increased dramatically and needs exceed treatment availability. This study undertook a comparative assessment of the health and economic return on investment (ROI) of interventions to prevent and treat mental disorders among adolescents (10–19 years) and examined intervention affordability and readiness.MethodsInterventions were identified following a review of published and grey literature. A Markov model followed a simulated adolescent cohort to estimate implementation costs and health, education, and economic benefits. Intervention affordability was assessed, comparing annual cost per adolescent with NHS England per capita spending, and an expert panel assessed intervention readiness using a validated framework.ResultsOver 10- and 80-year horizons, interventions to treat mild anxiety and mild depression were most cost-effective, with the highest individual lifetime ROI (GBP 5822 GBP 1 and GBP 257: GBP 1). Preventing anxiety and depression was most affordable and ‘implementation ready’ and offered the highest health and economic benefits. A priority package (anxiety and depression prevention; mild anxiety and mild depression treatment) would avert 5 million disability-adjusted life-years (DALYS) and achieve an ROI of GBP 15: GBP 1 over 10 years or 11.5 million DALYs (ROI of GBP 55: GBP 1) over 80 years.ConclusionThe economic benefits from preventing and treating common adolescent mental disorders equivalent to 25% of NHS England’s annual spending in 2021 over 10 years and 91% over 80 years. Preventing and early treatment for anxiety and depression had the highest ROIs and strong implementation readiness.<br/

An analysis of cosmological perturbations in hydrodynamical and field representations

Density fluctuations of fluids with negative pressure exhibit decreasing time behaviour in the long wavelength limit, but are strongly unstable in the small wavelength limit when a hydrodynamical approach is used. On the other hand, the corresponding gravitational waves are well behaved. We verify that the instabilities present in density fluctuations are due essentially to the hydrodynamical representation; if we turn to a field representation that lead to the same background behaviour, the instabilities are no more present. In the long wavelength limit, both approachs give the same results. We show also that this inequivalence between background and perturbative level is a feature of negative pressure fluid. When the fluid has positive pressure, the hydrodynamical representation leads to the same behaviour as the field representation both at the background and perturbative levels.Comment: Latex file, 18 page

Total number of lymph nodes and numer of metastatic lymph nodes harvested during radical mastectomy did not influence early postoperative drainage volume

Objectives: We aimed at evaluation of the influence of the extent of axillary lymph node dissection, measured by the total number of lymph nodes harvested, on the drainage volume. We also looked at the lymph node positivity (N+) and the number of metastatic axillary lymph nodes as a potential prognostic factors in this regard. Material and methods: We have analysed the data of 63 patients (F/M: 62/1) with breast cancer, who underwent radical modified mastectomy in 2008-2009 in the single department of surgical oncology. Results: We observed no significant correlation between the 1) total number of axillary lymph nodes harvested during lymphadenectomy, 2) presence of metastatic lymph nodes (node positive disease), 3) number of metastatic axillary lymph nodes and: drainage volume on the day of surgery, drainage volume on three consecutive postoperative days and drainage volume from the day of surgery to drain removal. Conclusion: The extent of axillary lymph node dissection, measured by the total number of lymph nodes excised, did not influence drainage volume after radical modified mastectomy. Neither total number of metastatic lymph nodes excised nor the node positivity (N+) were associated with increased drainage volume after mastectomy with axillary dissection

Quantum Stephani exact cosmological solutions and the selection of time variable

We study perfect fluid Stephani quantum cosmological model. In the present work the Schutz's variational formalism which recovers the notion of time is applied. This gives rise to Wheeler-DeWitt equation for the scale factor. We use the eigenfunctions in order to construct wave packets for each case. We study the time-dependent behavior of the expectation value of the scale factor, using many-worlds and deBroglie-Bohm interpretations of quantum mechanics.Comment: 19 pages, 7 figure

An Einstein-Hilbert Action for Axi-Dilaton Gravity in 4-Dimensions

We examine the axi-dilatonic sector of low energy string theory and demonstrate how the gravitational interactions involving the axion and dilaton fields may be derived from a geometrical action principle involving the curvature scalar associated with a non-Riemannian connection. In this geometry the antisymmetric tensor 3-form field determines the torsion of the connection on the frame bundle while the gradient of the metric is determined by the dilaton field. By expressing the theory in terms of the Levi-Civita connection associated with the metric in the ``Einstein frame'' we confirm that the field equations derived from the non-Riemannian Einstein-Hilbert action coincide with the axi-dilaton sector of the low energy effective action derived from string theory.Comment: 6 pages Plain Tex (No Figures), Letter to Editor Classical and Quantum Gravit

Opening up, closing down, or leaving ajar? How applications are used in engaging with publics about gene drive

This is the final version. Available from Taylor & Francis via the DOI in this record. Public engagement and responsible innovation are strongly emphasised in gene drive research, together with the goal of addressing societal challenges, notably, malaria and environmental conservation. We aim to explore whether public engagement is used to ‘open up' or ‘close down' opportunities to shape gene drive research. Drawing on interviews with gene drive developers and stakeholders, we investigate how the public communication of gene drive is conceived. We find that traditional closing-down tendencies remain, but that there are new and encouraging opening-up approaches. Consistent with responsible innovation thinking, these frame gene drive as multifaceted, context-dependent and requiring deeper deliberation. We also identify a third ‘leaving ajar’ approach that seeks to engage with and respond to local communities and modify technological applications to be more acceptable. Innovation system constraints may well temper current aspirations to open up; framing public conversations around understandings of public good could offer a way forward.Wellcome TrustCSIR

Bacteriological studies of blood, tissue fluid, lymph and lymph nodes in patients with acute dermatolymphangioadenitis (DLA) in course of ‘filarial’ lymphedema

Filarial lymphedema is complicated by frequent episodes of dermatolymphangioadenitis (DLA). Severe systemic symptoms during attacks of DLA resemble those of septicemia. The question we asked was whether bacterial isolates can be found in the peripheral blood of patients during the episodes of DLA. Out of 100 patients referred to us with ‘filarial’ lymphedema 14 displayed acute and five subacute symptoms of DLA. All were on admission blood microfilariae negative but had a positive test in the past. Blood bacterial isolates were found in nine cases, four acute (21%) and five subacute (26%). In 10 acute cases blood cultures were found negative. Six blood isolates belonged to Bacilli, four to Cocci and one was Sarcina. To identify the sites of origin of bacterial dissemination, swabs taken from the calf skin biopsy wounds and tissue fluid, lymph and lymph node specimens were cultured. Swabs from the calf skin biopsy wound contained isolates in nine (47%) cases. They were Bacilli in nine, Cocci in three, Acinetobacter and Erwinia in two cases. Tissue fluid was collected from 10 patients and contained Bacilli in four (40%) and Staphylococci in three (30%). Lymph was drained in four patients and contained isolates in all samples (100%). They were Staphylococcus epidermis, xylosus and aureus, Acinetobacter, Bacillus subtilis and Sarcina. Three lymph nodes were biopsied and contained Staphylococcus chromogenes, xylosus, Enterococcus and Bacillus cereus. In six cases the same phenotypically defined species of bacteria were found in blood and limb tissues or fluids. In the ‘control’ group of patients with lymphedema without acute or subacute changes all blood cultures were negative. Interestingly, swabs from biopsy wound of these patients contained isolates in 80%, tissue fluid in 68%, lymph in 70% and lymph nodes in 58% of cases. In healthy controls, tissue fluid did not contain bacteria, and lymph isolates were found only in 12% of cases. This study demonstrates that patients with acute episodes of DLA reveal bacteriemia in a high percentage of cases. Diversity of blood and tissue bacterial isolates in these patients points to a breakdown of the skin immune barrier in lymphedema and subsequently indiscriminate bacterial colonization of deep tissues and spread to an blood circulation. © 1999 Elsevier Science B.V. All rights reserved