Luther and Tamar

The George Frederick Harkins Lecture; discussion, pp 12-15; also presented as 1992 Lutheran Life Lecture. Reviewed Book: Steinmetz, David C. Luther and Tamar. Lutheran Theological Seminary Bulletin. Genesis 37-5

Luther and the Late Medieval Augustinians: Another Look

The question of the relationship of Martin Luther to the theological traditions of his own order, to which he was exposed in a lesser or greater degree, has remained one of the interesting, if unsolved problems of Luther research

The Effects of Gas Dynamics, Cooling, Star Formation, and Numerical Resolution in Simulations of Cluster Formation

We present the analysis of a suite of simulations of a Virgo mass galaxy cluster. Undertaken within the framework of standard cold dark matter cosmology, these simulations were performed at differing resolutions and with increasingly complex physical processes, with the goal of identifying the effects of each on the evolution of the cluster. We focus on the cluster at the present epoch and examine properties including the radial distributions of density, temperature, entropy and velocity. We also map `observable' projected properties such as the surface mass density, X-ray surface brightness and SZ signature. We identify significant differences between the simulations, which highlights the need for caution when comparing numerical simulations to observations of galaxy clusters. While resolution affects the inner density profile in dark matter simulations, the addition of a gaseous component, especially one that cools and forms stars, affects the entire cluster. We conclude that both resolution and included physical processes play an important role in simulating the formation and evolution of galaxy clusters. Therefore, physical inferences drawn from simulations that do not include a gaseous component that can cool and form stars present a poor representation of reality. (Abridged)Comment: Accepted for publication in the Astrophysical Journal. Several changes from previous version, including new materia

Single photon emission from silicon-vacancy centres in CVD-nano-diamonds on iridium

We introduce a process for the fabrication of high quality, spatially isolated nano-diamonds on iridium via microwave plasma assisted CVD-growth. We perform spectroscopy of single silicon-vacancy (SiV)-centres produced during the growth of the nano-diamonds. The colour centres exhibit extraordinary narrow zero-phonon-lines down to 0.7 nm at room temperature. Single photon count rates up to 4.8 Mcps at saturation make these SiV-centres the brightest diamond based single photon sources to date. We measure for the first time the fine structure of a single SiV-centre thus confirming the atomic composition of the investigated colour centres.Comment: 20 pages, 13 figures, accepted by New Journal of Physic

Rare Complications of Cervical Spine Surgery: Pseudomeningocoele.

STUDY DESIGN: This study was a retrospective, multicenter cohort study. OBJECTIVES: Rare complications of cervical spine surgery are inherently difficult to investigate. Pseudomeningocoele (PMC), an abnormal collection of cerebrospinal fluid that communicates with the subarachnoid space, is one such complication. In order to evaluate and better understand the incidence, presentation, treatment, and outcome of PMC following cervical spine surgery, we conducted a multicenter study to pool our collective experience. METHODS: This study was a retrospective, multicenter cohort study of patients who underwent cervical spine surgery at any level(s) from C2 to C7, inclusive; were over 18 years of age; and experienced a postoperative PMC. RESULTS: Thirteen patients (0.08%) developed a postoperative PMC, 6 (46.2%) of whom were female. They had an average age of 48.2 years and stayed in hospital a mean of 11.2 days. Three patients were current smokers, 3 previous smokers, 5 had never smoked, and 2 had unknown smoking status. The majority, 10 (76.9%), were associated with posterior surgery, whereas 3 (23.1%) occurred after an anterior procedure. Myelopathy was the most common indication for operations that were complicated by PMC (46%). Seven patients (53%) required a surgical procedure to address the PMC, whereas the remaining 6 were treated conservatively. All PMCs ultimately resolved or were successfully treated with no residual effects. CONCLUSIONS: PMC is a rare complication of cervical surgery with an incidence of less than 0.1%. They prolong hospital stay. PMCs occurred more frequently in association with posterior approaches. Approximately half of PMCs required surgery and all ultimately resolved without residual neurologic or other long-term effects

The accretion origin of the Milky Way's stellar halo

We have used data from the Sloan Digital Sky Survey (SDSS) Data Release 5 to explore the overall structure and substructure of the stellar halo of the Milky Way using about 4 million color-selected main sequence turn-off stars. We fit oblate and triaxial broken power-law models to the data, and found a `best-fit' oblateness of the stellar halo 0.5<c/a<0.8, and halo stellar masses between Galactocentric radii of 1 and 40kpc of (3.7+/-1.2)x10^8 M_sun. The density profile of the stellar halo is approximately r^{-3}; it is possible that the power law slope is shallower inside 20kpc and steeper outside that radius. Yet, we found that all smooth and symmetric models were very poor fits to the distribution of stellar halo stars because the data exhibit a great deal of spatial substructure. We quantified deviations from a smooth oblate/triaxial model using the RMS of the data around the model profile on scales >~100pc, after accounting for the (known) contribution of Poisson uncertainties. The fractional RMS deviation of the actual stellar distribution from any smooth, parameterized halo model is >~40%: hence, the stellar halo is highly structured. We compared the observations with simulations of galactic stellar halos formed entirely from the accretion of satellites in a cosmological context by analysing the simulations in the same way as the data. While the masses, overall profiles, and degree of substructure in the simulated stellar halos show considerable scatter, the properties and degree of substructure in the Milky Way's halo match well the properties of a `typical' stellar halo built exclusively out of the debris from disrupted satellite galaxies. Our results therefore point towards a picture in which an important fraction of the Milky Way's stellar halo has been accreted from satellite galaxies.Comment: Submitted to the Astrophysical Journal. 14 pages; 11 figure

Radial Mixing in Galactic Disks: The Effects of Disk Structure and Satellite Bombardment

We use a suite of numerical simulations to investigate the mechanisms and effects of radial migration of stars in disk galaxies like the Milky Way (MW). An isolated, collisionless stellar disk with a MW-like scale-height shows only the radial "blurring" expected from epicyclic orbits. Reducing the disk thickness or adding gas to the disk substantially increases the level of radial migration, induced by interaction with transient spiral arms and/or a central bar. We also examine collisionless disks subjected to gravitational perturbations from a cosmologically motivated satellite accretion history. In the perturbed disk that best reproduces the observed properties of the MW, 20% of stars that end up in the solar annulus 7 kpc < R < 9 kpc started at R < 6 kpc, and 7% started at R > 10 kpc. This level of migration would add considerable dispersion to the age-metallicity relation of solar neighborhood stars. In the isolated disk models, the probability of migration traces the disk's radial mass profile, but in perturbed disks migration occurs preferentially at large radii, where the disk is more weakly bound. The orbital dynamics of migrating particles are also different in isolated and perturbed disks: satellite perturbations drive particles to lower angular momentum for a given change in radius. Thus, satellite perturbations appear to be a distinct mechanism for inducing radial migration, which can operate in concert with migration induced by bars and spiral structure. We investigate correlations between changes in radius and changes in orbital circularity or vertical energy, identifying signatures that might be used to test models and distinguish radial migration mechanisms in chemo-dynamical surveys of the MW disk.Comment: Full resolution paper available at http://www.astronomy.ohio-state.edu/~bird/bkw11_fullres.pdf . 13 pages, 12 figures; emulate MNRAS format. Accepted for publication in MNRA

Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β during Dectin-1 signaling

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is produced by many cell types, but has predominantly been characterized as a secreted factor from epithelial cells which activates dendritic cells (DC) that subsequently prime T helper (TH) 2 immunity. However, DC themselves make significant amounts of TSLP in response to microbial products, but the functional role of DC-derived TSLP remains unclear. We show that TSLPR signaling negatively regulates IL-1β production during dectin-1 stimulation of human DC. This regulatory mechanism functions by dampening Syk phosphorylation and is mediated via NADPH oxidase-derived ROS, HIF-1α and pro-IL-1β expression. Considering the profound effect TSLPR signaling has on the metabolic status and the secretome of dectin-1 stimulated DC, these data suggest that autocrine TSLPR signaling could have a fundamental role in modulating immunological effector responses at sites removed from epithelial cell production of TSLP

An epidemic CC1-MRSA-IV clone yields false-negative test results in molecular MRSA identification assays: a note of caution, Austria, Germany, Ireland, 2020

We investigated why a clinical meticillin-resistant Staphylococcus aureus (MRSA) isolate yielded false-negative results with some commercial PCR tests for MRSA detection. We found that an epidemic European CC1-MRSA-IV clone generally exhibits this behaviour. The failure of the assays was attributable to a large insertion in the orfX/SCCmec integration site. To ensure the reliability of molecular MRSA tests, it is vital to monitor emergence of new SCCmec types and junction sites