Multiple organ failure - death of consumer protection?

The enormously profitable complementary medicines, dietary supplements and traditional medicines markets are largely unregulated internationally and South Africa. Attempts to ensure that consumers are not exposed to harmful or ineffective products have met with varying success around the world

Evaluating Needs of Older Adults in Massachusetts Communities

Throughout Massachusetts, the ongoing demographic shift toward an older population has required most cities and towns to reevaluate the adequacy of services and programs for older adults. By 2030, the vast majority of municipalities in Massachusetts will have unprecedented proportions of people age 60 or over

Mouse spleen lymphoblasts generated in vitro. Their replication and differentiation in vitro

Mouse spleen lymphoblasts induced with lipopolysaccharide and fetal calf serum were obtained in high yield and purity in their first proliferative cell cycle by floatation in dense bovine plasma albumin columns (3). The blasts were maintained in vitro for 3 more days. The cultures were examined in bulk on each day, and in addition, those cells in S phase initially were tagged with [(3)H]thymidine and followed continuously in vitro. Grain count dilution data indicated that most blasts divided but twice over a 2- to 3-day interval in vitro. [(3)H]Thymidine pulse radiolabeling and flow microfluorometry suggested that at least 50-70 percent of the proliferating blasts withdrew from proliferative activity after 2-3 days of culture. Morphologic studies demonstrated that lymphoblasts persisted as such for 1-2 days in vitro and then matured into typical plasma cells. Many of the blastprogeny had small nuclei and considerable basophilic cytoplasm on Giemsa-stained cell smears; abundant rough endoplasmic reticulum by electron microscopy; and readily detectable cytoplasmic Ig by immunocytochemistry. Reversion of blasts to small lymphocytes could not be detected; however, some blasts persisted even after 3 days of culture. The viability of the cultured lymphoblast was followed by initially tagging the cells with [(3)H]thymidine as well as several other techniques. Little cell death was documented during the first day of culture. The number of labeled progeny increased twofold whereas the grain count halved. But 40- 50 percent of the cell-associated label was lost during each of the second and third days, and fewer labeled progeny than predicted by grain count dilution were identified. The culture medium could not be implicated in this loss of lymphoblast progeny, and we suggest that the maturation of the lymphoblast to a short-lived plasma cell was responsible. Therefore mitogen-stimulated B blasts seem to mature into typical plasma cells after just two cycles of cell division. The plasma cells resemble those produced in situ during an immune response in their cytologic features, withdrawal from active proliferative activity, and short life-span

Assessing Current and Future Needs of Residents Aging in the Town of Andover

This report describes the collaborative efforts undertaken by the Town of Andover Division of Elder Services and the Center for Social and Demographic Research on Aging, within the McCormack Graduate School at the University of Massachusetts Boston. Beginning in Fall 2014, these organizations joined to conduct a needs assessment to investigate the needs, interests, preferences and opinions of the Town’s older resident population, with respect to aging in Andover. The focus of this report is on two cohorts of Andover residents—those who are age 50 to 59 (referred to as “Boomers”) and the cohort of individuals who are currently age 60 and older (“Seniors”). Within the older cohort of Seniors, we also conducted selected analyses on subgroups (e.g., ages 60 to 79; 60 to 69; 70 to 79; and 80 and older) to highlight important differences by age group. During this assessment, several research methods were utilized in order to sketch a multidimensional image of the Town’s older residents that could be used to plan and implement current and future services for older residents in Andover. We began the process by examining public data from the U.S. Census Bureau to describe basic demographic characteristics, as well as economic characteristics, disability status, and living situations of older people in the Town. Early in the project we invited Town residents to attend a community forum, to better understand how residents perceive current and future aging-related needs of the Town. We used information gathered at this meeting to develop a survey instrument to be administered to a randomly selected sample of residents from both age cohorts. We conducted two focus groups to obtain feedback from various stakeholders who regularly interact with older residents, regarding issues and concerns about aging in Andover. We conducted interviews with four key stakeholders to acquire input from local experts on the implications of the aging population, and the functioning of the Center at Punchard. We produced three maps depicting town resources that are perceived as assets to aging in place in Andover by older adult residents. Finally, we conducted a comparison of Senior Centers in three towns that are similar to Andover to assess how needs of older adults are met in other nearby communities. Collectively, the content of this report is intended to inform the Andover Division of Elder Services and the Center at Punchard, along with other offices within the Town with a stake in the aging of Andover, and organizations that provide services to older residents, as well as those who advocate for older people, and community members at large

Roughening of the (1+1) interfaces in two-component surface growth with an admixture of random deposition

We simulate competitive two-component growth on a one dimensional substrate of $L$ sites. One component is a Poisson-type deposition that generates Kardar-Parisi-Zhang (KPZ) correlations. The other is random deposition (RD). We derive the universal scaling function of the interface width for this model and show that the RD admixture acts as a dilatation mechanism to the fundamental time and height scales, but leaves the KPZ correlations intact. This observation is generalized to other growth models. It is shown that the flat-substrate initial condition is responsible for the existence of an early non-scaling phase in the interface evolution. The length of this initial phase is a non-universal parameter, but its presence is universal. In application to parallel and distributed computations, the important consequence of the derived scaling is the existence of the upper bound for the desynchronization in a conservative update algorithm for parallel discrete-event simulations. It is shown that such algorithms are generally scalable in a ring communication topology.Comment: 16 pages, 16 figures, 77 reference

Two classes of generalized functions used in nonlocal field theory

We elucidate the relation between the two ways of formulating causality in nonlocal quantum field theory: using analytic test functions belonging to the space $S^0$ (which is the Fourier transform of the Schwartz space $\mathcal D$) and using test functions in the Gelfand-Shilov spaces $S^0_\alpha$. We prove that every functional defined on $S^0$ has the same carrier cones as its restrictions to the smaller spaces $S^0_\alpha$. As an application of this result, we derive a Paley-Wiener-Schwartz-type theorem for arbitrarily singular generalized functions of tempered growth and obtain the corresponding extension of Vladimirov's algebra of functions holomorphic on a tubular domain.Comment: AMS-LaTeX, 12 pages, no figure

Eye movements and hazard perception in active and passive driving

Differences in eye movement patterns are often found when comparing passive viewing paradigms to actively engaging in everyday tasks. Arguably, investigations into visuomotor control should therefore be most useful when conducted in settings that incorporate the intrinsic link between vision and action. We present a study that compares oculomotor behaviour and hazard reaction times across a simulated driving task and a comparable, but passive, video-based hazard perception task. We found that participants scanned the road less during the active driving task and fixated closer to the front of the vehicle. Participants were also slower to detect the hazards in the driving task. Our results suggest that the interactivity of simulated driving places increased demand upon the visual and attention systems than simply viewing driving movies. We offer insights into why these differences occur and explore the possible implications of such findings within the wider context of driver training and assessment