4 research outputs found
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.
- Author
- Al-Shahrour F. (Fatima)
- Atwal G. (Gurnit)
- Atwal G. (Gurnit)
- Bailey P.J. (Peter J.)
- Biankin A.V. (Andrew)
- Boutros P.C. (Paul C.)
- Campbell P.J. (Peter)
- Chang D.K. (David K.)
- Cooke S.L. (Susanna)
- Cuppen E. (Edwin)
- Danyi A. (Alexandra)
- de Ridder J. (Jeroen)
- Deshpande V. (Vikram)
- Faltas B.M. (Bishoy M.)
- Faquin W.C. (William C.)
- Garraway L. (Levi)
- Getz G. (Gad)
- Getz G. (Gad)
- Grimmond S.M. (Sean)
- Haider S.A. (Syed A.)
- Herpen C.M.L. (Carla)
- Hoadley K.A. (Katherine A.)
- Jiao W. (Wei)
- Jiao W. (Wei)
- Kaiser V.B. (Vera B.)
- Karlic R. (Rosa)
- Kato M. (Mamoru)
- KĂŒbler K. (Kirsten)
- Lazar A.J. (Alexander J.)
- Li C.H. (Constance H.)
- Lolkema M.P. (Martijn)
- Louis D.N. (David)
- Margolin A. (Adam)
- Martin S. (Sandra)
- Morris Q. (Quaid)
- Nahal-Bose H.K. (Hardeep K.)
- Nielsen G.P. (G. Petur)
- Nik-Zainal S. (Serena)
- Omberg L. (Larsson)
- Perry M.D. (Marc D.)
- Polak P.
- Polak P. (Paz)
- Pâng C. (Christine)
- Rheinbay E. (Esther)
- Rubin M.A. (Mark A.)
- Semple C.A. (Colin A.)
- Sgroi D.C. (Dennis)
- Shibata T. (Tatsuhiro)
- Siebert R. (Reiner)
- Smith J. (Jaclyn)
- Steeghs N. (Neeltje)
- Stein L.D. (Lincoln D.)
- Stein L.D. (Lincoln)
- Stobbe M.D. (Miranda D.)
- Sun R.X. (Ren X.)
- Thai K. (Kevin)
- Wright D.W. (Derek W.)
- Wu C.-L. (Chin-Lee)
- Yuan K. (Ke)
- Zhang J. (Junjun)
- Publication venue
- Nat Commun
- Publication date
- 01/01/2020
- Field of study
In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA
References
- Author
- A. Anker A. Reinhart, T. Feeley
- A. Bandura
- A. Bandura
- A. Black
- A. Brine J. Feather
- A. Curry
- A. Dick
- A. Foster
- A. Foster C. Urquhart, J. Turner
- A. Foster N. Ford
- A. Giddens
- A. Giddens
- A. Glass K. Holyoak, J. Santa
- A. GonzĂĄlez-Teruel M.F. Abad-GarcĂa
- A. Goulding
- A. Gralewska-Vickery
- A. Green
- A. Hardy
- A. Hektor
- A. Lang J. Newhagen, B. Reeves
- A. Laplante J.S. Downie
- A. Large J. Beheshti, A. Breuleux
- A. Large V. Nesset, J. Beheshti
- A. MacIntosh-Murray C.W. Choo
- A. MacIntosh-Murray C.W. Choo
- A. Medaille
- A. PĂĄlsdĂłttir
- A. Rees T. Saracevic
- A. Sairanen R. Savolainen
- A. Sandstrom P.E. Sandstrom
- A. Schutz
- A. Schutz
- A. Schutz
- A. Spink
- A. Spink C. Cole
- A. Spink C. Cole
- A. Spink H.C. Ozmutlu, D.P. Lorence
- A. Spink K.E. Bray, M. Jaeckel, G. Sidberry
- A. Stone S. Shiffman
- A. Tinker C. McCreadie, A. Salvage
- A.D. Pratt
- A.E. Biesecker T.D. Biesecker
- A.F. Farhoomand D.H. Drury
- A.H. Maslow
- A.H. Maslow
- A.I. Goldman
- A.J. Flanagin M.J. Metzger
- A.J. Onwuegbuzie R.B. Johnson, K. Collins
- A.J. Whitt
- A.K. Feltwell C.E. Rees
- A.K. Matthews S.A. Sellergren, C. Manfredi, M. Williams
- A.K. Shenton P. Dixon
- A.K. Shenton P. Dixon
- A.K. Shenton P. Dixon
- A.K. Shenton P. Dixon
- A.K. Shenton S. Hayter
- A.M. Cox P.D. Clough, J. Marlow
- A.M. Rubin
- A.M. Rubin
- A.M. Turner Z. Stavri, D. Revere, R. Altamore
- A.N. Leontâev
- A.R. Cohen E. Stotland, D.M. Wolfe
- A.S. Babrow
- A.S. Babrow C.R. Kasch, L.A. Ford
- A.V. Cicourel
- Auerbach
- B. Berelson
- B. Boyce C. Meadow, D. Kraft
- B. Cronin
- B. Cronin C.A. Hert
- B. Crowley
- B. Dervin
- B. Dervin
- B. Dervin
- B. Dervin
- B. Dervin
- B. Dervin
- B. Dervin
- B. Dervin
- B. Dervin
- B. Dervin
- B. Dervin B.S. Greenberg
- B. Dervin M. Nilan
- B. Dervin M. Nilan, T. Jacobson
- B. Dervin P. Dewdney
- B. Dervin S. Ellyson, G. Hawkes, G. Guagnano, N. White
- B. Dervin T. Jacobson, M. Nilan
- B. Glaser A. Strauss
- B. Gratch
- B. Guo
- B. Henning P. Vorderer
- B. HjĂžrland
- B. HjĂžrland
- B. HjĂžrland
- B. HjĂžrland
- B. HjĂžrland
- B. HjĂžrland
- B. HjĂžrland
- B. HjĂžrland F.S. Christensen
- B. HjĂžrland H. Albrechtsen
- B. Huberman P. Pirollis, J. Pitkow, R. Lukose
- B. Latour S. Woolgar
- B. Mehra
- B. Reeves
- B. Schwartz
- B. Slife R.N. Williams
- B. Vavrek
- B. Xie
- B. Zelizer
- B.-A. Lipetz
- B.B. Stern
- B.B. Stern
- B.C. OâConnor J.H. Copeland, J.L. Kearns
- B.D. Ruben
- B.E. Ellis
- B.E. Ellis
- B.E. Ellis
- B.H. Westley Jr. Maclean
- B.H. Westley L.C. Barrow
- B.J. Jansen K. Sobel, G. Cook
- B.J. Jansen S.Y. Rieh
- B.K. Kaye T.J. Johnson
- B.L. Allen
- B.M. Hemminger D. Lu, K.T.L. Vaughan, S.J. Adams
- B.M. Wildemuth
- B.P. Frohmann
- C. Atkin
- C. Atkin
- C. Atkin
- C. Barry
- C. Barry
- C. Batson J. Coke, F. Chard, D. Smith, A. Taliaferro
- C. Chen P. Hernon
- C. Chu
- C. Cole
- C. Cole
- C. Cole
- C. Cole
- C. Cole J. Leide, J. Beheshti, A. Large, M. Brooks
- C. Cole S. Balasubramanian
- C. Cool
- C. Courtright
- C. Courtright
- C. Dee
- C. Fulton
- C. Fulton
- C. Fulton
- C. Fulton
- C. Gaziano
- C. Geertz
- C. Gould
- C. Gould G. Handler
- C. Gould K. Pearce
- C. Haras
- C. Haythornthwaite
- C. Larkin
- C. Lasch
- C. Marton
- C. Mellon
- C. Metoyer-Duran
- C. Metoyer-Duran
- C. Mnubi-Mchombu J. Mostert, D. Ocholla
- C. Muha K. Smith, S. Baum, J. Ter Maat, J. Ward
- C. Naumer
- C. Ostroff S.W. Kozlowski
- C. Pavitt
- C. Perrow
- C. Prabha L.S. Connaway, L. Olszewski, L.R. Jenkins
- C. Richmond
- C. Saunders J. Jones
- C. Shah
- C. Shannon
- C. Stilwell
- C. Tenopir D.W. King
- C. Tenopir D.W. King, J. Spencer, L. Wu
- C. Urquhart
- C. Urquhart
- C. Urquhart A. Light, R. Thomas, A. Barker, A. Yeoman, J. Cooper, C. Armstrong, R. Fenton, R. Lonsdale, A. Spink
- C. Walters
- C. Warwick J. Rimmer, A. Blandford, J. Gow, G. Buchanan
- C.A. Beverley P.A. Bath, R. Barber
- C.A. Johnson
- C.A. Johnson
- C.A. Lowe M.B. Eisenberg
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau
- C.C. Kuhlthau S.L. Tama
- C.C. Spencer
- C.D. Brown
- C.D. Brown
- C.D. Brown
- C.E. Nelson D.K. Pollock
- C.E. Rees P.A. Bath
- C.E. Rees P.A. Bath
- C.E. Rees P.A. Bath
- C.F. Landry
- C.F. Overhage R.J. Harman
- C.F. Timmers C.A.W. Glas
- C.G. Walker
- C.J. Fox
- C.K. Mick G.N. Lindsey, D. Callahan
- C.L. Borgman
- C.L. Borgman
- C.L. Borgman J. Furner
- C.L. Liew S.N. Ng
- C.L. Palmer
- C.L. Palmer
- C.L. Palmer L.J. Neumann
- C.M. Brown
- C.M. Dixon
- C.P. Lee C.B. Trace
- C.R. Berger
- C.R. Berger
- C.R. Berger
- C.R. Berger J.J. Bradac
- C.R. Berger R. Calabrese
- C.S. Knaus B.E. Pinkleton, E.W. Austin
- C.S. Ross
- C.S. Ross
- C.S. Ross
- C.W. Choo
- C.W. Choo
- C.W. Choo
- C.W. Choo E. Auster
- C.W. Choo P. Bergeron, B. Detlor, L. Heaton
- C.W. Eliot
- C.Y. Yoo
- D. Allen S. Karanasios, M. Slavova
- D. Allen T.D. Wilson
- D. Altheide
- D. Altheide
- D. Bawden L. Robinson
- D. Berlo
- D. Berlo
- D. Bilal
- D. Case
- D. Case G. Higgins
- D. Connelly E. Rich, S. Curley, J. Kelly
- D. Covell G. Uman, P. Manning
- D. Crane
- D. Crane
- D. Crane
- D. Dillman J. Smyth, L. Christian
- D. Dozier R. Rice
- D. Ellis
- D. Ellis
- D. Ellis
- D. Ellis D. Cox, K. Hall
- D. Ellis M. Haugan
- D. Elsweiler M. Wilson, B. Kirkegaard-Lunn
- D. Flaxbart
- D. Forsythe B. Buchanan, J. Osheroff, R. Miller
- D. Frey
- D. Frey M. Rosch
- D. Furse G. Punj, D. Stewart
- D. Goren
- D. Graber
- D. Graber
- D. Held
- D. Holt
- D. Katz R. Kahn
- D. Kelly
- D. Kemp
- D. Lajoie-Paquette
- D. Lehmann
- D. MacKay
- D. Mason C. Lamain
- D. McQuail M. Gurevitch
- D. McQuail S. Windahl
- D. Mick C. Buhl
- D. Mick M. DeMoss
- D. Nahl
- D. Nahl
- D. Nauta
- D. Nicholas P. Williams, A. Smith, P. Longbottom
- D. Nicholas P. Williams, P. Cole, H. Martin
- D. Price
- D. Raber
- D. Sears J. Freedman
- D. Sperber D. Wilson
- D. Tewksbury
- D. Turner
- D. Warner J.D. Procaccino
- D. Watts
- D. Wolton
- D. Zillmann J. Bryant
- D. Zillmann J. Bryant
- D. Zweizig
- D.A. Davis M.A. Thomson, A.D. Oxman, R.B. Haynes
- D.A. Ferguson E.M. Perse
- D.A. Wicks
- D.A. Wicks
- D.C. Stam
- D.C. Stam
- D.E. Agosto S. Hughes-Hassell
- D.E. Agosto S. Hughes-Hassell
- D.E. Berlyne
- D.E. Brashers
- D.E. Brashers D.J. Goldsmith, E. Hsieh
- D.E. Brashers J.L. Neidig, S.M. Haas, L.K. Dobbs, L.W. Cardillo, J.A. Russell
- D.H. Fischer
- D.H. Silvio
- D.H. Sonnenwald
- D.H. Sonnenwald B.M. Wildemuth, G.L. Harmon
- D.H. Sonnenwald L.G. Pierce
- D.H. Sonnenwald M. Iivonen
- D.J. Owen M.L.-E. Fang
- D.J. Saab U.V. Riss
- D.K. Allen T.D. Wilson, A. Norman, C. Knight
- D.K. Campbell
- D.L. Howard
- D.O. Case
- D.O. Case
- D.O. Case
- D.O. Case
- D.O. Case
- D.O. Case
- D.O. Case
- D.O. Case
- D.O. Case C.B. Borgman, C.T. Meadow
- D.O. Case E.M. Rogers
- D.O. Case J.D. Johnson, J.E. Andrews, S. Allard, K.M. Kelly
- D.O. Case J.D. Johnson, J.E. Andrews, S.L. Allard
- D.R. Longo
- D.T. Campbell J.C. Stanley
- D.W. King C. Tenopir
- D.W. King J. Casto, H. Jones
- D.W. Stephens J.R. Krebs
- E. Auster C. Choo
- E. Babbie
- E. Bierbaum
- E. Davenport
- E. Davenport H. Hall
- E. Davenport M. Higgins, I. Somerville
- E. Diener R. Crandall
- E. Dresang
- E. Durkheim
- E. Florio J. DeMartini
- E. Friedson
- E. Goffman
- E. Goffman
- E. Goffman
- E. Herman
- E. Herman
- E. Katz
- E. Katz J. Blumler, M. Gurevitch
- E. McCaughan H. McKenna
- E. Moyer-Gusé
- E. Prigoda P.J. McKenzie
- E. Strother D. Lancaster, J. Gardiner
- E. Swanson
- E. Thivant
- E. Tufte
- E. Warner A.D. Murray, V.E. Palmour
- E. Webb D. Campbell, R. Schwartz, L. Sechrest, J. Grove
- E. Wenger
- E. Whitmire
- E. Yakel
- E. Zerbinos
- E.A. Chatman
- E.A. Chatman
- E.A. Chatman
- E.A. Chatman
- E.A. Chatman
- E.A. Chatman
- E.A. Chatman
- E.A. Chatman
- E.A. Chatman
- E.A. Chatman V. Pendleton
- E.C. Hirschman M.B. Holbrook
- E.F.J. ter Huurne R.J. Griffen, J.M. Gutteling
- E.G. Detlefsen
- E.G. Guba Y.S. Lincoln
- E.G. Toms W. Duff
- E.M. Meyers K.E. Fisher, E. Marcoux
- E.M. Meyers K.E. Fisher, E. Marcoux
- E.M. Rogers
- E.M. Rogers
- E.M. Rogers
- E.T. Hewins
- E.W. Morrison
- E.W. Morrison
- F. Aguilar
- F. Campbell
- F. Chew
- F. Chew S. Palmer
- F. Dretske
- F. Hultgren L. Limberg
- F. Kerlinger
- F. Machlup
- F. Machlup U. Mansfield
- F. Thompson
- F. Williams H. Dordick, F. Horstmann
- F.I. Dretske
- F.I. Dretske
- F.M. Wolf
- F.X. Sligo A.M. Jameson
- G. Bateson
- G. Bateson
- G. Baxter R. Marcella, L. Illingworth
- G. Benoit
- G. Benoit
- G. Burnett M. Besant, E.A. Chatman
- G. Burnett P.T. Jaeger
- G. Burrell G. Morgan
- G. de Alwis S. Majid, A. Chaudhry
- G. Downey
- G. Huber R. Sorrentino
- G. Kelly
- G. Klein
- G. Krampen C. Fell, G. Schui
- G. Marchionini
- G. Marchionini
- G. McCracken
- G. Nunberg
- G. Ritzer
- G. Salton M. McGill
- G. Shapiro
- G. ThĂłrsteinsdĂłttir
- G. van der Rijt
- G. Wersig G. Windel
- G. Wersig U. Neveling
- G. Widén-Wulff
- G. Widén-Wulff E. Davenport
- G. Widén-Wulff M. Ginman
- G. Zipf
- G.A. Donohue C.N. Olien, P.J. Tichenor
- G.A. Miller
- G.A. Miller
- G.A. Miller
- G.A. Miller E. Galanter, K.H. Pribram
- G.J. Klir
- G.J. Leckie
- G.J. Leckie
- G.J. Leckie K.E. Pettigrew, C. Sylvain
- G.R. Foxall
- G.R. Miller
- G.W. Allport L. Postman
- G.W. Cermak
- H. Belefant-Miller D.W. King
- H. Belefant-Miller D.W. King
- H. Blumer
- H. Bruce
- H. Bruce
- H. Bruce
- H. Bruce R. Fidel, A.M. Pejtersen, S. Dumais, J. Grudin, S. Poltrock
- H. Cho R. LaRose
- H. Fabritius
- H. Gardner
- H. Garfinkel
- H. Hall
- H. Hörz
- H. Julien
- H. Julien
- H. Julien
- H. Julien
- H. Julien
- H. Julien D. Michels
- H. Julien J.L. Pecoskie, K. Reed
- H. Julien L. Duggan
- H. Julien L.M. Given
- H. Kenner
- H. Mason L. Robinson
- H. Mendelsohn
- H. Mendelsohn
- H. Menzel
- H. Menzel
- H. Menzel
- H. Menzel
- H. Mintzberg
- H. Mokros L. Mullins, T. Saracevic
- H. Morowitz
- H. Poole
- H. Proper P. Bruza
- H. Rosenbaum
- H. Schiller
- H. Simon
- H. Tibbo
- H. Wellisch
- H. Zuckerman
- H.A. Kitchin
- H.A. Murray
- H.D. White
- H.H. Hyman P.B. Sheatsley
- H.L. Shuchman
- H.P. Hogeweg de Haart
- H.R. Jamali D. Nicholas
- H.W.J. Meyer
- I. Cornelius
- I. Fourie
- I. Fourie
- I. Getz G. Weissman
- I. Hacking
- I. Haruna I. Mabawonku
- I. Huvila
- I. Huvila
- I. Roeh
- I.D.S. Price
- I.I. Ekoja
- I.V. Cornelius
- J. Agada
- J. Bichteler D. Ward
- J. Blythe J. Royle
- J. Bosman K. Renckstorf
- J. Bronstein
- J. Bronstein S. Baruchson-Arbib
- J. Brown P. Duguid
- J. Bryant D. Miron
- J. Bryant P. Vorderer
- J. Campbell
- J. Clements
- J. Coleman
- J. Creelman R.M. Harris
- J. Dewey
- J. Dewey
- J. Dimmick S. Kline, L. Stafford
- J. Dupuit
- J. Durlak
- J. Ely R. Burch, D. Vinson
- J. Foster
- J. Fry
- J. Furner
- J. Grunig
- J. Habermas
- J. Haider D. Bawden
- J. Hallmark
- J. Harrison M. Hepworth, P. de Chazal
- J. Hartel
- J. Hartel
- J. Hartel
- J. Hartel
- J. Hauser G. Urban, B. Weinberg
- J. Heap
- J. Heinström
- J. Heinström
- J. Henefer C. Fulton
- J. Hersberger
- J. Hersberger
- J. Hersberger
- J. Hirshleifer
- J. Hyldegard
- J. Jacoby
- J. Jacoby D.D. Speller, C.A. Berning
- J. Janes R. McKinney
- J. Johannisson O. Sundin
- J. Kari R. Savolainen
- J. Katzer K. Cook, W. Crouch
- J. Klapper
- J. Kormos
- J. Krikelas
- J. Lave E. Wenger
- J. Lechte
- J. Liebnau J. Backhouse
- J. March
- J. March Z. Shapira
- J. Marshall
- J. Martyn
- J. Newhagen
- J. Newhagen
- J. Niederdeppe
- J. Osheroff D. Forsythe, B. Buchanan, R. Bankowitz, B. Blumenfeld, R. Miller
- J. Otike
- J. Otto S. Metz, N. Ensmenger
- J. OâConnor
- J. OâMeara
- J. Palmer
- J. Piaget
- J. Potter
- J. Radway
- J. Reagan
- J. Rowley
- J. Salasin T. Cedar
- J. Schmidt R. Spreng
- J. Scott
- J. Searle
- J. Simon P. Burstein
- J. Stefl-Mabry
- J. Stefl-Mabry
- J. Stewart
- J. Urbany P. Dickson, W. Wilkie
- J. Ziman
- J.-N. Kim J.E. Grunig
- J.A. Abrahamson K.E. Fisher, A.G. Turner, J.C. Durrance, T.C. Turner
- J.A. Bates
- J.C. Durrance
- J.D. Brown K. Childers
- J.D. Haug
- J.D. Johnson
- J.D. Johnson
- J.D. Johnson
- J.D. Johnson D. Case, J.E. Andrews, S.L. Allard, N.E. Johnson
- J.D. Johnson D.O. Case
- J.D. Johnson H. Meischke
- J.D. Johnson J.E. Andrews, D.O. Case, S.L. Allard
- J.D. Johnson J.E. Andrews, S. Allard
- J.D. Lambert
- J.D. Rayburn P. Palmgreen
- J.E. Andrews J.D. Johnson, D.O. Case, S.L. Allard, K. Kelly
- J.E. Dunne
- J.G. Miller
- J.G. Miller
- J.H. Shera D.B. Cleveland
- J.J. Bradac
- J.L. Dorsch V. Pifalo
- J.L. Ozanne M. Brucks, D. Grewal
- J.M. Berryman
- J.M. Brittain
- J.M. Budd
- J.M. Budd
- J.M. Budd D. Raber
- J.M. Driscoll J.T. Lanzetta
- J.P. Spradley
- J.P. Spradley
- J.R. Schement
- J.R. Schement
- J.S. Bruner
- J.S. Bruner
- J.S. Hamer
- J.T. Cacioppo R.E. Petty
- J.T. Kitchens L. Powell, G. Williams
- J.W. Bowers J.J. Bradac
- J.W. Creswell V. Clark
- Jr. Gettier
- Jr. OâReilly
- Jr. Sherry
- Jr. Watt R. Krull
- K. Ankem
- K. Ankem
- K. Ankem
- K. Ankem
- K. Barzilai-Nahon
- K. Boulding
- K. Byström
- K. Byström K. JÀrvelin
- K. Chouhan B. Miles
- K. Davies
- K. Desouza Y. Awazu, Y. Wan
- K. Eriksson-Backa
- K. Eriksson-Backa
- K. Kellermann R. Reynolds
- K. Kelly A. Sturm, K. Kemp, J. Holland, A. Ferketich
- K. Krippendorff
- K. Krippendorff
- K. Lewin
- K. Martzoukou
- K. Oatley
- K. Ooi
- K. Popper
- K. Reuter
- K. Rioux
- K. Rosengren
- K. Rosengren
- K. Sweeny D. Melnyk, W. Miller, J. Shepperd
- K. Tuominen
- K. Tuominen S. Talja, R. Savolainen
- K. Viswanath J. Finnegan
- K. Weick
- K. Weick
- K. Williamson
- K. Williamson
- K. Williamson D.K. Smith
- K. Williamson R. Manaszewicz
- K. Williamson T. Asla
- K. Wise S. Alhabash, H. Park
- K. Yoon M.S. Nilan
- K.B. Levitan
- K.D. Knorr-Cetina
- K.E. Fisher
- K.E. Fisher C. Naumer, J.C. Durrance, L. Stromski, T. Christiansen
- K.E. Fisher C.F. Landry
- K.E. Fisher E. Marcoux, L.S. Miller, A. SĂĄnchez, E.R. Cunningham
- K.E. Fisher H. Julien
- K.E. Fisher J.C. Durrance, M.B. Hinton
- K.E. Pettigrew
- K.E. Pettigrew
- K.E. Pettigrew J.C. Durrance, K.T. Unruh
- K.E. Pettigrew L. McKechnie
- K.E. Pettigrew R. Fidel, H. Bruce
- K.L. Holmes E.R. Lenz
- K.M. Thompson
- K.W. Cogdill
- K.W. Deutsch
- L. Bebout J. Davis, D. Oehlerts
- L. Björneborn
- L. Bogart
- L. Bowler
- L. Donohew L. Tipton
- L. Donohew L. Tipton, R. Haney
- L. Donohew M. Nair, S. Finn
- L. Doyal I. Gough
- L. Floridi
- L. Freund E.G. Toms, J. Waterhouse
- L. Given
- L. Given
- L. Given
- L. Hussey
- L. Kahlor
- L. Kwasitsu
- L. Leung R. Wei
- L. Leung R. Wei
- L. Leydesdorff
- L. Lu Y. Yuan
- L. Mon
- L. Rosenblatt
- L. Salomon F. Koppelman
- L. Scott
- L. Seldén
- L. Seldén
- L. Thayer
- L. Van Snippenburg
- L. Vygotsky
- L. Westbrook
- L. Westbrook
- L. Westbrook
- L. Wheeler H. Reis
- L. Woudstra B. van den Hooff
- L. Zach
- L.A. Ford A.S. Babrow, C. Stohl
- L.D. Ritchie
- L.D. Ritchie
- L.D. Ritchie
- L.G. OâConnor
- L.I. Meho H.R. Tibbo
- L.I. Meho S.W. Haas
- L.I. Pearlin
- L.K. Gundry D.M. Rousseau
- L.M. Baker
- L.M. Baker
- L.M. Baker
- L.M. Baker
- L.M. Baker F.L. Wilson, C.K. Nordstrom, C. Legwand
- L.M. Baker K.E. Pettigrew
- L.M. Baker P. Case, D.L. Policicchio
- L.M. McKechnie K.E. Pettigrew
- L.M. McKechnie L. Baker, M. Greenwood, H. Julien
- L.P. Ayres A. McKinnie
- L.S. Connaway T.J. Dickey, M.L. Radford
- L.Z. Cooper
- M. Alexandersson L. Limberg
- M. Ansari N. Zuberi
- M. Anwar H. Supaat
- M. Anwar M. Asghar
- M. Bianchi
- M. Brucks
- M. Csikszentmihalyi
- M. Davis
- M. de Certeau
- M. du Preez I. Fourie
- M. Dupagne B. Garrison
- M. Ekström
- M. Fishbein I. Ajzen
- M. Foucault
- M. Foucault
- M. Frické
- M. Frické
- M. Friestad P. Wright
- M. Gross
- M. Gross
- M. Gross M. Saxton
- M. Heffernan
- M. Hepworth
- M. Hepworth J. Harrison
- M. Hepworth J. Harrison, N. James
- M. Hepworth J. Harrison, N. James
- M. Hertzum
- M. Hertzum
- M. Hertzum A.M. Pejtersen
- M. Higgins
- M. Hilbert
- M. Hunt
- M. Ignatieff
- M. Ipe
- M. Israel I. Hay
- M. Levine
- M. Levy S. Windahl
- M. Louis
- M. Masterman
- M. Max-Neef
- M. McCombs
- M. McCreadie R. Rice
- M. McKnight
- M. McKnight
- M. Miwa
- M. Morgan J. Shanahan
- M. Reneker
- M. Rokeach
- M. Slater
- M. Taylor A. Alman, A. David, D. Manchester
- M. Timko R.M.A. Loynes
- M. Voigt
- M. Wakeham
- M. Wikgren
- M. Yitzhaki G. Hammershlag
- M. Yovits C. Foulk
- M.-L. Huotari E.A. Chatman
- M.A. Robinson
- M.A. Spasser
- M.A. Wilkinson
- M.B. Eisenberg
- M.B. Line
- M.B. Ruvane
- M.C. Reddy B.J. Jansen
- M.C. Reddy P.R. Spence
- M.D. Kaplowitz T.D. Hadlock, R. Levine
- M.D. White
- M.D. White
- M.D. White E.E. Marsh
- M.D. White M. Matteson, E.G. Abels
- M.F. Stieg
- M.J. Bates
- M.J. Bates
- M.J. Bates
- M.J. Bates
- M.J. Bates
- M.J. Bates
- M.J. Bates
- M.J. Culnan
- M.J. Eppler J. Mengis
- M.K. Buckland
- M.K. Buckland
- M.K. Buckland
- M.K. Chelton
- M.L. Mackenzie
- M.L. Radford
- M.M. Bakhtin
- M.M. Davies P.A. Bath
- M.P. Holland C.K. Powell
- M.R. Olsson
- M.R. Olsson
- M.R. Olsson
- M.S. Dalton L. Charnigo
- M.S. Granovetter
- M.S. Granovetter
- N. Agarwal Y. Xu, D. Poo
- N. Awamura
- N. Bennett L. Casebeer, S. Zheng, R. Kristofco
- N. Caidi
- N. Caidi D. Allard
- N. Caidi D. Allard, L. Quirke
- N. Ford
- N. Ford
- N. Ford
- N. Godbold
- N. Kwak
- N. Kwon
- N. Kwon K. Kim
- N. Lin
- N. Lin W.D. Garvey
- N. Luhmann
- N. Roberts
- N.F. Rohde
- N.J. Belkin
- N.J. Belkin
- N.J. Belkin A. Vickery
- N.J. Belkin R. Oddy, H. Brooks
- N.J. Belkin S. Robertson
- N.O. Rosen B. KnÀuper
- N.P. Mooko
- N.P. Thomas J.M. Nyce
- N.S. Baldwin R.E. Rice
- North American Aviation
- O. Klapp
- O. Sundin
- O. Sundin
- O. Sundin J. Hedman
- P. Berger T. Luckmann
- P. Bloch D. Sherrell, N. Ridgway
- P. Bloch N. Ridgway, D. Sherrell
- P. Gerstberger T. Allen
- P. Gorman
- P. Gorman
- P. Gorman M. Helfand
- P. Gorman M. Lavelle, L. Delcambre, D. Maier
- P. Haig
- P. Hernon
- P. Holmöv
- P. Ingwersen
- P. Ingwersen K. JĂ€rvelin
- P. Katopol
- P. Liehr M. Smith
- P. Lunt S. Livingstone
- P. Mullaly-Quijas D. Ward, N. Woefl
- P. Norris
- P. Palmgreen
- P. Pirolli
- P. Pirolli S. Card
- P. Prekop
- P. Rothbauer
- P. Solomon
- P. Solomon
- P. Solomon
- P. Spacks
- P. Sturges
- P. Vakkari
- P. Vakkari
- P. Vorderer C. Klimmt, U. Ritterfeld
- P. Wang
- P. Wellstead
- P. Wilson
- P. Wilson
- P. Wilson
- P. Wilson
- P. Younger
- P. Zunde
- P.D. Reynolds
- P.E. Sandstrom
- P.E. Sandstrom
- P.F. Katopol
- P.J. McKenzie
- P.J. McKenzie
- P.J. McKenzie
- P.J. McKenzie
- P.J. McKenzie
- P.J. McKenzie
- P.J. McKenzie
- P.J. McKenzie
- P.J. Shoemaker
- P.J. Tichenor G.A. Donohue, C.N. Olien
- P.M. Edwards
- P.M. Rothbauer
- P.T. Jaeger G. Burnett
- P.T. Jaeger K.M. Thompson
- P.T. Manicas
- P.U. Kuruppu A.M. Gruber
- Q. Jiao A. Onwuegbuzie
- R. Abbott
- R. Atwood B. Dervin
- R. Bishop
- R. Capurro B. HjĂžrland
- R. Carter
- R. Carter
- R. Cherwitz J. Hikins
- R. Cyert H. Simon, D. Trow
- R. Czaja C. Manfredi, J. Price
- R. Darnton
- R. Davis C. Bailey
- R. Day
- R. Duncan
- R. Fairthorne
- R. Fidel
- R. Fidel A.M. Pejtersen, B. Cleal, H. Bruce
- R. Fidel M. Green
- R. Formanek
- R. Harré
- R. Harré
- R. Hayes
- R. Houston
- R. Ikoja-Odongo
- R. Ikoja-Odongo D.N. Ocholla
- R. Ikoja-Odongo D.N. Ocholla
- R. Ikoja-Odongo J. Mostert
- R. Krueger M.A. Casey
- R. Kubey M. Csikszentmihalyi
- R. Kubey R. Larson, M. Csikszentmihalyi
- R. Lachman J.L. Lachman, E.C. Butterfield
- R. Lion R.M. Meertens
- R. Little C. Williams, J. Yost
- R. Losee
- R. Marcella G. Baxter
- R. Marcella G. Baxter
- R. Marcella G. Baxter
- R. Mata L. Nunes
- R. Meier
- R. Merton
- R. Noble C. Coughlin
- R. Orr
- R. PerttilÀ S. Ek
- R. Rubin
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen J. Kari
- R. Savolainen J. Kari
- R. Savolainen J. Kari
- R. Schutt
- R. Schwarzer
- R. Stooke
- R. Thompson B. Croft
- R. Watson-Boone
- R. Wurman
- R. Yin
- R.A. Palmquist
- R.A. Stebbins
- R.A. Stebbins
- R.D. Daft J. Sormunen, D. Parks
- R.D. Daft R.H. Lengel
- R.D. Robertson
- R.E. Parks
- R.E. Rice C. Atkin
- R.E. Rice C.L. Borgman
- R.F. Carey L. McKechnie, P. McKenzie
- R.J. Gerrig D.A. Prentice
- R.J. Griffin S. Dunwoody, K. Neuwirth
- R.J. Todd
- R.J. Todd S. Edwards
- R.K. Merton
- R.K. Merton
- R.K. Merton M. Fiske, P. Kendall
- R.L. Derr
- R.L. Derr
- R.M. Harris
- R.M. Harris P. Dewdney
- R.M. Harris T.C. Veinot, L. Bella
- R.M. Roberts
- R.M. Sorrentino C.J.R. Roney
- R.S. Owen
- R.S. Taylor
- R.S. Taylor
- R.S. Taylor
- R.W. Belk
- R.W. Belk
- R.W. Belk J Sherry, M. Wallendorf
- R.W. Tardy C. Hale
- S. Allard K.J. Levine, C. Tenopir
- S. Apted
- S. Artandi
- S. Attfield A. Blandford, J. Dowell
- S. Attfield J. Dowell
- S. Baker
- S. Beer
- S. Borgatti A. Mehra, D. Brass, G. Labianca
- S. Bowler T. Donovan, J. Snipp
- S. Braman
- S. Braman
- S. Brier
- S. Chaffee
- S. Chang R. Rice
- S. Cobbledick
- S. Corcoran-Perry J. Graves
- S. Cowan
- S. Crawford
- S. Ek G. Widén-Wulff
- S. Ek J. Heinström
- S. Erdelez
- S. Erdelez
- S. Erdelez
- S. Erdelez
- S. Finn
- S. Finn
- S. Fish
- S. Folkman
- S. Fox
- S. Freud
- S. Hampshire
- S. Hayter
- S. Herner
- S. Herner M. Herner
- S. Hirsh
- S. Hirsh J. Dinkelacker
- S. Joyce
- S. Kiesler L. Sproull
- S. Livingstone
- S. Majid M. Anwar, T. Eisenschitz
- S. Makri C. Warwick
- S. Massey A. Druin, A. Weeks
- S. Massey A. Weeks, A. Druin
- S. Miller
- S. Mizzaro
- S. Neill
- S. Shugan
- S. Stone
- S. Sutton
- S. Talja
- S. Talja
- S. Talja
- S. Talja H. Keso, T. PietilÀinen
- S. Talja H. Maula
- S. Talja K. Tuominen, R. Savolainen
- S. Talja P. Hansen
- S. Thompson H. OâHair
- S. Turk-Charles B. Meyerowitz, M. Gatz
- S. Whittaker
- S.-C. Sin
- S.-J.L. Chang
- S.-J.L. Chang
- S.-J.L. Chang
- S.D. Lambert C.G. Loiselle
- S.E. Wiberley W.G. Jones
- S.E. Wiberley W.G. Jones
- S.E. Wiberley W.G. Jones
- S.H. Stocking P.H. Gross
- S.J. Tannenbaum
- S.L. Popkin
- S.M. Noar C.N. Benac, M.S. Harris
- S.P. Harter
- S.S. Adams
- S.S. Layne
- S.W. Littlejohn
- T. Ainslie
- T. Asla K. Williamson, J. Mills
- T. Childers J. Post
- T. Cook D. Campbell
- T. Cook L. Leviton
- T. Kuhn
- T. NĂžrretranders
- T. Park
- T. Pysczynski J. Greenberg, S. Solomon
- T. Rose
- T. Stonier
- T. Timpka E. Arborelius
- T.A. Finholt
- T.A. van Dijk W. Kintsch
- T.C. Veinot
- T.C. Veinot
- T.D. Afifi W.A. Afifi
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson D.R. Streatfield
- T.D. Wilson N. Ford, D. Ellis, A. Foster, A. Spink
- T.E. Pinelli
- T.E. Ruggiero
- T.J. Allen
- T.J. Allen
- T.J. Allen S.I. Cohen
- T.J. Froehlich
- T.J. Tidline
- T.J. Waldhart E.S. Waldhart
- T.L. Baker
- T.L. Mays
- T.L. von Thaden
- U. Josefsson
- V. Box M. Hepworth, J. Harrison
- V. Freimuth
- V. Freimuth T. Edgar, M. Fitzpatrick
- V. Jiyane D.N. Ocholla
- V. Palmour P. Rathbun, W. Brown, B. Dervin, P. Dowd
- V. Pifalo S. Hollander, C. Henderson, P. DeSalvo, G. Gill
- V. Rosenberg
- V.A. Walter
- V.D. Miller F.M. Jablin
- V.J. Janesick
- V.S. Freimuth J.A. Stein, T.J. Kean
- W. Beautyman A. Shenton
- W. Donnelly
- W. Gantz M. Fitzmaurice, E. Fink
- W. Hemmig
- W. Iser
- W. Jeong
- W. Schramm
- W. Shim
- W. Trochim J. Donnelly
- W. Weaver
- W.A. Afifi J.L. Weiner
- W.A. Afifi J.L. Weiner
- W.D. Garvey
- W.J. Paisley
- W.J. Paisley
- W.J. Paisley
- W.J. Paisley
- W.J. Paisley
- W.J. Paisley
- W.M. Duff C.A. Johnson
- W.M. Duff C.A. Johnson
- W.M. Goldstein R.M. Hogarth
- W.R. Garner
- X. Lan
- Y. Zhang
- Y. Zhao R. Zhang, K.K. Klein
- Y.B. Kafai M.J. Bates
- Y.J. Xu C.Y. Tan, L. Yang
- Y.L. Lu
- Y.L. Lu
- Y.S. Lincoln E.G. Guba
- Z. Correia T.D. Wilson
- Z. Stavri
- Publication venue
- 'Emerald'
- Publication date
- 01/01/2012
- Field of study
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
- Author
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Gonçalo R.)
- Abecasis G.R. (Gonçalo)
- Adair L.S. (Linda)
- Allison M.A. (Matthew)
- Altshuler D. (David)
- Altshuler D. (David)
- Amin N. (Najaf)
- An P. (Ping)
- Ardlie K.G. (Kristin)
- Ardlie K.G. (Kristin)
- Ariyurek Y. (Yavuz)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii)
- Bacquer O.L. (Olivier)
- Balkau B. (Beverley)
- Balkau B. (Beverley)
- Ballantyne C. (Christie)
- Ballantyne C.M. (Christie M.)
- Ballantyne C.M. (Christie M.)
- Bandinelli S. (Stefania)
- Bandinelli S. (Stefania)
- Barbalic M. (maja)
- Barroso I.
- Barroso I.E. (InĂȘs)
- Barroso I.E. (InĂȘs)
- Barter P. (Phil)
- Beekman M. (Marian)
- Beilby J.P. (John)
- Ben-Shlomo Y.
- Benediktsson R. (Rafn)
- Benediktsson R. (Rafn)
- Bennett A.J. (Amanda)
- Bennett A.J. (Amanda)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Bidulescu A. (Aurelian)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Bochud M. (Murielle)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E. (Eric)
- Boerwinkle E. (Eric)
- Boerwinkle E.A. (Eric)
- Bonnefond A. (Amélie)
- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret I)
- Boomsma D.I. (Dorret I.)
- Boomsma D.I. (Dorret)
- Borch-Johnsen K.
- Borecki I.B. (Ingrid B)
- Borja J.B. (Judith)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bravenboer B. (Bert)
- Brunner E. (Eric)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Bumpstead S. (Suzannah)
- Burtt N.P. (Noël P.)
- Burtt N.P. (Noël)
- Buxbaum S.G. (Sarah)
- Böhringer S. (Stefan)
- Böttcher Y. (Yvonne)
- Campbell H. (Harry)
- Campbell H. (Harry)
- Campbell H. (Harry)
- Cao A. (Antonio)
- Carlson O.D. (Olga)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Caulfield M.J. (Mark J.)
- Cavalcanti-Proença C. (Christine)
- Chambers J. (John)
- Chambers J.C. (John C.)
- Charpentier G. (Guillaume)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chen I. (Ida)
- Chen Y.-D.I. (Yii-Der Ida)
- Chen Y.D.I. (Yii-Der Ida)
- Chines P.S. (Peter S.)
- Chines P.S. (Peter)
- Cho Y.S. (Yoon Shin)
- Clarke R. (Robert)
- Coassin S. (Stefan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Cooper C. (Charles)
- Cooper C. (Cyrus)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Cornelis M. (Marilyn)
- Couper D.J. (David J.)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Crawford G. (Gabe)
- Crawford G. (Gabriel)
- Crisponi L. (Laura)
- Croteau-Chonka D.C. (Damien)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Dastani Z. (Zari)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Deloukas P. (Panagiotis)
- Delplanque J. (Jerome)
- DIAGRAM+ Consortium
- Dina C. (Christian)
- Dina C. (Christian)
- Dominiczak A. (Anna)
- Dominiczak A.F. (Anna F.)
- Doney A.S.F. (Alex S. F.)
- Doney A.S.F. (Alex)
- Duijn C.M. (Cornelia) van
- Duncan B.B. (Bruce)
- Dupuis J. (Josée)
- Dupuis J. (Josée)
- Dupuis J. (Josée)
- Döring A. (Angela)
- Ebrahim S. (Shanil)
- Egan J.M. (Josephine)
- Egan J.M. (Josephine)
- Ejebe K.G. (Kenechi)
- Elliott A.L. (Amanda)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Erdmann J. (Jeanette)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Erdos M.R. (Michael)
- Evans D.M. (David)
- Faire U. (Ulf) de
- Fedson A.C. (Annette)
- Feitosa M.F. (Mary Furlan)
- Ferreira T. (Teresa)
- Ferrucci L. (Luigi)
- Ferrucci L. (Luigi)
- Fischer-Rosinsky A. (Antje)
- Florez J.C. (Jose C.)
- Florez J.C. (Jose)
- Florez J.C. (Jose)
- Forouhi N.G. (Nita)
- Fouchier S.W. (Sigrid)
- Fox C.S. (Caroline)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Franklin C.S. (Christopher)
- Franks P.W. (Paul)
- Frants R. (Rune)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy)
- Froguel P. (Philippe)
- Froguel P. (Philippe)
- Fuchsberger C. (Christian)
- Gabriel S.B. (Stacey)
- Galan P. (Pilar)
- Ganser M. (Martha)
- Garcia M.E. (M.)
- Geus E.J.C. (Eco) de
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger C. (Christian)
- Glazer N.L. (Nicole)
- GLGC Investigators
- Gloyn A.L. (Anna L.)
- Gloyn A.L. (Anna)
- Go M.J. (Min Jin)
- Goel A. (Anuj)
- Gonzalez E. (Elena)
- Goodarzi M. (Mark)
- Graessler J. (JĂŒrgen)
- Grallert H. (Harald)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Grarup N. (Niels)
- Green T. (Todd)
- Greenwood C.M.T. (Celia)
- Griffin S. (Simon)
- Grimsby J. (Jonna)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Groves C.J. (Christopher)
- Grundy S.M. (Scott)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Guiducci C. (Candace)
- Guo X. (Xiuqing)
- Guo X. (Xiuqing)
- Gwilliam R. (Rhian)
- Gyllensten U. (Ulf)
- Gyllensten U. (Ulf)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair)
- Hallmans G. (Göran)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Han X. (Xijing)
- Hansen T. (Torben)
- Haritunians T. (Talin)
- Harris T.B. (Tamara B.)
- Harris T.B. (Tamara)
- Hartikainen A.L.
- Hassanali N. (Neelam)
- Hassanali N. (Neelam)
- Hastie N. (Nick)
- Hattersley A.T. (Andrew)
- Haun M. (Margot)
- Havulinna A.S. (Aki)
- Hayward C.
- Hayward C. (Caroline)
- Heath S.C. (Simon)
- Heemst D. (Diana) van
- Hegele R.A. (Robert)
- Heid I.M. (Iris)
- Heid I.M. (Iris)
- Hengstenberg C. (Christian)
- Henneman P. (Peter)
- Henneman P. (Peter)
- Hercberg S. (Serge)
- Herder C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew A.)
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hillman D.R. (David)
- Hingorani A. (Aroon)
- Hitman G.A. (Graham)
- Hivert M.-F. (Marie-France)
- Hoek M. (Mandy) van
- Hofman A.
- Hofman A. (Albert)
- Hofman A. (Albert)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Hottenga J.J. (Jouke Jan)
- Hottenga J.J. (Jouke Jan)
- Hovingh G.K. (Kees)
- Hu F.B. (Frank B)
- Hu F.B. (Frank B.)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Hung J. (Joe)
- Hunter D.J. (David)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Ingelsson E. (Erik)
- Ingelsson E. (Erik)
- Isaacs A. (Aaron)
- Isaacs A.J. (Aaron)
- Isomaa B. (Bo)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jackson A.U. (Anne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.-R. (Marjo-Riitta)
- Johansen C.T. (Christopher)
- Johansson A. (Ă sa)
- Johnson P.R.V. (Paul R. V.)
- Johnson P.R.V. (Paul)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jorgensen T. (Torben)
- Jorgensen T. (Torben)
- Jula A. (Antti)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kanaya A. (Alka)
- Kanoni S. (Stavroula)
- Kanoni S. (Stavroula)
- Kao W.H.L. (W. H. Linda)
- Kao W.H.L. (Wen H. L.)
- Kao W.H.L. (Wen)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaprio J. (Jaakko)
- Kapur K. (Karen)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Katsareli E. (Efi)
- Kedenko L. (Lyudmyla)
- Kesaniemi Y.A. (Antero)
- Khaw K.-T. (Kay-Tee)
- Khaw K.T.
- Kim Y-J. (Yong-Jin)
- Kim Y.J.
- Kivimaki M. (Mika)
- Kizer J.R. (Jorge)
- Klopp N. (Norman)
- Klopp N. (Norman)
- Kloppenburg M. (Margreet)
- Knight B. (Beatrice)
- Kong A. (Augustine)
- Kong A. (Augustine)
- Kooner J. (Jaspal)
- Koseki M. (Masahiro)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Kristiansson K. (Kati)
- Kronenberg F. (Florian)
- Kronenberg F. (Florian)
- Kumari M. (Meena)
- Kuusisto J. (Johanna)
- Kuzawa C.W. (Christopher W.)
- Kuzawa C.W. (Christopher)
- Kyvik K.O. (Kirsten O.)
- Kyvik K.O. (Kirsten Ohm)
- KÀhönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Ladouceur M. (Martin)
- Lajunen T. (Taina)
- Lakatta E.G. (Edward G.)
- Lamina C. (Claudia)
- Lamina C. (Claudia)
- Lange L.A. (Leslie)
- Lange L.A. (Leslie)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Lathrop G. (GMark)
- Launer L.J. (Lenore J.)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lecoeur C. (CĂ©cile)
- Lee J.-Y. (Jong-Young)
- LehtimÀki T. (Terho)
- Lettre G. (Guillaume)
- Li M. (Man)
- Li M. (Man)
- Li X. (Xiaohui)
- Li X. (Xiaohui)
- Li Y. (Yun)
- Lieverse A.G. (Aloysius)
- Lindgren C.M. (Cecilia M.)
- Lindgren C.M. (Cecilia)
- Liu C.-T. (Ching-Ti)
- Liu Y. (YongMei)
- Lohman K. (Kurt)
- Lokki M.L.
- Loo B.-M. (Britt-Marie)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Luan J. (Jianâan)
- Luan J. (Jianâan)
- Luben R.N. (Robert)
- Lucas G. (Gavin)
- Lyssenko V. (Valeriya)
- Lyssenko V. (Valeriya)
- LyytikÀinen L.-P. (Leo-Pekka)
- MAGIC Consortium
- Magnusson P.K. (Patrik)
- Magnusson P.K.E. (Patrik K. E.)
- Mahley R. (Robert)
- Mangino M. (Massimo)
- Mangino M. (Massimo)
- Manning A.K. (Alisa K.)
- Manning A.K. (Alisa)
- Marmot M. (Michael)
- Marre M. (Michel)
- Marroni F. (Fabio)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- Masson D. (David)
- McArdle W.L. (Wendy)
- McAteer J.B. (Jarred)
- McCarroll S.A. (Steve)
- McCarroll S.A. (Steven)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura J.)
- McCulloch L.J. (Laura)
- McPherson R. (Ruth)
- Meigs J.B. (James B.)
- Meigs J.B. (James)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Melzer D. (David)
- Meneton P. (Pierre)
- Meulenbelt I. (Ingrid)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Mitchell B.D. (Braxton)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen)
- Mooser V. (Vincent)
- Mooser V. (Vincent)
- Mooser V.E. (Vincent E.)
- Morken M.A. (Mario A.)
- Morken M.A. (Mario)
- Morris A.D. (Andrew D.)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew)
- Mukherjee S. (Sutapa)
- Munroe P. (Patricia)
- Musani S. (Solomon)
- Musunuru K. (Kiran)
- MuTHER Consortium
- MĂ€gi R. (Reedik)
- Naitza S. (Silvia)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Nathan D.M. (David)
- Navarro P. (Pau)
- Navarro P. (Pau)
- Neville M.J. (Matthew)
- Nickerson D.A. (Deborah A.)
- Nickerson D.A. (Deborah)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nuotio M.-L. (Marja-Liisa)
- Oostra B.A. (Ben A.)
- Oostra B.A. (Ben)
- Oostra B.A. (Ben)
- Ordovas J.M. (Jose M.)
- Ordovas J.M. (Jose)
- Orho-Melander M. (Marju)
- OrrĂč M. (Marco)
- Owen K.R. (Katharine)
- OâConnell J. (Jeffrey)
- Pakyz R. (Ruth)
- Palmer C. (Cameron)
- Palmer C.N.A. (Colin N. A.)
- Palmer C.N.A. (Colin)
- Pankow J.S. (James S.)
- Pankow J.S. (James)
- Paolisso G. (Giuseppe)
- Pare G. (Guillame)
- Park T. (Taesung)
- Parker A.N. (Alex)
- Pattaro C. (Cristian)
- Pattaro C. (Cristian)
- Pattou F. (François)
- Paulweber B. (Bernhard)
- Payne F. (Felicity)
- Payne F. (Felicity)
- Pearson D. (Daniel)
- Peden J. (John)
- Pedersen N.L. (Nancy)
- Pedersen O. (Oluf)
- Pedersen O. (Oluf)
- Peloso G.M. (Gina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Penninx B.W.J.H. (Brenda W. J. H.)
- Penninx B.W.J.H. (Brenda)
- Perola M. (Markus)
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John)
- Petersen A.K.
- Pfeiffer A.F.H. (Andreas)
- Pichler I. (Irene)
- Pichler I. (Irene)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Posthuma D. (Danielle)
- Potter S.C. (Simon)
- Pouta A. (Anneli)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter Paul)
- Pramstaller P.P. (Peter Paul)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Province M.A. (Mike)
- Psaty B.M. (Bruce M.)
- Psaty B.M. (Bruce)
- Qi L. (Lu)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quertermous T. (Thomas)
- Rader D.J. (Daniel)
- Raitakari O. (Olli)
- Randall J.C. (Joshua)
- Rasmussen-Torvik L.J. (Laura)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (Nigel W.)
- Rayner N.W. (Nigel William)
- Redline S. (Susan)
- Reilly M.P. (Muredach P.)
- Rice K.M. (Kenneth)
- Richards J.B. (J. Brent)
- Ricketts S.L. (Sally)
- Ridker P.M. (Paul)
- Rieder M. (Mark)
- Rieder M. (Mark)
- Ripatti S. (Samuli)
- Ripatti S. (Samuli)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Robertson N.R. (Neil)
- Roccasecca R.M.
- Rocheleau G. (Ghislain)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Roden M. (Michael)
- Rolandsson O. (Olov)
- Rose L.M. (Lynda)
- Rotter J.I. (Jerome I)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Ruokonen A. (Aimo)
- Ruokonen A. (Aimo)
- Rybin D. (Denis)
- Sabatti C. (Chiara)
- Saharinen J. (Juha)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampson M.J. (Michael J)
- Sampson M.J. (Michael)
- Sandbaek A. (Annelli)
- Sandhu M. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Sanna S. (Serena)
- Sattar N. (Naveed)
- Saxena R. (Richa)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric E.)
- Schadt E.E. (Eric)
- Scheet P. (Paul)
- Schlessinger D. (David)
- Schlessinger D. (David)
- Schunkert H. (Heribert)
- Schwarz P.E.H. (Peter)
- Scott L.J. (Laura J.)
- Scott L.J. (Laura)
- Scott R.A. (Robert)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Seedorf U. (Udo)
- SegrĂš A.V. (Ayellet)
- Seielstad M. (Mark)
- Semple R.K. (Robert K.)
- Serrano-RĂos M. (Manuel)
- Sethupathy P. (Praveen)
- Sharp S.J. (Stephen)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sigursson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric J. G.)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Silander K. (Kaisa)
- Silveira A. (Angela)
- Sim X. (Xueling)
- Sim X. (Xueling)
- Simpson L. (Laila)
- Singleton A. (Andrew)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Siscovick D.S. (David)
- Sladek R. (Rob)
- Sladek R. (Rob)
- Slagboom P.E. (Eline)
- Small K.S. (Kerrin)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith A.V. (Davey)
- Smith G.D. (George Davey)
- Smith J.D. (Joshua D.)
- Smith N.L. (Nicholas)
- Song K. (Kijoung)
- Soranzo N. (Nicole)
- Soranzo N. (Nicole)
- Sovio U. (Ulla)
- SparsĂž T. (Thomas)
- SparsĂž T. (Thomas)
- Spector T.D. (Tim D.)
- Spector T.D. (Timothy D.)
- Spector T.D. (Timothy)
- Spranger J. (Joachim)
- St Pourcain B. (Beate)
- Stefansson K. (Kari)
- Stefansson K. (Kari)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Steinthorsdottir V. (Valgerdur)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Stylianou I.M. (Ioannis M.)
- Stylianou I.M. (Ioannis)
- Sun Q. (Qi)
- Surakka I. (Ida)
- Swift A.J. (Amy)
- Swift A.J. (Amy)
- Syddall H. (Holly)
- SyvÀnen A.C.
- Tai E.-S. (E-Shyong)
- Tai E.S. (Shyong)
- Tall A.R. (Alan R.)
- Tanaka T. (Toshiko)
- Taylor H.A. (Herman A.)
- Taylor H.A. (Herman)
- Teslovich T.M. (Tanya M.)
- Teslovich T.M. (Tanya M.)
- Thompson J.R. (John)
- Thompson J.R. (John)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas J.)
- Timpson N.J. (Nicholas)
- Tracy R.P. (Russell)
- Tuomi T. (Tiinamaija)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uda M. (Manuela)
- Uh H.-W. (Hae-Won)
- Uitterlinden A. (Andre)
- Uitterlinden A.G. (Andre G.)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- van Duijn C. (Cornelia)
- van Duijn C.M. (Cornelia M.)
- van Duijn C.M. (Cornelia M.)
- van Hoek M. (Mandy)
- Varma D. (Dhiraj)
- Viikari J. (Jorma)
- Visvikis-Siest S. (Sophie)
- Vitart V. (Veronique)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Vogelzangs N. (Nicole)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Waeber G. (GĂ©rard)
- Waeber G. (GĂ©rard)
- Wagner P.J. (Peter)
- Walker M. (Mark)
- Walley A. (Andrew)
- Walters G. (GBragi)
- Walters G.B. (Bragi)
- Ward K.L. (Kim L.)
- Wareham N.J. (Nick J.)
- Wareham N.J. (Nick)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard M.)
- Watanabe R.M. (Richard)
- Waterworth D. (Dawn)
- Waterworth D. (Dawn)
- Waterworth D.M. (Dawn)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R.P. (Ryan)
- Wheeler E. (Eleanor)
- Whitfield J. (John)
- Wichmann H.-E. (H.-Erich)
- Wichmann H.E. (H. Erich)
- Wichmann H.E. (Heinz Erich)
- Wichmann H.E. (Heinz Erich)
- Wijmenga C. (Cisca)
- Wild S.H. (Sarah)
- Willems van Dijk J.A.P. (Ko)
- Willems S.M. (Sara)
- Willems-vanDijk K. (Ko)
- Willemsen G.
- Willemsen G.A.H.M. (Gonneke)
- Willer C.J. (Cristen J.)
- Willer C.J. (Cristen)
- Williams G.H. (Gordon)
- Wilson J.F. (James F.)
- Wilson J.F. (James)
- Wilson J.G. (James G.)
- Winkler T.W. (Thomas W.)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline C. M.)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C. M.)
- Wong T.Y. (Tien Y.)
- Wood A.R. (Andrew)
- Wright A.F. (Alan)
- Wright A.F. (Alan)
- Wu G. (Guanming)
- Wu Y. (Ying)
- Yarnell J.W.G. (John W.)
- Yuan X. (Xin)
- Zabena C. (Carina)
- Zee R.Y.L. (Robert)
- Zeggini E. (Eleftheria)
- Zeggini E. (Eleftheria)
- Zelenika D. (Diana)
- Zethelius B. (Björn)
- Zhai G. (Guangju)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zwart J-A. (John-Anker)
- Ădonnell C.J. (Christopher)
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5Ă10â8- 1.2 Ă10â43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3Ă10â4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3Ă10â3, n = 22,044), increased triglycerides (p = 2.6Ă10â14, n = 93,440), increased waist-to-hip ratio (p = 1.8Ă10â5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4Ă10â3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL- cholesterol concentrations (p = 4.5Ă10â13, n = 96,748) and decreased BMI (p = 1.4Ă10â4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Absher D. (Devin)
- Absher D. (Devin)
- Aherrahrou Z. (Zouhair)
- Ahlqvist E. (Emma)
- Ahmadi K.R. (Kourosh)
- Ahmed N. (Nabeel)
- Alavere H. (Helene)
- Alibrandi M.T.S. (Maria)
- Allayee H. (Hooman)
- Allen H.L.
- Almgren P. (Peter)
- Altshuler D. (David)
- Amin N. (Najaf)
- Anand S.S. (Sonia)
- Andersen K.K. (Karl)
- Ardissino D. (Diego)
- Ardlie K.G. (Kristin)
- Armitage J. (Jane)
- Arnold A.M. (Alice)
- Aspelund T. (Thor)
- Assimes T.L. (Themistocles)
- Assmann G. (Gerd)
- Aulchenko Y.S. (Yurii)
- Azhar M. (Muhammad)
- Balkau B. (Beverley)
- Ball S.G. (Stephen G.)
- Barbalic M. (maja)
- Barker A.M. (Adam)
- Barlassina C. (Christina)
- Barlera S. (Simona)
- Barnes D. (Daniel)
- Barnes T.A. (Timothy)
- Barrett A. (Angela)
- Barroso I.E. (InĂȘs)
- Bataille V. (Veronique)
- Becker D.M. (Diane)
- Becker L.C. (Lewis)
- Beckmann J.S. (Jacques)
- Beckmann J.S. (Jacques)
- Beilby J.P. (John)
- Bell J.T. (Jordana)
- Ben-Shlomo Y.
- Ben-Shlomo Y. (Yoav)
- Bennett A.J. (Amanda)
- Berger K. (Klaus)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Berndt S.I. (Sonja)
- Biebermann H. (Heike)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Blakemore A.I.F. (Alexandra)
- Blankenberg S. (Stefan)
- Boehm B.O. (Bernhard)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boeing H. (Heiner)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E.A. (Eric)
- Boes T. (Tanja)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret)
- Borecki I.B. (Ingrid)
- Bornstein S.R. (Stefan R.)
- Bornstein S.R. (Stefan)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bowman L.
- Braund P.S. (Peter)
- Bravenboer B. (Bert)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Burnett M.S.
- Burtt N.P. (Noël)
- Busonero F.
- Buysschaert I. (Ian)
- Cambien F. (François)
- Campbell H. (Harry)
- Cappuccio F.P. (Francesco P.)
- Cappuccio F.P. (Francesco)
- Carlquist J.F. (John)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Cavalcanti-Proença C. (Christine)
- Chambers J.C. (John C.)
- Chambers J.C. (John)
- Chanock S.J. (Stephen)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chatterjee N. (Nilanjan)
- Chen C.-M. (Chih-Mei)
- Chen H. (Han)
- Chen L. (Li)
- Chines P.S. (Peter)
- Cichon S. (Sven)
- Clarke R.
- Clarke R. (Robert)
- Codd V. (Veryan)
- Coin L. (Lachlan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Collins F.S. (Francis)
- Connell J. (John)
- Cooper C. (Charles)
- Cooper C.C. (Cyrus C.)
- Cooper M.N. (Matthew N.)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Cupples L.A. (Adrienne)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Danesh J. (John)
- Davies R.W. (Robert)
- Day I.N.M. (Ian N.M.)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Demissie S. (Serkalem)
- Den Heijer M. (Martin)
- Dennison E.M. (Elaine)
- Dermitzakis E.T. (Emmanouil T.)
- Devaney J.M. (Joseph M.)
- Di Meglio P. (Paola)
- Diemert P. (Patrick)
- Dimas A.S. (Antigone)
- Dina C. (Christian)
- Dixon A.L. (Anna)
- Do R. (Ron)
- Doering A. (Angela)
- Doney A.S.F. (Alex)
- Donnelly P. (Peter)
- Duan J. (Jubao)
- Duijn C.M. (Cornelia) van
- Dupuis J. (Josée)
- Durbin R. (Richard)
- Ebrahim S. (Shah)
- Ebrahim S. (Shanil)
- Eifert S. (Sandra)
- Eiriksdottir G. (Gudny)
- El Mokhtari N.E. (Nour Eddine)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Ellis S.G. (Stephen)
- Elosua R. (Roberto)
- Engert J.C. (James C.)
- Epstein S.E. (Stephen)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Eriksson P. (Per)
- Esko T. (Tonu)
- Esko T. (TÔnu)
- Estrada Gil K. (Karol)
- Eury E. (Elodie)
- Faire U. (Ulf) de
- Farooqi I.S. (I. Sadaf)
- Farooqi I.S. (Sadaf)
- Farrall M. (Martin)
- Feitosa M.F. (Mary Furlan)
- Felix S.B. (Stephan)
- Ferrannini E. (Ele)
- Ferreira T. (Teresa)
- Fischer M. (Marcus)
- Fischer-Posovszky P. (Pamela)
- Florez J.C. (Jose)
- Folkersen L. (Lasse)
- Folsom A.R. (Aaron)
- Forsen T. (Tom)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy)
- Freimer N.B. (Nelson B.)
- Freyer J. (Jennifer)
- Friedrich N. (Nele)
- Froguel P. (Philippe)
- Frossard R.
- Fu M. (Mao)
- Gaget S. (Stefan)
- Ganser M. (Martha)
- Gardezi A. (Ali)
- Gejman P.V. (Pablo)
- Geus E.J. (Eeco)
- Gieger C. (Christian)
- Gigante B. (Bruna)
- Girelli D. (Domenico)
- Gjesing A.P. (Anette)
- Glass D. (Daniel)
- Glazer N.L. (Nicole)
- Gloyn A.L. (Anna)
- Goddard M.E. (Michael E.)
- Goddard M.E. (Michael)
- Goel A. (Anuj)
- Goodall A.H. (Alison)
- Goyette P. (Philippe)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Green F. (Fiona)
- Green T. (Todd)
- Greenawalt D.M. (Danielle M.)
- Griffin S. (Simon)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Grundberg E. (Elin)
- GrĂ€sler J. (JĂŒrgen)
- Grönberg H. (Henrik)
- Gu H.F. (Harvest F.)
- Gudnason V. (Vilmundur)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Gulcher J.R. (Jeffrey)
- Gustafsson S. (Stefan)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair S.)
- Hall P. (Per)
- Halperin E. (Eran)
- Hammond C.J. (Christopher J.)
- Hammond C.J. (Christopher)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Hansen T. (T.)
- Haritunians T. (Talin)
- Harris T.B. (Tamara)
- Hartikainen A.-L. (Anna-Liisa)
- Hassanali N. (Neelam)
- Hattersley A.T. (Andrew)
- Havulinna A.S. (Aki)
- Hayes R.B. (Richard)
- Hayes R.B. (Richard)
- Hayward C. (Caroline)
- Hazen S.L. (Stanley)
- Heard-Costa N.L. (Nancy)
- Heath A.C. (Andrew C.)
- Hebebrand J. (Johannes)
- Hedman A.K. (Asa)
- Heid I.M. (Iris)
- Heijer M. (Martin) den
- Heinrich J. (Joachim)
- Hellénius M.-L. (Mai-Lis)
- Hengstenberg C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hinney A. (Anke)
- Hirschhorn J.N. (Joel)
- Hitman G.A. (Graham)
- Hoek M. (Mandy) van
- Hoesel V. (Volker)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Homuth G. (Georg)
- Hopewell J.
- Horikoshi M. (Momoko)
- Hottenga J.J. (Jouke Jan)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Huikuri H.V. (Heikki)
- Hunter D.J. (David J.)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Iribarren C. (Carlos)
- Ishaq M. (Muhammad)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jacobs K.B. (Kevin)
- James A. (Alan)
- Jameson K. (Karen)
- Jansson J.-O. (John-Olov)
- Jarick I. (Ivonne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jewell E. (Eelizabeth)
- Johansson A. (Asa)
- John U. (Ulrich)
- Johnson P. (Paul)
- Johnson P.R.V. (Paul R.V.)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jones G.T. (Gregory)
- Jorgensen T. (Torben)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kajantie E. (Eero)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaplan R.C. (Robert)
- Kaprio J. (Jaakko)
- Kaprio J. (Jaakko)
- Karpe F. (Fredrik)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Kathiresan S. (Sekar)
- Kerr-Conte J. (Julie)
- Kettunen J. (Johannes)
- Khaw K.T.
- Kiemeney L.A.L.M. (Bart)
- KilpelÀinen T.O. (Tuomas)
- Klopp N. (Norman)
- Knowles J.W. (Joshua)
- Kolovou G. (Genovefa)
- Kong A. (Augustine)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Krude H.
- Kutalik Z. (ZoltĂĄn)
- Kuusisto J. (Johanna)
- Kyriakou T. (Theodosios)
- KÀhönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Laitinen J. (Jaana)
- Lambrechts D. (Diether)
- Lamina C. (Claudia)
- Langenberg C. (Claudia)
- Lantieri O. (Olivier)
- Lanzani C. (Chiara)
- Launer L.J. (Lenore)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lawrence R.W. (Robert)
- Lecoeur C. (CĂ©cile)
- LehtimÀki T. (Terho)
- Lettre G. (Guillaume)
- Levinson D.F. (Douglas F.)
- Levinson D.F. (Douglas)
- Li M. (Man)
- Li S. (Shengxu)
- Li X. (Xiaohui)
- Liang L. (Liming)
- Lieb W. (Wolfgang)
- Lieverse A.G. (Aloysius)
- Linksted P. (Pamela)
- Liu J. (Jianjun)
- Liu J. (Jianjun)
- Lokki M.L.
- Loley C. (Christina)
- Loos R.J.F. (Ruth)
- Lorentzon M. (Mattias)
- Lotery A.J. (Andrew)
- Luan J.
- Ludwig B. (Barbara)
- Lyssenko V. (Valeriya)
- Macciardi F. (Fabio)
- Makrilakis K. (Konstantinos)
- Mallick C.B. (Chandana Basu)
- Mannila M.N. (Maria Nastase)
- Manning A.K. (Alisa)
- Mannucci P.M. (Pier)
- Manunta P. (Paolo)
- Maouche S. (Seraya)
- Marek D. (Diana)
- Marre M. (Michel)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- McCarroll S.A. (Steven)
- McCarthy A. (Anne)
- McCarthy M. (Mark)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura)
- McKnight B. (Barbara)
- McPherson R. (Ruth)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Merlini P.A. (Pier Angelica)
- Metspalu A. (Andres)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Min J. (Josine)
- Mohlke K.L. (Karen L.)
- Monda K.L. (Keri)
- Montgomery G.W. (Grant)
- Montgomery G.W. (Grant)
- Mooser V. (Vincent)
- Morgan T. (Thomas)
- Morken M.A. (Mario)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew)
- Muhlestein J.B. (Joseph)
- Mulic R. (Rosanda)
- Munroe P. (Patricia)
- Munroe P.B. (Patricia B.)
- Munzel T. (Thomas)
- Musunuru K. (Kiran)
- Myers R.H. (Richard)
- MĂ€gi R. (Reedik)
- MĂ€larstig A. (Anders)
- MĂ€rz W. (Winfried)
- Nahrstaedt J. (Janja)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Navarro P. (Pau)
- Nelis M. (Mari)
- Nelson C.P. (Christopher P.)
- Nemesh J. (James)
- Nestle F.O. (Frank)
- Neville M.J. (Matthew)
- Ngwa J.S.
- Nica A. (Alexandra)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nisbet J. (James)
- North K.E. (Kari)
- Nyholt D.R. (Dale)
- Nöthen M.M. (Markus)
- O'Connell J.R. (Jeffrey R.)
- O'Donnell C.J. (Christopher)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Steve)
- Offer A. (Alison)
- Ohlsson C. (Claes)
- Olivieri O. (Oliviero)
- Olsson G.
- Ongen H. (Halit)
- Oostra B.A. (Ben)
- Osmond C. (Clive)
- Ouwehand W.H. (Willem)
- Owen K.R. (Katharine)
- OÂŽConnell J.R.
- Palmer C.N.A. (Colin)
- Pankow J.S. (James)
- Pare G. (Guillame)
- Park J.H.
- Parker A.N. (Alex)
- Parts L. (Leopold)
- Pascoe L. (Laura)
- Patel R.S. (Riyaz)
- Patterson C.C. (Chris C.)
- Payne F. (Felicity)
- Peden J. (John)
- Pedersen O. (Oluf)
- Pellikka N. (Niina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John)
- Peters A. (Annette)
- Peters M.J. (Marjolein)
- Petersen A.K.
- Peto R. (R.)
- Petrie J.R. (John)
- Peyvandi F. (Flora)
- Pichler I. (Irene)
- Pietilainen K.H. (Kirsi Hannele)
- Platou C. (Carl)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Potter S.C. (Simon)
- Pramstaller P.P. (Peter P.)
- Preuss M. (Michael)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Purcell S. (Shaun)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quyyumi A.A. (Arshed)
- Rader D.J. (Daniel)
- Rafelt S. (Suzanne)
- Raitakari O. (Olli)
- Raitakari O.T. (Olli T.)
- Rallidis L.S. (Loukianos)
- Randall J.C. (Joshua)
- Rasheed A. (Asif)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (N. William)
- Rayner N.W. (Nigel William)
- Reilly M.P. (Muredach P.)
- Reinehr T. (Thomas)
- RidderstrÄle M. (Martin)
- Ridker P.M. (Paul)
- Rij A.M. (Andre) van
- Ripatti S. (Samuli)
- Rissanen A. (Aila)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Rosendaal F.R. (Frits R.)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rust S. (Stephan)
- Rybin D. (Denis)
- Rzehak P. (Peter)
- Sabater-Lleal M. (Maria)
- Saleheen D. (Danish)
- Salomaa V. (Veikko)
- Samad A. (Adbus)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampietro M.L. (Maria Lourdes)
- Sampson M.J. (Michael)
- Samuel M. (Maria)
- Sanders A.R. (Alan R.)
- Sandholt C. (Camilla)
- Sandhu M.S. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Saramies J. (Jouko)
- Savolainen M.J. (Markku)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric)
- Scherag A. (Andre)
- Schillert A. (Arne)
- Schipf S. (Sabine)
- Schlessinger D. (David)
- Schreiber S. (Stefan)
- Schrezenmeir J. (JĂŒrgen)
- Schunkert H. (Heribert)
- Schwartz S.M. (Stephen)
- Schwarz P.E.H. (Peter)
- SchÀfer A. (Arne)
- Scott J. (James)
- Scott L.J. (Laura)
- Scott L.J. (Laura)
- Seedorf U. (Udo)
- SegrĂš A.V. (Ayellet)
- Sehmi J.S. (Joban)
- Sekowska M. (Magdalena)
- Sennblad B. (Bengt)
- Serrano-RĂos M. (Manuel)
- Shah N. (Nisha)
- Shi J. (Jianxin)
- Shi J. (Jianxin)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Sivapalaratnam S. (Suthesh)
- Sladek R. (Rob)
- Sleight P. (Peter)
- Smit J.H. (Jan)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- SparsĂž T. (Thomas)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth)
- Spertus J.A. (John)
- StanÄcĂĄkovĂĄ A. (Alena)
- Stark K. (Klaus)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Stephens J. (Jonathan)
- Stewart A.F. (Alexandre F.)
- Stirrups K. (Kathy)
- Stoll M. (Monika)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- SyvÀnen A.C.
- Tammesoo M.L.
- Taneera J. (Jalal)
- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas)
- Tognoni G.
- Tomaszewski M. (Maciej)
- Travers M.E. (Mary E.)
- Travers M.E. (Mary)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Turrini F. (Fabiola)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- Van Dam R.M. (Rob M.)
- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (GĂ©rard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Ăhrvik J. (John)
- Ăstenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 Ă 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis