14 research outputs found
Proximity Induced Superconductivity in CdTe-HgTe Core-Shell Nanowires
In this letter we report on proximity superconductivity induced in CdTe-HgTe
core-shell nanowires, a quasi-one-dimensional heterostructure of the
topological insulator HgTe. We demonstrate a Josephson supercurrent in our
nanowires contacted with superconducting Al leads. The observation of a sizable
product, a positive excess current and multiple Andreev reflections
up to fourth order further indicate a high interface quality of the junctions.Comment: Accepted for publication in Nano Letter
Josephson Effect and Charge Distribution in Thin BiTe Topological Insulators
Thin layers of topological insulator materials are quasi-two-dimensional
systems featuring a complex interplay between quantum confinement and
topological band structure. To understand the role of the spatial distribution
of carriers in electrical transport, we study the Josephson effect,
magnetotransport, and weak anti-localization in bottom-gated thin BiTe
topological insulator films.We compare the experimental carrier densities to a
model based on the solutions of the self-consistent Schr\"odinger-Poisson
equations and find excellent agreement. The modeling allows for a quantitative
interpretation of the weak antilocalization correction to the conduction and of
the critical current of Josephson junctions with weak links made from such
films without any ad hoc assumptions.Comment: 18 pages, 6 figure
Conduction spectroscopy of a proximity induced superconducting topological insulator
The combination of superconductivity and the helical spin-momentum locking at
the surface state of a topological insulator (TI) has been predicted to give
rise to p-wave superconductivity and Majorana bound states. The
superconductivity can be induced by the proximity effect of a an s-wave
superconductor (S) into the TI. To probe the superconducting correlations
inside the TI, dI/dV spectroscopy has been performed across such S-TI
interfaces. Both the alloyed BiSbTeSe and the
stoichiometric BiSbTeSe have been used as three dimensional TI. In the case
of BiSbTeSe, the presence of disorder induced
electron-electron interactions can give rise to an additional zero-bias
resistance peak. For the stoichiometric BiSbTeSe with less disorder, tunnel
barriers were employed in order to enhance the signal from the interface. The
general observations in the spectra of a large variety of samples are
conductance dips at the induced gap voltage, combined with an increased sub-gap
conductance, consistent with p-wave predictions. The induced gap voltage is
typically smaller than the gap of the Nb superconducting electrode, especially
in the presence of an intentional tunnel barrier. Additional uncovered
spectroscopic features are oscillations that are linearly spaced in energy, as
well as a possible second order parameter component.Comment: Semiconductor Science and Technology; Special Issue on Hybrid Quantum
Materials and Device
Stencil lithography of superconducting contacts on MBE-grown topological insulator thin films
Topological insulator (Bi0.06Sb0.94)2Te3 thin films grown by molecular beam epitaxy have been capped in-situ with a 2 nm Al film to conserve the pristine topological surface states. Subsequently, a shadow mask - structured by means of focus ion beam - was in-situ placed underneath the sample to deposit a thick layer of Al on well-defined microscopically small areas. The 2 nm thin Al layer fully oxidizes after exposure to air and in this way protects the TI surface from degradation. The thick Al layer remains metallic underneath a 3–4 nm thick native oxide layer and therefore serves as (super-) conducting contacts. Superconductor-Topological Insulator-Superconductor junctions with lateral dimensions in the nm range have then been fabricated via an alternative stencil lithography technique. Despite the in-situ deposition, transport measurements and transmission electron microscope analysis indicate a low transparency, due to an intermixed region at the interface between topological insulator thin film and metallic Al
Electrotonic Signals along Intracellular Membranes May Interconnect Dendritic Spines and Nucleus
Synapses on dendritic spines of pyramidal neurons show a remarkable ability to induce phosphorylation of transcription factors at the nuclear level with a short latency, incompatible with a diffusion process from the dendritic spines to the nucleus. To account for these findings, we formulated a novel extension of the classical cable theory by considering the fact that the endoplasmic reticulum (ER) is an effective charge separator, forming an intrinsic compartment that extends from the spine to the nuclear membrane. We use realistic parameters to show that an electrotonic signal may be transmitted along the ER from the dendritic spines to the nucleus. We found that this type of signal transduction can additionally account for the remarkable ability of the cell nucleus to differentiate between depolarizing synaptic signals that originate from the dendritic spines and back-propagating action potentials. This study considers a novel computational role for dendritic spines, and sheds new light on how spines and ER may jointly create an additional level of processing within the single neuron
Dopamine Receptor Activation Increases HIV Entry into Primary Human Macrophages
Macrophages are the primary cell type infected with HIV in the central nervous system, and infection of these cells is a major component in the development of neuropathogenesis and HIV-associated neurocognitive disorders. Within the brains of drug abusers, macrophages are exposed to increased levels of dopamine, a neurotransmitter that mediates the addictive and reinforcing effects of drugs of abuse such as cocaine and methamphetamine. In this study we examined the effects of dopamine on HIV entry into primary human macrophages. Exposure to dopamine during infection increased the entry of R5 tropic HIV into macrophages, irrespective of the concentration of the viral inoculum. The entry pathway affected was CCR5 dependent, as antagonizing CCR5 with the small molecule inhibitor TAK779 completely blocked entry. The effect was dose-dependent and had a steep threshold, only occurring above 108 M dopamine. The dopamine-mediated increase in entry required dopamine receptor activation, as it was abrogated by the pan-dopamine receptor antagonist flupenthixol, and could be mediated through both subtypes of dopamine receptors. These findings indicate that the effects of dopamine on macrophages may have a significant impact on HIV pathogenesis. They also suggest that drug-induced increases in CNS dopamine may be a common mechanism by which drugs of abuse with distinct modes of action exacerbate neuroinflammation and contribute to HIV-associated neurocognitive disorders in infected drug abusers
Proximity-Induced Superconductivity in CdTe-HgTe Core-Shell Nanowires
In this Letter we report on proximity superconductivity induced in CdTe–HgTe core–shell nanowires, a quasi-one-dimensional heterostructure of the topological insulator HgTe. We demonstrate a Josephson supercurrent in our nanowires contacted with superconducting Al leads. The observation of a sizable IcRn product, a positive excess current, and multiple Andreev reflections up to fourth order further indicate a high interface quality of the junctions
Stencil lithography of superconducting contacts on MBE-grown topological insulator thin films
Topological insulator (Bi0.06Sb0.94)2Te3 thin films grown by molecular beam epitaxy have been capped in-situ with a 2 nm Al film to conserve the pristine topological surface states. Subsequently, a shadow mask - structured by means of focus ion beam - was in-situ placed underneath the sample to deposit a thick layer of Al on well-defined microscopically small areas. The 2 nm thin Al layer fully oxidizes after exposure to air and in this way protects the TI surface from degradation. The thick Al layer remains metallic underneath a 3–4 nm thick native oxide layer and therefore serves as (super-) conducting contacts. Superconductor-Topological Insulator-Superconductor junctions with lateral dimensions in the nm range have then been fabricated via an alternative stencil lithography technique. Despite the in-situ deposition, transport measurements and transmission electron microscope analysis indicate a low transparency, due to an intermixed region at the interface between topological insulator thin film and metallic Al