Death and rebirth of neural activity in sparse inhibitory networks

In this paper, we clarify the mechanisms underlying a general phenomenon present in pulse-coupled heterogeneous inhibitory networks: inhibition can induce not only suppression of the neural activity, as expected, but it can also promote neural reactivation. In particular, for globally coupled systems, the number of firing neurons monotonically reduces upon increasing the strength of inhibition (neurons' death). However, the random pruning of the connections is able to reverse the action of inhibition, i.e. in a sparse network a sufficiently strong synaptic strength can surprisingly promote, rather than depress, the activity of the neurons (neurons' rebirth). Thus the number of firing neurons reveals a minimum at some intermediate synaptic strength. We show that this minimum signals a transition from a regime dominated by the neurons with higher firing activity to a phase where all neurons are effectively sub-threshold and their irregular firing is driven by current fluctuations. We explain the origin of the transition by deriving an analytic mean field formulation of the problem able to provide the fraction of active neurons as well as the first two moments of their firing statistics. The introduction of a synaptic time scale does not modify the main aspects of the reported phenomenon. However, for sufficiently slow synapses the transition becomes dramatic, the system passes from a perfectly regular evolution to an irregular bursting dynamics. In this latter regime the model provides predictions consistent with experimental findings for a specific class of neurons, namely the medium spiny neurons in the striatum.Comment: 19 pages, 10 figures, submitted to NJ

Numerical and experimental characterization of a railroad switch machine

This contribution deals with the numerical and experimental characterization of the structural behavior of a railroad switch machine. Railroad switch machines must meet a number of safety-related conditions such as, for instance, exhibiting the appropriate resistance against any undesired movements of the points due to the extreme forces exerted by a passing train. This occurrence can produce very high stress on the components, which has to be predicted by designers. In order to assist them in the development of new machines and in defining what the critical components are, FEA models have been built and stresses have been calculated on the internal components of the switch machine. The results have been validated by means of an ad-hoc designed experimental apparatus, now installed at the facilities of the Department of Industrial Engineering of the University of Bologna. This apparatus is particularly novel and original, as no Standards are available that provide recommendations for its design, and no previous studies have dealt with the development of similar rigs. Moreover, it has wide potential applications for lab tests aimed at assessing the safety of railroad switch machines and the fulfilment of the specifications by many railway companies

On Hirth Ring Couplings: Design Principles Including the Effect of Friction

Rings with Hirth couplings are primarily used for the accurate positioning of axial-symmetric components in the machine tool industry and, generally, in mechanical components. It is also possible to use Hirth rings as connection tools. Specific industries with special milling and grinding machines are able to manufacture both tailor made and standard Hirth rings available on stock. Unfortunately, no international standard (for instance ISO, DIN or AGMA) is available for the production and the design of such components. In the best-case scenario, it is possible to find simplified design formulae in the catalogue of the suppliers. The aim of this work is to provide some accurate formulae and computational methods for design to provide better awareness on the limitations and the potential of this type of connection. The work consists of five parts: (i) a review of the base calculation derived mainly from the catalogues of manufacturers; (ii) an improved calculation based on a new analytical method including the friction phenomenon; (iii) an experimentation run for validating the method; (iv) a case study applied to a machine tool; and, (v) a closed form formulation to determine an upper threshold for friction, thus ensuring the Hirth coupling regular performance

Collective dynamics in sparse networks

The microscopic and macroscopic dynamics of random networks is investigated in the strong-dilution limit (i.e. for sparse networks). By simulating chaotic maps, Stuart-Landau oscillators, and leaky integrate-and-fire neurons, we show that a finite connectivity (of the order of a few tens) is able to sustain a nontrivial collective dynamics even in the thermodynamic limit. Although the network structure implies a non-additive dynamics, the microscopic evolution is extensive (i.e. the number of active degrees of freedom is proportional to the number of network elements).Comment: 5 pages, 4 figures, to appear in Physical Review Letter

INFLUENCE OF THE STIFFNESS AND FRICTIONAL CHARACTERISTICS ON THE SHANK TORQUE OF SCREWS IN BOLTED JOINTS

This work aims at determining the influence of tribological and stiffness characteristics of a bolted joint on the residual shank torque of the screw. Even if it is commonly accepted to consider such a residual torque equal to half the torque at the thread, the literature lacks experimental data about the topic. The residual shank torque combines with the axial preload and the external loads to bring about the overall stress on the screw. Hence, the higher the residual torque, the lower the admissible external load for given size and class of the screw. From there stems the need for an analytical tool allowing the designer to calculate the residual torque as a function of the key parameters of the joint

A methodology for the lightweight design of modern transfer machine tools

This paper deals with a modern design approach via finite elements in the definition of the main structural elements (rotary table and working unit) of an innovative family of transfer machine tools. Using the concepts of green design and manufacture, as well as sustainable development thinking, the paper highlights the advantages derived from their application in this specific field (i.e., the clever use of lightweight materials to allow ruling out high-consumption hydraulic pump systems). The design is conceived in a modular way, so that the final solution can cover transfers from four to 15 working stations. Two versions of the machines are examined. The first one has a rotary table with nine divisions, which can be considered as a prototype: this machine has been studied in order to set up the numerical predictive model, then validated by experimental tests. The second one, equipped with a rotary table with 15 divisions, is the biggest of the range: this machine has been entirely designed with the aid of the previously developed numerical model. The loading input forces for the analyses have been evaluated experimentally via drilling operations carried out on a three-axis CNC unit. The definition of the design force made it possible to accurately assess both the rotary table and the working units installed in the machine