Evidence that large vessels do affect near infrared spectroscopy

The influence of large vessels on near infrared spectroscopy (NIRS) measurement is generally considered negligible. Aim of this study is to test the hypothesis that changes in the vessel size, by varying the amount of absorbed NIR light, could profoundly affect NIRS blood volume indexes. Changes in haemoglobin concentration (tHb) and in tissue haemoglobin index (THI) were monitored over the basilic vein (BV) and over the biceps muscle belly, in 11 subjects (7 M – 4 F; age 31 ± 8 year) with simultaneous ultrasound monitoring of BV size. The arm was subjected to venous occlusion, according to two pressure profiles: slow (from 0 to 60 mmHg in 135 s) and rapid (0 to 40 mmHg maintained for 30 s). Both tHb and THI detected a larger blood volume increase (1.7 to 4 fold; p < 0.01) and exhibited a faster increase and a greater convexity on the BV than on the muscle. In addition, NIRS signals from BV exhibited higher correlation with changes in BV size than from muscle (r = 0.91 vs 0.55, p < 0.001 for THI). A collection of individual relevant recordings is also included. These results challenge the long-standing belief that the NIRS measurement is unaffected by large vessels and support the concept that large veins may be a major determinant of blood volume changes in multiple experimental conditions

Tattoo-Associated Skin Reaction: The Importance of an Early Diagnosis and Proper Treatment

Tattoo is going to be a very common practice especially among young people and we are witnessing a gradual increase of numerous potential complications to tattoo placement which are often seen by physicians, but generally unknown to the public. The most common skin reactions to tattoo include a transient acute inflammatory reaction due to trauma of the skin with needles and medical complications such as superficial and deep local infections, systemic infections, allergic contact dermatitis, photodermatitis, granulomatous and lichenoid reactions, and skin diseases localized on tattooed area (eczema, psoriasis, lichen, and morphea). Next to these inflammatory skin reactions we have to consider also the possibility of the development of cutaneous conditions such as pseudolymphomatous reactions and pseudoepitheliomatous hyperplasia. The aim of this study is to underline the importance of an early diagnosis by performing a histological examination especially when we are in front of suspected papulonodular lesions arising from a tattoo, followed by a proper treatment, since cutaneous neoplastic evolution is known to be a rare but possible complication

Letture Idromorfiche del Territorio: La città di Matera

Hydromorphic analysis uses the concept of hydrographic basin, interpreted in its dynamic meaning, to analyze territorial contexts of any size. This allows multi-scalar analyzes that allow to overcome urban fragmentation and interpret the territory differently, integrating the morphological characteristics with the more urban planning and land use aspects. In this schematization, the different territorial portions are connected by the dynamics of the respective surface outflows, thus also highlighting the mutual influence that each area exerts on the other. The declination of the role attributed to the different areas: upper mountain, intermediate slope and lower valley, helps to highlight the relationships between the different urbanized and non-urbanized places, ensures an effective reading of the hydromorphic complexities involved in urban transformation processes and territorial, and allows to evaluate the adaptability of a territory, based on the morphological conformation that characterizes it and on the dynamics of the surface outflows that are established there. The proposed approach allows to quantitatively express the response of each analyzed context and, therefore, to develop comparisons between different scenarios, providing useful information and support for decision-making choices.L’analisi idromorfica utilizza il concetto di bacino idrografico, interpretato nel suo significato dinamico, per analizzare contesti territoriali di qualunque dimensione. Ciò permette analisi multi scalari che permettono di superare la frammentazione urbanistica e leggere diversamente il territorio, integrando le caratteristiche morfologiche con gli aspetti più urbanistici e di uso del suolo. In tale schematizzazione, le diverse porzioni territoriali vengono ad essere connesse dalla dinamica dei rispettivi deflussi superficiali, evidenziando così anche l’influenza reciproca che ciascuna area esercita sull’altra. La declinazione del ruolo attribuito alle diverse aree: alta di monte, intermedia di versante e bassa di valle, contribuisce a mettere in evidenza i rapporti fra i differenti luoghi urbanizzati e non, assicura un’efficacie lettura delle complessità idromorfiche coinvolte nei processi di trasformazione urbana e territoriale, e permette di valutare la capacità di adattamento di un territorio, basandosi sulla conformazione morfologica che lo caratterizza e sulla dinamica dei deflussi superficiali che vi si instaurano. L’approccio proposto permette di esprimere quantitativamente la risposta di ogni contesto analizzato e, quindi, di sviluppare confronti tra differenti scenari, fornendo utili indicazioni e supporto alle scelte decisionali

Genetic polymorphisms involved in mitochondrial metabolism and pancreatic cancer risk

The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC aetiology. However, a systematic investigation of the genetic variability of mitochondrial genome (mtSNPs) and of all the nuclear genes involved in its functioning (n-mtSNPs) has never been reported.We conducted a two-phase association study of mtSNPs and n-mtSNPs to assess their effect on PDAC risk. We analysed 35,297 n-mtSNPs and 101 mtSNPs in up to 55,870 individuals (12,884 PDAC cases and 42,986 controls). In addition, we also conducted a gene-based analysis on 1,588 genes involved in mitochondrial metabolism using MAGMA software.In the discovery phase we identified 49 n-mtSNPs and no mtSNPs associated with PDAC risk (P <0.05). In the second phase none of the findings were replicated. In the gene-level analysiswe observed that three genes (TERT, SUGCT and SURF1) involved in the mitochondrial metabolismshowed an association below the Bonferroni-corrected threshold of statistical significance (P=0.05/1588=3.1 x10-5).Even though the mitochondrial metabolism might be involved in PDAC aetiology, our results, obtained in a study with one of the largest sample sizes to date, show that neither n-mtSNPs nor mtSNPs are associated with PDAC risk.This large case-control study does not support a role of the genetic variability of the mitochondrial function in PDAC risk

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging the SLC22A3 gene sequence and regulatory elements were selected for analysis. Of these, 22 were successfully evaluated in the discovery phase while six significant or suggestive variants entered the validation phase, comprising a total study number of 1,518 cases and 3,908 controls. In the discovery phase, rs2504938, rs9364554, and rs2457571 SNPs were significantly associated with pancreatic cancer risk. Moreover, rs7758229 associated with the presence of distant metastases, while rs512077 and rs2504956 correlated with overall survival of patients. Although replicated, the association for rs9364554 did not pass multiple testing corrections in the validation phase. Contrary to the discovery stage, rs2504938 associated with survival in the validation cohort, which was more pronounced in stage IV patients. In conclusion, common variation in the SLC22A3 gene is unlikely to significantly contribute to pancreatic cancer risk. The rs2504938 SNP in SLC22A3 significantly associates with an unfavorable prognosis of pancreatic cancer patients. Further investigation of this SNP effect on the molecular and clinical phenotype is warranted

The AXIOM platform for next-generation cyber physical systems

Cyber-Physical Systems (CPSs) are widely used in many applications that require interactions between humans and their physical environment. These systems usually integrate a set of hardware-software components for optimal application execution in terms of performance and energy consumption. The AXIOM project (Agile, eXtensible, fast I/O Module), presented in this paper, proposes a hardware-software platform for CPS coupled with an easy parallel programming model and sufficient connectivity so that the performance can scale-up by adding multiple boards. AXIOM supports a task-based programming model based on OmpSs and leverages a high-speed, inexpensive communication interface called AXIOM-Link. The board also tightly couples the CPU with reconfigurable resources to accelerate portions of the applications. As case studies, AXIOM uses smart video surveillance, and smart home living applicationsThis work is partially supported by the European Union H2020 program through the AXIOM project (grant ICT-01-2014 GA 645496) and HiPEAC (GA 687698), by the Spanish Government through Programa Severo Ochoa (SEV-2015-0493), by the Spanish Ministry of Science and Technology through TIN2015-65316-P project, and by the Generalitat de Catalunya (contracts 2014-SGR-1051 and 2014-SGR-1272). We also thank the Xilinx University Program for its hardware and software donations.Peer ReviewedPostprint (author's final draft

The body of evidence of late-life depression: the complex relationship between depressive symptoms, movement, dyspnea and cognition

Background: Physical symptoms play an important role in late-life depression and may contribute to residual symptomatology after antidepressant treatment. In this exploratory study, we examined the role of specific bodily dimensions including movement, respiratory functions, fear of falling, cognition, and physical weakness in older people with depression.Methods: Clinically stable older patients with major depression within a Psychiatric Consultation-Liaison program for Primary Care underwent comprehensive assessment of depressive symptoms, instrumental movement analysis, dyspnea, weakness, activity limitations, cognitive function, and fear of falling. Network analysis was performed to explore the unique adjusted associations between clinical dimensions.Results: Sadness was associated with worse turning and walking ability and movement transitions from walking to sitting, as well as with worse general cognitive abilities. Sadness was also connected with dyspnea, while neurovegetative depressive burden was connected with activity limitations.Discussion: Limitations of motor and cognitive function, dyspnea, and weakness may contribute to the persistence of residual symptoms of late-life depression