Treating childhood cancer in Rwanda: the nephroblastoma example

Introduction: Wilms tumor (WT) or nephroblastoma is the commonest childhood cancer in Rwanda. Nephroblastoma is regarded as one of the successes of pediatric oncology with long-term survival approaching 90%. The Objectives to evaluate the feasibilityof treating childhood cancer using the nephroblastoma example and to calculate its cost of treatment in Rwanda. Methods: Prospective study over a 2 year period: 01 Jan 2010- 31 December 2011.A questionnaire was completed by all participants in the study and the following variables were collected at Kigali University Teaching Hospital: age at diagnosis, gender, transport cost, cost of investigations, staging, treatment and outcome, cost of hospitalization, type of medical, surgical, radiological interventions and their costs, number of admissions per patient and factors related to non compliance to treatment. All patients had a confirmed diagnosis on histopathology examination. The cost for treatment was calculated for early and late stage and was expressed in USA dollars. Analysis was done with SPSS 16.0. Results: There were 25 patients diagnosed and treated for WT during the study period. Almost half of the patients 14/25 (56%) had advanced disease, seven children (28%) had stage IV, seven children stage III, six patients (24%) with stage II, while the remaining five (20%) had stage I with high risk tumor. The direct cost of management ranged from1,831.2 USD for early disease to 2,418.7 USD for advanced disease. The cost of transport, investigations and drugs were recorded as main contributing factors to the feasibility and cost of the treatment in 80% of the responses, followed by late presentation (56%) and poor compliance to treatment. Conclusion: Most challenges are related to unaffordable treatment and late presentation. The management of WT is feasible in Rwandan setting but efforts should be made in order to improve awareness of childhood cancer, early diagnosis and access to care. The government of Rwanda is committed to improve cancer care in the country and organized the first pediatric international oncology conference in Kigali, in March 2012 to develop National protocols for the top five most common cancers in children

Area distribution of two-dimensional random walks on a square lattice

The algebraic area probability distribution of closed planar random walks of length N on a square lattice is considered. The generating function for the distribution satisfies a recurrence relation in which the combinatorics is encoded. A particular case generalizes the q-binomial theorem to the case of three addends. The distribution fits the L\'evy probability distribution for Brownian curves with its first-order 1/N correction quite well, even for N rather small.Comment: 8 pages, LaTeX 2e. Reformulated in terms of q-commutator

Electrospun nanosystems based on PHBV and ZnO for ecological food packaging

The electrospun nanosystems containing poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and 1 wt% Fe doped ZnO nanoparticles (NPs) (with the content of dopant in the range of 0–1 wt% Fe) deposited onto polylactic acid (PLA) film were prepared for food packaging application. They were investigated by scanning electron microscopy (SEM), energy dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), antimicrobial analysis, and X-ray photoelectron spectrometry (XPS) techniques. Migration studies conducted in acetic acid 3% (wt/wt) and ethanol 10% (v/v) food simulants as well as by the use of treated ashes with 3% HNO3 solution reveal that the migration of Zn and Fe falls into the specific limits imposed by the legislation in force. Results indicated that the PLA/PHBV/ZnO:Fex electrospun nanosystems exhibit excellent antibacterial activity against the Pseudomonas aeruginosa (ATCC-27853) due to the generation of a larger amount of perhydroxyl (¿OOH) radicals as assessed using electron para-magnetic resonance (EPR) spectroscopy coupled with a spin trapping method. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

A Higher Dimensional Stationary Rotating Black Hole Must be Axisymmetric

A key result in the proof of black hole uniqueness in 4-dimensions is that a stationary black hole that is ``rotating''--i.e., is such that the stationary Killing field is not everywhere normal to the horizon--must be axisymmetric. The proof of this result in 4-dimensions relies on the fact that the orbits of the stationary Killing field on the horizon have the property that they must return to the same null geodesic generator of the horizon after a certain period, $P$. This latter property follows, in turn, from the fact that the cross-sections of the horizon are two-dimensional spheres. However, in spacetimes of dimension greater than 4, it is no longer true that the orbits of the stationary Killing field on the horizon must return to the same null geodesic generator. In this paper, we prove that, nevertheless, a higher dimensional stationary black hole that is rotating must be axisymmetric. No assumptions are made concerning the topology of the horizon cross-sections other than that they are compact. However, we assume that the horizon is non-degenerate and, as in the 4-dimensional proof, that the spacetime is analytic.Comment: 24 pages, no figures, v2: footnotes and references added, v3: numerous minor revision

Complementarity, quantum erasure and delayed choice with modified Mach-Zehnder interferometers

Often cited dictums in Quantum Mechanics include "observation disturbance causes loss of interference" and "ignorance is interference". In this paper we propose and describe a series of experiments with modified Mach-Zehnder interferometers showing that one has to be careful when applying such dictums. We are able to show that without interacting in any way with the light quantum (or quanta) expected to behave "wave-like", interference fringes can be lost by simply gaining (or having the potential to gain) the which-path knowledge. Erasing this information may revive the interference fringes. Delayed choice can be added, arriving to an experiment in line with Wheeler's original proposal. We also show that ignorance is not always synonym with having the interference fringes. The often-invoked "collapse of the wavefunction" is found to be a non-necessary ingredient to describe our experiments.Comment: 8 pages, 3 figures; to appear in EPJ

On the `Stationary Implies Axisymmetric' Theorem for Extremal Black Holes in Higher Dimensions

All known stationary black hole solutions in higher dimensions possess additional rotational symmetries in addition to the stationary Killing field. Also, for all known stationary solutions, the event horizon is a Killing horizon, and the surface gravity is constant. In the case of non-degenerate horizons (non-extremal black holes), a general theorem was previously established [gr-qc/0605106] proving that these statements are in fact generally true under the assumption that the spacetime is analytic, and that the metric satisfies Einstein's equation. Here, we extend the analysis to the case of degenerate (extremal) black holes. It is shown that the theorem still holds true if the vector of angular velocities of the horizon satisfies a certain "diophantine condition," which holds except for a set of measure zero.Comment: 30pp, Latex, no figure

Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy

Polymersomes have the potential to be applied in targeted alpha radionuclide therapy, while in addition preventing release of recoiling daughter isotopes. In this study, we investigated the cellular uptake, post uptake processing and intracellular localization of polymersomes. Methods: High-content microscopy was used to validate polymersome uptake kinetics. Confocal (live cell) microscopy was used to elucidate the uptake mechanism and DNA damage induction. Intracellular distribution of polymersomes in 3-D was determined using super-resolution microscopy. Results: We found that altering polymersome size and concentration affects the initial uptake and overall uptake capacity; uptake efficiency and eventual plateau levels varied between cell lines;

Making (remote) sense of lianas

Lianas (woody vines) are abundant and diverse, particularly in tropical ecosystems. Lianas use trees for structural support to reach the forest canopy, often putting leaves above their host tree. Thus they are major parts of many forest canopies. Yet, relatively little is known about distributions of lianas in tropical forest canopies, because studying those canopies is challenging. This knowledge gap is urgent to address because lianas compete strongly with trees, reduce forest carbon uptake and are thought to be increasing, at least in the Neotropics. Lianas can be difficult to study using traditional field methods. Their pliable stems often twist and loop through the understorey, making it difficult to assess their structure and biomass, and the sizes and locations of their crowns. Furthermore, liana stems are commonly omitted from standard field surveys. Remote sensing of lianas can help overcome some of these obstacles and can provide critical insights into liana ecology, but to date there has been no systematic assessment of that contribution. We review progress in studying liana ecology using ground-based, airborne and space-borne remote sensing in four key areas: (i) spatial and temporal distributions, (ii) structure and biomass, (iii) responses to environmental conditions and (iv) diversity. This demonstrates the great potential of remote sensing for rapid advances in our knowledge and understanding of liana ecology. We then look ahead, to the possibilities offered by new and future advances. We specifically consider the data requirements, the role of technological advances and the types of methods and experimental designs that should be prioritised. Synthesis. The particular characteristics of the liana growth form make lianas difficult to study by ground-based field methods. However, remote sensing is well suited to collecting data on lianas. Our review shows that remote sensing is an emerging tool for the study of lianas, and will continue to improve with recent developments in sensor and platform technology. It is surprising, therefore, how little liana ecology research has utilised remote sensing to date—this should rapidly change if urgent knowledge gaps are to be addressed. In short, liana ecology needs remote sensing

Simulating rewetting events in intermittent rivers and ephemeral streams: A global analysis of leached nutrients and organic matter

Climate change and human pressures are changing the global distribution and the ex‐ tent of intermittent rivers and ephemeral streams (IRES), which comprise half of the global river network area. IRES are characterized by periods of flow cessation, during which channel substrates accumulate and undergo physico‐chemical changes (precon‐ ditioning), and periods of flow resumption, when these substrates are rewetted and release pulses of dissolved nutrients and organic matter (OM). However, there are no estimates of the amounts and quality of leached substances, nor is there information on the underlying environmental constraints operating at the global scale. We experi‐ mentally simulated, under standard laboratory conditions, rewetting of leaves, river‐ bed sediments, and epilithic biofilms collected during the dry phase across 205 IRES from five major climate zones. We determined the amounts and qualitative character‐ istics of the leached nutrients and OM, and estimated their areal fluxes from riverbeds. In addition, we evaluated the variance in leachate characteristics in relation to selected environmental variables and substrate characteristics. We found that sediments, due to their large quantities within riverbeds, contribute most to the overall flux of dis‐ solved substances during rewetting events (56%–98%), and that flux rates distinctly differ among climate zones. Dissolved organic carbon, phenolics, and nitrate contrib‐ uted most to the areal fluxes. The largest amounts of leached substances were found in the continental climate zone, coinciding with the lowest potential bioavailability of the leached OM. The opposite pattern was found in the arid zone. Environmental vari‐ ables expected to be modified under climate change (i.e. potential evapotranspiration, aridity, dry period duration, land use) were correlated with the amount of leached sub‐ stances, with the strongest relationship found for sediments. These results show that the role of IRES should be accounted for in global biogeochemical cycles, especially because prevalence of IRES will increase due to increasing severity of drying event