Prospective surveillance of invasive group a streptococcal disease, Fiji, 2005-2007.

We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type. Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention

Constraints on the fundamental string coupling from B-mode experiments

We study signatures of cosmic superstring networks containing strings of multiple tensions and Y-junctions, on the cosmic microwave background (CMB) temperature and polarisation spectra. Focusing on the crucial role of the string coupling constant $g_s$, we show that the number density and energy density of the scaling network are dominated by different types of string in the $g_s \sim 1$ and $g_s \ll 1$ limits. This can lead to an observable shift in the position of the B-mode peak --- a distinct signal leading to a direct constraint on $g_s$. We forecast the joint bounds on $g_s$ and the fundamental string tension $\mu_F$ from upcoming and future CMB polarisation experiments, as well as the signal to noise in detecting the difference between B-mode signals in the limiting cases of large and small $g_s$. We show that such a detectable shift is within reach of planned experiments.Comment: 4 pages, 4 figures; v2: matches version published in PR

Prospective Surveillance of Invasive Group A Streptococcal Disease, Fiji, 2005–2007

These infections are more common and case-fatality rate is higher in Fiji than in industrialized countries

High Burden of Impetigo and Scabies in a Tropical Country

Scabies and impetigo are often thought of as nuisance diseases, but have the potential to cause a great deal of morbidity and even mortality if infection becomes complicated. Accurate assessments of these diseases are lacking, particularly in tropical developing countries. We performed a series of studies in infants and primary school children in Fiji, a tropical developing country in the South Pacific. Impetigo was very common: more than a quarter of school-aged children and 12% of infants had active impetigo. Scabies was also very common affecting 18% of school children and 14% of infants. The group A streptococcus was the most common infective organism followed by Staphylococcus aureus. The size of the problem has been underestimated, particularly in the Pacific. It is time for more concerted public health efforts in controlling impetigo and scabies

Comparing methods of measuring sea-ice density in the East Antarctic

Remotely sensed derivation of sea-ice thickness requires sea·ice density. Sea-ice density was estimated with three techniques during the second Sea Ice Physics and Ecosystem eXperiment (SIPEX-II, September-November 2012, East Antarctica). The sea ice was first-year highly deformed, mean thickness 1.2 m with layers, consistent with rafting, and 6-7/10 columnar ice and 3/10 granular ice. Ice density was found to be lower than values (900-920 kg m⁻³ used previously to derive ice thickness, with columnar ice mean density of 870 kg m⁻³. At two different ice stations the mean density of the ice was 870 and 800 kg m⁻³, the lower density reflecting a high percentage of porous granular ice at the second station. Error estimates for mass/volume and liquid/solid water methods are presented. With 0.1 m long, 0.1 m core samples, the error on individual density estimates is 28 kg m⁻³. Errors are larger for smaller machined blocks. Errors increase to 46 kg m⁻³ if the liquid/solid volume method is used. The mass/volume method has a low bias due to brine drainage of at least 5%. Bulk densities estimated from ice and snow measurements along 100 m transects were high, and likely unrealistic as the assumption of isostatic balance is not suitable over these length scales in deformed ice

BronchUK:protocol for an observational cohort study and biobank in bronchiectasis

Bronchiectasis has been a largely overlooked disease area in respiratory medicine. This is reflected by a shortage of large-scale studies and lack of approved therapies, in turn leading to a variation of treatment across centres. BronchUK (Bronchiectasis Observational Cohort and Biobank UK) is a multicentre, prospective, observational cohort study working collaboratively with the European Multicentre Bronchiectasis Audit and Research Collaboration project. The inclusion criteria for patients entering the study are a clinical history consistent with bronchiectasis and computed tomography demonstrating bronchiectasis. Main exclusion criteria are 1) patients unable to provide informed consent, 2) bronchiectasis due to known cystic fibrosis or where bronchiectasis is not the main or co-dominant respiratory disease, 3) age <18 years, and 4) prior lung transplantation for bronchiectasis. The study is aligned to standard UK National Health Service (NHS) practice with an aim to recruit a minimum of 1500 patients from across at least nine secondary care centres. Patient data collected at baseline includes demographics, aetiology testing, comorbidities, lung function, radiology, treatments, microbiology and quality of life. Patients are followed up annually for a maximum of 5 years and, where able, blood and/or sputa samples are collected and stored in a central biobank. BronchUK aims to collect robust longitudinal data that can be used for analysis into current NHS practice and patient outcomes, and to become an integral resource to better inform future interventional studies in bronchiectasis