13,297 research outputs found

    Investigating microstructural variation in the human hippocampus using non-negative matrix factorization

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    In this work we use non-negative matrix factorization to identify patterns of microstructural variance in the human hippocampus. We utilize high-resolution structural and diffusion magnetic resonance imaging data from the Human Connectome Project to query hippocampus microstructure on a multivariate, voxelwise basis. Application of non-negative matrix factorization identifies spatial components (clusters of voxels sharing similar covariance patterns), as well as subject weightings (individual variance across hippocampus microstructure). By assessing the stability of spatial components as well as the accuracy of factorization, we identified 4 distinct microstructural components. Furthermore, we quantified the benefit of using multiple microstructural metrics by demonstrating that using three microstructural metrics (T1-weighted/T2-weighted signal, mean diffusivity and fractional anisotropy) produced more stable spatial components than when assessing metrics individually. Finally, we related individual subject weightings to demographic and behavioural measures using a partial least squares analysis. Through this approach we identified interpretable relationships between hippocampus microstructure and demographic and behavioural measures. Taken together, our work suggests non-negative matrix factorization as a spatially specific analytical approach for neuroimaging studies and advocates for the use of multiple metrics for data-driven component analyses

    The Automatic Real-Time GRB Pipeline of the 2-m Liverpool Telescope

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    The 2-m Liverpool Telescope (LT), owned by Liverpool John Moores University, is located in La Palma (Canary Islands) and operates in fully robotic mode. In 2005, the LT began conducting an automatic GRB follow-up program. On receiving an automatic GRB alert from a Gamma-Ray Observatory (Swift, INTEGRAL, HETE-II, IPN) the LT initiates a special override mode that conducts follow-up observations within 2-3 min of the GRB onset. This follow-up procedure begins with an initial sequence of short (10-s) exposures acquired through an r' band filter. These images are reduced, analyzed and interpreted automatically using pipeline software developed by our team called "LT-TRAP" (Liverpool Telescope Transient Rapid Analysis Pipeline); the automatic detection and successful identification of an unknown and potentially fading optical transient triggers a subsequent multi-color imaging sequence. In the case of a candidate brighter than r'=15, either a polarimetric (from 2006) or a spectroscopic observation (from 2007) will be triggered on the LT. If no candidate is identified, the telescope continues to obtain z', r' and i' band imaging with increasingly longer exposure times. Here we present a detailed description of the LT-TRAP and briefly discuss the illustrative case of the afterglow of GRB 050502a, whose automatic identification by the LT just 3 min after the GRB, led to the acquisition of the first early-time (< 1 hr) multi-color light curve of a GRB afterglow.Comment: PASP, accepted (8 pages, 3 figures

    Higher Order Stability of a Radiatively Induced 220 GeV Higgs Mass

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    The effective potential for radiatively broken electroweak symmetry in the single Higgs doublet Standard Model is explored to four sequentially subleading logarithm-summation levels (5-loops) in the dominant Higgs self-interaction couplant λ\lambda. We augment these results with all contributing leading logarithms in the remaining large but sub-dominant Standard Model couplants (t-quark, QCD and SU(2)U(1)SU(2)\otimes U(1) gauge couplants) as well as next to leading logarithm contributions from the largest of these, the t-quark and QCD couplants. Order-by-order stability is demonstrated for earlier leading logarithm predictions of an order 220 GeV Higgs boson mass in conjunction with fivefold enhancement of the value for λ\lambda over that anticipated from conventional spontaneous symmetry breaking.Comment: revtex, 6 pages. Analysis and text is expanded in revised versio

    PPl 15: The First Brown Dwarf Spectroscopic Binary

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    PPl 15 is the first object to have been confirmed as a brown dwarf by the lithium test (in 1995), though its inferred mass was very close to the substellar limit. It is a member of the Pleiades open cluster. Its position in a cluster color-magnitude diagram suggested that it might be binary, and preliminary indications that it is a double-lined spectroscopic binary were reported by us in 1997. Here we report on the results of a consecutive week of Keck HIRES observations of this system, which yield its orbit. It has a period of about 5.8 days, and an eccentricity of 0.4+/-0.05. The rotation of the stars is slow for this class of objects. Because the system luminosity is divided between 2 objects with a mass ratio of 0.85, this renders each of them an incontrovertible brown dwarf, with masses between 60-70 jupiters. We show that component B is a little redder than A by studying their wavelength-dependent line ratios, and that this variation is compatible with the mass ratio. We confirm that the system has lithium, but cannot support the original conclusion that it is depleted (which would be surprising, given the new masses). This is a system of very close objects which, if they had combined, would have produced a low mass star. We discuss the implications of this discovery for the theories of binary formation and formation of very low mass objects.Comment: Latex, 18 pages, 4 figures, submitted to Astron.

    The 2010 M 87 VHE flare and its origin: the multi-wavelength picture

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    The giant radio galaxy M 87, with its proximity (16 Mpc) and its very massive black hole ((3 - 6) \times 10^9 M_solar), provides a unique laboratory to investigate very high energy (E>100 GeV; VHE) gamma-ray emission from active galactic nuclei and, thereby, probe particle acceleration to relativistic energies near supermassive black holes (SMBH) and in relativistic jets. M 87 has been established as a VHE gamma-ray emitter since 2005. The VHE gamma-ray emission displays strong variability on timescales as short as a day. In 2008, a rise in the 43 GHz Very Long Baseline Array (VLBA) radio emission of the innermost region (core; extension of < 100 Rs ; Schwarzschild radii) was found to coincide with a flaring activity at VHE. This had been interpreted as a strong indication that the VHE emission is produced in the direct vicinity of the SMBH. In 2010 a flare at VHE was again detected triggering further multi-wavelength (MWL) observations with the VLBA, Chandra, and other instruments. At the same time, M 87 was also observed with the Fermi-LAT telescope at MeV/GeV energies, the European VLBI Network (EVN), and the Liverpool Telescope (LT). Here, preliminary results from the 2010 campaign will be reported.Comment: 6 pages, 2 figures; Procceedings of the workshop "High Energy Phenomena in Relativistic Outflows III" (HEPRO III), Barcelona, June 27 - July 1, 201

    Potential Alteration of Analogue Regolith by X-Ray Computed Tomography

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    The Mars 2020 rover mission will collect and cache samples from the martian surface for possible retrieval and subsequent return to Earth. Mars Returned Samples may provide definitive information about the presence of organic compounds that could shed light on the existence of past or present life on Mars. Post-mission analyses will depend on the development of a set of reliable sample handling and analysis procedures that cover the full range of materials which may or may not contain evidence of past or present martian life [1]

    Mapping pontocerebellar connectivity with diffusion MRI

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    The cerebellum's involvement in cognitive, affective and motor functions is mediated by connections to different regions of the cerebral cortex. A distinctive feature of cortico-cerebellar loops that has been demonstrated in the animal work is a topographic organization that is preserved across its corticopontine, pontocerebellar, and cerebello-thalmo-cortical segments. Here we used tractography derived from diffusion imaging data to characterize the connections between the pons and the individual lobules of the cerebellum and generate a parcellation of the pons and middle cerebellar peduncle based on the pattern of connectivity. We identified a rostral to caudal gradient in the pons, similar to that observed in the animal work, such that rostral regions were preferentially connected to cerebellar lobules involved in non-motor, and caudal regions with motor regions. These findings advance our fundamental understanding of the cerebellum, and the parcellations we generated provide context for future research into the pontocerebellar tract's involvement in health and disease
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