Feature Selection for Monitoring Erosive Cavitation on a Hydroturbine

This paper presents a method for comparing and evaluating cavitation detection features - the first step towards estimating remaining useful life (RUL) of hydroturbine runners that are impacted by erosive cavitation. The method can be used to quickly compare features created from cavitation survey data collected on any type of hydroturbine, sensor type, sensor location, and cavitation sensitivity parameter (CSP). Although manual evaluation and knowledge of hydroturbine cavitation is still required for our feature selection method, the use of principal component analysis greatly reduces the number of plots that require evaluation. We present a case study based on a cavitation survey data collected on a Francis hydroturbine located at a hydroelectric plant and demonstrate the selection of the most advantageous sensor type, sensor location, and CSP to use on this hydroturbine for long-term monitoring of erosive cavitation. Our method provides hydroturbine operators and researchers with a clear and effective means to determine preferred sensors, sensor placements, and CSPs while also laying the groundwork for determining RUL in the future

A Method for Automated Cavitation Detection with Adaptive Thresholds

Hydroturbine operators who wish to collect cavitation intensity data to estimate cavitation erosion rates and calculate remaining useful life (RUL) of the turbine runner face several practical challenges related to long term cavitation detection. This paper presents a novel method that addresses these challenges including: a method to create an adaptive cavitation threshold, and automation of the cavitation detection process. These two strategies result in collecting consistent cavitation intensity data. While domain knowledge and manual interpretation are used to choose an appropriate cavitation sensitivity parameter (CSP), the remainder of the process is automated using both supervised and unsupervised learning methods. A case study based on ramp-down data, taken from a production hydroturbine, is presented and validated using independently gathered survey data from the same hydroturbine. Results indicate that this fully automated process for selecting cavitation thresholds and classifying cavitation performs well when compared to manually selected thresholds. This approach provides hydroturbine operators and researchers with a clear and effective way to perform automated, long term, cavitation detection, and assessment

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting

A Method for Automated Cavitation Detection with Adaptive Thresholds

The article of record as published may be found at https://doi.org/10.1016/j.procs.2019.05.089Hydroturbine operators who wish to collect cavitation intensity data to estimate cavitation erosion rates and calculate remaining useful life (RUL) of the turbine runner face several practical challenges related to long term cavitation detection. This paper presents a novel method that addresses these challenges including: a method to create an adaptive cavitation threshold, and automation of the cavitation detection process. These two strategies result in collecting consistent cavitation intensity data. While domain knowledge and manual interpretation are used to choose an appropriate cavitation sensitivity parameter (CSP), the remainder of the process is automated using both supervised and unsupervised learning methods. A case study based on ramp-down data, taken from a production hydroturbine, is presented and validated using independently gathered survey data from the same hydroturbine. Results indicate that this fully automated process for selecting cavitation thresholds and classifying cavitation performs well when compared to manually selected thresholds. This approach provides hydroturbine operators and researchers with a clear and effective way to perform automated, long term, cavitation detection, and assessment.Funded in part by the Office of Energy Efficiency and Renewable Energy (EERE), U.S. Department of Energy, under Award Number DE-EE0002668 and the Hydro Research Foundation.Funded in part by the Office of Energy Efficiency and Renewable Energy (EERE), U.S. Department of Energy, under Award Number DE-EE0002668 and the Hydro Research Foundation

Development of a thin section device for space exploration: Rock cutting mechanism

We have developed a rock cutting mechanism for in situ planetary exploration based on abrasive diamond impregnated wire. Performance characteristics of the rock cutter, including cutting rate on several rock types, cutting surface lifetime, and cut rock surface finish are presented. The rock cutter was developed as part of a broader effort to develop an in situ automated rock thin section (IS-ARTS) instrument. The objective of IS-ARTS was to develop an instrument capable of producing petrographic rock thin sections on a planetary science spacecraft. The rock cutting mechanism may also be useful to other planetary science missions with in situ instruments in which sub-sampling and rock surface preparation are necessary. © 2012 COSPAR. Published by Elsevier Ltd. All rights reserved

Development of a thin section device for space exploration: Overview and system performance estimates

In this paper we present a conceptual design of a spaceborne instrument for the in situ production of rock thin sections on planetary surfaces. The in situ Automated Rock Thin Section Instrument (IS-ARTS) conceptual design demonstrates that the in situ production of thin sections on a planetary body is a plausible new instrument capability for future planetary exploration. Thin section analysis would reduce much ambiguity in the geological history of a sampled site that is present with instruments currently flown. The technical challenge of producing a thin section device compatible with the spacecraft environment is formidable and has been thought too technically difficult to be practical. Terrestrial thin section preparation requires a skilled petrographist, several preparation instruments that individually exceed typical spacecraft mass and power limits, and consumable materials that are not easily compatible with spaceflight. In two companion papers we present research and development work used to constrain the capabilities of IS-ARTS in the technical space compatible with the spacecraft environment. For the design configuration shown we conclude that a device can be constructed that is capable of 50 sample preparations over a 2 year lifespan with mass, power, and volume constraints compatible with current landed Mars mission configurations. The technical requirements of IS-ARTS (mass, power and number of samples produced) depend strongly on the sample mechanical properties, sample processing rate, the sample size and number of samples to be produced. © 2012 COSPAR. Published by Elsevier Ltd. All rights reserved

A MODELING APPROACH TO HYDRATE WALL GROWTH AND SLOUGHING IN A WATER SATURATED GAS PIPELINE

A hydrate plugging and formation model for oil and gas pipelines is becoming increasingly important as producers continue to push flow assurance boundaries. A key input for any hydrate plugging model is the rate of hydrate growth and the volume fraction of hydrate at a given time. This work investigates a fundamental approach toward predicting hydrate growth and volume fraction in a water saturated gas pipeline. This works suggests that, in the absence of free water, hydrate volume fraction can be predicted using a wall growth and sloughing model. Wall growth can be predicted using a one-dimensional, moving boundary, heat and mass transfer model. It is hypothesized that hydrate sloughing can be predicted when a coincident frequency exists between hydrate natural frequency and flow induced vibrations over the hydrate surface.Non UBCUnreviewe

Development of a thin section device for space exploration: Overview and system performance estimates

In this paper we present a conceptual design of a spaceborne instrument for the in situ production of rock thin sections on planetary surfaces. The in situ Automated Rock Thin Section Instrument (IS-ARTS) conceptual design demonstrates that the in situ production of thin sections on a planetary body is a plausible new instrument capability for future planetary exploration. Thin section analysis would reduce much ambiguity in the geological history of a sampled site that is present with instruments currently flown. The technical challenge of producing a thin section device compatible with the spacecraft environment is formidable and has been thought too technically difficult to be practical. Terrestrial thin section preparation requires a skilled petrographist, several preparation instruments that individually exceed typical spacecraft mass and power limits, and consumable materials that are not easily compatible with spaceflight. In two companion papers we present research and development work used to constrain the capabilities of IS-ARTS in the technical space compatible with the spacecraft environment. For the design configuration shown we conclude that a device can be constructed that is capable of 50 sample preparations over a 2 year lifespan with mass, power, and volume constraints compatible with current landed Mars mission configurations. The technical requirements of IS-ARTS (mass, power and number of samples produced) depend strongly on the sample mechanical properties, sample processing rate, the sample size and number of samples to be produced. © 2012 COSPAR. Published by Elsevier Ltd. All rights reserved

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors : a Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group : Part 1 : Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy