Multigrid methods for compressible Navier-Stokes equations in low-speed flows

AbstractThe multigrid performance of pointwise, linewise and blockwise Gauss-Seidel relaxations for compressible laminar and turbulent Navier-Stokes equations is illustrated on two low-speed test problems: a flat plate and a backward facing step. The line method is an Alternating Symmetric Line Gauss-Seidel relaxation. In the block methods, the grid is subdivided into geometric blocks of n × n points with one point overlap. With in the blocks, the solution is obtained by a direct method or with an alternating modified incomplete lower-upper decomposition. The analysis is focused on flows typical for boundary layers, stagnation and recirculation regions. These are characterized by very small Mach numbers, high Reynolds numbers and high mesh aspect ratios

Life-Cycle Cost Estimation for High-Speed Vehicles: from the engineers’ to the airline’s perspective

This paper aims at upgrading the holistic Cost Estimation methodology for High-Speed Vehicles already developed by Politecnico di Torino and the European Space Agency (ESA) to encompass different stakeholders’ perspectives. In details, the presented methodology combines International Air Transport Association (IATA) best practices with a detailed Life- Cycle Cost (LCC) assessment, which includes the evaluation of Research, Development, Test and Evaluation (RDTE) Costs, Production costs and of Direct and Indirect Operating Costs (DOC and IOC). The integrated approach allows to further extend the capabilities of the inhouse developed HyCost tool to support all the actors of the product value-chain (including engineers, manufacturers, airlines and customers) in assessing the economic sustainability of a newly under-development high-speed vehicle. However, considering the need of providing all these cost analyses perspectives since the early design stages, the derived Cost Estimation Relationships are mainly derived on statistical bases. To cope with the uncertainties that affect the initial statistical population and consequently, the CERs, this paper presents each cost item together with the estimation of related prediction intervals. Finally, results of the application of the upgraded cost estimation methodology and of the upgraded tool to the LAPCAT MR2.4 high-speed civil transport are reported and discussed

EUFOREA Rhinology Research Forum 2016: report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis

The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collaboration with the European Rhinologic Society (ERS) and the Global Allergy and Asthma European Network (GA2LEN). One hundred and thirty participants (medical doctors from different specialties, researchers, as well as patients and industry representatives) from 27 countries took part in the multiple perspective discussions including brainstorming sessions on care pathways and research needs in rhinitis and rhinosinusitis. The debates started with an overview of the current state of the art, including weaknesses and strengths of the current practices, followed by the identification of essential research needs, thoroughly integrated in the context of Precision Medicine (PM), with personalized care, prediction of success of treatment, participation of the patient and prevention of disease as key principles for improving current clinical practices. This report provides a concise summary of the outcomes of the brainstorming sessions of the European Rhinology Research Forum 2016

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS