Syntheses of new binucleating heterocyclic ligands

The syntheses of five new mixed azine–azole binucleating ligands are described

Thermodynamic properties of thin films of superfluid 3He-A

The pairing correlations in superfluid He-3 are strongly modified by quasiparticle scattering off a surface or an interface. We present theoretical results and predictions for the order parameter, the quasiparticle excitation spectrum and the free energy for thin films of superfluid He-3. Both specular and diffuse scattering by a substrate are considered, while the free surface is assumed to be a perfectly reflecting specular boundary. The results are based on self-consistent calculations of the order parameter and quasiparticle excitation spectrum at zero pressure. We obtain new results for the phase diagram, free energy, entropy and specific heat of thin films of superfluid He-3.Comment: Replaced with an updated versio

The importance of age effects on performance in the assessment of clinical trials

Forty young adult normal subjects, 10 Parkinson's disease patients and their 10 matched normal subjects, and 10 multiple sclerosis patients and their 10 matched normal subjects were evaluated in the Quantitative Examination of Neurological Function to determine age effects and the importance of selecting closely matched normal control groups for assessing the performance of patients. Where there are significant differences among the three normal subject groups, it is the oldest normal subject group that differs from the two younger subject groups. Significant decreases in performance with increasing age were found for the steadiness tests performed in the supported position, the sensation tests, two or five tests in the Neuro-Psychological Examination and tests requiring fine skilled movements primarily with the dominant hand. It was found that older subjects made fewer errors in coordinated tasks.A normalization technique, expressing performance as a percentage of normal function, was introduced. A method was developed to provide quantitative and meaningful indices of neurological function. The measure is obtained by averaging the percentage of normal function scores over several tests that belong to a primary category of neurological function.Young adult normal subjects do not perform significantly better than normal subjects in the age range of multiple sclerosis patients; however, young adult normal subjects do perform significantly better than normal subjects in the age range of Parkinson's disease patients, especially on tasks requiring fine skilled movements of the dominant hand and coordinated activities of the lower extremities. These results indicate that the performance of multiple sclerosis patients can be expressed as a percentage of the function of either age-matched normal controls or young adult normal controls. However, the performance of Parkinson's disease patients should be expressed only as a percentage of the function of age-matched normal controls.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33791/1/0000046.pd

The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review

Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended in humans. Here we present a brief review of the information availabile regarding the pharmacokinetics and interactions of ivermectin in humans. Awareness of these characteristics could improve the clinical efficacy of Ivermectin. All Authors declare that they do not have any Conflict of interest and that the work is original. All Authors agree that the contents of the manuscript are confidential and will not be copyrighted, submitted, or published elsewhere (including the Internet), in any language, while acceptance by the Journal is under consideration

Perspectives in visual imaging for marine biology and ecology: from acquisition to understanding

Durden J, Schoening T, Althaus F, et al. Perspectives in Visual Imaging for Marine Biology and Ecology: From Acquisition to Understanding. In: Hughes RN, Hughes DJ, Smith IP, Dale AC, eds. Oceanography and Marine Biology: An Annual Review. 54. Boca Raton: CRC Press; 2016: 1-72