Health of children and young people in secure settings

This small-scale descriptive study was commissioned by the Children and Young People's Public Health team within the Department of Health, in partnership with Offender Health, in order to inform preparation and implementation of an Offender Health Strategy document for children and young people. The overall aim was to review what is currently known about healthcare for children and young people in the secure estate, covering all three types of settings (Young Offender Institution, Secure Training Centre and Secure Children's Home) and all aspects of health, but with a particular focus on physical health since more is already known about mental health and substance misuse among young people in secure settings

Promoting the emotional wellbeing and mental health of unaccompanied young people seeking asylum in the UK - Research Summary

This research summary provides an overview of findings from an 18-month, in-depth research project: The social functioning, emotional wellbeing and mental health of unaccompanied young people seeking asylum in the UK. The research was conducted by the Thomas Coram Research Unit, at the Institute of Education, University of London. It was commissioned and funded by the Department of Health, although the views expressed in this summary do not necessarily reflect those of the Department. The key findings from the study are presented and some of the specific implications for policy and practice for those working with unaccompanied children and young people in a range of health, social care, education, immigration and legal settings are discussed

Healthy early years settings: a scoping study

This briefing paper considers the diversity in early years provision. It was produced for the Healthy Early Years study, which was funded by the Department of Health, to help inform decisions about extending the Healthy Schools Programme approach to early years settings. The paper focuses on childcare and early education provision for children aged from birth to five years: maintained and private nursery schools, Sure Start local programmes, children's centres, day nurseries, pre-school playgroups and childminders. An overview of the relevant issues and of the distinguishing features of each type of setting is provided

Mental health and emotional well-being of students in further education - a scoping study

This study aimed to explore how FE colleges in England are engaging with and addressing the mental health needs of their young students (aged 16-19), both in terms of promoting positive mental health and emotional well-being and in responding to identified mental health problems

Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control

Background Mental health disorders commonly co-occur, even between conceptually distinct syndromes, such as internalizing and externalizing disorders. The current study investigated whether phenotypic, genetic, and environmental variance in negative emotionality and behavioral control account for the covariation between major depressive disorder (MDD) and alcohol use disorder (AUD). Method A total of 3623 members of a national twin registry were administered structured diagnostic telephone interviews that included assessments of lifetime histories of MDD and AUD, and were mailed self-report personality questionnaires that assessed stress reactivity (SR) and behavioral control (CON). A series of biometric models were fitted to partition the proportion of covariance between MDD and AUD into SR and CON. Results A statistically significant proportion of the correlation between MDD and AUD was due to variance specific to SR (men = 0.31, women = 0.27) and CON (men = 0.20, women = 0.19). Further, genetic factors explained a large proportion of this correlation (0.63), with unique environmental factors explaining the rest. SR explained a significant proportion of the genetic (0.33) and environmental (0.23) overlap between MDD and AUD. In contrast, variance specific to CON accounted for genetic overlap (0.32), but not environmental overlap (0.004). In total, SR and CON accounted for approximately 70% of the genetic and 20% of the environmental covariation between MDD and AUD. Conclusions This is the first study to demonstrate that negative emotionality and behavioral control confer risk for the co-occurrence of MDD and AUD via genetic factors. These findings are consistent with the aims of NIMH's RDoC proposal to elucidate how transdiagnostic risk factors drive psychopathology

Effects of Different Production Systems on the Nutrient Density of Beef

As concerns regarding beef production systems on human health and animal welfare become more apparent, consumer interest in pasture-raised livestock has been steadily on the rise in the US. Such interest has increasingly led to questions about potential nutritional composition differences in beef from different production systems, such as grass-fed beef and grain-fed beef. The goal of this work was to conduct untargeted metabolomics analysis on a broad range of samples from the US beef supply chain to provide insight into how different finishing systems impact the beef metabolome and nutrient density. Here, we found that 191 out of 802 profiled compounds were different between grass-fed and grain-fed ribeye steaks (all, p \u3c 0.05), with phytochemicals, vitamins, lipid, and amino acid metabolites emerging as the most discriminatory metabolite classes. On average, phytochemicals were 1.7-fold higher in grass-fed beef compared to grain-fed beef (p \u3c 0.05) with considerable variation (4.4-fold) amongst individual farms, particularly within grass-fed beef systems. Alpha-tocopherol was 2-fold elevated in grass-fed beef, while nicotinamide was 1.3-fold elevated in grain-fed beef, respectively (p \u3c 0.05). We also observed that 4- hydroxy-nonenal-glutathione, a common marker of oxidative stress, was 2.7-fold elevated in grain-fed beef samples (p \u3c 0.05), with a 20-fold variation across individual farms. Future work will identify the source(s) of variation and best practices in beef systems to improve beef nutrient density and animal metabolic health

Climate change and cattle farming

Issues raised by cattle farming in relation to climate change extend beyond discussion of greenhouse gas emissions and global warming. There are profound consequences for water availability, soil degradation, biodiversity and local ecology, as well as in terms of conflict for energy supplies. Although climate change impacts on cattle farming (through effects on water availability, heat stress and flooding, for example), this article focuses on how cattle farming impacts on climate change. It explores the issues in terms of the impact of cattle farming on the environment, and how to measure and reduce climate change impacts at farm level. Managing the complex and conflicting balance of factors required for sustainable food production offers an important role for the veterinary surgeon

Cannabis and depression: A twin model approach to co-morbidity

Cannabis use disorder (CUD) co-occurs with major depressive disorder (MDD) more frequently than would be expected by chance. However, studies to date have not produced a clear understanding of the mechanisms underlying this co-morbidity. Genetically informative studies can add valuable insight to this problem, as they allow the evaluation of competing models of co-morbidity. This study uses data from the Australian Twin Registry to compare 13 co-morbidity twin models initially proposed by Neale and Kendler (Am J Hum Genet 57:935–953, 1995). The analysis sample comprised 2410 male and female monozygotic and dizygotic twins (average age 32) who were assessed on CUD and MDD using the SSAGA-OZ interview. Data were analyzed in OpenMx. Of the 13 different co-morbidity models, two fit equally well: CUD causes MDD and Random Multiformity of CUD. Both fit substantially better than the Correlated Liabilities model. Although the current study cannot differentiate between them statistically, these models, in combination, suggest that CUD risk factors may causally influence the risk to develop MDD, but only when risk for CUD is high

Capillary Liquid Acquisition Device Heat Entrapment

Cryogenic liquid acquisition devices (LADs) for space-based propulsion interface directly with the feed system, which can be a significant heat leak source. Further, the accumulation of thermal energy within LAD channels can lead to the loss of subcooled propellant conditions and result in feed system cavitation during propellant outflow. Therefore, the fundamental question addressed by this program was: To what degree is natural convection in a cryogenic liquid constrained by the capillary screen meshes envisioned for LADs? Testing was first conducted with water as the test fluid, followed by LN2 tests. In either case, the basic experimental approach was to heat the bottom of a cylindrical column of test fluid to establish stratification patterns measured by temperature sensors located above and below a horizontal screen barrier position. Experimentation was performed without barriers, with screens, and with a solid barrier. The two screen meshes tested were those typically used by LAD designers, 200x1400 and 325x2300, both with Twill Dutch Weave. Upon consideration of both the water and LN2 data, it was concluded that heat transfer across the screen meshes was dependent upon barrier thermal conductivity and that the capillary screen meshes were impervious to natural convection currents

Ice sheets as a significant source of highly reactive nanoparticulate iron to the oceans

The Greenland and Antarctic Ice Sheets cover ~\n10% of global land surface, but are rarely considered as active components of the global iron cycle. The ocean waters around both ice sheets harbour highly productive coastal ecosystems, many of which are iron limited. Measurements of iron concentrations in subglacial runoff from a large Greenland Ice Sheet catchment reveal the potential for globally significant export of labile iron fractions to the near-coastal euphotic zone. We estimate that the flux of bioavailable iron associated with glacial runoff is 0.40–2.54?Tg per year in Greenland and 0.06–0.17?Tg per year in Antarctica. Iron fluxes are dominated by a highly reactive and potentially bioavailable nanoparticulate suspended sediment fraction, similar to that identified in Antarctic icebergs. Estimates of labile iron fluxes in meltwater are comparable with aeolian dust fluxes to the oceans surrounding Greenland and Antarctica, and are similarly expected to increase in a warming climate with enhanced melting