575 research outputs found
Experimental study of a liquid Xenon PET prototype module
A detector using liquid Xenon in the scintillation mode is studied for
Positron Emission Tomography (PET). The specific design aims at taking full
advantage of the liquid Xenon properties. It does feature a promising
insensitive to any parallax effect. This work reports on the performances of
the first LXe prototype module, equipped with a position sensitive PMT
operating in the VUV range (178 nm).Comment: Proc. of the 7th International Workshops on Radiation Imaging
Detectors (IWORID-7), Grenoble, France 4-7 July 200
Detection of the Cherenkov light diffused by Sea Water with the ULTRA Experiment
The study of Ultra High Energy Cosmic Rays represents one of the most
challenging topic in the Cosmic Rays and in the Astroparticle Physics fields.
The interaction of primary particles with atmospheric nuclei produces a huge
Extensive Air Shower together with isotropic emission of UV fluorescence light
and highly directional Cherenkov photons, that are reflected/diffused
isotropically by the impact on the Earth's surface or on high optical depth
clouds. For space-based observations, detecting the reflected Cherenkov signal
in a delayed coincidence with the fluorescence light improves the accuracy of
the shower reconstruction in space and in particular the measurement of the
shower maximum, giving a strong signature for discriminating hadrons and
neutrinos, and helping to estimate the primary chemical composition. Since the
Earth's surface is mostly covered by water, the ULTRA (UV Light Transmission
and Reflection in the Atmosphere)experiment has been designed to provide the
diffusing properties of sea water, overcoming the lack of information in this
specific field. A small EAS array, made up of 5 particle detectors, and an UV
optical device, have been coupled to detect in coincidence both electromagnetic
and UV components. The detector was in operation from May to December, 2005, in
a small private harbor in Capo Granitola (Italy); the results of these
measurements in terms of diffusion coefficient and threshold energy are
presented here.Comment: 4 pages, 3 figures, PDF format, Proceedings of 30th ICRC,
International Cosmic Ray Conference 2007, Merida, Yucatan, Mexico, 3-11 July
200
ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells
Lipid Droplets (LDs) are emerging as crucial players in colon cancer development and maintenance. Their expression has been associated with high tumorigenicity in Cancer Stem Cells (CSCs), so that they have been proposed as a new functional marker in Colorectal Cancer Stem Cells (CR-CSCs). They are also indirectly involved in the modulation of the tumor microenvironment through the production of pro-inflammatory molecules. There is growing evidence that a possible connection between metabolic alterations and malignant transformation exists, although the effects of nutrients, primarily glucose, on the CSC behavior are still mostly unexplored. Glucose is an essential fuel for cancer cells, and the connections with LDs in the healthy and CSC populations merit to be more deeply investigated. Here, we showed that a high glucose concentration activated the PI3K/AKT pathway and increased the expression of CD133 and CD44v6 CSC markers. Additionally, glucose was responsible for the increased amount of Reactive Oxygen Species (ROS) and LDs in both healthy and CR-CSC samples. We also investigated the gene modulations following the HG treatment and found out that the healthy cell gene profile was the most affected. Lastly, Atorvastatin, a lipid-lowering drug, induced the highest mortality on CR-CSCs without affecting the healthy counterpart
Radio emission of extensive air shower at CODALEMA: Polarization of the radio emission along the v*B vector
Cosmic rays extensive air showers (EAS) are associated with transient radio
emission, which could provide an efficient new detection method of high energy
cosmic rays, combining a calorimetric measurement with a high duty cycle. The
CODALEMA experiment, installed at the Radio Observatory in Nancay, France, is
investigating this phenomenon in the 10^17 eV region. One challenging point is
the understanding of the radio emission mechanism. A first observation
indicating a linear relation between the electric field produced and the cross
product of the shower axis with the geomagnetic field direction has been
presented (B. Revenu, this conference). We will present here other strong
evidences for this linear relationship, and some hints on its physical origin.Comment: Contribution to the 31st International Cosmic Ray Conference, Lodz,
Poland, July 2009. 4 pages, 8 figures. v2: Typo fixed, arxiv references adde
Results from the ULTRA experiment in the framework of the EUSO project
The detection of Cerenkov light from EAS in a delayed coincidence with fluorescence light gives a strong signature to discriminate protons and neutrinos in cosmic rays. For this purpose, the ULTRA experiment has been designed with 2 detectors: a small EAS array (ETscope) and an UV optical device including wide field (Belenos) and narrow field (UVscope) Cerenkov light detectors. The array measures the shower size and the arrival direction of the incoming EAS, while the UV devices, pointing both to zenith and nadir, are used to determine the amount of direct and diffused coincident Cerenkov light. This information, provided for different diffusing surfaces, will be used to verify the possibility of detecting from Space the Cerenkov light produced by UHECRs with the EUSO experiment, on board the ISS
Ultrahigh-energy neutrino follow-up of Gravitational Wave events GW150914 and GW151226 with the Pierre Auger Observatory
On September 14, 2015 the Advanced LIGO detectors observed their first
gravitational-wave (GW) transient GW150914. This was followed by a second GW
event observed on December 26, 2015. Both events were inferred to have arisen
from the merger of black holes in binary systems. Such a system may emit
neutrinos if there are magnetic fields and disk debris remaining from the
formation of the two black holes. With the surface detector array of the Pierre
Auger Observatory we can search for neutrinos with energy above 100 PeV from
point-like sources across the sky with equatorial declination from about -65
deg. to +60 deg., and in particular from a fraction of the 90% confidence-level
(CL) inferred positions in the sky of GW150914 and GW151226. A targeted search
for highly-inclined extensive air showers, produced either by interactions of
downward-going neutrinos of all flavors in the atmosphere or by the decays of
tau leptons originating from tau-neutrino interactions in the Earth's crust
(Earth-skimming neutrinos), yielded no candidates in the Auger data collected
within s around or 1 day after the coordinated universal time (UTC)
of GW150914 and GW151226, as well as in the same search periods relative to the
UTC time of the GW candidate event LVT151012. From the non-observation we
constrain the amount of energy radiated in ultrahigh-energy neutrinos from such
remarkable events.Comment: Published version. Added journal reference and DOI. Added Report
Numbe
Multi-resolution anisotropy studies of ultrahigh-energy cosmic rays detected at the Pierre Auger Observatory
We report a multi-resolution search for anisotropies in the arrival
directions of cosmic rays detected at the Pierre Auger Observatory with local
zenith angles up to and energies in excess of 4 EeV ( eV). This search is conducted by measuring the angular power spectrum
and performing a needlet wavelet analysis in two independent energy ranges.
Both analyses are complementary since the angular power spectrum achieves a
better performance in identifying large-scale patterns while the needlet
wavelet analysis, considering the parameters used in this work, presents a
higher efficiency in detecting smaller-scale anisotropies, potentially
providing directional information on any observed anisotropies. No deviation
from isotropy is observed on any angular scale in the energy range between 4
and 8 EeV. Above 8 EeV, an indication for a dipole moment is captured; while no
other deviation from isotropy is observed for moments beyond the dipole one.
The corresponding -values obtained after accounting for searches blindly
performed at several angular scales, are in the case of
the angular power spectrum, and in the case of the needlet
analysis. While these results are consistent with previous reports making use
of the same data set, they provide extensions of the previous works through the
thorough scans of the angular scales.Comment: Published version. Added journal reference and DOI. Added Report
Numbe
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