Energie- und Ressourceneffizienz an der Hochschule Reutlingen: Betriebshalle, Vorlesungsgebäude Textil & Design, Hochschulservicezentrum

In der heutigen Zeit ist es wichtig mit den Ressourcen sparsam umzugehen. Deshalb wird in dieser Projektarbeit die Ressourcen- und Energieeffizienz der Hochschule Reutlingen untersucht. Mit dem Aufzeigen der Potentiale in diesem Bereich können Kosten eingespart und die Umweltbelastung der Hochschule verringert werden. Es handelt sich hierbei um eine Erstanalyse mit begrenztem Detaillierungsgrad. Dieser beinhaltet den aktuellen Status quo in Bezug auf elektrische Energie, Wärmeenergie, Wasserverbrauch und Gas. Mit Hilfe einer Verbraucheranalyse werden die Hauptverbraucher ermittelt. Anhand dieser Ergebnisse werden dann die wesentlichen Potentiale deutlich gemacht. Aus Gründen der begrenzten Zeit und der Komplexität des Themas wird nach dem Pareto- Prinzip (20/80 Regel) vorgegangen. Es soll ein Gesamtüberblick über die Ressourcennutzung geschaffen und Ansatzpunkte für spätere Projektarbeiten ermittelt werden. Die Bewertung der Wirtschaftlichkeit dieser Potentiale ist aus zeitlichen Gründen kein Bestandteil dieser Projektarbeit

Morphosyntax of Tae' Language (Morfosintaksis Bahasa Tae')

Abstract: This research aims to convey the morphosyntax in Tae’ language. This is descriptive qualitative research supported by library and field method. The library and field research method aims to find the detail and complete data. Moreover, the research analyzes words, phrases, clauses, and sentences in Tae’ language as primary data. The results show that there are some features that mark morphosyntax in Tae’ language. They are reduplication process, derivational affixation, and sentence structures that describe the word orders of Tae’ language. Reduplications of Tae’ language are containing of full and partial reduplication. Whereas, the derivational affixations of Tae’ language are containing of prefixes and suffixes. The form of prefixes is ma-, ku-, na- di-, and si-. And, the form of suffixes is –i, - ko, and –mu. Those affixes are derived from derivation process namely the basic construction or sentence structure

Recurrence and survival after resection of adenocarcinoma of the gastric cardia

In a retrospective study, the results after resection of carcinoma of the gastric cardia in the era without neoadjuvant therapy or extended lymph node dissection were evaluated. All 184 patients who underwent resection between January 1983 and December 1993 were included. Recurrence of disease, survival and prognostic factors were determined. The overall cumulative 5-year recurrence rate was 71% and the survival rate 23%. Multivariate analysis identified locoregional lymph node and distant metastases as the crucial prognosticators of recurrence of disease and survival. These results were similar to those from a previous study concerning our patients operated during the years 1983-88. The prognosis of a resected cardiacarcinoma has remained unchanged in our hands over the past 10 years. These results stress the importance of exploring new ways, such as the use of new diagnostic tools, to optimize preoperative patient selection and more aggressive treatment regimens to improve final outcom

Most Lung and Colon Cancer Susceptibility Genes Are Pair-Wise Linked in Mice, Humans and Rats

Genetic predisposition controlled by susceptibility quantitative trait loci (QTLs) contributes to a large proportion of common cancers. Studies of genetics of cancer susceptibility, however, did not address systematically the relationship between susceptibility to cancers in different organs. We present five sets of data on genetic architecture of colon and lung cancer susceptibility in mice, humans and rats. They collectively show that the majority of genes for colon and lung cancer susceptibility are linked pair-wise and are likely identical or related. Four CcS/Dem recombinant congenic strains, each differing from strain BALB/cHeA by a different small random subset of ±12.5% of genes received from strain STS/A, suggestively show either extreme susceptibility or extreme resistance for both colon and lung tumors, which is unlikely if the two tumors were controlled by independent susceptibility genes. Indeed, susceptibility to lung cancer (Sluc) loci underlying the extreme susceptibility or resistance of such CcS/Dem strains, mapped in 226 (CcS-10×CcS-19)F2 mice, co-localize with susceptibility to colon cancer (Scc) loci. Analysis of additional Sluc loci that were mapped in OcB/Dem strains and Scc loci in CcS/Dem strains, respectively, shows their widespread pair-wise co-localization (P = 0.0036). Finally, the majority of published human and rat colon cancer susceptibility genes map to chromosomal regions homologous to mouse Sluc loci. 12/12 mouse Scc loci, 9/11 human and 5/7 rat colon cancer susceptibility loci are close to a Sluc locus or its homologous site, forming 21 clusters of lung and colon cancer susceptibility genes from one, two or three species. Our data shows that cancer susceptibility QTLs can have much broader biological effects than presently appreciated. It also demonstrates the power of mouse genetics to predict human susceptibility genes. Comparison of molecular mechanisms of susceptibility genes that are organ-specific and those with trans-organ effects can provide a new dimension in understanding individual cancer susceptibility

Pilot Medical Monitoring: State of the Science Review on Identification of Pilot Incapacitation

693KA8-22-C-00001Organizations have begun to explore the use of human physiological monitoring technologies in critical safety systems to mitigate risk and adapt to evolving operator concepts. This report describes the initial capabilities needed to support safe flight operations in the case of an incapacitated pilot. We describe aspects of a pilot\u2019s physiological state which, in the absence of a second flight deck crewmember, would instead need to be monitored through sensing technology. We review the maturity of the science of sensing technologies for incapacitation detection. Six types of incapacitation were identified to review the state of the science for incapacitation detection technology: sudden cardiac death, sleep, epileptic seizure, stroke, hypoxia, and acute pain syndrome

Optimized dithranol-imiquimod-based transcutaneous immunization enables tumor rejection

Introduction: Transcutaneous immunization (TCI) is a non-invasive vaccination method promoting strong cellular immune responses, crucial for the immunological rejection of cancer. Previously, we reported on the combined application of the TLR7 agonist imiquimod (IMQ) together with the anti-psoriatic drug dithranol as novel TCI platform DIVA (dithranol/IMQ based vaccination). In extension of this work, we further optimized DIVA in terms of drug dose, application pattern and established a new IMQ formulation. Methods: C57BL/6 mice were treated on the ear skin with dithranol and IMQ-containing ointments together with ovalbumin-derived peptides. T cell responses were determined by flow cytometry and IFN-ɤ ELISpot assay, local skin inflammation was characterized by ear swelling. Results: Applying the adjuvants on separate skin sites, a reduced number of specific CD8+ T cells with effector function was detectable, indicating that the local concurrence of adjuvants and peptide antigens is required for optimal vaccination. Likewise, changing the order of dithranol and IMQ resulted in an increased skin inflammatory reaction, but lower frequencies of antigen-specific CD8+ T cells indicating that dithranol is essential for superior T cell priming upon DIVA. Dispersing nanocrystalline IMQ in a spreadable formulation (IMI-Sol+) facilitated storage and application rendering comparable immune responses. DIVA applied one or two weeks after the first immunization resulted in a massive increase in antigen-specific T cells and up to a ten-fold increased memory response. Finally, in a prophylactic tumor setting, double but no single DIVA treatment enabled complete control of tumor growth, resulting in full tumor protection. Discussion: Taken together, the described optimized transcutaneous vaccination method leads to the generation of a strong cellular immune response enabling the effective control of tumor growth and has the potential for clinical development as a novel non-invasive vaccination method for peptide-based cancer vaccines in humans