The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037)

Background: Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy. The objective of this study is to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm) and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis). Methods/Design: In this multicentre randomised trial all patients with perforated diverticulitis are included. Upon laparoscopy, patients with purulent peritonitis are treated with laparoscopic lavage and drainage, Hartmann's procedure or sigmoidectomy with primary anastomosis in a ratio of 2:1:1 (LOLA-arm). Patients with faecal peritonitis will be randomised 1:1 between Hartmann's procedure and resection with primary anastomosis (DIVA-arm). The primary combined endpoint of the LOLA-arm is major morbidity and mortality. A sample size of 132:66:66 patients will be able to detect a difference in the primary endpoint from 25% in resectional groups compared to 10% in the laparoscopic lavage group (two sided alpha = 5%, power = 90%). Endpoint of the DIVA-arm is stoma free survival one year after initial surgery. In this arm 212 patients are needed to significantly demonstrate a difference of 30% (log rank test two sided alpha = 5% and powe

Influencing factors on the health of nurses—a regression analysis considering individual and organizational determinants in Germany

Abstract Background The care sector is characterized by high absenteeism of nursing care employees due to illness. Organizational determinants that can affect the mental health of nurses are known. Although nurses are confronted with different framework conditions in different care settings, there is a lack of comparative data in Germany. Methods The purpose of this study was to examined the relationship between work demands and employee health in different care settings. This cross-sectional survey was conducted between June and October 2021 in four acute care hospitals, seven inpatient care facilities, and five outpatient care services in Germany. 528 nursing care employees (acute care hospitals n = 234; inpatient care facilities n = 152; outpatient care services n = 142) participated in the survey (participation rate: 22.6%-27.9%). For each care setting, data was collected via questionnaire on individual determinants (gender, age, profession, working time), organizational work demands (quantitative workload, qualitative workload, organization of work, social work climate, after work situation, verbal violence, threats, physical violence) and employee health (subjective health status and work ability). Descriptive statistics and binary logistic regressions were performed. Results Increasing age (OR = 0.650, 95% CI = 0.424—0.996) as an individual determinant and organization of work (OR = 0.595, CI = 0.362—0.978) as an organizational determinant were negatively associated with subjective health. Furthermore, age (OR = 0.555, 95% CI = 0.353—0.875), a demanding organization of work (OR = 0.520, CI = 0.315—0.858), increasing quantitative workloads (OR = 0.565, CI = 0.343—0.930) and a poorer perceived social work climate (OR = 0.610, CI = 0.376—0.991) were associated with lower work ability. Conclusions Based on the study results, health programs should target both individual and organizational factors. The findings seem to support the importance to include nursing care employees in the planning process, as it can have an impact on their health. Trial registration The project was registered in the German Clinical Trial Register (DRKS00024961, 09/04/2021)

Health literacy, health status and health behaviors of German students– study protocol for the “Healthy Habits” cohort study

Background!#!The emerging adulthood is traditionally viewed as a time of optimal health, but also as a critical life span, characterized by changing life circumstances and the establishment of an individual lifestyle. Especially university life seems to hold several challenges impeding the manifestation of a health supporting manner, as many students tend to show a poorer health behavior and a higher amount of health-related problems than comparable age groups. This, along with a steady growth of the higher education sector, brings increased attention to the university setting in the context of prevention. To date, there are few empirical longitudinal and coherent cross-sectional data on the status of students' health literacy, health status, and health behaviors, and on the impact of the study format on students' health. The aim of this prospective cohort study is to reduce this research gap.!##!Methods!#!Starting during winter semester 2020/21, the prospective cohort study collects data on health literacy, health status and health behavior on a semester-by-semester basis. All enrolled students of the IST University of Applied Sciences, regardless of study format and discipline, can participate in the study at the beginning of their first semester. The data are collected digitally via a specifically programmed app. A total of 103 items assess the subjectively perceived health status, life and study satisfaction, sleep quality, perceived stress, physical activity, diet, smoking, alcohol consumption, drug addiction and health literacy. Statistical analysis uses (1) multivariate methods to look at changes within the three health dimensions over time and (2) the association between the three health dimensions using multiple regression methods and correlations.!##!Discussion!#!This cohort study collects comprehensive health data from students on the course of study. It is assumed that gathered data will provide information on how the state of health develops over the study period. Also, different degrees of correlations of health behavior and health literacy will reveal different impacts on the state of students' health. Furthermore, this study will contribute to empirically justified development of target group-specific interventions.!##!Trial registration!#!German Clinical Trials Register: DRKS00023397 (registered on October 26, 2020)

Health literacy promotion among young adults: a web-based intervention in German vocational schools.

Stassen G, Grieben C, Sauzet O, Frobose I, Schaller A. Health literacy promotion among young adults: a web-based intervention in German vocational schools. Health education research. 2020;35(2):87-98.Against the background of an ageing population, the target group of young adults holds strong societal relevance as the future workforce. At the same time, young adults find themselves in a critical phase of life regarding the manifestation of a healthy lifestyle. In this context, young adults' health literacy gains importance. Web-based interventions implemented in educational settings offer the potential for promoting health literacy, although longitudinal studies remain scarce. Within a pre-post cluster randomized controlled trial with 6-month follow-up, this study investigated whether an 8-week web-based intervention in vocational schools (with or without an additional initial face-to-face measure) improves individual competencies within a structural model of health literacy ('self-perception', 'proactive approach to health', 'dealing with health information', 'self-control', 'self-regulation' and 'communication and cooperation').The control condition was regular school lessons following the curriculum only. A multi-level regression analysis was performed using the control group as reference. None of the interventions showed a significant improvement in any of the dimensions. Significant differences between the intervention and control were obtained for some dimensions, albeit showing reductions. Future research must examine how to build impactful health literacy promotion in educational settings. Investigations into linking digital and face-to-face measures should continue. © The Author(s) 2020. Published by Oxford University Press

Questionnaire choice affects the prevalence of recommended physical activity: an online survey comparing four measuring instruments within the same sample

Background: Since prevalence estimates of recommended physical activity (PA) considerably vary between different surveys, prevalence might be crucially affected by the choice of measuring instrument. The aim of the present study is to compare the results of four PA questionnaires regarding the current moderate- and vigorous-intensity aerobic PA (MVPA) recommendations of the World Health Organization. Methods: Within an online survey, participants answered the German Health Interview and Examination Survey for Adults (DEGS), the European Health Interview Survey PA Questionnaire (EHIS), the Eurobarometer (EURO), and a single-item measure (SIM). Weekly volume of MVPA was compared via a Friedman test and the prevalence of participants achieving the WHO’s MVPA recommendation via Cochran’s Q. Agreement between all questionnaire pairs was evaluated via Kappa statistics. Results: One hundred seventy-six participants were included in the analyses (70.5% female, mean age: 33.1 years (SD=12.2)). Between the four questionnaires, the weekly volume of MVPA statistically significant differed (SIM: MED=90.0 (MIN=0.0, MAX=210.0), DEGS: MED=120.0 (MIN=0.0, MAX=420.0), EHIS: MED=240.0 (MIN=0.0, MAX=1395.0), EURO: MED=510.0 (MIN=0.0, MAX=2430.0), p<.001, all pairwise comparisons p<.01), as well as the prevalence of participants achieving the MVPA recommendations (SIM 31.3% (95% CI 24.5–38.7), DEGS 43.2% (95% CI 35.8–50.8), EHIS 67.0% (95% CI 59.6–73.9), EURO 87.5% (95% CI 81.7–92.0), p<.001), except between SIM and DEGS (p=.067). Agreement was weak between all questionnaire pairs (all κ< 0.60). Conclusions: Questionnaire choice crucially affects the resulting MVPA data and hence the prevalence of achieving recommended PA levels within the same sample. Therefore, for PA surveillance, standardised survey and analysis methods and efforts to harmonise monitoring systems are needed, since whether recommended levels of PA are achieved should not be determined by the choice of one measuring instrument or another

Experiences of Practical Actors in Medical Rehabilitation Facilities in the Context of Research Projects - A Qualitative Study

Schaller A, Xyländer M, Stassen G, Exner A-K, Sauzet O. Erfahrungen von Praxisakteuren in medizinischen Rehabilitations- einrichtungen im Rahmen von Forschungsprojekten – eine qualitative Studie. Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin . 2020.Zusammenfassung Ziel der Studie Ziel der vorliegenden Arbeit war es, die Erfahrungen von versorgungsnahen Praxisakteuren der medizinischen Rehabilitation im Rahmen ihrer Mitwirkung bei Forschungsprojekten zu beschreiben. Methodik Es wurden 8 halbstrukturierte Leitfadeninterviews mit Mitarbeitenden in medizinischen Rehabilitationseinrichtungen durchgefuhrt (3 Frauen, 5 Manner). Die mittlere Berufserfahrung der befragten Therapeut/innen, Arzt/innen und Verwaltungsmitarbeitenden lag bei 21 (10) Jahren und die Befragten waren durchschnittlich an 2 (1) Forschungsprojekten beteiligt (min: 1; max: 7). Die Auswertung erfolgte nach der inhaltlich-strukturierenden Inhaltsanalyse nach Mayring. Ergebnisse Die Erfahrungen der Praxisakteure machten die Relevanz um das Wissen der unterschiedlichen strukturellen Rahmenbedingungen von Wissenschaft und Praxis deutlich. Dies zeigte sich in 6 Hauptkategorien: Projektinitiierung, projektbezogener Erstkontakt, Motivation zur Mitwirkung, subjektive Wahrnehmung projektbezogener Tatigkeiten, Erfahrungen in der Projektarbeit und Wunsche bzw. Verbesserungsbedarfe. Dabei zeigte sich, dass neben dem Wissen um die Rahmenbedingungen der Praxisakteure auch projektbezogene Kommunikationsstrukturen von gro ss er Bedeutung fur das Gelingen von Forschungsprojekten sind. Schlussfolgerung Die Ergebnisse der vorliegenden explorativen Studie konnen als Ausgangspunkt dienen, um konkrete Empfehlungen fur Forschende hinsichtlich der Zusammenarbeit mit Praxisakteuren in anwendungsorientierten Rehabilitationsforschungsprojekten systematisch zu entwickeln. Abstract Purpose The aim of the present study was to describe the experiences of health care-related practitioners in medical rehabilitation in the context of their participation in research projects. Methods Eight semi-structured guideline interviews were conducted with employees in medical rehabilitation facilities (3 women, 5 men). The average professional experience of the therapists, doctors and administrative staff interviewed was 21 (+/- 10) years and the respondents were involved in an average of 2 (+/- 1) research projects (min: 1; max: 7). The evaluation was based on the content-structured content analysis according to Mayring. Results The experiences of the practical actors pointed out the relevance of the knowledge of the different structural framework conditions of science and practice. Six main categories became apparent: Project initiation, project-related initial contact, motivation to participate, subjective perception of project-related activities, experiences in project work and wishes or need for improvement. It was shown that, in addition to knowledge of the general conditions of the actors in practice, project-related communication structures are also of great importance for the success of research projects. Conclusion The results of this exploratory study can serve as a starting point for systematically developing concrete recommendations for researchers regarding cooperation with practitioners in application-oriented rehabilitation research projects

Robotic Assisted Cannulation of Occluded Retinal Veins.

PURPOSE: To develop a methodology for cannulating porcine retinal venules using a robotic assistive arm after inducing a retinal vein occlusion using the photosensitizer rose bengal. METHODOLOGY: Retinal vein occlusions proximal to the first vascular branch point were induced following intravenous injection of rose bengal by exposure to 532nm laser light delivered by slit-lamp or endolaser probe. Retinal veins were cannulated by positioning a glass catheter tip using a robotically controlled micromanipulator above venules with an outer diameter of 80μm or more and performing a preset piercing maneuver, controlled robotically. The ability of a balanced salt (BSS) solution to remove an occlusion by repeat distention of the retinal vein was also assessed. RESULTS: Cannulation using the preset piercing program was successful in 9 of 9 eyes. Piercing using the micromanipulator under manual control was successful in only 24 of 52 attempts, with several attempts leading to double piercing. The best location for cannulation was directly proximal to the occlusion. Infusion of BSS did not result in the resolution of the occlusion. CONCLUSION: Cannulation of venules using a robotic microassistive arm can be achieved with consistency, provided the piercing is robotically driven. The model appears robust enough to allow testing of therapeutic strategies aimed at eliminating a retinal vein thrombus and its evolution over time

Influence of Health Literacy on the Physical Activity of Working Adults: A Cross-Sectional Analysis of the TRISEARCH Trial

Studies show that high health literacy (HL) can support the promotion and maintenance of healthy behavior such as physical activity (PA). However, most studies rely on subjective data. The aim of the present study is to investigate the relationship between HL and PA, not only with subjectively but also with objectively measured PA data. The present study is a pooled analysis of baseline data from the research association TRISEARCH (2015-2018), which focused on the HL of working adults. HL was measured by Lenartz' questionnaire, and PA by the Global Physical Activity Questionnaire (GPAQ; n = 1056). A subsample (n = 124) also received accelerometers (Actigraph GT3X+) to provide more objective PA data. Partial correlations and regression models were used to investigate the relationship between HL and questionnaire- and accelerometer-derived PA. Very low and medium partial correlations could be found for HL subscales and daily PA by questionnaire (r = -0.06, p 0.05). Not all subscales of HL seem to have an influence on the occurrence of healthy behavior, such as PA. This should be considered when HL-based interventions are designed. Further investigation of the relationship between HL and PA is needed. Objective assessments of both HL and PA can provide additional information for this task

Release of experimental retinal vein occlusions by direct intraluminal injection of ocriplasmin

\u3cp\u3ePurpose Retinal vein occlusions (RVO) are a major cause of vision loss in people aged 50years and older. Current therapeutic options limit the consequences of RVO but do not eliminate the cause. Cannulation of the involved vessel and removal of the clot may provide a more permanent solution with a less demanding follow-up. However, cannulation of smaller retinal veins remains challenging. This paper explores the use of ocriplasmin (recombinant plasmin without its kringles) to clear RVO, using a robotic micromanipulator. Methods Branch RVO were induced in a porcine model with rose bengal followed by 532nm endolaser to the superior venous branch of the optic nerve. The vein was cannulated proximal to the occlusion or beyond the first branching vessel from the obstruction. The vein was infused with a physiologic citric acid buffer solution (CAM) or CAM/ocriplasmin. The time of cannulation, number of attempts, and the ability to release the thrombus were recorded. Results Cannulation and infusion was possible in all the cases. The use of a micromanipulator allowed for a consistent cannulation of the retinal vein and positional stability allowed the vein to remain cannulated for up to 20min. In none of the attempts (5/5) with CAM did the thrombus dissolve, despite repeat infusion/relaxation cycles. In 7/7 injections of CAM/ocriplasmin near to the point of obstruction, the clot started to dissolve within a few minutes of injection. An infusion, attempted beyond the first venous branch point proximal to the clot, was unsuccessful in 2/3 attempts. Conclusions Ocriplasmin is effective in resolving RVO if injected close to the site of occlusion with the use of a micromanipulator.\u3c/p\u3