887 research outputs found
Organic small molecule field-effect transistors with Cytop(TM) gate dielectric: eliminating gate bias stress effects
We report on organic field-effect transistors with unprecedented resistance
against gate bias stress. The single crystal and thin-film transistors employ
the organic gate dielectric Cytop(TM). This fluoropolymer is highly water
repellent and shows a remarkable electrical breakdown strength. The single
crystal transistors are consistently of very high electrical quality: near zero
onset, very steep subthreshold swing (average: 1.3 nF V/(dec cm2)) and
negligible current hysteresis. Furthermore, extended gate bias stress only
leads to marginal changes in the transfer characteristics. It appears that
there is no conceptual limitation for the stability of organic semiconductors
in contrast to hydrogenated amorphous silicon.Comment: 4 pages, 3 figures, to be published in Appl. Phys. Let
Influence of the gate leakage current on the stability of organic single-crystal field-effect transistors
We investigate the effect of a small leakage current through the gate
insulator on the stability of organic single-crystal field-effect transistors
(FETs). We find that, irrespective of the specific organic molecule and
dielectric used, leakage current flowing through the gate insulator results in
an irreversible degradation of the single-crystal FET performance. This
degradation occurs even when the leakage current is several orders of magnitude
smaller than the source-drain current. The experimental data indicate that a
stable operation requires the leakage current to be smaller than $10^{-9} \
\mathrm{A/cm}^2$. Our results also suggest that gate leakage currents may
determine the lifetime of thin-film transistors used in applications.Comment: submitted to Appl. Phys. Let
THE ACCUSED IS ENTERING THE COURTROOM: THE LIVE-TWEETING OF A MURDER TRIAL.
© 2017 Informa UK Limited, trading as Taylor & Francis GroupThe use of social media is now widely accepted within journalism as an outlet for news information. Live tweeting of unfolding events is standard practice. In March 2014, Oscar Pistorius went on trial in the Gauteng High Court for murder. Hundreds of journalists present began live-tweeting coverage, an unprecedented combination of international interest, permission to use technology and access which resulted in massive streams of consciousness reports of events as they unfolded. Based on a corpus of Twitter feeds of twenty-four journalists covering the trial, this study analyses the content and strategies of these feeds in order to present an understanding of how microblogging is used as a live reporting tool. This study shows the development of standardised language and strategies in reporting on Twitter, concluding that journalists adopt a narrow range of approaches, with no significant variation in terms of gender, location, or medium. This is in contrast to earlier studies in the field (Awad, 2006, Hedman, 2015; Kothari, 2010; Lariscy, Avery, Sweetser, & Howes, 2009 Lasorsa, 2012; Lasorsa, Lewis, & Holton, 2011; Sigal, 1999, Vis, 2013).Peer reviewe
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Improving the mechanical stability of zirconium-based metal-organic frameworks by incorporation of acidic modulators
Acidic modulating ligands have been shown to stabilize UiO metal-organic frameworks against structural collapse under ball-milling.T.D.B. would like to thank Trinity Hall for funding, along with Professor Anthony K. Cheetham for use of lab facilities. D.D.V. is grateful to IWT (MOF Shape), KU Leuven for support in the Metusalem grant CASAS and IAP 7/05 Functional Supramolecular Systems. I.S. and B.B. thank Research Foundation – Flanders (FWO) for Ph.D. fellowships.This is the accepted manuscript. The final published version is available from RSC at http://pubs.rsc.org/en/Content/ArticleLanding/2015/TA/c4ta06396a#!divAbstract
The role of pancreatoscopy in the diagnostic work-up of intraductal papillary mucinous neoplasms : a systematic review and meta-analysis
Background Confirming the diagnosis, invasiveness, and disease extent of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas is challenging. The aim of this study was to summarize the literature on the efficacy and safety of peroral pancreatoscopy (POP) in the diagnosis of IPMN, including the impact of pre- and intraoperative POP on the management of IPMN. Methods The EMBASE, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar databases were systematically searched for articles. Eligible articles investigated cohorts of patients who underwent POP for (suspected) IPMN. Results 25 articles were identified and included in this review; with 22 of these reporting on the diagnostic yield of POP in IPMN and 11 reporting on the effect of pre- or intraoperative POP on clinical decision-making. Cannulation and observation rates, and overall diagnostic accuracy were high across all studies. Frequently reported visual characteristics of IPMN were intraductal fish-egg-like lesions, hypervascularity, and granular mucosa. Overall, the adverse event rate was 12 %, primarily consisting of post-endoscopic retrograde cholangiopancreatography pancreatitis, with a pooled rate of 10 %, mostly of mild severity. Regarding the impact of POP on clinical decision-making, POP findings altered the surgical approach in 13%- 62% of patients. Conclusion POP is technically successful in the vast majority of patients with (suspected) IPMN, has a consistently high diagnostic accuracy, but an adverse event rate of 12 %. Data on intraoperative pancreatoscopy are scarce, but small studies suggest its use can alter surgical management. Future studies are needed to better define the role of POP in the diagnostic work-up of IPMN.Peer reviewe
Measurement of the analyzing powers in pd elastic and pn quasi-elastic scattering at small angles
The analyzing powers in proton-deuteron elastic and proton-neutron
quasi-elastic scattering have been measured at small angles using a polarized
proton beam at the COSY storage ring incident on an unpolarized deuterium
target. The data were taken at 796MeV and five higher energies from 1600MeV to
2400MeV. The analyzing power in pd elastic scattering was studied by detecting
the low energy recoil deuteron in telescopes placed symmetrically in the COSY
plane to the left and right of the beam whereas for pn quasi-elastic scattering
a low energy proton was registered in one of the telescopes in coincidence with
a fast scattered proton measured in the ANKE magnetic spectrometer. Though the
experiment explores new domains, the results are consistent with the limited
published information.Comment: 10 pages with 8 figure
The host immune response contributes to Haemophilus influenzae virulence
SummaryBackgroundThere is compelling evidence that infections with non-typeable Haemophilus influenzae (NTHi) are associated with exacerbations in COPD patients. However, NTHi has also been isolated frequently during clinically stable disease. In this study we tested the hypothesis that genetically distinct NTHi isolates obtained from COPD patients differ in virulence which could account for dissimilarities in the final outcome of an infection (stable vs. exacerbation).ResultsNTHi isolates (n = 32) were obtained from stable COPD patients, or during exacerbations. Genetically divergent NTHi isolates were selected and induction of inflammation was assessed as an indicator of virulence using different in vitro models. Despite marked genomic differences among NTHi isolates, in vitro studies could not distinguish between NTHi isolates based on their inflammatory capacities. Alternatively, when using a whole blood assay results demonstrated marked inter-, but not intra-individual differences in cytokine release between healthy volunteers irrespective of the origin of the NTHi isolate used.ConclusionResults suggest that the individual immune reactivity might be an important predictor for the clinical outcome (exacerbation vs. no exacerbation) following NTHi infection
Canine NAPEPLD-associated models of human myelin disorders
Canine leukoencephalomyelopathy (LEMP) is a juvenile-onset neurodegenerative disorder of the CNS white matter currently described in Rottweiler and Leonberger dogs. Genome-wide association study (GWAS) allowed us to map LEMP in a Leonberger cohort to dog chromosome 18. Subsequent whole genome re-sequencing of a Leonberger case enabled the identification of a single private homozygous non-synonymous missense variant located in the highly conserved metallo-beta-lactamase domain of the N-acyl phosphatidylethanolamine phospholipase D (NAPEPLD) gene, encoding an enzyme of the endocannabinoid system. We then sequenced this gene in LEMP-affected Rottweilers and identified a different frameshift variant, which is predicted to replace the C-terminal metallo-beta-lactamase domain of the wild type protein. Haplotype analysis of SNP array genotypes revealed that the frameshift variant was present in diverse haplotypes in Rottweilers, and also in Great Danes, indicating an old origin of this second NAPEPLD variant. The identification of different NAPEPLD variants in dog breeds affected by leukoencephalopathies with heterogeneous pathological features, implicates the NAPEPLD enzyme as important in myelin homeostasis, and suggests a novel candidate gene for myelination disorders in people
Measurement of the analysing power in proton-proton elastic scattering at small angles
The proton analysing power in elastic scattering has been measured
at small angles at COSY-ANKE at 796 MeV and five other beam energies between
1.6 and 2.4 GeV using a polarised proton beam. The asymmetries obtained by
detecting the fast proton in the ANKE forward detector or the slow recoil
proton in a silicon tracking telescope are completely consistent. Although the
analysing power results agree well with the many published data at 796 MeV, and
also with the most recent partial wave solution at this energy, the ANKE data
at the higher energies lie well above the predictions of this solution at small
angles. An updated phase shift analysis that uses the ANKE results together
with the World data leads to a much better description of these new
measurements.Comment: 5 pages, 3 figure
Measurement of the absolute differential cross section of proton-proton elastic scattering at small angles
The differential cross section for proton-proton elastic scattering has been
measured at a beam energy of 1.0 GeV and in 200 MeV steps from 1.6 to 2.8 GeV
for centre-of-mass angles in the range from 12-16 degrees to 25-30 degrees,
depending on the energy. Absolute normalisations of typically 3% were achieved
by studying the energy losses of the circulating beam of the COSY storage ring
as it passed repeatedly through the windowless hydrogen target of the ANKE
magnetic spectrometer. It is shown that the data have a significant impact upon
a partial wave analysis. After extrapolating the differential cross sections to
the forward direction, the results are broadly compatible with the predictions
of forward dispersion relations
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