The architecture for testing central heating control algorithms with feedback from wireless temperature sensors

The energy consumption of buildings is a significant contributor to overall energy con- sumption in developed countries. Therefore, there is great demand for intelligent buildings in which energy consumption is optimized. Online control is a crucial aspect of such optimization. The imple- mentation of modern algorithms that take advantage of developments in information technology, artificial intelligence, machine learning, sensors, and the Internet of Things (IoT) is used in this context. In this paper, an architecture for testing central heating control algorithms as well as the control algorithms of the heating system of the building is presented. In particular, evaluation metrics, the method for seamless integration, and the mechanism for real-time performance monitoring and control are put forward. The proposed tools have been successfully tested in a residential building, and the conducted tests confirmed the efficiency of the proposed solution

Design, synthesis, and in vitro and in vivo characterization of 1-4-[4-(substituted)piperazin-1-yl]butyl guanidines and their piperidine analogues as histamine H-3 receptor antagonists

Previously, we have shown that 1-substituted-[4-(7-phenoxyheptylpiperazin-1-yl)butyl]guanidine with electron withdrawing substituents at position 4 in the benzyl moiety exhibits high in vitro affinities toward the guinea pig jejunal histamine H 3 receptor with pA 2 ranging from 8.49 to 8.43. Here, we present data on the impact of replacement of the piperazine scaffold by the piperidine ring (compounds 2a and 2b), moving benzyl- and 4-trifluoromethylbenzyl substituents from position 1 to 3 of the guanidine moiety (compounds 2c and 2d), which decreases the guanidine basicity (compound 2e), and the influence of individual synthons (compounds 2f-h), present in the lead compounds 1b and 1c, on the antagonistic activity against the histamine H 3 receptor. Additionally, the most active compounds 1a, 1c, and 1d were evaluated for their affinity to the rat histamine H 3 receptor and the human histamine H 3 and H 4 receptors. It was also shown that compounds 1a, 1c and 1d, given parenterally for five days, reduced the food intake of rats and did not influence the brain histamine or noradrenaline concentrations; however, significantly reduced serotonin and dopamine concentrations were found in rats administered with compounds 1a and 1c, respectively