Efficacy of Probiotics for Reducing the Incidence of Lameness in Broilers Grown on Wire Flooring

Growing broilers on wire flooring provides an excellent experimental model for reproducibly triggering significant levels of lameness. In Pilot Study #1 using broilers from Line C grown on wire flooring, adding the Biomin probiotic PoultryStar® to the feed reduced the percentage of lameness by half when compared with broilers that received the control diet alone. In Pilot Study # 2 using broilers from Line B grown on wire flooring, adding the PoultryStar® probiotic reduced the percentage of lameness to 8% when compared with 28% lameness in broilers that received the control diet alone. The objective of this study was to conduct a replicated experiment to determine if probiotics consistently reduced the incidence of lameness in broilers reared on wire flooring. Male broiler chicks from Cobb-Vantress Line B were placed at 1 day of age in pens having flat wire flooring within environmental chambers 1 through 10 inside the Poultry Environmental Research Lab at the University of Arkansas Poultry Research Farm. On day 14, birds were culled to 50 per pen, yielding a density of 1ft²/chick. A corn and soybean meal-based diet formulated to meet minimum National Research Council standards (1994) for all ingredients was provided ad libitum as the control feed. Broilers in chambers 1, 3, 5, 7 and 9 were provided the control feed while chambers 2, 4, 6, 8 and 10 were provided the same feed mixed with the probiotic throughout the experiment (50 lbs of control feed blended with 12.5 g PoultryStar® probiotic). The birds in all pens were walked and observed for lameness every two days starting on day 15 and continuing until the end of the experiment on day 56. Birds unable or unwilling to walk were diagnosed as clinically lame and humanely euthanized with CO2 gas. They were then necropsied to assess sub-clinical lesion incidences including femoral head separation, femoral head transitional degeneration, femoral head necrosis, tibial head necrosis, and tibial dyschondroplasia. Findings from the study indicate that for broilers grown on wire flooring, diets containing the probiotic PoultryStar® consistently reduced the incidence of lameness when compared with birds fed the control diet alone

Anti-Social Realism

Work included in a group exhibition at Charlie Smith Gallery, London curated by Juan Bolivar and John Stark. Exhibting artists include: Juan Bolivar, Dan Coombs, Graham Crowley, Karen David, Nathan Eastwood, Geraint Evans, John Greenwood, Sigrid Holmwood, Kate Lyddon, Maharishi x Rebecca & Mike, John Salt, John Stark. The term 'Anti-Social Realism', which acts as this exhibitions title, is not one that is commonly understood. It is intended to pose questions such as: is 'revolutionary' art a viable possibility today? What does it mean to be (anti) social in an increasingly interconnected but physically separated society? Can we, through archaic practices such as painting and sculpture, engage with notions of 'social realism’ now presented on a daily basis through the new silver-screen veneer of the digital age? In response, this exhibition attempts to pose pictorial possibilities and create tensions through the selected artworks, tackling notions of contemporary realism and in turn offering us a distant echo of a political reality. The wry misnomer of the exhibition title slips between many interwoven threads, simultaneously conjuring up images of 'anti-social behaviour orders' (ASBO), anarchist riots, or the solitary artist locked away from the world attempting to connect on a higher level. In this light, the exhibiting artists are presented as 'social mystics' and it could be said that their work operates by a means of turning inwards to create social radiation

CARMIL family proteins as multidomain regulators of actin-based motility

CARMILs are large multidomain proteins that regulate the actin-binding activity of capping protein (CP), a major capper of actin filament barbed ends in cells. CARMILs bind directly to CP and induce a conformational change that allosterically decreases but does not abolish its actin-capping activity. The CP-binding domain of CARMIL consists of the CP-interaction (CPI) and CARMIL-specific interaction (CSI) motifs, which are arranged in tandem. Many cellular functions of CARMILs require the interaction with CP; however, a more surprising result is that the cellular function of CP in cells appears to require binding to a CARMIL or another protein with a CPI motif, suggesting that CPI-motif proteins target CP and modulate its actin-capping activity. Vertebrates have three highly conserved genes and expressed isoforms of CARMIL with distinct and overlapping localizations and functions in cells. Various domains of these CARMIL isoforms interact with plasma membranes, vimentin intermediate filaments, SH3-containing class I myosins, the dual-GEF Trio, and other adaptors and signaling molecules. These biochemical properties suggest that CARMILs play a variety of membrane-associated functions related to actin assembly and signaling. CARMIL mutations and variants have been implicated in several human diseases. We focus on roles for CARMILs in signaling in addition to their function as regulators of CP and actin. </jats:p

Neural tube-ectoderm interactions are required for trigeminal placode formation

Cranial sensory ganglia in vertebrates develop from the ectodermal placodes, the neural crest, or both. Although much is known about the neural crest contribution to cranial ganglia, relatively little is known about how placode cells form, invaginate and migrate to their targets. Here, we identify Pax-3 as a molecular marker for placode cells that contribute to the ophthalmic branch of the trigeminal ganglion and use it, in conjunction with DiI labeling of the surface ectoderm, to analyze some of the mechanisms underlying placode development. Pax-3 expression in the ophthalmic placode is observed as early as the 4-somite stage in a narrow band of ectoderm contiguous to the midbrain neural folds. Its expression broadens to a patch of ectoderm adjacent to the midbrain and the rostral hindbrain at the 8- to 10-somite stage. Invagination of the first Pax-3-positive cells begins at the 13-somite stage. Placodal invagination continues through the 35-somite stage, by which time condensation of the trigeminal ganglion has begun. To challenge the normal tissue interactions leading to placode formation, we ablated the cranial neural crest cells or implanted barriers between the neural tube and the ectoderm. Our results demonstrate that, although the presence of neural crest cells is not mandatory for Pax-3 expression in the forming placode, a diffusible signal from the neuroectoderm is required for induction and/or maintenance of the ophthalmic placode

Automated translation of digital logic equations into optimized VHDL code

It was desired to develop an algorithm for the automated translation of\u27 finite slate machines from state table form to optimized VHDL form. To do this, algorithms arc needed for reducing the state machine to simplest form, making state assignments, producing minimal logic equations to represent the state machine, and producing VHDL code which describes the intended circuit. Various such algorithms were examined and a prototype program written to perform this translation --Abstract, page ii

XXX. Observations on Two Species of Pholas, found on the Sea-coast in the neighbourhood of Edinburgh

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The Capital Market as a Growth Engine

Internationaler Finanzmarkt, Wirtschaftswachstum, Markteffizienz, International financial market, Economic growth, Market efficiency