50 research outputs found
Antidiabetic Drug Prescription Pattern in Hospitalized Older Patients with Diabetes
Objective: To describe the prescription pattern of antidiabetic and cardiovascular drugs in a cohort of hospitalized older patients with diabetes. Methods: Patients with diabetes aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro POliterapuie SIMIâSocietĂ Italiana di Medicina Interna) registry from 2010 to 2019 and discharged alive were included. Results: Among 1703 patients with diabetes, 1433 (84.2%) were on treatment with at least one antidiabetic drug at hospital admission, mainly prescribed as monotherapy with insulin (28.3%) or metformin (19.2%). The proportion of treated patients decreased at discharge (N = 1309, 76.9%), with a significant reduction over time. Among those prescribed, the proportion of those with insulin alone increased over time (p = 0.0066), while the proportion of those prescribed sulfonylureas decreased (p < 0.0001). Among patients receiving antidiabetic therapy at discharge, 1063 (81.2%) were also prescribed cardiovascular drugs, mainly with an antihypertensive drug alone or in combination (N = 777, 73.1%). Conclusion: The management of older patients with diabetes in a hospital setting is often sub-optimal, as shown by the increasing trend in insulin at discharge, even if an overall improvement has been highlighted by the prevalent decrease in sulfonylureas prescription
The âDiabetes Comorbidomeâ: A Different Way for Health Professionals to Approach the Comorbidity Burden of Diabetes
(1) Background: The disease burden related to diabetes is increasing greatly, particularly in older subjects. A more comprehensive approach towards the assessment and management of diabetesâ comorbidities is necessary. The aim of this study was to implement our previous data identifying and representing the prevalence of the comorbidities, their association with mortality, and the strength of their relationship in hospitalized elderly patients with diabetes, developing, at the same time, a new graphic representation model of the comorbidome called âDiabetes Comorbidomeâ. (2) Methods: Data were collected from the RePoSi register. Comorbidities, socio-demographic data, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), and functional status (Barthel Index), were recorded. Mortality rates were assessed in hospital and 3 and 12 months after discharge. (3) Results: Of the 4714 hospitalized elderly patients, 1378 had diabetes. The comorbidities distribution showed that arterial hypertension (57.1%), ischemic heart disease (31.4%), chronic renal failure (28.8%), atrial fibrillation (25.6%), and COPD (22.7%), were the more frequent in subjects with diabetes. The graphic comorbidome showed that the strongest predictors of death at in hospital and at the 3-month follow-up were dementia and cancer. At the 1-year follow-up, cancer was the first comorbidity independently associated with mortality. (4) Conclusions: The âDiabetes Comorbidomeâ represents the perfect instrument for determining the prevalence of comorbidities and the strength of their relationship with risk of death, as well as the need for an effective treatment for improving clinical outcomes
Beta-Blocker Use in Older Hospitalized Patients Affected by Heart Failure and Chronic Obstructive Pulmonary Disease: An Italian Survey From the REPOSI Register
Beta (ÎČ)-blockers (BB) are useful in reducing morbidity and mortality in patients with heart failure (HF) and concomitant chronic obstructive pulmonary disease (COPD). Nevertheless, the use of BBs could induce bronchoconstriction due to ÎČ2-blockade. For this reason, both the ESC and GOLD guidelines strongly suggest the use of selective ÎČ1-BB in patients with HF and COPD. However, low adherence to guidelines was observed in multiple clinical settings. The aim of the study was to investigate the BBs use in older patients affected by HF and COPD, recorded in the REPOSI register. Of 942 patients affected by HF, 47.1% were treated with BBs. The use of BBs was significantly lower in patients with HF and COPD than in patients affected by HF alone, both at admission and at discharge (admission, 36.9% vs. 51.3%; discharge, 38.0% vs. 51.7%). In addition, no further BB users were found at discharge. The probability to being treated with a BB was significantly lower in patients with HF also affected by COPD (adj. OR, 95% CI: 0.50, 0.37-0.67), while the diagnosis of COPD was not associated with the choice of selective ÎČ1-BB (adj. OR, 95% CI: 1.33, 0.76-2.34). Despite clear recommendations by clinical guidelines, a significant underuse of BBs was also observed after hospital discharge. In COPD affected patients, physicians unreasonably reject BBs use, rather than choosing a ÎČ1-BB. The expected improvement of the BB prescriptions after hospitalization was not observed. A multidisciplinary approach among hospital physicians, general practitioners, and pharmacologists should be carried out for better drug management and adherence to guideline recommendations
Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both
Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF.
Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death.
Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16-2.61) and patients with dementia (HR 1.75, 95% CI 1.06-2.90) had a higher risk of death at one year. The Kaplan-Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009).
Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population
Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both
Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPDâ+âHF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPDâ+âHF. Patients with COPDâ+âHF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPDâ+âHF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16-2.61) and patients with dementia (HR 1.75, 95% CI 1.06-2.90) had a higher risk of death at one year. The Kaplan-Meier curves showed a higher mortality risk in the group of patients with COPDâ+âHF for all causes (pâ=â0.010), respiratory causes (pâ=â0.006), cardiovascular causes (pâ=â0.046) and respiratory plus cardiovascular causes (pâ=â0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population
Unpublished Mediterranean and Black Sea records of marine alien, cryptogenic, and neonative species
To enrich spatio-temporal information on the distribution of alien, cryptogenic, and neonative species in the Mediterranean and the Black Sea, a collective effort by 173 marine scientists was made to provide unpublished records and make them open access to the scientific community. Through this effort, we collected and harmonized a dataset of 12,649 records. It includes 247 taxa, of which 217 are Animalia, 25 Plantae and 5 Chromista, from 23 countries surrounding the Mediterranean and the Black Sea. Chordata was the most abundant taxonomic group, followed by Arthropoda, Mollusca, and Annelida. In terms of species records, Siganus luridus, Siganus rivulatus, Saurida lessepsianus, Pterois miles, Upeneus moluccensis, Charybdis (Archias) longicollis, and Caulerpa cylindracea were the most numerous. The temporal distribution of the records ranges from 1973 to 2022, with 44% of the records in 2020â2021. Lethrinus borbonicus is reported for the first time in the Mediterranean Sea, while Pomatoschistus quagga, Caulerpa cylindracea, Grateloupia turuturu, and Misophria pallida are first records for the Black Sea; Kapraunia schneideri is recorded for the second time in the Mediterranean and for the first time in Israel; Prionospio depauperata and Pseudonereis anomala are reported for the first time from the Sea of Marmara. Many first country records are also included, namely: Amathia verticillata (Montenegro), Ampithoe valida (Italy), Antithamnion amphigeneum (Greece), Clavelina oblonga (Tunisia and Slovenia), Dendostrea cf. folium (Syria), Epinephelus fasciatus (Tunisia), Ganonema farinosum (Montenegro), Macrorhynchia philippina (Tunisia), Marenzelleria neglecta (Romania), Paratapes textilis (Tunisia), and Botrylloides diegensis (Tunisia).Stelios Katsanevakis, Michail Ragkousis, Maria Sini, Markos Digenis and Vasilis Gerovasileiou were supported by the Hellenic Foundation for Research and Innovation (HFRI) under the âFirst Call for HFRI Research Projects to support Faculty members and Researchers and the procurement of high-cost research equipment grantâ (Project ALAS â âALiens in the Aegean â a Sea under siegeâ (Katsanevakis et al. 2020b); Project Number: HFRI-FM17-1597). Konstantinos Tsirintanis was co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme âHuman Resources Development, Education and Lifelong Learningâ, 2014-2020, in the context of the Act âEnhancing Human Resources Research Potential
by undertaking a Doctoral Researchâ Sub-action 2: IKY Scholarship Programme for PhD candidates in the Greek Universities. Maria Zotou was supported by the project âCoastal Environment Observatory and Risk Management in Island Regions AEGIS+â (MIS 5047038), implemented within the Operational Programme âCompetitiveness, Entrepreneurship and Innovationâ (NSRF 2014-2020), co financed by the Hellenic Government (Ministry of Development and Investments) and the European Union (European Regional Development Fund, Cohesion Fund). Razy Hoffman was supported by Yad-Hanadiv Foundation, through the Israel Society of Ecology and Environmental Sciences and Israel Nature and Parks Authority, an integrated program for establishing biological baselines and monitoring protocols for marine reserves in
the Israeli Mediterranean Sea (Grant #10669). Tatiana Begun, Adrian Teaca and Mihaela
Muresan were supported by the European Unionâs Horizon 2020 BRIDGE-BS project under
grant agreement no. 101000240. Fiona Tomas was supported by the project âInvasion of the
tropical alga Halimeda incrassata in the Balearic Islands: ecology and invasion dynamics
(AAEE119/2017)â, funded by the Vicepresidencia y ConsejerĂa de InnovaciĂłn, InvestigaciĂłn y
Turismo del Govern de les Illes Balears, with support from the European Union and FEDER
funds, and the project âUna nueva alga invasora en el MediterrĂĄneo: invasibilidad, detecciĂłn y
erradicaciĂłn del alga tropical Halimeda incrassata (INVHALI)â, funded by the FundaciĂłn
Biodiversidad, del Ministerio para la TransiciĂłn EcolĂłgica y el Reto DemogrĂĄfico. Simonetta
Fraschetti, Laura Tamburello, Antonia Chiarore were supported by the project PO FEAMP
2014-2020 - DRD n. 35/2019, âInnovazione, sviluppo e sostenibilitĂ nel settore della pesca e
dell'acquacoltura per la Regione Campaniaâ (ISSPA 2.51) and the EU EASME - EMFF
(Sustainable Blue Econ-omy) Project AFRIMED (http://afrimed-project.eu/, grant agreement N.
789059). Carlos Jimenez, Louis Hadjioannou, Vasilis Resaikos, Valentina Fossati, Magdalene
Papatheodoulou, and Antonis Petrou were supported by MedPan Small Projects, Mava, and
LIFE-IP. Louis Hadjioannou, Manos L. Moraitis and Neophytos Agrotis received funding from
the European Unionâs Horizon 2020 research and innovation program within the framework of
the CMMI/MaRITeC-X project under grant agreement No. 857586. Ernesto Azzurro was
supported by the project USEIt - Utilizzo di Sinergie operative per la gestione integrata specie
aliene Invasive in Italia, funded by the research programme @CNR. Antonietta Rosso and
Francesco Sciuto were supported by the University of Catania through âPiaCeRi-Piano
Incentivi per la Ricerca di Ateneo 2020â22 linea di intervento 2.â This is the Catania
Paleoecological Research Group contribution n. 484. Diego K. Kersting was supported by the
Beatriu de PinĂłs programme funded by the Secretary of Universities and Research
(Government of Catalonia) and the Horizon 2020 programme of research and innovation of the
European Union under the Marie Sklodowska-Curie grant agreement No 801370. Francesco
Tiralongo was supported by the AlienFish project of Ente Fauna Marina Mediterranea
(Scientific Organization for Research and Conservation of Marine Biodiversity, 96012 Avola,
Italy), a citizen science project for monitoring and studying rare and non-indigenous fish in
Italian waters. Adriana Vella, was supported by funds through the BioCon_Innovate Research
Excellence Grant from the University of Malta awarded to her. Noel Vella was supported by
REACH HIGH Scholars Programme-Post Doctoral Grant for the FINS project. Some of the
records provided by Victor Surugiu were obtained during surveys carried out within the
framework of the project âAdequate management of invasive species in Romania, in accordance
with EU Regulation 1143/2014 on the prevention and management of the introduction and spread
of invasive alien speciesâ, SMIS 2014+ 120008, coordinated by the Romanian Ministry of
Environment, Water and Forests in partnership with the University of Bucharest (2018â2022).
Alan Deidun and Alessio Marrone were supported by the âSpot The Alienâ citizen science
campaign for the monitoring of the Alien species in the Maltese archipelago and by the Interreg
Italia-Malta Harmony project. The authors from the National Institute of Biology (Slovenia)
acknowledge the financial support of the Slovenian Research Agency (Research Core Funding
No. P1-0237) and of the Ministry of Agriculture, Forestry and Food (project âSurvey of the
species richness and abundance of alien species in the Slovenian Seaâ). Emanuele Mancini and
Fabio Collepardo Coccia were supported by the project PO-FEAMP 2014-2020 âBIOBLITZ:
research, knowledge and participation for the sustainable management of marine resources
(BioBlitz Blu 2020)â coordinated by CURSA for MIPAAF, the Italian Ministry of Agricultural,
Food and Forestry Policies, Measure 1.40 - Protection and restoration of biodiversity and marine
ecosystems and compensation schemes in the context of sustainable fishing activities. Daniele
Grech was supported by the PO-FEAMP 2014-2020 project ECOGESTOCK âApproccio
ECOsistemico per la tutela e la GEStione delle risorse biologiche e STOCK ittici nelle acque
interneâ, the citizen science project Progetto Fucales: chi le ha viste? and the Paralenz Every
dive counts sponsor. Jamila Rizgalla was supported by the project Snowball for the monitoring
of alien species in Libyan waters ÙÙ Ű§ÙŰȘÙŰŽ ÙÙ Ű§ÙŰȘۯ۷۔ۧ Ű) have you seen it have you fished it?).
Gerasimos Kondylatos and Dimitrios Mavrouleas were supported by the project âEXPLIASâ
(MIS (ÎÎ ÎŁ): 5049912), design and piloting methods of commercial exploitation of invasive
alien species with a view to contributing to their population control, coordinated by the National
Technical University of Athens with the collaboration of the Hellenic Centre for Marine
Research and the University of the Aegean and co-founded by Greece and the European Union.
G. Kondylatos and Savvas Nikolidakis were supported by the project âSAMOSâ (ID CODE:
32.2072004/001), a study for a submarine productive park in Marathokampos of Samos.
Paraskevi K. Karachle, Aikaterini Dogrammatzi, Giorgos A. Apostolopoulos, Kassiani Konida
and Melina Nalmpanti were supported by the project â4ALIEN: Biology and the potential
economic exploitation of four alien species in the Hellenic Seasâ, funded by NRSF 2017-2020
(MIS (ÎÎ ÎŁ): 5049511). Fabio Crocetta and Riccardo Virgili were partially funded by the
project PO FEAMP Campania 2014â2020, DRD n. 35 of 15th March 2018, Innovazione,
sviluppo e sostenibilitĂ nel settore della pesca e dellâacquacoltura per la regione Campania, Misura 2.51, WP5, Task 5.5 Presenza e distribuzione di specie non indigene del macrozoobenthos e del
necton in Campania. Michel Bariche was partially funded by the University Research Board of
the American University of Beirut (DDF 103951/2592). Constantinos G. Georgiadis, Dimitra
Lida Rammou, Paschalis Papadamakis and Sotiris Orfanidis were supported by the MSFD
monitoring program. Sonia Smeraldo was supported by the MPA-Engage project, led by the
Institute of Marine Sciences of the Spanish National Research Council and funded by the
Interreg MED program. Evgeniia Karpova acknowledge that the publication of this article was
in part carried out within the framework of the state assignment of the FRC IBSS âPatterns of
Formation and Anthropogenic Transformation of Biodiversity and Bioresources of the Azovâ
Black Sea Basin and Other Regions of the World Oceanâ (No. 121030100028-0). Elena Slynkoâs
work was carried out within the framework of a State Assignment no. 121051100109-1 of
IBIW RAS. Manuela Falautano and Luca Castriota were supported by ISPRA citizen science
campaigns for the monitoring of alien species through the dedicated institutional project
([email protected]). MarĂa Altamirano was supported by the project RUGULOPTERYX
funded by FundaciĂłn Biodiversidad-Ministerio para la TransiciĂłn EcolĂłgica y el reto DemogrĂĄfico
(Spain) and the project UMA20-FEDERJA-006 with support from the European Union and
FEDER funds and Junta de AndalucĂa. Records provided by L. Mangialajo were collected in
the framework of projects funded by the Pew Charitable Trust, by the European Commission
(AFRIMED, http://afrimed-project.eu/, grant agreement N. 789059) and by the Académie 3 de
lâUniversitĂ© CĂŽte dâAzur (projet CONVOST).Peer reviewe
Unpublished Mediterranean and Black Sea records of marine alien, cryptogenic, and neonative species
To enrich spatio-temporal information on the distribution of alien, cryptogenic, and
neonative species in the Mediterranean and the Black Sea, a collective effort by 173
marine scientists was made to provide unpublished records and make them open
access to the scientific community. Through this effort, we collected and harmonized
a dataset of 12,649 records. It includes 247 taxa, of which 217 are Animalia, 25 Plantae
and 5 Chromista, from 23 countries surrounding the Mediterranean and the Black
Sea. Chordata was the most abundant taxonomic group, followed by Arthropoda,
Mollusca, and Annelida. In terms of species records, Siganus luridus, Siganus rivulatus,
Saurida lessepsianus, Pterois miles, Upeneus moluccensis, Charybdis (Archias)
longicollis, and Caulerpa cylindracea were the most numerous. The temporal
distribution of the records ranges from 1973 to 2022, with 44% of the records in
2020â2021. Lethrinus borbonicus is reported for the first time in the Mediterranean
Sea, while Pomatoschistus quagga, Caulerpa cylindracea, Grateloupia turuturu,
and Misophria pallida are first records for the Black Sea; Kapraunia schneideri is
recorded for the second time in the Mediterranean and for the first time in Israel;
Prionospio depauperata and Pseudonereis anomala are reported for the first time
from the Sea of Marmara. Many first country records are also included, namely:
Amathia verticillata (Montenegro), Ampithoe valida (Italy), Antithamnion
amphigeneum (Greece), Clavelina oblonga (Tunisia and Slovenia), Dendostrea cf.
folium (Syria), Epinephelus fasciatus (Tunisia), Ganonema farinosum (Montenegro),
Macrorhynchia philippina (Tunisia), Marenzelleria neglecta (Romania), Paratapes
textilis (Tunisia), and Botrylloides diegensis (Tunisia).peer-reviewe
Fattori di rischio per la legionellosi: parametri immunologici e rapporto con alcuni elementi in traccia.
Surveillance of legionellosis within a hospital in northern Italy: May 1998 to September 1999
In May 1998, a single case of nosocomial legionellosis was discovered in a 1000 bed hospital in Milan, which included departments serving immunocompromised and severely ill patients (transplant recipients, AIDS cases, patients receiving corticosteroids, etc.). This infection provided an opportunity to undertake a long term epidemiological and environmental survey. After 15 months of active surveillance, we have generated some suggestions for management of legionnairesâ disease acquired both in hospital and in the community