The implementation of the "Bologna process" into the subject of animation in tourism, as a significant part of the hotel industry products promotion

Since the academic year 2001/2002, the programme of studies at the Department of Geography, Tourism and Hotel Industry has been adjusted to the requirements of the Bologna Declaration. All the exams, including optional subject Animation in Tourism, during the studies are organised into one-semester exam, and obligatory student’s intership has been introduced. Animation in tourism with it\u27s animation programmes, introduces very important segment in touristic offer of one destination. In this way tourists are able to feel local atmosphere. Also, that is an original instrument to oblige them to have a significant role in creating the ’’genius loci’’. In the most hotels and restaurants, on a famous destinations, authentic food is served to guests in the course of animation programmes. The programme should be enriched with the folkloric caracteristics of one nation, which we want to represent to visitors. The main goal of this essay, with theory aspects and concrete examples, is to point out the importance of animation, as a considerable factor and new trend in a process of promoting the hotel product

Exploring The Motives Of Religious Travel By Applying The Ahp Method – The Case Study Of Monastery Vujan (Serbia)

Religious tourism is considered as the oldest form of people’s travel. Thousands of years ago people travelled miles led by religious motives. Even though pilgrimage is older than most of the other tourism forms, research on the major motives for religious travel still occupies scientific attention. Vujan Monastery represents one of the main riddles among religious tourism researchers in Serbia. After the mysterious healing of Serbian Patriarch Pavle in 1946 who suffered from tuberculosis, this monastery became one of the most famous sacred places for orthodox Christians. The principle aim of this paper is to propose a new way for exploring and ranking the religious motivation using the Analytical Hierarchy Process (AHP) approach. In addition, the study proposes a set of motives – both religious and secular, which can be applied for exploring the motivations for visiting any sacred site. The method was applied to discover the main motives which drive people to visit Vujan Monastery, get their rankings, as well as their preferences between different types of secular and religious motives. The results indicated a strong preference for religious motives compared to secular motives of visit of this sacred site. On balance, the research provides us with a complete ranking structure, encompassing all analyzed motives of visit which show us a clear picture of the main motivation for visits to Vujan monastery

Sadržaj

Metastasis is a multi-step process in which direct crosstalk between cancer cells and their microenvironment plays a key role. Here, we assessed the effect of paired tumor-associated and normal lung tissue mesenchymal stem cells (MSCs) on the growth and dissemination of primary human lung carcinoma cells isolated from the same patients. We show that the tumor microenvironment modulates MSC gene expression and identify a four-gene MSC signature that is functionally implicated in promoting metastasis. We also demonstrate that tumor-associated MSCs induce the expression of genes associated with an aggressive phenotype in primary lung cancer cells and selectively promote their dissemination rather than local growth. Our observations provide insight into mechanisms by which the stroma promotes lung cancer metastasis

LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma

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World Society of Emergency Surgery (WSES) guidelines for management of skin and soft tissue infections

Peer reviewe

The extracellular matrix glycoprotein tenascin-C and matrix metalloproteinases modify cerebellar structural plasticity by exposure to an enriched environment

The importance of the extracellular matrix (ECM) glycoprotein tenascin-C (TnC) and the ECM degrading enzymes, matrix metalloproteinases (MMPs) -2 and -9, in cerebellar histogenesis is well established. This study aimed to examine whether there is a functional relationship between these molecules in regulating structural plasticity of the lateral deep cerebellar nucleus. To this end, starting from postnatal day 21, TnC- or MMP-9-deficient mice were exposed to an enriched environment (EE). We show that 8 weeks of exposure to EE leads to reduced lectin-based staining of perineuronal nets (PNNs), reduction in the size of GABAergic and increase in the number and size of glutamatergic synaptic terminals in wild-type mice. Conversely, TnC-deficient mice showed reduced staining of PNNs compared to wild-type mice maintained under standard conditions, and exposure to EE did not further reduce, but even slightly increased PNN staining. EE did not affect the densities of the two types of synaptic terminals in TnC-deficient mice, while the size of inhibitory, but not excitatory synaptic terminals was increased. In the time frame of 4-8 weeks, MMP-9, but not MMP-2, was observed to influence PNN remodeling and cerebellar synaptic plasticity as revealed by measurement of MMP-9 activity and colocalization with PNNs and synaptic markers. These findings were supported by observations on MMP-9-deficient mice. The present study suggests that TnC contributes to the regulation of structural plasticity in the cerebellum and that interactions between TnC and MMP-9 are likely to be important for these processes to occur

Tenascin-C deficiency protects mice from experimental autoimmune encephalomyelitis

The extracellular matrix glycoprotein tenascin-C (TnC) has been increasingly appreciated as a molecule susceptibly reacting to abnormalities in the mammalian immune system. TnC expression is elevated in inflamed tissues outside the immune system, but also in lymphoid organs. It participates in the promotion of inflammatory responses. Here, the role of TnC in a paradigm of CNS autoimmunity was investigated. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, was induced in mice deficient in TnC (TnC(-/-)mice). Amelioration of EAE was observed in these mice in comparison to their wild-type (TnC(+/+)) littermates. Since T helper (Th)1 and Th17 cells play a dominant role in the pathogenesis of EAE, these cells were investigated in addition to analyzing locomotor functions and pro-inflammatory cytokine levels. Smaller numbers of interferon-gamma-producing Th1 cells and reduced ability of Th17 cells to produce interleukin-17 were observed in spleens of TnC(-/-) mice challenged by immunization with the myelin associated glycoprotein (MOG) when compared to TnC(+/+) mice. There was no difference in Th1 and Th17 responses in non-immunized TnC(-/-) and TnC(+/+) mice, thus excluding generalized immunosuppression in TnC(-/-) mice. These results show that TnC is important for the pathogenesis of CNS autoimmunity and that its deficiency interferes with Thl and Th17 encephalitogenic potentials. (C) 2016 Elsevier B.V. All rights reserved

Hydroxyapatite Coatings on Cp-Titanium Grade-2 Surfaces Prepared with Plasma Spraying

Thin hydroxyapatite coatings were produced on Cp-Titanium Grade-2 samples, with new high-voltage pulse-power equipment PJ-100 (Plasma Jet, Serbia) in order to get a more stable implant structure appropriate for further clinical applications. A comparative analysis of differently prepared surfaces of the Cp-Titanium Grade-2 samples was done before the hydroxyapatite was applied. Microstructural observation of the modified hydroxyapatite/implant surface was done using scanning-electron-microscopy imaging and Auger electron spectroscopy, with the aim of detecting the morphology and the elements contained in the new surfaces of the samples. The results confirmed that the surface of Cp-Titanium Grade-2 modified with hydroxyapatite is very similar to the bone structure