Калькулирование себестоимости продукции и учет затрат на предприятии АО «Алмалыкский ГМК»

Объектом исследования данной дипломной работы является хозяйственная деятельность предприятия АО "Алмалыкский ГМК" ЦРМЗ. Предметом исследования данной работы являются методы учета затрат и калькулирования себестоимости продукции предприятия.The Object of study of this thesis is the economic activity of the enterprise JSC "Almalyksky GMK" CRMZ. The subject of this study is the methods of cost accounting and costing of production costs of the enterprise

Enhanced Recovery After Surgery (ERAS) Pathways for Aesthetic Breast Surgery: A Prospective Cohort Study on Patient-Reported Outcomes

Background Patients’ expectations of an anticipated timeline of recovery and fear of anesthesia in aesthetic breast surgery have not been studied. Objective This study aims to assess patient anxiety, expectations, and satisfaction after Enhanced Recovery after Surgery (ERAS) pathways for aesthetic breast surgery and the progress of postoperative recovery. Materials and methods All consecutive patients who underwent aesthetic breast surgery between April 2021 and August 2022 were included in this single-center prospective cohort study. The ERAS protocol consists of more than 20 individual measures in the pre-, intra-, and postoperative period. Epidemiological data, expectations, and recovery were systematically assessed with standardized self-assessment questionnaires, including the International Pain Outcome Questionnaire (IPO), the BREAST-Q or BODY-Q, and data collection forms. Results In total, 48 patients with a median of 30 years of age were included. Patients returned to most daily activities within 5 days. Eighty-eight percent of patients were able to accomplish daily activities sooner than expected. The time of return to normal daily activities was similar across all procedure types. There was no statistically significant difference regarding postoperative satisfaction between patients who recovered slower (12%) and patients who recovered as fast or faster (88%) than anticipated (p=0.180). Patients reporting fear of anesthesia in the form of conscious sedation significantly diminished from 17 to 4% postoperatively (p<0.001). Conclusion Enhanced Recovery after Surgery (ERAS) pathways for aesthetic breast surgery are associated with rapid recovery and high patient satisfaction. This survey study provides valuable insight into patients’ concerns and perspectives that may be implemented in patient education and consultations to improve patient satisfaction following aesthetic treatments. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266

Геолого-геофизическая и фациально-петрофизическая характеристика пласта Ю[1]{3} Казанского нефтегазоконденсатного месторождения

Выделение границ высокопродуктивной зоны, выделение карбонатных прослоев и граница их распространения, построение карты фаций, расчёт петрофизической модели на основе геофизических исследований скважины, оценка влияния распространения карбонатных тел на разработку.Identification of high-productive zone boundaries, identification of carbonate interlayers and boundary of their distribution, construction of facies map, calculation of petrophysical model on the basis of geophysical studies of the well, assessment of the influence of carbonate bodies distribution on the development

Monitoring Algal Blooms with Complementary Sensors on Multiple Spatial and Temporal Scales

Climate change, and other human-induced impacts, are severely increasing the intensity and occurrences of algal blooms in coastal regions (IPCC, 2022). Ocean warming, marine heatwaves, and eutrophication promote suitable conditions for rapid phytoplankton growth and biomass accumulation. An increase in such primary producers provides food for marine organisms, and phytoplankton play an important global role in fixing atmospheric carbon dioxide and producing much of the oxygen we breathe. But harmful algal blooms (HABs) can also form, and they may adversely affect the ecosystem by reducing oxygen availability in the water, releasing toxic substances, clogging fish gills, and diminishing biodiversity. Understanding, forecasting, and ultimately mitigating HAB events could reduce their impact on wild fish populations, help aquaculture producers avoid losses, and facilitate a healthy ocean. Phytoplankton respond rapidly to changes in the environment, and measuring the distribution of a bloom and its species composition and abundance is essential for determining its ecological impact and potential for harm. Satellite remote sensing of chlorophyll concentration has been used extensively to observe the development of algal blooms. Although this tool has wide spatial and temporal (nearly daily) coverage, it is limited to surface ocean waters and cloud-free days. Microscopic analyses of water and net samples allow much closer examination of the species present in a bloom and their abundance, but this is a time-consuming process that collects only discrete point samples, sparsely distributed in space and time. Neither of these methods alone captures the rapid evolution of algal blooms, the spatial and temporal patchiness of their distributions, or their high local variability. In situ optical devices and imaging sensors mounted on mobile platforms such as autonomous underwater vehicles (AUVs) and uncrewed surface vehicles (USVs) capture fine-scale temporal trends in plankton communities, while uncrewed aerial vehicles (UAVs) complement satellite remote sensing. Use of such autonomous platforms offers the flexibility to react to local conditions with adaptive sampling techniques in order to examine the marine environments in real time. Here we present an integrated approach to observing blooms—an “observational pyramid”—that includes both classical and newer, complementary observation methods (Figure 1). We aim to identify trends in phytoplankton blooms in a region with strong aquaculture activity on the Atlantic coast of mid-Norway. Field campaigns were carried out in consecutive springs (2021 and 2022) in Frohavet, an area of sea sheltered by the Froan archipelago (Figure 2). The region is a shallow, highly productive basin with abundant fishing and a growing aquaculture industry. Typically, there are one or more large algal blooms here during the spring months. We use multi-instrumentation from macro- to a microscale perspectives, combined with oceanographic modeling and ground truthing, to provide tools for early algal bloom detection

Impact of a booster dose on SARS-CoV2 mRNA vaccine-specific humoral-, B- and T cell immunity in pediatric stem cell transplant recipients

Stem cell transplant recipients (SCTR) are imperiled to increased risks after SARS-CoV2 infection, supporting the need for effective vaccination strategies for this vulnerable group. With respect to pediatric patients, data on immunogenicity of SARS-CoV2 mRNA-based vaccination is limited. We therefore comprehensively examined specific humoral, B- and T cell responses in a cohort of 2-19 year old SCTR after the second and third vaccine dose. Only after booster vaccination, transplant recipients reached similar levels of vaccine-specific IgG, IgA and neutralizing antibodies against omicron variant as age-matched controls. Although frequencies of SARS-CoV2 specific B cells increased after the third dose, they were still fourfold reduced in patients compared to controls. Overall, the majority of individuals enrolled mounted SARS-CoV2 Spike protein-specific CD4+ T helper cell responses with patients showing significantly higher portions than controls after the third dose. With respect to functionality, however, SCTR were characterized by reduced frequencies of specific interferon gamma producing CD4+ T cells, along with an increase in IL-2 producers. In summary, our data identify distinct quantitative and qualitative impairments within the SARS-CoV2 vaccination specific B- and CD4+ T cell compartments. More importantly, humoral analyses highlight the need for a booster vaccination of SCTR particularly for development of neutralizing antibodies