Tomografia por impedância elétrica e seus possíveis usos na agropecuária.

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A mechatronic platform for computer aided detection of nodules in anatomopathological analyses via stiffness and ultrasound measurements

This study presents a platform for ex-vivo detection of cancer nodules, addressing automation of medical diagnoses in surgery and associated histological analyses. The proposed approach takes advantage of the property of cancer to alter the mechanical and acoustical properties of tissues, because of changes in stiffness and density. A force sensor and an ultrasound probe were combined to detect such alterations during force-regulated indentations. To explore the specimens, regardless of their orientation and shape, a scanned area of the test sample was defined using shape recognition applying optical background subtraction to the images captured by a camera. The motorized platform was validated using seven phantom tissues, simulating the mechanical and acoustical properties of ex-vivo diseased tissues, including stiffer nodules that can be encountered in pathological conditions during histological analyses. Results demonstrated the platform’s ability to automatically explore and identify the inclusions in the phantom. Overall, the system was able to correctly identify up to 90.3% of the inclusions by means of stiffness in combination with ultrasound measurements, paving pathways towards robotic palpation during intraoperative examinations

Mandatory reporting of sexual and gender-based violence in humanitarian settings: a qualitative analysis of international guidelines for humanitarian practitioners and scoping review of existing evidence

Background: Mandatory reporting requirements create an ethical and legal dilemma for humanitarian practitioners working with survivors of sexual and gender-based violence (SGBV), as they are required to report known instances of SGBV to law enforcement, sometimes without the consent of victims or as a precondition to administering care. However, there remains a paucity of research on this topic in the context of humanitarian settings to guide practitioners on how to navigate mandatory reporting requirements from a survivor-centered approach. This study seeks to contribute to the existing knowledge and debate on mandatory reporting for SGBV in humanitarian settings by reviewing the current literature and international GBV guidelines for humanitarian practitioners. Methods: We conducted an abductive thematic analysis of key international GBV guidelines for humanitarian workers to explore the practices and guidance developed around mandatory reporting. GBV guidelines were identified by a search on agencies’ websites under consultations with experts in the field of sexual and reproductive health. In parallel, we conducted a scoping review of five academic databases with no earliest inclusion date, and a final inclusion date of 31 March 2023 to identify the scope and extent of research on SGBV mandatory reporting in humanitarian settings. Findings: We identified thirty-one relevant international GBV guideline documents which provide guidance for humanitarian practitioners on implementing mandatory reporting requirements. The availability and depth of information regarding mandatory reporting varies in the international guidelines. Three themes, including “GBV guiding principles”, “consideration for the impact of mandatory reporting and the reporting obligations” and “guidance for humanitarian providers on how to implement mandatory reporting requirements” emerged from the GBV guideline content analysis. As part of the scoping review, 1474 records were reviewed, with only 5 publications meeting our eligibility criteria. The 5 selected publications contained only limited information about mandatory reporting. Conclusion: Existing guidelines would benefit from incorporating more systematic and detailed guidance on how to navigate mandatory reporting requirements while upholding survivor-centered responses. There remains little evidence on the implementation or effectiveness of mandatory reporting in humanitarian settings, and of the implementation of guidance pertaining to mandatory reporting included in international GBV guidelines. Further research is necessary to clarify its implications and support evidence-based guidance for humanitarian personnel

Proceedings of the Merck & Elsevier Young Chemists Symposium (MEYCS 2018)

Dear participants, welcome to the 18th edition of the Merck & Elsevier Young Chemists Symposium, formerly SAYCS and MYCS. This conference is an international scientific event organized by the Young Group of the Italian Chemical Society (SCI Giovani) with the financial support of Merck and Elsevier. This symposium is fully devoted to young researchers, such as MSc and PhD students, post-doc fellows and young researchers in companies. All the disciplines of Chemistry are covered: analytical, physical, industrial, organic, inorganic, theoretical, pharmaceutical, biological, environmental, macromolecular and electrochemistry. This year, a special emphasis will be given to chemistry from knowledge to innovation: how chemistry is increasingly present in all of the fields that are essential for human life, and how chemical fundamentals are pushing novel technologies? This year we have the exceptional number of 212 participants; we thank you for the great trust shown towards SCI Giovani, Merck and Elsevier. Enjoy the conference

Oral dysbiosis in pancreatic cancer and liver cirrhosis: A review of the literature

The human body is naturally colonized by a huge number of different commensal microbial species, in a relatively stable equilibrium. When this microbial community undergoes dysbiosis at any part of the body, it interacts with the innate immune system and results in a poor health status, locally or systemically. Research studies show that bacteria are capable of significantly influencing specific cells of the immune system, resulting in many diseases, including a neoplastic response. Amongst the multiple different types of diseases, pancreatic cancer and liver cirrhosis were significantly considered in this paper, as they are major fatal diseases. Recently, these two diseases were shown to be associated with increased or decreased numbers of certain oral bacterial species. These findings open the way for a broader perception and more specific investigative studies, to better understand the possible future treatment and prevention. This review aims to describe the correlation between oral dysbiosis and both pancreatic cancer and liver cirrhotic diseases, as well as demonstrating the possible diagnostic and treatment modalities, relying on the oral microbiota, itself, as prospective, simple, applicable non-invasive approaches to patients, by focusing on the state of the art. PubMed was electronically searched, using the following key words: "oral microbiota" and "pancreatic cancer" (PC), "liver cirrhosis", "systemic involvement", and "inflammatory mediators". Oral dysbiosis is a common problem related to poor oral or systemic health conditions. Oral pathogens can disseminate to distant body organs via the local, oral blood circulation, or pass through the gastrointestinal tract and enter into the systemic circulation. Once oral pathogens reach an organ, they modify the immune response and stimulate the release of the inflammatory mediators, this results in a disease. Recent studies have reported a correlation between oral dysbiosis and the increased risk of pancreatic and liver diseases and provided evidence of the presence of oral pathogens in diseased organs. The profound impact that microbial communities have on human health, provides a wide domain towards precisely investigating and clearly understanding the mechanism of many diseases, including cancer. Oral microbiota is an essential contributor to health status and imbalance in this community was correlated to oral and systemic diseases. The presence of elevated numbers of certain oral bacteria, particularly P. gingivalis, as well as elevated levels of blood serum antibodies, against this bacterial species, was associated with a higher risk of pancreatic cancer and liver cirrhosis incidence. Attempts are increasingly directed towards investigating the composition of oral microbiome as a simple diagnostic approach in multiple diseases, including pancreatic and liver pathosis. Moreover, treatment efforts are concerned in the recruitment of microbiota, for remedial purposes of the aforementioned and other different diseases. Further investigation is required to confirm and clarify the role of oral microbiota in enhancing pancreatic and liver diseases. Improving the treatment modalities requires an exertion of more effort, especially, concerning the microbiome engineering and oral microbiota transplantation