Transportation in Michigan: older adults and caregivers

Michigan Department of Transportationhttp://deepblue.lib.umich.edu/bitstream/2027.42/90963/1/102858.pd

Knowledge co-creation in participatory policy and practice: Building community through data-driven direct democracy

Engaging citizens with digital technology to co-create data, information and knowledge has widely become an important strategy for informing the policy response to COVID-19 and the ‘infodemic’ of misinformation in cyberspace. This move towards digital citizen participation aligns well with the United Nations’ agenda to encourage the use of digital tools to enable data-driven, direct democracy. From data capture to information generation, and knowledge co-creation, every stage of the data lifecycle bears important considerations to inform policy and practice. Drawing on evidence of participatory policy and practice during COVID-19, we outline a framework for citizen ‘e-participation’ in knowledge co-creation across every stage of the policy cycle. We explore how coupling the generation of information with that of social capital can provide opportunities to collectively build trust in institutions, accelerate recovery and facilitate the ‘e-society’. We outline the key aspects of realising this vision of data-driven direct democracy by discussing several examples. Sustaining participatory knowledge co-creation beyond COVID-19 requires that local organisations and institutions (e.g. academia, health and welfare, government, business) incorporate adaptive learning mechanisms into their operational and governance structures, their integrated service models, as well as employing emerging social innovations

Recommendations for meeting the transportation needs of Michigan’s aging population

Mobility, or the ability to get from place to place, is important for everyone. Mobility enables people to conduct activities of daily life, stay socially connected with their world, participate in activities that make life enjoyable, and increase their quality of life. In the United States, and indeed in Michigan, personal mobility is frequently equated with being able to drive a personal automobile. However, because of age related medical conditions and the medications used to treat them, as people age into older adulthood they are more likely to experience declines in abilities needed for safe driving. Because of the preference for the personal automobile, and the lack of acceptable mobility alternatives, one focus of efforts to enhance safe mobility for older adults is to keep older adults driving for as long as they can safely do so. At the same time, society has a responsibility to help maintain mobility for those who are unable or choose not to drive. As the population of older adults in Michigan continues to grow, it is becoming more and more critical that the Michigan Department of Transportation (MDOT) understand the mobility needs of older adults and incorporate these needs into transportation facility design and planning. This project provided the background information needed to help MDOT identify where to concentrate resources to maximize the safe mobility of Michigan’s aging population. The overall goal of the project was to help maintain the safety and well-being of Michigan’s older adult residents by developing a set of low-cost, high-impact measures that could be implemented by MDOT. This goal was achieved through a literature review, an analysis of demographic data, and statewide surveys of older adults and family members/caregivers for Michigan older adults in order to gain a better understanding of the travel and residency patterns, gaps in transportation services, and the transportation needs and wants of Michigan older adult residents and the population of adults who provide care and/or transportation assistance to Michigan older adults. The complete results of these research activities, a list of measures for improving older adult mobility in Michigan, and an implementation plan are included in this report.Michigan Department of Transportationhttp://deepblue.lib.umich.edu/bitstream/2027.42/90961/1/102857.pd

Transportation, mobility, and older adults in rural Michigan

A deliverable for project number OR 10-037: “Transportation Patterns of Older Drivers in Rural Michigan”Michigan Department of Transportation, Lansing, MIhttp://deepblue.lib.umich.edu/bitstream/2027.42/91979/1/102872.pd

Evaluation of the Michigan TACT Program

This report documents the evaluation of the Michigan Ticketing Aggressive Cars and Trucks (TACT) program. The TACT program was conducted in three 2-week waves in the fall of 2013 near Grand Rapids, Michigan. Comparable sites in southeast Michigan served as a comparison area. The TACT program combined high visibility enforcement with a public information and education (PI&E) campaign focused on unsafe driving behaviors of cars and trucks near each other. An evaluation of the TACT implementation found that that the enforcement and PI&E plans were followed reasonably well. Outcomes in terms of driver behaviors, attitudes, and traffic safety were tested by means of surveys of motorists and truck drivers; an observational study of passing and merging behaviors of passenger cars near large trucks; and analysis of crash data. A before/after with comparison design was used to measure any effect in each outcome. Results indicated that the PI&E messages reached the drivers in the program area. Analysis of the survey data did not identify any statistically significant changes in self-reported behaviors among the drivers in the program area. The proportion of safe passing and merging maneuvers recorded in the observational study were quite high before the program and did not change significantly after the program. A Poisson crash rate model adjusted for over-dispersion and using six-years of monthly crash data from the program and comparison areas was developed. It accounted for traffic volumes, proportion of trucks in the traffic, snowfall and precipitation, and the economy. The crash data analysis did not identify significant effects of the program on crash rates.Michigan Office of Highway Safety Planning, Michigan State Policehttp://deepblue.lib.umich.edu/bitstream/2027.42/109414/1/103138.pd

Recommendations for meeting the mobility needs of older adults in rural Michigan

The populations of the United States (US) and Michigan are aging. This demographic trend will continue to have a significant impact on society for the next few decades, particularly in the area of safe mobility in rural areas. As the population of Michigan’s rural older adults continues to grow, it is becoming increasingly crucial that the Michigan Department of Transportation (MDOT) understand the mobility needs and issues of rural older adults, including the issues faced by Indian Tribes in rural Michigan, and be proactive in addressing these needs and issues in their activities. This project provides the background and suggestions to help MDOT identify areas where they significantly impact the safe mobility of Michigan’s rural older adults. The overall goal of the project is to help maintain the safety and well-being of Michigan’s rural older adult residents by providing recommendations on how current alternative transportation services could be improved to be more attractive to older adults while addressing cultural and psychological barriers to using these services. This goal was achieved through a literature review, an analysis of demographic data, a statewide survey of older adults living in six rural counties of Michigan, structured interviews with public and community transportation providers, and group discussions with representatives of three Indian Tribes located in rural Michigan. The complete results of these research activities, a list of recommendations for improving rural older adult mobility in Michigan, and an implementation plan are included in this report.Michigan Department of Transportationhttp://deepblue.lib.umich.edu/bitstream/2027.42/95709/1/102924.pd

Physicochemical attack against solid tumors based on the reversal of direction of entropy flow: an attempt to introduce thermodynamics in anticancer therapy

BACKGROUND: There are many differences between healthy tissue and growing tumor tissue, including metabolic, structural and thermodynamic differences. Both structural and thermodynamic differences can be used to follow the entropy differences in cancerous and normal tissue. Entropy production is a bilinear form of the rates of irreversible processes and the corresponding "generalized forces". Entropy production due to various dissipation mechanisms based on temperature differences, chemical potential gradient, chemical affinity, viscous stress and exerted force is a promising tool for calculations relating to potential targets for tumor isolation and demarcation. METHODS: The relative importance of five forms of entropy production was assessed through mathematical estimation. Using our mathematical model we demonstrated that the rate of entropy production by a cancerous cell is always higher than that of a healthy cell apart from the case of the application of external energy. Different rates of entropy production by two kinds of cells influence the direction of entropy flow between the cells. Entropy flow from a cancerous cell to a healthy cell transfers information regarding the cancerous cell and propagates its invasive action to the healthy tissues. To change the direction of entropy flow, in addition to designing certain biochemical pathways to reduce the rate of entropy production by cancerous cells, we suggest supplying external energy to the tumor area, changing the relative rate of entropy production by the two kinds of cells and leading to a higher entropy accumulation in the surrounding normal cells than in the tumorous cells. CONCLUSION: Through the use of mathematical models it was quantitatively demonstrated that when no external force field is applied, the rate of entropy production of cancerous cells is always higher than that of healthy cells. However, when the external energy of square wave electric pulses is applied to tissues, the rate of entropy production of normal cells may exceed that of cancerous cells. Consequently, the application of external energy to the body can reverse the direction of the entropy current. The harmful effect brought about by the entropy flow from cancerous to healthy tissue can be blocked by the reversed direction of entropy current from the irradiated normal tissue around the tumor

Accuracy of SenseWear Pro2 armband to predict resting energy expenditure in childhood obesity.

OBJECTIVE: We evaluate the accuracy of the SenseWear Pro2 Armband (SWA) in estimating resting energy expenditure (REE) in children and adolescents with obesity, using indirect calorimetry (IC) as a reference. DESIGN AND METHODS: REE was assessed using both the SWA and IC in 40 obese subjects (26 M/14 F, age 11.5±2.57 years, z-score BMI 3.14±0.53). The agreement between methods was assessed by the Bland-Altman procedure. The relationship between REE assessments and patients' characteristics was also analyzed. RESULTS: SWA- and IC-derived estimates of REE showed a significant correlation (r=0.614; P<0.001), but the SWA overestimated mean REE by 13% (P<0.001). Age and kg of fat-free mass (kgFFM) were significantly correlated with both REE estimation by SWA (r=0.434 and r=0.564; respectively) and IC (r=0.401 and r=0.518; respectively). Only kgFFM was demonstrated to be the main predictor factor of REE variability (r2 79% SWA; 75% IC). CONCLUSIONS: The SWA overestimated mean REE in childhood obesity, suggesting that the SWA and IC are not yet interchangeable methods. This would require improving the SWA by developing better algorithms for predicting REE and, probably, bias in each individual REE could be reduced by an adjustment for subjects' kgFFM

miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity

miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function. We describe here the generation and initial characterisation of a miR-132/212 double knockout mouse. These mice were viable and fertile with no overt adverse phenotype. Analysis of innate immune responses, including TLR-induced cytokine production and IFNβ induction in response to viral infection of primary fibroblasts did not reveal any phenotype in the knockouts. In contrast, the loss of miR-132 and miR-212, while not overtly affecting neuronal morphology, did affect synaptic function. In both hippocampal and neocortical slices miR-132/212 knockout reduced basal synaptic transmission, without affecting paired-pulse facilitation. Hippocampal long-term potentiation (LTP) induced by tetanic stimulation was not affected by miR-132/212 deletion, whilst theta burst LTP was enhanced. In contrast, neocortical theta burst-induced LTP was inhibited by loss of miR-132/212. Together these results indicate that miR-132 and/or miR-212 play a significant role in synaptic function, possibly by regulating the number of postsynaptic AMPA receptors under basal conditions and during activity-dependent synaptic plasticity