5,795 research outputs found
Oceanography Professional Development in Virginia Via Collaboration, Field Integration, and Inquiry
Seventy-nine in-service teachers completed one of six sections of a grant-funded, graduate-level, summer course entitled, Oceanography, that was offered at four different locations in Virginia between 2005 and 2007. The majority of the teachers enrolled with the objective of obtaining their add-on earth science endorsement through the Virginia Earth Science Collaborative (VESC). Oceanography was designed to integrate the following: 1) the ocean science disciplines of geology, chemistry, physics, and biology; 2) inquiry-based learning strategies, quantitative activities, and technology; and, 3) Virginia Institute of Marine Science (VIMS) field experience with classroom experiences. These design themes were informed by ocean science content standards and science education best practices, and supported the goal that, upon completion of the course, teachers would be confident and competent in their abilities to teach oceanography concepts to grades 6-12 [1-3]. Learning outcomes, instructor feedback, and participant feedback suggest that the VESC’s Oceanography can serve as an instructional model for teacher professional development in oceanography. A collaborative instructional framework (marine educators, master teacher, and university faculty), small class size, and end-of-course field synthesis projects are additional elements that contributed to positive learning outcomes in course sections. The primary challenge in the course was the compressed, two-week time frame of face-to-face instruction
Clothes make the rider? Equestrian competition dress and sporting identity
Tailored jackets, long boots and white gloves are clothes not normally associated with sport, yet they make up required competition dress within equestrianism. The modern equestrian sports of dressage and showjumping have their origins in the military and on the hunting field, and this highly formal, masculine style persists in contemporary equestrian circles. Perceived by many non-participants as archaic, comical and distinctly unsporty, equestrian competition dress requirements have remained relatively unchanged for a century and are one factor (amongst many others) that visibly marks equestrianism as different to most other sporting practices. This paper draws on an ethnographic study of equestrian sport in Britain in order to consider how participants today relate to and experience formal competition dress in the course of regular sporting activities. Formal competition dress is an important aspect of individual sporting identity for contemporary riders and is understood by participants to represent the unusual ethos of equestrian sport
Concerns with AED conversion: comparison of patient and physician perspectives.
When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clinician's perspective of patient concerns. Findings of a literature review of articles that report patient-expressed concerns regarding their epilepsy and treatment were also reviewed. Results showed that the specialist panel appropriately identified patient-reported concerns of driving ability, medication cost, seizure control, and medication side effects. Additionally, patient-reported concerns of independence, employment issues, social stigma, medication dependence, and undesirable cognitive effects are important to address when considering and initiating AED conversion
Quantitative characterization of viscoelastic behavior in tissue-mimicking phantoms and ex vivo animal tissues.
Viscoelasticity of soft tissue is often related to pathology, and therefore, has become an important diagnostic indicator in the clinical assessment of suspect tissue. Surgeons, particularly within head and neck subsites, typically use palpation techniques for intra-operative tumor detection. This detection method, however, is highly subjective and often fails to detect small or deep abnormalities. Vibroacoustography (VA) and similar methods have previously been used to distinguish tissue with high-contrast, but a firm understanding of the main contrast mechanism has yet to be verified. The contributions of tissue mechanical properties in VA images have been difficult to verify given the limited literature on viscoelastic properties of various normal and diseased tissue. This paper aims to investigate viscoelasticity theory and present a detailed description of viscoelastic experimental results obtained in tissue-mimicking phantoms (TMPs) and ex vivo tissues to verify the main contrast mechanism in VA and similar imaging modalities. A spherical-tip micro-indentation technique was employed with the Hertzian model to acquire absolute, quantitative, point measurements of the elastic modulus (E), long term shear modulus (η), and time constant (τ) in homogeneous TMPs and ex vivo tissue in rat liver and porcine liver and gallbladder. Viscoelastic differences observed between porcine liver and gallbladder tissue suggest that imaging modalities which utilize the mechanical properties of tissue as a primary contrast mechanism can potentially be used to quantitatively differentiate between proximate organs in a clinical setting. These results may facilitate more accurate tissue modeling and add information not currently available to the field of systems characterization and biomedical research
The struggle for power in education: The nation-state versus the supranational in the evolution of European Union education policy, 1945-1976
European integration is a curious concept. There is stark disparity between some areas of policy that seemingly glide through the integration process, while others lag behind and despite decades of attempts, never reach the status of a fully-fledged area of European Union competence. Once such area is education.
Through integration theories, political scientists have sought to explain how policies develop and are implemented at European level. This interdisciplinary study borrows the opposing theories of neofunctionalism and intergovernmentalism with the aim of identifying the influence of the supranational and the strength of the state in the evolution of a European Union education policy. It seeks to pinpoint how education can be placed within the construction of Europe and the process of early European integration to determine the feasibility of these integration theories in explaining the journey of education policy in the European context.
Historical methodology is adopted, based on archival research at the Historical Archives of the European Union, using documentary analysis to trace the history of activities and initiatives relating to education between 1945-1976. Collective biography methodology is adopted to give space to the role of states in driving the scope, direction and extent of integration based on domestic interests, while a case study implements methodological triangulation to stress-test the case of education.
The study proposes that education is a complex case that does not slot neatly into a theory of integration. Education is multifaceted, a cultural – while at the same time – economic component: it is woven into the fabric of nation-states, it contributes to increasing global competitiveness, it diversifies across borders, and its development is attached to temporality and context. Despite suggestions that the state is diminishing in power, education serves as an example to demonstrate that the state is very much alive and at the centre of certain areas of policy development at European level
The Role of Politics and Proximity in Sea Level Rise Policy Salience: A Study of Virginia Legislators’ Perceptions
The acceleration of sea level rise (SLR) has become a threat to the stability of nation-states worldwide and associated with risks to environmental sustainability, economic infrastructure, and public health. However, from both an international and U.S. perspective, there is a lack of research examining legislative decision makers’ perceptions about policies regarding SLR. This study addresses that gap by examining how politics and proximity affects Virginia state legislators’ perceptions of the saliency of SLR. A survey of these legislators reveals their perceptions of credible sources of information, SLR-related risk, and who should take the lead to address SLR. While this study confirms other research about the effects of political party, it finds that proximity to coastal areas also greatly influences the perceived saliency of SLR. The findings from this research project enhance our understanding of the challenges inherent in addressing SLR at the state level. Finally, this study points to implications for agenda setting and suggests areas of further study regarding SLR policy at the state and local government levels
The identification of mitochondrial DNA variants in glioblastoma multiforme
Background:
Mitochondrial DNA (mtDNA) encodes key proteins of the electron transfer chain (ETC), which produces ATP through oxidative phosphorylation (OXPHOS) and is essential for cells to perform specialised functions. Tumor-initiating cells use aerobic glycolysis, a combination of glycolysis and low levels of OXPHOS, to promote rapid cell proliferation and tumor growth. Glioblastoma multiforme (GBM) is an aggressively malignant brain tumor and mitochondria have been proposed to play a vital role in GBM tumorigenesis.
Results:
Using next generation sequencing and high resolution melt analysis, we identified a large number of mtDNA variants within coding and non-coding regions of GBM cell lines and predicted their disease-causing potential through in silico modeling. The frequency of variants was greatest in the D-loop and origin of light strand replication in non-coding regions. ND6 was the most susceptible coding gene to mutation whilst ND4 had the highest frequency of mutation. Both genes encode subunits of complex I of the ETC. These variants were not detected in unaffected brain samples and many have not been previously reported. Depletion of HSR-GBM1 cells to varying degrees of their mtDNA followed by transplantation into immunedeficient mice resulted in the repopulation of the same variants during tumorigenesis. Likewise, de novo variants identified in other GBM cell lines were also incorporated. Nevertheless, ND4 and ND6 were still the most affected genes. We confirmed the presence of these variants in high grade gliomas.
Conclusions:
These novel variants contribute to GBM by rendering the ETC. partially dysfunctional. This restricts metabolism to anaerobic glycolysis and promotes cell proliferation
Combining Spatiotemporal Corridor Design for Reindeer Migration with Harvest Scheduling in Northern Sweden
Reindeer husbandry and commercial forestry seek to co-exist in the forests of Northern Sweden. As interwoven as the two industries are, conflicts have arisen. Forest practices have reduced the distribution of lichen, the main winter diet for reindeer. Forest practices have also increased forest density, compromising the animals’ ability to pass through forested areas on their migration routes. In an attempt to reduce impacts on reindeer husbandry, we present a spatially explicit harvest scheduling model that includes reindeer corridors with user-defined spatial characteristics. We illustrate the model in a case study and explore the relationship between timber revenues and the selection and maintenance of reindeer corridors. The corridors are not only to include sufficient lichen habitat, but they are also supposed to ensure access for reindeer by connecting lichen areas with linkages that allow unobstructed travel. Since harvest scheduling occurs over a planning horizon, the spatial configuration of corridors can change from one time period to the next in order to accommodate harvesting activities. Our results suggest that maintaining reindeer corridors in harvest scheduling can be done at minimal cost. Also, we conclude that including corridor constraints in the harvest scheduling model is critical to guarantee connectivity of reindeer pastures
The Sea Is Rising… But Not Onto the Policy Agenda: A Multiple Streams Approach to Understanding Sea Level Rise Policies
There has been little policy effort to address sea level rise in coastal states in the US. It is important to examine, at the state level, how the multitude of different (and changing) actors with different preferences and perspectives contribute to such inertia. This study examines state-level legislative inaction with regards to sea level rise. Using Kingdon\u27s multiple streams framework, we draw a picture of the policy landscape in Virginia as one where the problem of sea level rise is perceived as a low priority, with little consensus on achievable policy solutions, and is politically controversial. We find that policy inertia in Virginia is a result of (1) fractious viewpoints regarding sea level rise as a problem, (2) a lack of clear consensus on policy solutions, and (3) conflicting perspectives of the role of the state
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