Local approach to fracture based prediction of the ΔT56J and ΔTKIc 100 shifts due to irradiation for an A508 pressure vessel steel

International audienceNuclear pressure vessel steels are subjected to irradiation embrittlement which is monitored using Charpy tests. Reference index temperatures, such as the temperature for which the mean Charpy rupture energy is equal to 56 J (T56J), are used as embrittlement indicators. The safety integrity evaluation is performed assuming that the shift of the nil-ductility reference temperature RTNDT due to irradiation is equal to the shift of T56J. A material model integrating a description of viscoplasticity, ductile damage and cleavage brittle fracture is used to simulate both the Charpy test and the fracture toughness test (CT geometry). The model is calibrated on the Charpy data obtained on an unirradiated A508 Cl.3 steel. It is then applied to irradiated materials assuming that irradiation affects solely hardening. Comparison with Charpy energy data for different amounts of irradiation shows that irradiation possibly also affects brittle fracture. The model is then applied to predict the fracture toughness shifts (ΔTKIc,100) for different levels of irradiation

Local approach to fracture based prediction of the ∆T56J and ∆T K1C100 shifts due to irradiation for an A508 pressure vessel steel

International audienceA material model integrating a description of viscoplasticity, ductile damage and brittle fracture is used to simulate both the impact (Charpy) test and the toughness (CT) fracture test. The model is calibrated on the Charpy data obtained on an unirradiated A508 Cl.3 steel. It is then applied to irradiated material assuming that irradiation affects solely hardening. Comparison with Charpy energy data for different amounts of irradiation shows that irradiation probably also affects brittle fracture. The model is then used to predict the DTKIc100 shifts for different levels of irradiation

Introduction. L’artiste et la Grande Guerre : le conflit comme inspiration de 1914 à nos jours

C’est sous les auspices de « l’ange au sourire » de la cathédrale de Reims que nous souhaitons ouvrir ce numéro spécial sur l’artiste et la Grande Guerre. S’il est difficile de nommer celui qui, cherchant à représenter la lumière de la foi éclairant le regard d’un fidèle, en façonna les traits fragiles au xiiie siècle, nombreux sont en réalité celles et ceux qui ont créé « l’ange au sourire ». Avant 1914, la statuaire de Reims suscite déjà une admiration ce..

Transferability of cleavage fracture parameters between notched and cracked geometries

International audienceThe present study investigates the temperature ...

Cosmic Statistics of Statistics

The errors on statistics measured in finite galaxy catalogs are exhaustively investigated. The theory of errors on factorial moments by Szapudi & Colombi (1996) is applied to cumulants via a series expansion method. All results are subsequently extended to the weakly non-linear regime. Together with previous investigations this yields an analytic theory of the errors for moments and connected moments of counts in cells from highly nonlinear to weakly nonlinear scales. The final analytic formulae representing the full theory are explicit but somewhat complicated. Therefore as a companion to this paper we supply a FORTRAN program capable of calculating the described quantities numerically (abridged).Comment: 18 pages, 9 figures, Latex (MN format), published in MNRAS 310, 428 with slight correction

Negative regulation of EB1 turnover at microtubule plus ends by interaction with microtubule-associated protein ATIP3

International audienceThe regulation of microtubule dynamics is critical to ensure essential cell functions. End binding protein 1 (EB1) is a master regulator of microtubule dynamics that autonomously binds an extended GTP/GDP-Pi structure at growing microtubule ends and recruits regulatory proteins at this location. However, negative regulation of EB1 association with growing microtubule ends remains poorly understood. We show here that microtubule-associated tumor suppressor ATIP3 interacts with EB1 through direct binding of a non-canonical proline-rich motif. Results indicate that ATIP3 does not localize at growing microtubule ends and that in situ ATIP3-EB1 molecular complexes are mostly detected in the cytosol. We present evidence that a minimal EB1-interacting sequence of ATIP3 is both necessary and sufficient to prevent EB1 accumulation at growing microtubule ends in living cells and that EB1-interaction is involved in reducing cell polarity. By fluorescence recovery of EB1-GFP after photobleaching, we show that ATIP3 silencing accelerates EB1 turnover at microtubule ends with no modification of EB1 diffusion in the cytosol. We propose a novel mechanism by which ATIP3-EB1 interaction indirectly reduces the kinetics of EB1 exchange on its recognition site, thereby accounting for negative regulation of microtubule dynamic instability. Our findings provide a unique example of decreased EB1 turnover at growing microtubule ends by cytosolic interaction with a tumor suppressor. INTRODUCTION Microtubules (MTs) are polarized structures that continuously switch between periods of polymerization and depolymerization at their growing (plus) ends. This process, termed MT dynamic instability, allows rapid reorganization of the MT cytoskeleton during essential cell functions such as cell polarity and migration, mitosi

MoMaF : The Mock Map Facility

We present the Mock Map Facility, a powerful tool to generate mock catalogues or images from semi-analytically post-processed snapshots of cosmological N-body simulations. The paper describes in detail an efficient technique to create such mocks from the GALICS semi-analytic model, providing the reader with an accurate quantification of the artifacts it introduces at every step. We show that replication effects introduce a negative bias on the clustering signal -- typically peaking at less than 10 percent around the correlation length. We also thoroughly discuss how the clustering signal is affected by finite volume effects, and show that it vanishes at scales larger than about a tenth of the simulation box size. For the purpose of analysing our method, we show that number counts and redshift distributions obtained with GALICS and MOMAF compare well to K-band observations and to the 2dFGRS. Given finite volume effects, we also show that the model can reproduce the APM angular correlation function. The MOMAF results discussed here are made publicly available to the astronomical community through a public database. Moreover, a user-friendly Web interface (http://galics.iap.fr) allows any user to recover her/his own favourite galaxy samples through simple SQL queries. The flexibility of this tool should permit a variety of uses ranging from extensive comparisons between real observations and those predicted by hierarchical models of galaxy formation, to the preparation of observing strategies for deep surveys and tests of data processing pipelines.Comment: 19 pages, 15 Figs, significantly modified version now accepted for publication in MNRAS. High-resolution version available at http://galics.cosmologie.fr/papers/momaf.ps.g

Calibration of the Spectrometer aboard the INTEGRAL satellite

SPI, the Spectrometer on board the ESA INTEGRAL satellite, to be launched in October 2002, will study the gamma-ray sky in the 20 keV to 8 MeV energy band with a spectral resolution of 2 keV for photons of 1 MeV, thanks to its 19 germanium detectors spanning an active area of 500 cm2. A coded mask imaging technique provides a 2 deg angular resolution. The 16 deg field of view is defined by an active BGO veto shield, furthermore used for background rejection. In April 2001 the flight model of SPI underwent a one-month calibration campaign at CEA in Bruy\`eres le Ch\^atel using low intensity radioactive sources and the CEA accelerator for homogeneity measurements and high intensity radioactive sources for imaging performance measurements. After integration of all scientific payloads (the spectrometer SPI, the imager IBIS and the monitors JEM-X and OMC) on the INTEGRAL satellite, a cross-calibration campaign has been performed at the ESA center in Noordwijk. A set of sources has been placed in the field of view of the different instruments in order to compare their performances and determine their mutual influence. Some of those sources had already been used in Bruy\`eres during the SPI standalone test. For the lowest energy band calibration an X-ray generator has been used. We report on the scientific goals of this calibration activity, and present the measurements performed as well as some preliminary results.Comment: 12 pages, 19 figures, Published in Proceedings of SPIE conference, 24-28 August 2002, Waikoloa, Hawaii, US

The Phospholipid Scramblases 1 and 4 Are Cellular Receptors for the Secretory Leukocyte Protease Inhibitor and Interact with CD4 at the Plasma Membrane

Secretory leukocyte protease inhibitor (SLPI) is secreted by epithelial cells in all the mucosal fluids such as saliva, cervical mucus, as well in the seminal liquid. At the physiological concentrations found in saliva, SLPI has a specific antiviral activity against HIV-1 that is related to the perturbation of the virus entry process at a stage posterior to the interaction of the viral surface glycoprotein with the CD4 receptor. Here, we confirm that recombinant SLPI is able to inhibit HIV-1 infection of primary T lymphocytes, and show that SLPI can also inhibit the transfer of HIV-1 virions from primary monocyte-derived dendritic cells to autologous T lymphocytes. At the molecular level, we show that SLPI is a ligand for the phospholipid scramblase 1 (PLSCR1) and PLSCR4, membrane proteins that are involved in the regulation of the movements of phospholipids between the inner and outer leaflets of the plasma membrane. Interestingly, we reveal that PLSCR1 and PLSCR4 also interact directly with the CD4 receptor at the cell surface of T lymphocytes. We find that the same region of the cytoplasmic domain of PLSCR1 is involved in the binding to CD4 and SLPI. Since SLPI was able to disrupt the association between PLSCR1 and CD4, our data suggest that SLPI inhibits HIV-1 infection by modulating the interaction of the CD4 receptor with PLSCRs. These interactions may constitute new targets for antiviral intervention