METHOD DEVELOPMENT AND VALIDATION BY GC-MS FOR QUANTIFICATION OF 1-CHLOROETHYL CYCLOHEXYL CARBONATE AS A GENOTOXIC IMPURITY IN CANDESARTAN CILEXETIL DRUG SUBSTANCE

Objective: Candesartan Cilexetil is an Angiotension II receptor antagonist used mainly for the treatment of hypertension. The synthesis process of Candesartan uses 1-Chloroethyl Cyclohexyl Carbonate (CECC), which is potential genotoxic impurity as per the EMEA guideline. The method development and later validation activity was proposed and performed for the analysis of 1-Chloroethyl Cyclohexyl Carbonate (CECC) in Candesartan Cilexetil drug substance. Based on daily dose basis evaluation limit required was 0.49 µg/mL (i. e. 49 µg/g). Methods: The development activity was conducted by Gas chromatography technique with Mass spectrometer as detector. DB-5 make Agilent J&W column with length 50 meter, internal diameter 0.32 mm, film thickness 0.52 µm was used. Phase of DB-5 is 5% phenyl, 95% dimethyl polysiloxane and is an intermediate polarity phase with very good selectivity for polar compounds. Hexane was selected as diluent considering the selective solubility of CECC.  Results: Validation activity was planned and completed based on the International Conference on Harmonization (ICH) guidelines. The LOD and LOQ values were found to be 0.70 and 2.11 µg/g (i. e. 0.007 and 0.021 µg/mL) for CECC. Method very sensitive as method was related to genotoxic impurity. Also accuracy results were well in the range of 99 to 105 %. Linearity curve showed correlation coefficient of 0.99997. Conclusion: From validation data it was confirmed that the method is specific, precise, accurate, linear and sensitive for the required purpose. During the same activity three commercial batches were analyzed. Validation data as well as commercial batch data was enough to prove the method suitability

A Budget Planning Model for Health Care Hospitals

This paper is devoted to the application of goal programming to Health care planning. More specifically, the paper presents the goal programming approach to the budget planning of health care Hospitals and drawing valid decisions for further improvement in future not only for healthcare but also for quality healthcare administration and resources. Key Words: Financial Catastrophe, Business Manager, Optimization Techniques, Health Servic

SOCIAL ENREPRENEURSHIP: IMPACT OF OCCUPATIONAL HEALTH AND SAFETY (OHS) FACTORS ON WORKERS’ BEHAVIOR IN DIFFERENT CONSTRUCTION SECTORS IN OMAN

PURPOSE This paper critically analyzes and assesses the various factors of occupational health and safety (OHS), and elucidate the factors affecting construction workers’ behavior in different construction projects of Oman. It aims to create Occupational Health and Safety awareness in construction workers working for Social Entrepreneurs in Oman. DESIGN/METHODOLOGY/APPROACH Two hundred and fifty-two construction workers from various projects were selected based on a simple random sampling basis, and the data was collected through a well-defined questionnaire. FINDINGS The study shows that workers favor communication in the improvement of workers’ behavior in the industrial and infrastructure construction projects.Education and training help in capacity building and skills development and contributes towards sustainable positive OHS result in petrochemical construction projects. Management commitment plays a major part to maintain a sustained hazard free environment in building construction projects. The study also shows that the Occupational Health and Safety (OHS) factors –OHS policies, health care, communication, management commitment, education and training and workers’ behavior, have a direct impact on health and safety results towards social entrepreneurship of creating awareness in the construction sectors of Oman. RESEARCH LIMITATIONS/ IMPLICATIONS A model named Construction Industries Influencing Factors Framework (CIIFF) Model, has been developed with the orientation of workers’ behavior which can be developed further making improvements in the existing mechanism and the factors influencing can be dealt with wider procedures to ensure improvements. SOCIAL IMPLICATIONS The model may help in creating tools that are more effective to reduce Occupational Health and Safety related accidents and property damages in a construction project.&nbsp

Strong Fuzzy Chromatic Polynomial of Intuitionistic Fuzzy Graphs (IFGs) Based on α,β-Levels

This research introduces a new idea of (α,β)-level based strong fuzzy chromatic polynomial of intuitionistic fuzzy graph(IFGs). In addition, some characteristics of (α,β)-level based strong fuzzy chromatic polynomials of IFGs are specified and proven. Besides, the strong (α,β)-fundamental set and the strong (α,β)-level graphs are defined with clear examples. Moreover, some algebraic characteristics of the strong (α,β)-level graph of IFGs and their chromatic polynomials are also projected and shown

An Approach of Stipulation Change Management Using Cloud Computing

Every technology project's successful implementation depends on the requirements. Changes in stipulations at any point of the software development life cycle are considered a healthy operation. Nevertheless, this transition is a little simpler in a co-located setting than in a decentralized system in which participants are spread over more than one area. This presents numerous challenges, such as coordination, communication & control, effective and efficient management of changes and the management of central repositories. Cloud computing can therefore be used to mitigate these stakeholder problems. We used a case study to test the system of cloud computing

Applying Three Port Converter with Dual Battery Storage System for Hybrid Power Generation

640-646The proposed research work used three power sources, namely wind energy, solar energy and grid. Wind and solar constitute the primary energy sources while the grid acted as the secondary one; added to that, we have the battery storage system. The priority between the two forms of energy in the primary source is determined by their availability. The solar irradiance is available during daytime, whereas during cloudy and night times, energy extraction is impossible; besides that wind energy is also not reliable. Thus the central level controller (CLC) is used, which serves as a deciding authority for the selection of primary source. When none of the energies in the primary sources are available the grid supplies the required power to the load. When there is a surplus energy from primary sources, it is stored in a battery or exported to the grid. In addition DBSS is also introduced for effective utilization of battery storage system. The proposed model is connected with micro grid to provide utilization path for surplus power. The overall design and simulation is performed by using MATLAB/SIMULINK

Tensile Properties of Martensitic Stainless Steels at Elevated Temperatures

Tensile properties of quenched and tempered martensitic alloys EP-823, HT-9, and 422 were evaluated at temperatures ranging from ambient to 600 °C as a function of three different tempering times. The results indicated that the yield strength, ultimate tensile strength, and the failure strength were gradually reduced with increasing temperature. The ductility parameters were enhanced at elevated temperatures due to increased plastic flow. However, the tempering time did not significantly influence these properties. The evaluation of the fracture surfaces by scanning electron microscopy revealed reduced cracking and dimpled microstructures, indicating enhanced ductility at higher testing temperatures

Large spontaneous exchange bias in a weak ferromagnet Pb6Ni9(TeO6)5

We report the magnetic and dielectric behavior of Pb6Ni9(TeO6)5, a new compound comprising the honeycomb-like layers of S=1 spins, through detailed structural, magnetic and dielectric investigation. An antiferromagnetic-type transition at 25 K (TN) with weak-ferromagnetic behavior is revealed. Interestingly, a large value of coercive field of 1.32 T at 2 K is observed. The isothermal magnetization after zero-field-cooled condition, it exhibits the presence of large spontaneous exchange bias (SEB) with a magnitude of 0.19 T at 2 K; which is rare in single bulk materials, especially without external doping. The value of |HEB| further enhances to 0.24 T under 16 T field-cooled condition, confirming the presence of large exchange bias in the material. In addition, the dielectric constant shows an anomaly at the onset of TN, indicating the presence of magnetodielectric coupling.Comment: 16 pages, 6 figures, 2 supplimentory figures, under revision of Scientific Report

DEVELOPMENT AND VALIDATION OF A NEW AND STABILITY INDICATING LC METHOD FOR ANALYSIS OF PINAVERIUM BROMIDE IN BULK DRUG AND PHARMA- CEUTICAL DOSAGE FORM

ABSTRACT A simple, rapid, and stability indicating reverse phase high performance liquid chromatographic assay method was developed for pinaverium bromide in the presence of its degradation products generated from decomposition studies.LC separation was achieved isocratic mode on a Zorbax SB C8 (4.6x250) mm, 5 µm column using mobile phase containing solution A (0.1% ortho phosphoric acid) with solution B (acetonitrile) (30:70) (v/v) at flow rate 1.0 ml/min. The UV detector was operated at 245 nm and temperature was 25˚C. The retention time was 4.84 min and linearity was observed in the concentration range of 20-150µg/ml with correlation coefficient of 0.9999. The percentage relative standard deviation in accuracy and precision studies was found to be less than 2%. The method was successfully validated as per International Conference on Harmonization (ICH) guidelines. pinaverium bromide undergoes degradation under acidic, basic, oxidation, dry heat and photolytic conditions, degradation impurities did not interfere with the retention time of pinaverium bromide, and assay method is thus stability indicating