Sticky policies approach within cloud computing

This paper discusses a secure document sharing approach, which addresses confidentiality, integrity and authenticity concerns related to cloud-based data sharing. This research is focused on a secure construct that would integrate with other cloud ready standards and products for data protection. Sticky policies recently considered as one of the preferred cloud data protection techniques are here combined with standardized OOXML data package. The defined model leverages the Identity Based Encryption (IBE) scheme to attach sticky policies to the data. This paper also shows several security features and functions that are suitable for secure data sharing in the cloud. Technologies used for proposed construction are not new, therefore only their unique combination with AES key derived from XACML sticky policy via IBE and OOXML wrapper constitutes novelty of this research

Cloud-based identity and identity meta-data: secure and control own data in globalization era.

This paper proposes a new identity, and its underlying meta-data, model. The approach enables secure spanning of identity meta-data across many boundaries such as health-care, financial and educational institutions, including all others that store and process sensitive personal data. It introduces the new concepts of Compound Personal Record (CPR) and Compound Identifiable Data (CID) ontology, which aim to move toward own your own data model. The CID model ensures: authenticity of identity meta-data; high availability via unified Cloud-hosted XML data structure; and privacy through encryption, obfuscation and anonymity applied to Ontology-based XML distributed content. Additionally CID via XML ontologies is enabled for identity federation. The paper also proposes that access over sensitive data is strictly governed through an access control model with granular policy enforcement on the service side. This includes the involvement of relevant access control model entities which are enabled to authorize an ad-hoc break-glass data access which should give high accountability for data access attempts

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition

Malignant peripheral nerve sheath tumours (MPNST) are rare, hereditary cancers associated with neurofibromatosis type I. MPNSTs lack effective treatment options as they often resist chemotherapies and have high rates of disease recurrence. Aurora kinase A (AURKA) is an emerging target in cancer and an aurora kinase inhibitor (AKI), termed MLN8237, shows promise against MPNST cell lines in vitro and in vivo. Here, we test MLN8237 against two primary human MPNST grown in vivo as xenotransplants and find that treatment results in tumour cells exiting the cell cycle and undergoing endoreduplication, which cumulates in stabilized disease. Targeted therapies can often fail in the clinic due to insufficient knowledge about factors that determine tumour susceptibilities, so we turned to three MPNST cell-lines to further study and modulate the cellular responses to AKI. We find that the sensitivity of cell-lines with amplification of AURKA depends upon the activity of the kinase, which correlates with the expression of the regulatory gene products TPX2 and HMMR/RHAMM. Silencing of HMMR/RHAMM, but not TPX2, augments AURKA activity and sensitizes MPNST cells to AKI. Furthermore, we find that AURKA activity is critical to the propagation and self-renewal of sphere-enriched MPNST cancer stem-like cells. AKI treatment significantly reduces the formation of spheroids, attenuates the self-renewal of spheroid forming cells, and promotes their differentiation. Moreover, silencing of HMMR/RHAMM is sufficient to endow MPNST cells with an ability to form and maintain sphere culture. Collectively, our data indicate that AURKA is a rationale therapeutic target for MPNST and tumour cell responses to AKI, which include differentiation, are modulated by the abundance of HMMR/RHAMM

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Mathematical model of dynamic work conditions in the measuring chamber of an air gauge

The goal of the proposed computational model was to evaluate the dynamical properties of air gauges in order to exploit them in such industrial applications as in-process control, form deviation measurement, dynamical measurement. The model is based on Reynolds equations complemented by the k-ε turbulence model. The boundary conditions were set in different areas (axis of the chamber, side surfaces, inlet pipeline and outlet cross-section) as Dirichlet's and Neumann's ones. The TDMA method was applied and the efficiency of the calculations was increased due to the "line-by-line" procedure. The proposed model proved to be accurate and useful for non-stationary two-dimensional flow through the air gauge measuring chamber

Integrated framework for stakeholder participation: Methods and tools for identifying and addressing human–wildlife conflicts

As wild areas disappear and agricultural lands expand, understanding how people and wildlife can coexist becomes increasingly important. Human–wildlife conflicts (HWCs) are obstacles to coexistence and negatively affect both wildlife populations and the livelihood of people. To facilitate coexistence, a number of frameworks have been developed to both understand the drivers of conflict and then to find solutions that mitigate conflict. However, each framework has different foci and strengths in particular stages of analysis. Here, we propose an integrated framework that leverages the individual strengths of previously fairly isolated methodologies, allowing for holistic HWC analysis. The framework for participatory impact assessment (FoPIA) provides a toolset for developing wildlife scenarios, selecting assessment indicators and assessing the impact of different scenarios. The social-ecological framework of ecosystem services and disservices (SEEDS) analyzes the ecosystem services trade-offs related to scenarios, and the 3i stakeholder analysis approach, supports the identification of stakeholders and provides a mechanism to explore, in detail stakeholders' interests, relative influence, and how outcomes of research are likely to impact different stakeholders. We apply these approaches to eastern Germany, where the increase in several wildlife populations (i.e., wild boar, common crane, gray wolf, and European bison) has contributed to conflict with people. We demonstrate the complementarity of FoPIA, SEEDS, and 3i in identifying stakeholder needs and showing how wildlife dynamics may affect coexistence and create imbalanced ecosystem service and disservice distributions. The integrated framework introduced here provides guidelines for analyzing the multistage process of stakeholder participation and enables a comprehensive approach to the complex challenge of HWCs.Leibniz Centre for Agricultural Landscape ResearchMarianne and Dr. Fritz Walter Fischer‐FoundationPeer Reviewe