Immunological parameters in girls with Turner syndrome

Disturbances in the immune system has been described in Turner syndrome, with an association to low levels of IgG and IgM and decreased levels of T- and B-lymphocytes. Also different autoimmune diseases have been connected to Turner syndrome (45, X), thyroiditis being the most common. Besides the typical features of Turner syndrome (short stature, failure to enter puberty spontaneously and infertility due to ovarian insufficiency) ear problems are common (recurrent otitis media and progressive sensorineural hearing disorder). Levels of IgG, IgA, IgM, IgD and the four IgG subclasses as well as T- and B-lymphocyte subpopulations were investigated in 15 girls with Turners syndrome to examine whether an immunodeficiency may be the cause of their high incidence of otitis media. No major immunological deficiency was found that could explain the increased incidence of otitis media in the young Turner girls

Big Word Club Evaluation

PIs: Ariel Kalil, Susan E. Mayer, and Philip Oreopoulos. Abstract: The purpose of the evaluation is to assess the effectiveness of a classroom-based program intended to increase the vocabulary of preschool and primary school children. The program, called the Big Word Club (BWC), consists of videos, books and activities intended to help children learn one new word per day over a school year. The intent of the program is not only to teach specific new words, but also to increase children’s interest in words and literacy in general and thereby improve school success. The evaluation will assess the program’s success in achieving the narrow goal of increasing children’s receptive vocabulary. Specifically, we will assess receptive vocabulary using a test that includes words from the BWC as well as a set of age-appropriate words not included in the BWC. The evaluation will include a minimum of 50 schools and maximum of 65 schools all located in the Southwestern United States. AEA RCT Registration: https://www.socialscienceregistry.org/trials/263