Regioselective Preparation of 2,4-, 3,4-, and 2,3,4-Substituted Furan Rings. 1. [1,4] O C and [1,4] C O Sily1 Migrations of Silyl Ethers and Esters Attached to Furan and Thiophene Rings

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Regioselective Preparation of 2,4-, 3,4-, and 2,3,4-Substituted Furan Rings. 2. Regioselective Lithiation of 2-Silylated-3-substituted Furan Rings

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Particulate matter indoors: a strategy to sample and monitor size-selective fractions

Particulate matter (PM) is an important player in indoor air quality. Even though PM limit values are in force for more than a decade in Europe and reference methods are well in place for ambient air, measuring indoor PM concentration still remains a challenge and standardizing a measurement protocol is complex. As people stay most of their time indoors, indoor PM is of great interest in terms of public health, as concentration can be drastically different to the one outdoors. This review aims to provide key information to the indoor air monitoring communities, to better understand principal methods suitable for the analysis of indoor PM with their respective main influencing parameters. Advantages and drawbacks of each method are discussed and specific awareness is raised to avoid wrong data interpretation in specific situations. The inter-instrument deviation is also explained and, when possible, methods to correct are proposed

Dataset related to article "Muscle quality and not quantity as a predictor of survival in head and neck squamous cell carcinoma "

<p>This record contains raw data related to article "Muscle quality and not quantity as a predictor of survival in head and neck squamous cell carcinoma"</p><p><strong>Abstract</strong></p><p>Background: Sarcopenia is frequent in head and neck squamous cell carcinoma (HNSCC), as a consequence of malnutrition related to risk factors or tumoral mass. Treatment is associated with toxicities that lead to reduced calories intake and muscle mass wasting. Sarcopenia has been negatively associated with tumor control and survival outcomes.</p><p>Purpose: Our aim is to evaluate the prognostic impact of sarcopenia on overall survival (OS) and progression free survival (PFS) in HNSCC patients undergoing chemoradiation therapy within a prospective clinical trial of chemoradiation vs induction chemotherapy followed by radiation and cetuximab (INTERCEPTOR).</p><p>Materials and methods: On baseline CT or MRI, we investigated the association between OS and PFS with radiological markers of sarcopenia, measured at the third cervical vertebra level. We studied paravertebral skeletal muscles area (cm2), muscle density (HU), muscle index (cm2/m2), and intermuscular adipose tissue (IMAT) area (cm2).</p><p>Results: Imaging of 128 patients was evaluable. We found out that higher body mass index (BMI) was associated with better OS (p = 0.02), and PFS (p = 0.04). Skeletal muscle area (p = 0.02), and IMAT (p = 0.02) were negatively associated with PFS. IMAT was positively correlated with muscle area (Correlation coefficient 0.6, CI95% 0.47-0.7), and negatively associated with muscle density (Correlation coefficient -0.37, CI95% -0.53 - -0.18).</p><p>Conclusions: IMAT can be used as predictor of PFS in HNC patients undergoing chemoradiation therapy. The amount of intermuscular fat deposits induces alterations of muscle quality, without alterations of muscle quantity, influencing patients' prognosis.</p&gt

Features of admissions.

<p>*the prevalent symptom at the time of admission was recorded.</p><p>Features of admissions.</p

Patient characteristics.

<p>*the prevalent symptom at the time of admission was recorded.</p><p>Patient characteristics.</p