Changes in PTSD, depression, and generalized anxiety before and during the COVID-19 pandemic in Ireland

Background: : In this study, we compared the prevalence of posttraumatic stress disorder (PTSD), depression, and generalized anxiety disorder (GAD) before and during the COVID-19 pandemic across nationally representative samples of Irish adults. Methods: : Participants were sampled in February 2019 (N = 1,020), April 2020 (N = 1,041), May 2020 (N = 1,032), and December 2020 (N = 1,100) using the same self-report measures. Results: : The prevalence of PTSD significantly increased from 12.5% in 2019 to 18.0% in April 2020, to 22.0% in May, and returning to 17.6% in December 2020. PTSD increases were most consistently observed in males, those aged 18–34 years, those without a university qualification, and those living in the Leinster region of Ireland, where the capital city of Dublin is located. There were no significant changes in the prevalence of depression or GAD. Limitations: : The 2020 samples were not completely independent of one another and while the analysis took this into account, this bias cannot be completely removed. Conclusions: : These findings show an increase in PTSD during the initial stages of the COVID-19 pandemic compared to the pre-pandemic period and suggest specificity in mental health responses to the COVID-19 pandemic

Trajectories of change in internalizing symptoms during the COVID-19 pandemic: A longitudinal population-based study

Background: Longitudinal data indicates that the mental health of the general population may not have been as badly affected by the COVID-19 pandemic as some had feared. Most studies examining change in mental health during the pandemic have assumed population homogeneity which may conceal evidence of worsening mental health for some. In this study, we applied a heterogeneous perspective to determine if there were distinct groups in the population characterised by different patterns of change in internalizing symptoms during the pandemic. Methods: Self-report data were collected from a nationally representative sample of Irish adults (N = 1,041) at four time-points between April and December 2020. Results: In the entire sample, mean levels of internalizing symptoms significantly declined from March to December 2020. However, we identified four distinct groups with different patterns of change. The most common response was ‘Resilience’ (66.7%), followed by ‘Improving’ (17.9%), ‘Worsening’ (11.3%), and ‘Sustained’ (4.1%). Belonging to the ‘Worsening’ class was associated with younger age, city dwelling, current and past treatment for a mental health problem, higher levels of empathy, and higher levels of loneliness. Limitations: Sample attrition was relatively high and although this was managed using robust statistical methods, bias associated with non-responses cannot be entirely ruled out. Conclusion: The majority of adults experienced no change, or an improvement in internalizing symptoms during the pandemic, and a relatively small proportion of adults experienced a worsening of internalizing symptoms. Limited public mental health resources should be targeted toward helping these at-risk individuals

Mental health of adults in Ireland during the first year of the COVID-19 pandemic: Results from a nationally representative, longitudinal study

No abstract available

Mental health of adults in Ireland during the first year of the COVID-19 pandemic: Results from a nationally representative, longitudinal study

No abstract available

Identifying service-related predictors of community reintegration difficulties in Northern Irish military Veterans

Background: Military-to-civilian community reintegration in Northern Irish (NI) veterans has not been previously examined. Existing reintegration studies indicate that post-military service life can be challenging for many veterans. Objective: The current study aimed to identify service-related predictors of community reintegration difficulties in a sample of 749 NI veterans. Method: Data was collected through a cross-sectional self-report survey of UK Armed Forces veterans residing in NI. Service-related variables were examined as predictors of overall and subdomain-specific reintegration difficulties. Results: Combat exposure, time spent deployed in NI, length of service, being medically discharged, and being physically injured during service were significant predictors of reintegration difficulties. Receiving a mental health diagnosis since discharge and having been medically discharged were the two strongest predictors. Further results and implications are also discussed. Conclusion: Post-service adjustment to civilian life is affected by service variables, with implications for military/post-military interventions aimed at mitigating difficult transition experiences

Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression

Transcriptional control of oxytocinergic cell development influences social, sexual, and appetite related behaviors and is implicated in disorders such as autism and Prader-Willi syndrome. Mediator 12 (Med12) is a transcriptional coactivator required for multiple facets of brain development including subsets of serotonergic and dopaminergic neurons. We surveyed hormone gene expression within the hypothalamo-pituitary axis of med12 mutant zebrafish embryos with a focus on oxytocin (oxt) expression. Some transcripts, such as oxt, vasopressin (avp) and corticotrophin releasing hormone (crh) are undetectable in the med12 mutant, while others are upregulated or downregulated to varying degrees. In med12 mutants, the expression patterns of upstream transcriptional regulators of oxytocinergic cell development remain largely intact in the pre-optic area, suggesting a more direct influence of Med12 on oxt expression. We show that Med12 is required for Wnt signaling in zebrafish. However, oxt expression is unaffected in Wnt-inhibited embryos indicating independence of Wnt signaling. In fact, overactive Wnt signaling inhibits oxt expression, and we identify a Wnt-sensitive period starting at 24 h post fertilization (hpf). Thus, Med12 and repression of Wnt signaling display critical but unrelated roles in regulating oxt expression

Irish Longitudinal Survey During COVID-19 - Mental Health ASAP

Funded by the Health Research Board and the Irish Research Council, this project was launched to determine what effect the pandemic has had on the mental health of the people of Ireland during the first year of the pandemic