Cenozoic extension and magmatism in Arizona

The Basin and Range Province of Arizona was the site of two episodes of Cenozoic extension that can be distinguished on the basis of timing, direction and style of extension, and associated magmatism. The first episode of extension occurred during Oligocene to mid-Miocene time and resulted in the formation of low-angle detachment faults, ductile shear zones (metamorphic core complexes), and regional domains of tilted fault blocks. Evidence for extreme middle Tertiary crustal extension in a NE to SW to SW to ENE to WSW direction has been recognized in various parts of the Basin and Range of Arizona, especially in the Lake Mead area and along the belf of metamorphic core complexes that crosses southern Arizona from Parker to Tucson. New geologic mapping and scrutiny of published geologic maps indicates that significant middle Tertiary extension is more widely distributed than previously thought. The state can be subdivided into regional tilt-block domains in which middle Tertiary rocks dip consistently in one direction. The dip direction in any tilt-block domain is generally toward the breakaway of a low-angle detachment fault that underlies the tilt-block domain; we interpret this an indicating that normal faults in the upper plate of a detechment fault are generally synthetic, rather than antithetic, with respect to the detachment fault

The sign problem in full configuration interaction quantum Monte Carlo: Linear and sub-linear representation regimes for the exact wave function

We investigate the sign problem for full configuration interaction quantum Monte Carlo (FCIQMC), a stochastic algorithm for finding the ground state solution of the Schr\"odinger equation with substantially reduced computational cost compared with exact diagonalisation. We find $k$-space Hubbard models for which the solution is yielded with storage that grows sub-linearly in the size of the many-body Hilbert space, in spite of using a wave function that is simply linear combination of states. The FCIQMC algorithm is able to find this sub-linear scaling regime without bias and with only a choice of Hamiltonian basis. By means of a demonstration we solve for the energy of a 70-site half-filled system (with a space of $10^{38}$ determinants) in 250 core hours, substantially quicker than the $\sim$10$^{36}$ core hours that would be required by exact diagonalisation. This is the largest space that has been sampled in an unbiased fashion. The challenge for the recently-developed FCIQMC method is made clear: expand the sub-linear scaling regime whilst retaining exact on average accuracy. This result rationalizes the success of the initiator adaptation (i-FCIQMC) and offers clues to improve it. We argue that our results changes the landscape for development of FCIQMC and related methods.Comment: 6 pages, 4 figures. The mentioned supplementary material is included as "Ancillary files". Comments welcom

Managing rapport in intercultural business interactions: a comparison of two Chinese-British welcome meetings

This paper explores the management of rapport in intercultural business interactions. It compares two Chinese-British business welcome meetings that were held by the same British company. Despite many similarities between the two meetings, both the British and the Chinese were very satisfied with the first meeting, while the Chinese were very annoyed by the second. This paper describes the similarities and differences between the two meetings, and explores why they were evaluated so differently. It argues that research into the management of relations in intercultural communication needs to use a broader analytic framework than is typical of intercultural discourse research, and that it needs to gather a wider range of data types

Intranasal melanoma treated with radiation therapy in three dogs

Three dogs were investigated for chronic unilateral nasal discharge. In all cases CT imaging showed an intranasal mass causing turbinate lysis and no evidence of metastasis. Cytology in cases 1 (a 14-year-old neutered male crossbreed dog) and 2 (a five-year-old neutered male German Shepherd dog) demonstrated a pleomorphic cell population with variable intracellular pigment suspicious of melanocytic neoplasia. Histopathology with immunohistochemistry (Melan-A and vimentin, plus PNL-2 in one case) confirmed the diagnosis of melanoma in all dogs. All dogs were treated with megavoltage radiotherapy using linear accelerators. Cases 1 and 3 (a nine-year-old neutered female beagle dog) received a hypofractionated (4 × 8 Gy) protocol and case 2 received a definitive (12 × 4 Gy) protocol. Complete remission was demonstrated on repeat CT scan five months after diagnosis in case 1 and seven months in case 2. Stable disease was documented on CT at four months for case 3; however, clinical signs in this dog remained controlled for 10 months in total. Case 1 died of unrelated causes five months after diagnosis, case 2 was euthanased due to the development of seizures 13 months after diagnosis, and case 3 was lost to follow-up 12 months after diagnosis. Melanoma should be considered as a rare differential diagnosis for primary nasal neoplasia in the dog and radiation therapy can be used as effective local therapy

The Gut Microbiome in Neuromyelitis Optica.

Neuromyelitis optica (NMO) is a rare, disabling, sometimes fatal central nervous system inflammatory demyelinating disease that is associated with antibodies ("NMO IgG") that target the water channel protein aquaporin-4 (AQP4) expressed on astrocytes. There is considerable interest in identifying environmental triggers that may elicit production of NMO IgG by AQP4-reactive B cells. Although NMO is considered principally a humoral autoimmune disease, antibodies of NMO IgG are IgG1, a T-cell-dependent immunoglobulin subclass, indicating that AQP4-reactive T cells have a pivotal role in NMO pathogenesis. When AQP4-specific proliferative T cells were first identified in patients with NMO it was discovered that T cells recognizing the dominant AQP4 T-cell epitope exhibited a T helper 17 (Th17) phenotype and displayed cross-reactivity to a homologous peptide sequence within a protein of Clostridium perfringens, a commensal bacterium found in human gut flora. The initial analysis of gut microbiota in NMO demonstrated that, in comparison to healthy controls (HC) and patients with multiple sclerosis, the microbiome of NMO is distinct. Remarkably, C. perfringens was the second most significantly enriched taxon in NMO, and among bacteria identified at the species level, C. perfringens was the one most highly associated with NMO. Those discoveries, along with evidence that certain Clostridia in the gut can regulate the balance between regulatory T cells and Th17 cells, indicate that gut microbiota, and possibly C. perfringens itself, could participate in NMO pathogenesis. Collectively, the evidence linking microbiota to humoral and cellular immunity in NMO underscores the importance for further investigating this relationship

Space station architectural elements model study

The worksphere, a user controlled computer workstation enclosure, was expanded in scope to an engineering workstation suitable for use on the Space Station as a crewmember desk in orbit. The concept was also explored as a module control station capable of enclosing enough equipment to control the station from each module. The concept has commercial potential for the Space Station and surface workstation applications. The central triangular beam interior configuration was expanded and refined to seven different beam configurations. These included triangular on center, triangular off center, square, hexagonal small, hexagonal medium, hexagonal large and the H beam. Each was explored with some considerations as to the utilities and a suggested evaluation factor methodology was presented. Scale models of each concept were made. The models were helpful in researching the seven beam configurations and determining the negative residual (unused) volume of each configuration. A flexible hardware evaluation factor concept is proposed which could be helpful in evaluating interior space volumes from a human factors point of view. A magnetic version with all the graphics is available from the author or the technical monitor

Compact steep-spectrum sources from the S4 sample

We present the results of 5-GHz observations with the VLA A-array of a sample of candidate Compact Steep Spectrum sources (CSSs) selected from the S4 survey. We also estimate the symmetry parameters of high-luminosity CSSs selected from different samples of radio sources, and compare these with the larger sources of similar luminosity to understand their evolution and the consistency of the CSSs with the unified scheme for radio galaxies and quasars. The majority of CSSs are likely to be young sources advancing outwards through a dense asymmetric environment. The radio properties of CSSs are found to be consistent with the unified scheme, in which the axes of the quasars are observed close to the line of sight, while radio galaxies are observed close to the plane of the sky.Comment: accepted for publication in mnras; 8 pages, figure 1 with 21 images, and two additional figures; 2 table