Ceramics and Socio-Economic Statues of the Green Family, Windsor, Vermont

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A Kerr-microresonator optical clockwork

Kerr microresonators generate interesting and useful fundamental states of electromagnetic radiation through nonlinear interactions of continuous-wave (CW) laser light. Using photonic-integration techniques, functional devices with low noise, small size, low-power consumption, scalable fabrication, and heterogeneous combinations of photonics and electronics can be realized. Kerr solitons, which stably circulate in a Kerr microresonator, have emerged as a source of coherent, ultrafast pulse trains and ultra-broadband optical-frequency combs. Using the f-2f technique, Kerr combs support carrier-envelope-offset phase stabilization for optical synthesis and metrology. In this paper, we introduce a Kerr-microresonator optical clockwork based on optical-frequency division (OFD), which is a powerful technique to transfer the fractional-frequency stability of an optical clock to a lower frequency electronic clock signal. The clockwork presented here is based on a silicon-nitride (Si$_3$N$_4$) microresonator that supports an optical-frequency comb composed of soliton pulses at 1 THz repetition rate. By electro-optic phase modulation of the entire Si$_3$N$_4$ comb, we arbitrarily generate additional CW modes between the Si$_3$N$_4$ comb modes; operationally, this reduces the pulse train repetition frequency and can be used to implement OFD to the microwave domain. Our experiments characterize the residual frequency noise of this Kerr-microresonator clockwork to one part in $10^{17}$, which opens the possibility of using Kerr combs with high performance optical clocks. In addition, the photonic integration and 1 THz resolution of the Si$_3$N$_4$ frequency comb makes it appealing for broadband, low-resolution liquid-phase absorption spectroscopy, which we demonstrate with near infrared measurements of water, lipids, and organic solvents

Correcting the extended-source calibration for the <i>Herschel</i>-SPIRE Fourier-transform spectrometer

We describe an update to the Herschel-Spectral and Photometric Imaging Receiver (SPIRE) Fourier-transform spectrometer (FTS) calibration for extended sources, which incorporates a correction for the frequency-dependent far-field feedhorn efficiency, ηff. This significant correction affects all FTS extended-source calibrated spectra in sparse or mapping mode, regardless of the spectral resolution. Line fluxes and continuum levels are underestimated by factors of 1.3–2 in thespectrometer long wavelength band (447–1018 GHz; 671–294 μm) and 1.4–1.5 in the spectrometer short wavelength band (944–1568 GHz; 318–191 μm). The correction was implemented in the FTS pipeline version 14.1 and has also been described in the SPIRE Handbook since 2017 February. Studies based on extended-source calibrated spectra produced prior to this pipeline version should be critically reconsidered using the current products available in the Herschel Science Archive. Once the extended-source calibrated spectra are corrected for ηff, the synthetic photometry and the broad-band intensities from SPIRE photometer maps agree within 2–4 per cent – similar levels to the comparison of point-source calibrated spectra and photometry from point-source calibrated maps. The two calibration schemes for the FTS are now self-consistent: the conversion between the corrected extended-source and point-source calibrated spectra can be achieved with the beam solid angle and a gain correction that accounts for the diffraction loss

Blocking Zika virus vertical transmission.

The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvir (SOF), an FDA-approved nucleotide analog inhibitor of the Hepatitis C (HCV) RNA-dependent RNA polymerase (RdRp) was recently shown to be protective against ZIKV both in vitro and in vivo. Here, we show that SOF protected human neural progenitor cells (NPC) and 3D neurospheres from ZIKV infection-mediated cell death and importantly restored the antiviral immune response in NPCs. In vivo, SOF treatment post-infection (p.i.) decreased viral burden in an immunodeficient mouse model. Finally, we show for the first time that acute SOF treatment of pregnant dams p.i. was well-tolerated and prevented vertical transmission of the virus to the fetus. Taken together, our data confirmed SOF-mediated sparing of human neural cell types from ZIKV-mediated cell death in vitro and reduced viral burden in vivo in animal models of chronic infection and vertical transmission, strengthening the growing body of evidence for SOF anti-ZIKV activity

The evolution of cyclopropenium ions into functional polyelectrolytes

Versatile polyelectrolytes with tunable physical properties have the potential to be transformative in applications such as energy storage, fuel cells and various electronic devices. Among the types of materials available for these applications, nanostructured cationic block copolyelectrolytes offer mechanical integrity and well-defined conducting paths for ionic transport. To date, most cationic polyelectrolytes bear charge formally localized on heteroatoms and lack broad modularity to tune their physical properties. To overcome these challenges, we describe herein the development of a new class of functional polyelectrolytes based on the aromatic cyclopropenium ion. We demonstrate the facile synthesis of a series of polymers and nanoparticles based on monomeric cyclopropenium building blocks incorporating various functional groups that affect physical properties. The materials exhibit high ionic conductivity and thermal stability due to the nature of the cationic moieties, thus rendering this class of new materials as an attractive alternative to develop ion-conducting membranes