Milagro limits and HAWC sensitivity for the rate-density of evaporating Primordial Black Holes

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Associations between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth: A Pooled Study of 16 US Cohorts

Importance: Phthalate exposure is widespread among pregnant women and may be a risk factor for preterm birth. Objective: To investigate the prospective association between urinary biomarkers of phthalates in pregnancy and preterm birth among individuals living in the US. Design, Setting, and Participants: Individual-level data were pooled from 16 preconception and pregnancy studies conducted in the US. Pregnant individuals who delivered between 1983 and 2018 and provided 1 or more urine samples during pregnancy were included. Exposures: Urinary phthalate metabolites were quantified as biomarkers of phthalate exposure. Concentrations of 11 phthalate metabolites were standardized for urine dilution and mean repeated measurements across pregnancy were calculated. Main Outcomes and Measures: Logistic regression models were used to examine the association between each phthalate metabolite with the odds of preterm birth, defined as less than 37 weeks of gestation at delivery (n = 539). Models pooled data using fixed effects and adjusted for maternal age, race and ethnicity, education, and prepregnancy body mass index. The association between the overall mixture of phthalate metabolites and preterm birth was also examined with logistic regression. G-computation, which requires certain assumptions to be considered causal, was used to estimate the association with hypothetical interventions to reduce the mixture concentrations on preterm birth. Results: The final analytic sample included 6045 participants (mean [SD] age, 29.1 [6.1] years). Overall, 802 individuals (13.3%) were Black, 2323 (38.4%) were Hispanic/Latina, 2576 (42.6%) were White, and 328 (5.4%) had other race and ethnicity (including American Indian/Alaskan Native, Native Hawaiian, >1 racial identity, or reported as other). Most phthalate metabolites were detected in more than 96% of participants. Higher odds of preterm birth, ranging from 12% to 16%, were observed in association with an interquartile range increase in urinary concentrations of mono-n-butyl phthalate (odds ratio [OR], 1.12 [95% CI, 0.98-1.27]), mono-isobutyl phthalate (OR, 1.16 [95% CI, 1.00-1.34]), mono(2-ethyl-5-carboxypentyl) phthalate (OR, 1.16 [95% CI, 1.00-1.34]), and mono(3-carboxypropyl) phthalate (OR, 1.14 [95% CI, 1.01-1.29]). Among approximately 90 preterm births per 1000 live births in this study population, hypothetical interventions to reduce the mixture of phthalate metabolite levels by 10%, 30%, and 50% were estimated to prevent 1.8 (95% CI, 0.5-3.1), 5.9 (95% CI, 1.7-9.9), and 11.1 (95% CI, 3.6-18.3) preterm births, respectively. Conclusions and Relevance: Results from this large US study population suggest that phthalate exposure during pregnancy may be a preventable risk factor for preterm delivery

Shallow-level decompression crystallisation and deep magma supply at Shiveluch Volcano

Recent petrological studies indicate that some crustal magma chambers may be built up slowly by the intermittent ascent and amalgamation of small packets of magma generated in a deep-seated source region. Despite having little effect on whole-rock compositions, this process should be detectable as variable melt trace element composition, preserved as melt inclusions trapped in phenocrysts. We studied trace element and H2O contents of plagioclase- and hornblende-hosted melt inclusions from andesite lavas and pumices of Shiveluch Volcano, Kamchatka. Melt inclusions are significantly more evolved than the whole rocks, indicating that the whole rocks contain a significant proportion of recycled foreign material. H2O concentrations indicate trapping at a wide range of pressures, consistent with shallow decompression-driven crystallisation. The variation of trace element concentrations indicates up to ∼30% decompression crystallisation, which accounts for crystallisation of the groundmass and rims on phenocrysts. Trace element scatter could be explained by episodic stalling during shallow magma ascent, allowing incompatible element concentrations to increase during isobaric crystallisation. Enrichment of Li at intermediate pH2O reflects influx and condensation of metal-rich vapours. A set of "exotic melts", identified by their anomalous incompatible trace element characteristics, indicate variable source chemistry. This is consistent with evolution of individual magma batches with small differences in trace element chemistry, and intermittent ascent of magma pulses. © Springer-Verlag 2007

["The Eager Artists Living Room Planning Project"]

Video footage provided by The Black Academy of Arts and Letters recorded during the planning stage of the University of Buffalo's collaboration with Eager Artists' "Living Room Project". The footage shows interviews with leadership on the planning, concept, and logistics of the endeavor mixed with clips of African American performers during rehearsals

["The Eager Artists Living Room Planning Project"]

Video footage provided by The Black Academy of Arts and Letters recorded during the planning stage of the University of Buffalo's collaboration with Eager Artists' "Living Room Project". The footage shows interviews with leadership on the planning, concept, and logistics of the endeavor mixed with clips of African American performers during rehearsals