133 research outputs found
Contextual anomaly detection in crowded surveillance scenes
AbstractThis work addresses the problem of detecting human behavioural anomalies in crowded surveillance environments. We focus in particular on the problem of detecting subtle anomalies in a behaviourally heterogeneous surveillance scene. To reach this goal we implement a novel unsupervised context-aware process. We propose and evaluate a method of utilising social context and scene context to improve behaviour analysis. We find that in a crowded scene the application of Mutual Information based social context permits the ability to prevent self-justifying groups and propagate anomalies in a social network, granting a greater anomaly detection capability. Scene context uniformly improves the detection of anomalies in both datasets. The strength of our contextual features is demonstrated by the detection of subtly abnormal behaviours, which otherwise remain indistinguishable from normal behaviour
Bathymetry Based Modeling of Subaxial Magma Flows Under the Mid-Atlantic Ridge, 0 to 30° N
Fracture patterns of the Mid-Atlantic Ridge (MAR) provide evidence of tectonic forces related to divergence and magma upwelling at the ridge axis. In this study, we focus on the MAR from 0 to 30° N, where the N-S ridge exhibits slow spreading rates (2-4 cm/yr) and pronounced axial topography. Ridge segments and transform faults identified in bathymetry data were analyzed for strike orientation and axial depth profiles. Azimuths of transform faults and ridge segments exhibit increasing clockwise rotation with latitude, and all have left lateral displacement. Bathymetric sampling along ridge segments occurred at 9 km intervals with 20 km sampling radii, producing axial lithostatic pressure gradients. One-dimensional magma flows parallel to the ridge axis at 10 and 50 km depths were modeled using Darcy’s law based on published parameters and calculated gradients. Subaxial magma velocities of up to 4 cm/yr were predicted for horizontal flow at depth and are comparable in magnitude to upwelling rates in published literature. Average flow magnitudes (n = 422) within the melt generation region are predicted at 0.8 and 0.2 cm/yr for 10 and 50 km depths respectively. Flow velocities up to five times higher are expected with this model in the high-porosity boundary layer below the solidus. The Coriolis parameter would affect the movement of the flows predicted by our model and may be linked to rotational patterns observed at the MAR. Future research of magma migration below divergent margins would benefit from incorporating axial lithostatic load variations as a driver of flow
Putting Towns on the Policy Map: Understanding Scottish Places (USP)
Studies of places have been dichotomised as rural or urban. Towns, however, are neither rural nor urban. Towns have been neglected in research and policy agendas. In England the recent focus has been on high streets whereas in Scotland it has been on places and towns. Understanding Scottish Places (USP) is a web based platform that has become a key tool for evidence gathering, town comparison, knowledge exchange, regeneration planning and informed decision making for Scottish towns. USP is novel and contemporary and is engaging new ways of looking at, and planning in, and for, towns. This paper places USP in the research context and considers its development and use
Crowd-sourced Archaeological Research: The MicroPasts Project
This paper offers a brief introduction to MicroPasts, a web-enabled crowd-sourcing and crowd-funding project whose overall goal is to promote the collection and use of high quality research data via institutional and community collaborations, both on- and off-line. In addition to introducing this initiative, the discussion below is a reflection of its lead author’s core contribution to the project and will dwell in more detail on one particular aspect of MicroPasts: its relevance to research and practice in public archaeology, cultural policy and heritage studies
Citizen Archaeologists. Online Collaborative Research about the Human Past
Archaeology has a long tradition of volunteer involvement but also faces considerable challenges in protecting and understanding a geographically widespread, rapidly dwindling and ever threatened cultural resource. This paper considers a newly launched, multi-application crowdsourcing project called MicroPasts that enables both community-led and massive online contributions to high quality research in archaeology, history and heritage. We reflect on preliminary results from this initiative with a focus on the technical challenges, quality control issues and contributors motivations
Police and community in twentieth-century Scotland:The uses of social history
Drawing on archival research and oral history interviews, this article compares the characteristics of the relationships between police officers and communities in the Glasgow conurbation with those in the highlands and islands of Scotland in the period c. 1900–70. Rejecting the uniform or linear narrative suggested by existing historiography, it argues that these relationships were diverse, complex and shaped by local cultural, social and economic factors. By analysing the grassroots or everyday policing delivered by the urban beat officer and village constable, it reconstructs a social history of policing in twentieth-century Scotland. Moreover, the article identifies key constitutive elements that enabled or disrupted the forging of trust and legitimacy in Glasgow and the highlands in an era still associated by some with a ‘golden age of policing’. The article focuses in particular on the capacity of discretion, ‘insider’ status and embeddedness within local settlements to deliver effective policing, enhancing conclusions about best practice that have been drawn from studies of more recently formalized ‘community policing’ initiatives
Crowd-sourced archaeological research. The MicroPasts project. Open Access: http://www.ai-journal.com/article/view/ai.1705
This paper offers a brief introduction to MicroPasts, a web-enabled crowd-sourcing and crowd-funding project whose overall goal is to promote the collection and use of high quality research data via institutional and community collaborations, both on- and off-line. In addition to introducing this initiative, the discussion below is a reflection of its lead author’s core contribution to the project and will dwell in more detail on one particular aspect of MicroPasts: its relevance to research and practice in public archaeology, cultural policy and heritage studies
Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1
IL-1α and IL-1β were evaluated for their ability to provide adjuvant activity for the induction of serum antibody responses when nasally-administered with protein antigens in mice and rabbits. In mice, intranasal (i.n.) immunization with pneumococcal surface protein A (PspA) or tetanus toxoid (TT) combined with IL-1β induced protective immunity that was equivalent to that induced by parenteral immunization. Nasal immunization of awake (i.e., not anesthetized) rabbits with IL-1-adjuvanted vaccines induced highly variable serum antibody responses and was not as effective as parenteral immunization for the induction of antigen-specific serum IgG. However, i.n. immunization of deeply anesthetized rabbits with rPA + IL-1α consistently induced rPA-specific serum IgG ELISA titers that were not significantly different than those induced by intramuscular (IM) immunization with rPA + alum although lethal toxin neutralizing titers induced by nasal immunization were lower than those induced by IM immunization. Gamma scintigraphy demonstrated that the enhanced immunogenicity of nasal immunization in anesthetized rabbits correlated with an increased nasal retention of i.n. delivered non-permeable radio-labeled colloidal particles. Our results demonstrate that, in mice, IL-1 is an effective adjuvant for nasally-administered vaccines for the induction of protective systemic immunity and that in non-rodent species, effective induction of systemic immunity with nasally-administered vaccines may require formulations that ensure adequate retention of the vaccine within the nasal cavity
PGC1α
PGC1α, a transcriptional coactivator, interacts with PPARs and others to regulate skeletal muscle metabolism. PGC1α undergoes splicing to produce several mRNA variants, with the NTPGC1α variant having a similar biological function to the full length PGC1α (FLPGC1α). CVD is associated with obesity and T2D and a lower percentage of type 1 oxidative fibers and impaired mitochondrial function in skeletal muscle, characteristics determined by PGC1α expression. PGC1α expression is epigenetically regulated in skeletal muscle to determine mitochondrial adaptations, and epigenetic modifications may regulate mRNA splicing. We report in this paper that skeletal muscle PGC1α  −1 nucleosome (−1N) position is associated with splice variant NTPGC1α but not FLPGC1α expression. Division of participants based on the −1N position revealed that those individuals with a −1N phased further upstream from the transcriptional start site (UP) expressed lower levels of NTPGC1α than those with the −1N more proximal to TSS (DN). UP showed an increase in body fat percentage and serum total and LDL cholesterol. These findings suggest that the −1N may be a potential epigenetic regulator of NTPGC1α splice variant expression, and −1N position and NTPGC1α variant expression in skeletal muscle are linked to CVD risk. This trial is registered with clinicaltrials.gov, identifier NCT00458133
Determinants of the changes in glycemic control with exercise training in type 2 diabetes:A randomized trial
To assess the determinants of exercise training-induced improvements in glucose control (HbA1C) including changes in serum total adiponectin and FFA concentrations, and skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) protein content.A sub-cohort (n = 35; 48% men; 74% Caucasian) from the HART-D study undertaking muscle biopsies before and after 9 months of aerobic (AT), resistance (RT), or combination training (ATRT).Changes in HbA1C were associated with changes in adiponectin (r = -0.45, P = 0.007). Participants diagnosed with type 2 diabetes for a longer duration had the largest increase in PGC-1α (r = 0.44, P = 0.008). Statistical modeling examining changes in HbA1C suggested that male sex (P = 0.05), non-Caucasian ethnicity (P = 0.02), duration of type 2 diabetes (r = 0.40; P<0.002) and changes in FFA (r = 0.36; P<0.004), adiponectin (r = -0.26; P<0.03), and PGC-1α (r = -0.28; P = 0.02) explain ∼65% of the variability in the changes in HbA1C.Decreases in HbA1C after 9 months of exercise were associated with shorter duration of diabetes, lowering of serum FFA concentrations, increasing serum adiponectin concentrations and increasing skeletal muscle PGC-1α protein expression.ClinicalTrials.gov NCT00458133
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