Thin endometrial lining during frozen embryo cycles: a case-control study of risk factors and natural history

Objective: To identify predictors of thin endometrial lining in the first frozen embryo transfer cycles and to characterize the natural history of this condition over subsequent cycles. Design: Retrospective case-control study Conclusions: This study shows that prognosis after a diagnosis of thin endometrial lining is favorable. Lower weight and thinner fresh cycle lining are predictors of thin endometrial lining in FET cycles. Most importantly, women with a diagnosis of thin endometrial lining have similar live birth rates as those with adequate endometrial lining, although their time to achieve live birth is slightly longer

Dual trigger protocol is an effective IVF strategy in both normal and high responders without compromising pregnancy outcomes

To compare pregnancy outcomes between normal versus high responders after dual trigger of final oocyte maturation with gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) in fresh in-vitro fertilization (IVF) cycles, where ovarian stimulation was achieved by a flexible GnRH antagonist protocol

Upscaling models, downscaling data or the right model for the right scale of application?

Plant epidemiological models are used in a range of applications, from detailed simulation models that closely follow pathogen infection and dispersal, to generic template-based models for rapid assessment of invasive species. There is increasing interest in applying small scale models - e.g., based on tissue, organ or whole plants - using remotely collected daily data, to generate regional risk information (e.g., maps). The assumption made is that such small scale models “scale-up” appropriately to regional, continental or even global scale. However, these models are often constructed using locally collected, hourly data. By necessity data available are often at much coarser scale, both temporally and spatially, than the data used to develop the model. Computational requirements increase considerably when more detailed models that require fine resolution data (if available) are applied to large areas, while small scale models often add little useful information at these scales and may lead to error propagation. Ideally, detailed models should be used at small temporal and spatial scales and less detailed models used for larger temporal and spatial scales. This paper presents examples of different approaches for changing scales - including upscaling models, downscaling data, and developing new models - and the issues that these approaches create or solve, along with ideas about how we can ensure that the scale of model and data match the desired application

Effect of endometrial thickness on live birth rates in fresh and frozen embryo transfers in women under 38 years of age

Many IVF clinics use endometrial thickness as a predictive factor for IVF outcomes, as research has shown a positive association between endometrial thickness and favorable IVF outcomes. A thickness of 6-8 mm is often used as a cut-off in for the decision of whether or not to transfer an embryo in both fresh and frozen cycles. However, prior studies investigating the relationship between a thin endometrium and IVF outcomes have overwhelmingly been performed in fresh cleavage stage embryo transfers. Given the recent trend toward the transfer of frozen blastocyst transfers, we aimed to determine whether endometrial thickness predicts live birth in both fresh and frozen blastocyst stage single embryo transfers

Prospectus, May 13, 1974

CLASS OF \u2774 COMMENCEMENT; Openhouse Set For May 19; 648 Parkland Students Eligible To Participate; Dr. Winters To Speak At Graduation; Parkland Groups Win Awards At Jazz Fest; StuGo President Offers Welcome; Dental Students Capped At Banquet; The Short Circuit; Letters To The Editor; New Stu-Go Officer; President\u27s Report; Crosswords; Parkland College Student Life; Instructional Programs; Admission: Who may Enroll?; Tuition & Fees; Financial Aid; Counseling; Placement; Veterans; Student Life; Summer Session 1974; Academic Calendar 1974-1975; Semester System Fall 1975; In Campus Design, Parkland: Not Just Another School; No Golden Quill This Quarter; Petitioned and Qualified Candidates Spring Quarter 1973-1974; One-Punch Leads To Death Of UI Student; Movie Projector Reported Missing; A Column By and For Women; A Column By and For Men; Self-Help Clinic Set For Women; Vet\u27s Corner; Field Trip Meeting Set; Pig Guards Pot Plot From Police Raid; Blood Drive; Summer Field Course In American Southwest; P/C Student Wins Distinguished Award; Allerton Day Shows Ecological Benefits Of Park; Debate Team Finishes Best Year Ever; Monday\u27s Coach; Thank You; High-Scoring Henrichs Opts For Parkland Cage Team; Parkland Coaches Review Year; Cobras Bat Way Over .500; P/C Players Thrill Audience; Bartow On His Way; Pritchett Not To Be Outdone; On The Way Out; Classified Ads; End-Of-Year Gala Planned By Phys Ed. Dept.; Social, Religious Traditions Expressed In Roots Afrikana; Jones Cites Improvements In Prospectus; Prospectus Staff Positions Open For New School Year; Business Student Wins Award; Krannert Art Schedule; Many Financial Awards Open To Incoming Parkland Students; Parkland Vets Info Center On Wheelshttps://spark.parkland.edu/prospectus_1974/1012/thumbnail.jp

E-cadherin can limit the transforming properties of activating β-catenin mutations

Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating mutations in β-catenin (CTNNB1). We have compared the dynamics and the potency of β-catenin mutations in vivo. Within the murine small intestine (SI), an activating mutation of β-catenin took much longer to achieve a Wnt deregulation and acquire a crypt-progenitor-cell (CPC) phenotype than Apc or Gsk3 loss. Within the colon, a single activating mutation of β-catenin was unable to drive Wnt deregulation or induce the CPC phenotype. This ability of β-catenin mutation to differentially transform the SI versus the colon correlated with significantly higher expression of the β-catenin binding partner E-cadherin. This increased expression is associated with a higher number of E-cadherin:β-catenin complexes at the membrane. Reduction of E-cadherin synergised with an activating mutation of β-catenin so there was now a rapid CPC phenotype within the colon and SI. Thus there is a threshold of β-catenin that is required to drive transformation and E-cadherin can act as a buffer to prevent β-catenin accumulation

Skunk River Review September 1993, vol 5

https://openspace.dmacc.edu/skunkriver/1008/thumbnail.jp

Prospectus, April 29, 1974

STUDENTS SEEK GOVERNMENT POSTS; 14 Candidates Run For Major Stu-Go Positions; College Construction Nearing Completion; I.O.C. Sponsors Spring Carnival; Cruisin\u27 \u2774; President\u27s Report; Raines To Speak On Education; Parkland\u27s New School Fight Song; P/C Sponsors Festival Of Foreign Films; A Film For The Times; Doobie\u27s Latest Disappointing; A Column By and For Women; Going Back To Work; Hypertension Screening Tests May 6; Candidates\u27 Platforms; Let\u27s Go To The Bars; Fire Destroys Campus Building; Monday\u27s Coach; IM Department Still Scheduling Sports Events; Give The Girls A Break; Parkland College Baseball (Tentative 1974 Scehdule); Bowling Bulletin Board; Cobra Statistics Reveal Good Odds; Classified Ads; Prepare For Graduation; Graduation Calendar Events; Cobra Tracksters Run To Second At Harper Meet; Crosswords; Parkland Events; Krannert Art Schedule; P/C Jazz Band To Perform In J/C Competition; Committee Announced Special Day; SCI Plans Symposium; Attention E. I. U. Transfer Students; Mime Group Performs Visual Composition; Blood Bank I.D. Cards; Summer Field Course In American Southwesthttps://spark.parkland.edu/prospectus_1974/1014/thumbnail.jp

Monogenic conditions and central nervous system anomalies:A prospective study, systematic review and meta-analysis

Objectives: Determine the incremental diagnostic yield of prenatal exome sequencing (pES) over chromosome microarray (CMA) or G-banding karyotype in fetuses with central nervous system (CNS) abnormalities.Methods: Data were collected via electronic searches from January 2010 to April 2022 in MEDLINE, Cochrane, Web of Science and EMBASE. The NHS England prenatal exome cohort was also included. Incremental yield was calculated as a pooled value using a random-effects model. Results: Thirty studies were included (n = 1583 cases). The incremental yield with pES for any CNS anomaly was 32% [95%CI 27%–36%; I2 = 72%]. Subgroup analysis revealed apparent incremental yields in; (a) isolated CNS anomalies; 27% [95%CI 19%–34%; I2 = 74%]; (b) single CNS anomaly; 16% [95% CI 10%–23%; I2 = 41%]; (c) more than one CNS anomaly; 31% [95% Cl 21%–40%; I2 = 56%]; and (d) the anatomical subtype with the most optimal yield was Type 1 malformation of cortical development, related to abnormal cell proliferation or apoptosis, incorporating microcephalies, megalencephalies and dysplasia; 40% (22%–57%; I2 = 68%). The commonest syndromes in isolated cases were Lissencephaly 3 and X-linked hydrocephalus. Conclusions: Prenatal exome sequencing provides a high incremental diagnostic yield in fetuses with CNS abnormalities with optimal yields in cases with multiple CNS anomalies, particularly those affecting the midline, posterior fossa and cortex.</p