The aspherical Cavicchioli-Hegenbarth-Repovš generalized Fibonacci groups

The Cavicchioli–Hegenbarth–Repovš generalized Fibonacci groups are defined by the presentations Gn (m, k) = 〈x 1, … , xn | xixi+m = xi+k (1 ⩽ i ⩽ n)〉. These cyclically presented groups generalize Conway's Fibonacci groups and the Sieradski groups. Building on a theorem of Bardakov and Vesnin we classify the aspherical presentations Gn (m, k). We determine when Gn (m, k) has infinite abelianization and provide sufficient conditions for Gn (m, k) to be perfect. We conjecture that these are also necessary conditions. Combined with our asphericity theorem, a proof of this conjecture would imply a classification of the finite Cavicchioli–Hegenbarth–Repovš groups

Development and prototyping of SMA-metamaterial biaxial composite actuators

Shape memory alloys (SMA) are excellent candidates for implementation in actuator systems due to their ability to recover their original shape after high-strain loading through a thermally-induced phase transition. In this work, we propose and develop a novel SMA-metamaterial actuator which is capable of exhibiting a reversible, global elongation in multiple directions induced by the unidirectional contraction upon heating of a single SMA component. This actuator consists of (a) an SMA component, (b) a bias component and (c) the metamaterial geometry, with each component having a distinct function: (a) actuation activation, (b) reversibility of actuation upon deactivation and (c) amplifying and re-directing the uni-directional SMA actuation globally throughout the actuator, respectively. A prototype actuator was designed and tested in various configurations over multiple activation/deactivation cycles in order to demonstrate the functionality and reusability of this system. Furthermore, a theoretical model which predicts the actuation stroke of the system on the basis of the material properties of the SMA and bias components as well as the geometry of the metamaterial system was developed and validated. The findings of this work demonstrate the considerable potential of SMA-metamaterial actuators for implementation in systems requiring a multi-axial actuation output

Structural analysis of a subduction-related contact in southern Sesia-Lanzo Zone (Austroalpine Domain, Italian Western Alps)

A new foliation trajectory map at 1:10000 scale, represented here with an interpretative structural map, is derived from an original field analysis at 1:5000 scale in the southern Sesia-Lanzo Zone (SLZ). It shows the relative chronology of overprinting foliations, characterised by the mineral assemblages that mark superposed fabrics in each rock type. This map and the associated cross-sections, which synthesise the 3D structural outline of the tectonic contact between the Eclogitic Micaschists Complex (EMC), the Rocca Canavese Thrust Sheets and the Lanzo Ultramafic Complex, allow the correlation of the structural and metamorphic imprints that developed in these crustal and mantle complexes during Alpine subduction. Furthermore, the map and cross-sections allow the immediate perception of the metamorphic environments in which the structural imprints developed in each complex successively under eclogite, blueschist and greenschist facies conditions. The represented structural and metamorphic evolution of the southern end of the SLZ (internal Western Alps) has been inferred based on multiscale structural analysis. The dominant fabrics at the regional scale are two superposed mylonitic foliations that developed under blueschist and greenschist facies conditions, respectively. Metamorphic assemblages underlying the successive fabrics in the different metamorphic complexes allow us to identify contrasting metamorphic evolutions indicating that the tectonic contacts between the EMC, the Rocca Canavese Thrust Sheets and the Lanzo Ultramafic Complex developed under blueschist facies conditions and were successively reactivated during the greenschist facies retrogression

Objective Selection Criteria between ALT and Radial Forearm Flap in Oral Soft Tissues Reconstruction

Different locoregional and free flaps were described for oral soft tissues reconstruction after oncological resections; however, free flaps remain the first choice. Among free flaps, the radial forearm flap (RFF) and the anterolateral thigh perforator flap (ALT) are preferred the most. The lack of standardization of the flap choice leaves the selection to the surgeon's experience. The purpose of our observational study is to provide an algorithm to support the flap choice for the reconstruction of oral soft tissues. Sixty patients with squamous cell carcinoma of oral soft tissues were enrolled in our study. All the patients underwent preoperative magnetic resonance imaging (MRI) to measure the three-dimensional size of the tumor. During the follow-up, the patients were evaluated by using the University of Washington-Quality of Life Questionnaire. The questionnaire score was better for small tumors and worse for large tumors in both functional and relational fields. We observed that most of the overlapping results were obtained for small defects and the choice of RFF, as well as for large defects and the use of ALT. We observed that in the preoperative time, it is possible to select which flap between radial forearm and ALT is more appropriate for oral soft tissues defects reconstruction, according to the size of the tumor evaluated by MRI. We propose a decisional algorithm that suggests the type of flap to use between ALT and RFF

Exploitation of drainage water heat: A novel solution experimented at the Brenner Base Tunnel

Deep tunnels in permeable fractured rock-masses and under high piezometric levels can drain notable volumes of warm water, which are collected under gravity in specific conduits towards the portals, where heat can be exploited. The utilization of this energy source is generally narrowed by the limited presence of end-users near the portals, while other promising heating and cooling needs can be found directly along the tunnel length. The work presents the design, construction and installation of a geothermal system prototype exploiting the drainage water heat directly inside the tunnel. The prototype was named Smart Flowing due to the peculiarity of its heat exchange process. The system was realized and installed inside the exploratory tunnel of the Brenner Base Tunnel, near the border between Italy and Austria. The Smart Flowing modules were built outside and later moved inside the tunnel, where they were placed and assembled concurrently to the advancement of the Tunnel Boring Machine. A design procedure was proposed and validated against a testing and monitoring campaign. The data from the experimental activity confirmed that the drainage water flow guarantees long-term stabilization of circulating water temperature and fast heat recovery afterwards, thus securing the considerable power and performance values of a water-water heat pump connected to the system. A sensitivity analysis allowed the reproduction of different working scenarios, in order to generalize the application of Smart Flowing beyond the specific installation context

Neoproterozoic reworking of the Palaeoproterozoic Capricorn Orogen of Western Australia and implications for the amalgamation of Rodinia

Argon isotopic data from mica from the southern Capricorn region of Western Australia record complex intra- and inter-grain systematics that reflect modification due to a range of processes. However, 40Ar/39Ar age distributions, though complex, generally show early Neoproterozoic ages in the west, increasing to Mesoproterozoic ages in the east. Palaeoproterozoic ages associated with cooling after the c.1.8 Ga Capricorn Orogen or c.1.6 Ga Mangaroon Orogen are not preserved. These data reflect cooling from a ~300C thermal overprint that took place prior to 960 Ma that is related to the enigmatic Edmunian Orogeny. These data, combined with sediment provenance data from the Early Neoproterozoic Officer Basin and U-Pb age data from the nearby Pinjarra Orogen, indicate that the late Mesoproterozoic - Neoproterozoic Pinjarra and Edmundian events are dynamically linked and reflect tectonic activity on the western margin of the amalgamated West Australian Craton. The temporal framework for this event suggest a link to the evolving Rodinian supercontinent and reflect the oblique collision of either Greater India or Kalahari cratons with the West Australian Craton. These results illustrate that the temporal evolution of poorly preserved orogens can be constrained by low-temperature thermochronology in the adjacent cratons

Semi-annual seasonal pattern of serum thyrotropin in adults

Circannual rhythmicity in thyroid-stimulating hormone (TSH) secretion is proposed, whereas evidences on seasonal peripheral thyroid hormones' fluctuation are contradictory. This study was designed to evaluate hypothalamic-pituitary-thyroid (HPT) seasonal secretion pattern using a big data approach. An observational, retrospective, big data trial was carried out, including all TSH measurements performed in a single laboratory between January 2010 and December 2017. A large dataset was created matching TSH data with patients' age, gender, environmental temperature exposure, and free triiodothyronine (fT3) and free thyroxine (fT4) when available. The trend and seasonal distributions were analysed using autoregressive integrated moving average models. A total of 1,506,495 data were included in the final database with patients mean age of 59.00 +/- 18.44 years. The mean TSH serum levels were 2.08 +/- 1.57 microIU/mL, showing a seasonal distribution with higher levels in summer and winter seasons, independently from age, gender and environmental temperatures. Neither fT3 nor fT4 showed a seasonal trend. TSH seasonal changes occurred independently from peripheral thyroid hormone variations, gender, age and environmental temperatures. Although seasonal TSH fluctuation could represent a residual ancestral mechanism to maintain HPT homeostasis, the underlying physiological mechanism remains unclear and specific studies are needed to clarify its impacting role in humans

Seasonal Changes of Serum Gonadotropins and Testosterone in Men Revealed by a Large Data Set of Real-World Observations Over Nine Years

Environmental rhythmicity is able to affect the hypothalamic-pituitary-gonadal axis in several animals to achieve reproductive advantages. However, conflicting results were obtained when assessing the environmental-dependent rhythmicity on reproductive hormone secretion in humans. This study was designed to evaluate seasonal fluctuations of the main hormones involved in the hypothalamic-pituitary-gonadal axis in men, using a big data approach. An observational, retrospective, big data trial was carried out, including all testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) measurements performed in a single laboratory between January 2010 and January 2019 using Chemiluminescent Microparticle Immunoassay. Subjects presenting any factor interfering with the hypothalamic-pituitary-gonadal axis were excluded. The trend and seasonal distributions were analyzed using autoregressive integrated moving average (ARIMA) models. A total of 12,033 data, accounting for 7,491 men (mean age 47.46 \ub1 13.51 years, range 18\u201391 years) were included. Testosterone serum levels (mean 5.34 \ub1 2.06 ng/dL, range 1.70\u201315.80 ng/dL) showed a seasonal distribution with higher levels in summer and a direct correlation to environmental temperatures and daylight duration. LH levels (mean 4.64 \ub1 2.54 IU/L, range 1.00\u201315.00 IU/L) presented 2 peaks of secretion in autumn and spring, independently from environmental parameters. FSH levels (mean 5.51 \ub1 3.24 IU/L) did not show any seasonal distribution. A clear seasonal fluctuation of both LH and testosterone was demonstrated in a large cohort of adult men, although a circannual seasonality of hypothalamic-pituitary-gonadal hormones in humans could be not strictly evolutionarily required. Testosterone seasonality seems independent from LH fluctuations, which could be regulated by cyclic central genes expression, and more sensible to environmental temperatures and daylight duration.Environmental rhythmicity is able to affect the hypothalamic-pituitary-gonadal axis in several animals to achieve reproductive advantages. However, conflicting results were obtained when assessing the environmental-dependent rhythmicity on reproductive hormone secretion in humans. This study was designed to evaluate seasonal fluctuations of the main hormones involved in the hypothalamic-pituitary-gonadal axis in men, using a big data approach. An observational, retrospective, big data trial was carried out, including all testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) measurements performed in a single laboratory between January 2010 and January 2019 using Chemiluminescent Microparticle Immunoassay. Subjects presenting any factor interfering with the hypothalamic-pituitary-gonadal axis were excluded. The trend and seasonal distributions were analyzed using autoregressive integrated moving average (ARIMA) models. A total of 12,033 data, accounting for 7,491 men (mean age 47.46 \ub1 13.51 years, range 18\u201391 years) were included. Testosterone serum levels (mean 5.34 \ub1 2.06 ng/dL, range 1.70\u201315.80 ng/dL) showed a seasonal distribution with higher levels in summer and a direct correlation to environmental temperatures and daylight duration. LH levels (mean 4.64 \ub1 2.54 IU/L, range 1.00\u201315.00 IU/L) presented 2 peaks of secretion in autumn and spring, independently from environmental parameters. FSH levels (mean 5.51 \ub1 3.24 IU/L) did not show any seasonal distribution. A clear seasonal fluctuation of both LH and testosterone was demonstrated in a large cohort of adult men, although a circannual seasonality of hypothalamic-pituitary-gonadal hormones in humans could be not strictly evolutionarily required. Testosterone seasonality seems independent from LH fluctuations, which could be regulated by cyclic central genes expression, and more sensible to environmental temperatures and daylight duration