Spiritual Well-Being and Religion of Doctoral Students in Community University

The spiritual well-being connects to the meaning of life in a broad way, enabling emotional balance, quality of life and development of ethical and moral values that can interfere in the biological, psychological and social issues of the individual. This study aimed to evaluate spiritual well-being in doctoral students of a community university Pelotas-RS in order to verify its association with sociodemographic factors and self-assessment of health and life. This is a cross-sectional study with convenience sample, which will examine the spiritual well-being in PhD Graduate Programs. Participants responded the questionnaire with socio-demographic factors, self-assessment of health and life and the instrument - long version of Spiritual Well-Being Scale (EBE) - which are self-administered. The t, ANOVA and Pearson correlation tests were used for the analysis. The results showed higher levels of spiritual well-being and religious in doctoral students that have any religion, perform religious practices and has frequency in activity; significant correlation was observed of religious well-being with the family income. The study shows the importance of the spiritual well-being as a protective factor in social, psychological and professional issues, especially in tense moments and overload living doctoral students. Keywords: Spirituality, Religion, Higher Educatio

Depressive Symptoms and Relationship Between Genders: Differences in Young Adults in a Randomized Clinical Trial

Depression has a high prevalence in the general population, especially among women. There is no consensus in the scientific literature about differences between men and women in the manifestations of depressive symptoms, nor about psychotherapy indications according to gender. This research aimed to verify differences in depressive symptoms and symptoms improvement between young adult men and women with current Major Depressive Disorder and to identify differences between two brief Cognitive Psychotherapy models. Randomized clinical trial in which participants were randomized between: Cognitive Behavioral Therapy and Narrative Cognitive Therapy. Depressive symptoms pre and post-intervention were evaluated using the Hamilton Depression Rating Scale. The sample was composed of 25 men and 95 women. Genital symptoms and insight were significantly different between genders. Concerning improvement in symptoms according to the psychotherapy model, CBT presented a trend toward being more effective in men. Therefore, the symptoms and improvement in depressive symptoms are manifested differently between genders.La depresión tiene una alta prevalencia en la población general, especialmente entre las mujeres. No hay consenso en la literatura científica sobre las diferencias en las manifestaciones de síntomas depresivos entre hombres y mujeres, ni sobre las indicaciones de las psicoterapias según el género. Este estudio tuvo como objetivo determinar las diferencias en los síntomas depresivos y la mejora de los síntomas en hombres y mujeres jóvenes adultos con Trastorno Depresivo Mayor actual y comprobar las diferencias entre los dos modelos de psicoterapia cognitiva. En este ensayo clínico, los participantes fueron asignados aleatoriamente entre: Psicoterapia Cognitivo Comportamental y Psicoterapia Cognitiva Narrativa. Los síntomas de depresión pre y post intervención se evaluaron mediante la Escala de Depresión de Hamilton. La muestra estuvo constituida por 25 hombres y 95 mujeres. Síntomas genitales y de conciencia fueron significativamente diferentes entre los géneros. En cuanto a la mejoría de los síntomas de acuerdo con el modelo psicoterapéutico, el PCC tuvo una tendencia a ser más eficaz entre los hombres. Es posible observar que la sintomatología y la mejora en los síntomas depresivos se manifiestan de forma diferente entre géneros.A depressão apresenta elevada prevalência na população geral, especialmente entre as mulheres. Não existe consenso na literatura científica a respeito de diferenças das manifestações de sintomas depressivos entre homens e mulheres, bem como, quanto à indicações de psicoterapias conforme o gênero. O objetivo deste estudo foi verificar as diferenças na sintomatologia depressiva e melhora dos sintomas em homens e mulheres adultos jovens com Transtorno Depressivo Maior e identificar as diferenças entre dois modelos de Psicoterapia Cognitiva. Em ensaio clínico, os participantes foram randomizados entre: Psicoterapia Cognitivo Comportamental e Psicoterapia Cognitiva Narrativa. A sintomatologia depressiva pré e pós intervenção foi avaliada pela Hamilton Depression Scale. Participaram do estudo 25 homens e 95 mulheres. Os sintomas genitais e de consciência foram significativamente diferentes entre os gêneros. Quanto à melhora dos sintomas de acordo com o modelo psicoterapêutico, a PCC apresentou uma tendência a ser mais eficaz entre os homens. Sendo assim, é possível observar que a sintomatologia e a melhora dos sintomas depressivos manifestam-se diferentemente entre os gêneros

Early trauma and mood disorders in youngsters

OBJETIVO: Verificar vivências precoces de abuso e negligência na infância entre jovens com transtorno bipolar (TB), transtorno depressivo maior (TDM) e controles populacionais. MÉTODO: Estudo de caso-controle aninhado a um estudo transversal de base populacional. A confirmação do diagnóstico foi realizada por meio de entrevista clínica estruturada para transtornos de eixo I do DSM-IV (SCID) e os eventos traumáticos foram verificados pelo Questionário sobre traumas na infância (CTQ). RESULTADOS: A amostra foi composta por 231 jovens, sendo 95 indivíduos no grupo controle, 82 com TDM e 54 com TB (32 do tipo I e 22 do tipo II). A prevalência de trauma na infância foi de 42,2%, sendo 54,7% entre aqueles com TB, 62,2% entre os jovens com TDM e 18,1% entre o grupo controle. Os jovens com TB ou TDM apresentaram maiores médias no CTQ total e entre seus componentes quando comparados aos jovens do grupo controle, exceto o componente abuso sexual, em que se observou diferença estatística apenas entre o grupo controle e o grupo de jovens com transtorno bipolar. CONCLUSÃO: O relato de vivências traumáticas precoces foi mais presente entre os jovens com transtornos de humor do que na população geral, confirmando o que a literatura traz sobre o tema. Nesse sentido, as vivências de trauma na infância parecem contribuir para o aparecimento dos transtornos de humor.OBJECTIVE: To verify early experiences of childhood abuse and neglect among young with bipolar disorder (BD), major depression (MDD), and controls. METHOD: Case-control study nested to a population-based cross-sectional study. The diagnosis was performed via the structured clinical interview for DSM-IV Axis I Disorders (SCID). Traumatic events were analyzed using the Portuguese version - Questionário sobre Traumas na Infância (CTQ) - based on the Childhood Trauma Questionnaire. RESULTS: The sample comprised 231 adolescents with 95 individuals in the control group, 82 with MDD and 54 with BD (32 of type I and 22 type II). The prevalence of trauma or violence in childhood was 42.2%; among those, 54.7% had BD, 62.2% had MDD and 18.1% were in the control group. Young people with BD or MDD obtained higher means in total CTQ and among their components when compared with those in the control group. DISCUSSION: Reports on early traumatic experiences were more frequent among young people with mood disorders than in the general population, corroborating the literature on the subject. In this sense, the traumatic experiences during childhood seemed to contribute to the onset of the disorder

Aging, neurocognitive impairment and adherence to antiretroviral therapy in human immunodeficiency virus-infected individuals

AbstractBackground/objectiveThere is an increasing number of older patients with human immunodeficiency virus infection due to the success of antiretroviral therapy, the improved prognosis and life expectancy of patients, and the higher number of new infections among older individuals. The main objective of the present study was to compare the characteristics of older human immunodeficiency virus patients with those of younger patients.Materials and methodsWe conducted a cross-sectional study with human immunodeficiency virus-infected patients who were treated at the Specialized Care Service (Serviço de Assistência Especializada) for human immunodeficiency virus/AIDS in the city of Pelotas, South Brazil. Sociodemographic information as well as data on human immunodeficiency virus infection and treatment were collected. All participants underwent psychiatric and neurocognitive assessments, and their adherence to antiretroviral therapy was evaluated.ResultsA total of 392 patients participated in the study, with 114 patients aged 50 years and older. The characteristics showing significant differences between older and younger human immunodeficiency virus-infected patients included race/ethnicity, comorbidities, duration and adherence to antiretroviral therapy, currently undetectable viral load, and cognitive impairment. Compared to younger patients, older patients were at higher risk of exhibiting cognitive impairment [OR 2.28 (95% CI: 1.35–3.82, p=0.002)] and of having increased adherence to antiretroviral therapy [OR 3.11 (95% CI: 1.67–5.79, p<0.001)].ConclusionsThe prevalence of neurocognitive impairment remained high in human immunodeficiency virus-infected patients despite antiretroviral therapy. In the present study, the prevalence of this type of impairment was significantly higher in patients aged ≥50 years, most likely due to aging, human immunodeficiency virus infection, and a possible synergistic effect between these factors. Despite this higher prevalence, older patients exhibited higher rates of adherence to antiretroviral therapy and of undetectable human immunodeficiency virus viral load

Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.

Generalized Anxiety Disorder (GAD) presents a high prevalence in the population, leading to distress and disability. Immune system alterations have been associated with anxiety-related behaviors in rodents and GAD patients. CD300f immune receptors are highly expressed in microglia and participate not only in the modulation of immune responses but also in pruning and reshaping synapses. It was recently demonstrated that CD300f might be influential in the pathogenesis of depression in a sex-dependent manner. Here, we evaluated the role of CD300f immune receptor in anxiety, using CD300f knockout mice (CD300f-/-) and patients with GAD. We observed that male CD300f-/- mice had numerous behavioral changes associated with a low-anxiety phenotype, including increased open field central locomotion and rearing behaviors, more exploration in the open arms of the elevated plus-maze test, and decreased latency to eat in the novelty suppressed feeding test. In a cross-sectional population-based study, including 1111 subjects, we evaluated a common single-nucleotide polymorphism rs2034310 (C/T) in the cytoplasmatic tail of CD300f gene in individuals with GAD. Notably, we observed that the T allele of the rs2034310 polymorphism conferred protection against GAD in men, even after adjusting for confounding variables. Overall, our data demonstrate that CD300f immune receptors are involved in the modulation of pathological anxiety behaviors in a sex-dependent manner. The biological basis of these sex differences is still poorly understood, but it may provide significant clues regarding the neuropathophysiological mechanisms of GAD and can pave the way for future specific pharmacological interventions

Socioeconomic and substance use changes in emerging adults and their relationship with mood disorders in a population-based cohort

In this report, we aim to assess the interaction of bipolar disorder and major depressive disorder with the evolution of social roles, economic classification, and substance misuse in emerging adults. This is a longitudinal population-based study (n = 231 at baseline), in which participants were reassessed at a mean of 5 years after baseline. A structured clinical interview was used to diagnose the participants with bipolar disorder and major depression; a control group without mood disorders was included. Men with mood disorders were less likely to be married in the beginning of the study and less likely to work in the follow-up. Women with major depression were less likely to study and more likely to be in a lower economic class at the beginning of the study. In comparison, women with bipolar disorder were less likely to live with their parents and more likely to live with their children in the first wave of the study. Substance misuse was more likely in people with mood disorders, especially in men, and women with bipolar disorder had the highest likelihood in the follow-up. Albeit longitudinal analyses were limited by a possibly insufficient sample size and mediating mechanisms for change, such as stigma, were not explored, the study suggests sex-related specificities regarding the change in social roles and substance use in people with mood disorders. Emerging adults, especially those with mood disorders, are in a period of change and instability and at a greater risk for substance use and abuse

Metabolic syndrome and psychiatric disorders : a population-based study

Objective: To identify the association of metabolic syndrome (MetS) and psychiatric disorders in young adults in southern Brazil. Methods: This population based cross-sectional study involved a total of 1,023 young adults between the ages of 21 and 32 years. Current episodes of psychiatric disorders were assessed using the Mini International Neuropsychiatric Interview – Plus version. MetS was evaluated using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III). Results: Of the 1,023 participants, 24.3% were identified with MetS, 13.5% were diagnosed with anxiety disorders, 7.5% with current depression, 3.9% with bipolar disorders and 10.1% were at risk of suicide. MetS was associated with ethnicity (p = 0.022), excess weight (p o 0.001), current anxiety disorders (p o 0.001), current mood disorders (bipolar disorder in mood episode and current depression) (p o 0.001), and suicide risk (p o 0.001). Conclusions: MetS was associated with psychiatric disorders. Awareness of factors associated with MetS can help identify high-risk individuals and stimulate disease prevention and control programs, as well as lifestyle changes

Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10

AbstractBackgroundCocaine abuse is capable of activating the innate immune system in the CNS resulting in deregulation of homeostasis between pro and antiinflammatory cytokines. The aim of this study was to investigate serum levels of pro and antiinflammatory cytokines, IL-6 and IL-10 respectively, in cocaine users from a young population-based sample.MethodsThis is a case–control study nested in a cross-sectional population-based survey, with individuals of 18 and 35 years old. Two groups were selected: 24 healthy controls and 12 subjects who reported cocaine use. Serum IL-6 and IL-10 were measured by ELISA using a commercial kit.ResultsThere was a statistically significant increase in IL-6 (p=0.037) and decrease in IL-10 (p=0.007) serum levels, between cocaine users and the control group. There was also an increase in the ratio IL-6/IL-10 (p=0.013) among cocaine users individuals, when compared to the control group.ConclusionsOur results suggest that cocaine users showed an activation of the immune system when compared a control group, demonstrating a disruption in the balance of pro and antiinflammatory cytokines. Thus, peripheral cytokines may represent a putative biomarkers for cocaine users, contributing to the development of diagnosis and effective treatments

Early trauma and mood disorders in youngsters

Objetivo: Verificar vivências precoces de abuso e negligência na infância entre jovens com transtorno bipolar (TB), transtorno depressivo maior (TDM) e controles populacionais. Método: Estudo de caso-controle aninhado a um estudo transversal de base populacional. A confirmação do diagnóstico realizou-se por meio de entrevista clínica estruturada para transtornos de eixo I do DSM-IV (SCID) e os eventos traumáticos foram verificados pelo Questionário sobre Traumas na Infância (QUESI). Resultados: A amostra foi composta por 231 jovens, sendo 95 indivíduos no grupo controle, 82 com TDM e 54 com TB (32 do tipo I e 22 do tipo II). A prevalência de trauma na infância foi de 42,2%, sendo 54,7% entre aqueles com TB, 62,2% entre os jovens com TDM e 18,1% entre o grupo controle. Os jovens com TB ou TDM apresentaram maiores médias no QUESI total e entre seus componentes quando comparados a jovens do grupo controle, exceto o componente abuso sexual, em que se observou diferença estatística apenas entre o grupo controle e o grupo de jovens com transtorno bipolar. Conclusão: O relato de vivências traumáticas precoces foi mais presente entre os jovens com transtornos de humor que na população geral, confirmando o que a literatura traz sobre o tema. Nesse sentido, as vivências de trauma na infância parecem contribuir para o aparecimento dos transtornos de humor.Objective: To verify early experiences of childhood abuse and neglect among young with bipolar disorder (BD), major depression (MDD), and controls. Method: Case-control study nested to a population-based cross-sectional study. The diagnosis was performed via the structured clinical interview for DSM- -IV Axis I Disorders (SCID). Traumatic events were analyzed using the Portuguese version – Questionário sobre Traumas na Infância (QUESI) – based on the Childhood Trauma Questionnaire. Results: The sample comprised 231 young adults with 95 individuals in the control group, 82 with MDD and 54 with BD (32 of type I and 22 type II). The prevalence of trauma or violence in childhood was 42.2%.; among those, 54.7% had BD, 62.2% had MDD and 18.1% were in the control group. Young people with BD or MDD obtained higher means in total QUESI and among their components when compared with those in the control group. Discussion: Reports on early traumatic experiences were more frequent among young people with mood disorders than in the general population, corroborating the literature on the subject. In this sense, the traumatic experiences during childhood seemed to contribute to the onset of the disorder