Quest for Eros: Browning and \u27Fifine\u27

Students of Browning have long been puzzled by the discrepancies between the dramatic framework of Fifine and its symbolic development, but these difficulties are resolved in Southwell’s explication by a biographical hypothesis. The powerful influence of the memory of his beloved wife, Elizabeth, involved Browning in a deep ambivalence, and Fifine at the Fair represents his effort to escape the effects of the profound inhibitions associated with her memory, while at the same time remaining loyal to it. The poem is itself a flawed quest for Eros. Browning’s symbolic vision of sexuality as the central vitalizing force in human culture—a supreme achievement of the poem—is followed by a renunciation of the quest, but the validity of the vision is explicitly affirmed and its promise recognized. In Fifine at the Fair Browning’s artistic powers are splendidly in evidence. Southwell’s fresh examination of the tensions within the poem offers new understanding of its power. Samuel B. Southwell is professor of English at the University of Houston.https://uknowledge.uky.edu/upk_english_language_and_literature_british_isles/1053/thumbnail.jp

Not Just Asking Questions: Effects of Implicit and Explicit Conspiracy Information About Vaccines and Genetic Modification

This is the author accepted manuscript. The final version is available from Taylor & Francis (Routledge) via the DOI in this record.While conspiracy ideation has attracted overdue attention from social scientists in recent years, little work focuses on how different pro-conspiracy messages affect the take-up of conspiracy beliefs. In this study, we compare the effect of explicit and implicit conspiracy cues on the adoption of conspiracy beliefs. We also examine whether corrective information can undo conspiracy cues, and whether there are differences in the effectiveness of corrective information based on whether a respondent received an explicit or implicit conspiracy cue. We examine these questions using a real-world but low-salience conspiracy theory concerning Zika, GM mosquitoes, and vaccines. Using a preregistered experiment (N = 1018: https://osf.io/hj2pw/), we find that both explicit and implicit conspiracy cues increase conspiracy beliefs, but in both cases corrections are generally effective. We also find reception of an explicit conspiracy cue and its correction is conditional on feelings toward the media and pharmaceutical companies. Finally, we find that examining open-ended conspiracy belief items reveals similar patterns, but with a few key differences. These findings have implications for how news media cover controversial public health issues going forward.European Research Counci

Perturbation with Intrabodies Reveals That Calpain Cleavage Is Required for Degradation of Huntingtin Exon 1

Background: Proteolytic processing of mutant huntingtin (mHtt), the protein that causes Huntington's disease (HD), is critical for mHtt toxicity and disease progression. mHtt contains several caspase and calpain cleavage sites that generate N-terminal fragments that are more toxic than full-length mHtt. Further processing is then required for the degradation of these fragments, which in turn, reduces toxicity. This unknown, secondary degradative process represents a promising therapeutic target for HD. Methodology/Principal Findings: We have used intrabodies, intracellularly expressed antibody fragments, to gain insight into the mechanism of mutant huntingtin exon 1 (mHDx-1) clearance. Happ1, an intrabody recognizing the proline-rich region of mHDx-1, reduces the level of soluble mHDx-1 by increasing clearance. While proteasome and macroautophagy inhibitors reduce turnover of mHDx-1, Happ1 is still able to reduce mHDx-1 under these conditions, indicating Happ1-accelerated mHDx-1 clearance does not rely on these processes. In contrast, a calpain inhibitor or an inhibitor of lysosomal pH block Happ1-mediated acceleration of mHDx-1 clearance. These results suggest that mHDx-1 is cleaved by calpain, likely followed by lysosomal degradation and this process regulates the turnover rate of mHDx-1. Sequence analysis identifies amino acid (AA) 15 as a potential calpain cleavage site. Calpain cleavage of recombinant mHDx-1 in vitro yields fragments of sizes corresponding to this prediction. Moreover, when the site is blocked by binding of another intrabody, V_L12.3, turnover of soluble mHDx-1 in living cells is blocked. Conclusions/Significance: These results indicate that calpain-mediated removal of the 15 N-terminal AAs is required for the degradation of mHDx-1, a finding that may have therapeutic implications

ORFEUS II Far-UV Spectroscopy of AM Herculis

Six high-resolution (\lambda/\Delta\lambda ~ 3000) far-UV (\lambda\lambda = 910-1210 \AA) spectra of the magnetic cataclysmic variable AM Herculis were acquired in 1996 November during the flight of the ORFEUS-SPAS II mission. AM Her was in a high optical state at the time of the observations, and the spectra reveal emission lines of O VI \lambda\lambda 1032, 1038, C III \lambda 977, \lambda 1176, and He II \lambda 1085 superposed on a nearly flat continuum. Continuum flux variations can be described as per Gansicke et al. by a ~ 20 kK white dwarf with a ~ 37 kK hot spot covering a fraction f~0.15 of the surface of the white dwarf, but we caution that the expected Lyman absorption lines are not detected. The O VI emission lines have narrow and broad component structure similar to that of the optical emission lines, with radial velocities consistent with an origin in the irradiated face of the secondary and the accretion funnel, respectively. The density of the narrow- and broad-line regions is n_{nlr} ~ 3\times 10^{10} cm^{-3} and n_{blr} ~ 1\times 10^{12} cm^{-3}, respectively, yet the narrow-line region is optically thick in the O VI line and the broad-line region is optically thin; apparently, the velocity shear in the broad-line region allows the O VI photons to escape, rendering the gas effectively optically thin. Unexplained are the orbital phase variations of the emission-line fluxes.Comment: 15 pages, 6 Postscript figures; LaTeX format, uses aaspp4.sty; table2.tex included separately because it must be printed sideways - see instructions in the file; accepted on April 17, 1998 for publication in The Astrophysical Journa

The Far-Ultraviolet Spectrum and Short Timescale Variability of AM Herculis from Observations with the Hopkins Ultraviolet Telescope

Using the Hopkins Ultraviolet Telescope (HUT), we have obtained 850-1850 angstrom spectra of the magnetic cataclysmic variable star AM Her in the high state. These observations provide high time resolution spectra of AM Her in the FUV and sample much of the orbital period of the system. The spectra are not well-modelled in terms of simple white dwarf (WD) atmospheres, especially at wavelengths shortward of Lyman alpha. The continuum flux changes by a factor of 2 near the Lyman limit as a function of orbital phase; the peak fluxes are observed near magnetic phase 0.6 when the accreting pole of the WD is most clearly visible. The spectrum of the hotspot can be modelled in terms of a 100 000 K WD atmosphere covering 2% of the WD surface. The high time resolution of the HUT data allows an analysis of the short term variability and shows the UV luminosity to change by as much as 50% on timescales as short as 10 s. This rapid variability is shown to be inconsistent with the clumpy accretion model proposed to account for the soft X-ray excess in polars. We see an increase in narrow line emission during these flares when the heated face of the secondary is in view. The He II narrow line flux is partially eclipsed at secondary conjunction, implying that the inclination of the system is greater than 45 degrees. We also present results from models of the heated face of the secondary. These models show that reprocessing on the face of the secondary star of X-ray/EUV emission from the accretion region near the WD can account for the intensities and kinematics of most of the narrow line components observed.Comment: 19 pp., 12 fig., 3 tbl. To appear in The Astrophysical Journal. Also available at http://greeley.pha.jhu.edu/papers/amherpp.ps.g

Macroscopic invisibility cloaking of visible light

Invisibility cloaks, which used to be confined to the realm of fiction, have now been turned into a scientific reality thanks to the enabling theoretical tools of transformation optics and conformal mapping. Inspired by those theoretical works, the experimental realization of electromagnetic invisibility cloaks has been reported at various electromagnetic frequencies. All the invisibility cloaks demonstrated thus far, however, have relied on nano- or micro-fabricated artificial composite materials with spatially varying electromagnetic properties, which limit the size of the cloaked region to a few wavelengths. Here, we report the first realization of a macroscopic volumetric invisibility cloak constructed from natural birefringent crystals. The cloak operates at visible frequencies and is capable of hiding, for a specific light polarization, three-dimensional objects of the scale of centimetres and millimetres. Our work opens avenues for future applications with macroscopic cloaking devices

Density Can Be Misleading for Low-Density Species: Benefits of Passive Acoustic Monitoring

Climate-induced changes may be more substantial within the marine environment, where following ecological change is logistically difficult, and typically expensive. As marine animals tend to produce stereotyped, long-range signals, they are ideal for repeatable surveying. In this study we illustrate the potential for calling rates to be used as a tool for determining habitat quality by using an Antarctic pack-ice seal, the leopard seal, as a model. With an understanding of the vocal behavior of a species, their seasonal and diurnal patterns, sex and age-related differences, an underwater passive-acoustic survey conducted alongside a visual survey in an arc of 4,225 km across the Davis Sea, Eastern Antarctica, showed that while acoustic and visual surveys identified similar regions as having high densities, the acoustic surveys surprisingly identified the opposite regions as being 'critical' habitats. Density surveys of species that cannot be differentiated into population classes may be misleading because overall density can be a negative indicator of habitat quality. Under special circumstances acoustics can offer enormous advantage over traditional techniques and open up monitoring to regions that are remote, difficult and expensive to work within, no longer restricting long-term community assessment to resource-wealthy communities. As climatic change affects a broad range of organisms across geographic boundaries we propose that capitalizing on the significant advances in passive acoustic technology, alongside physical acoustics and population modeling, can help in addressing ecological questions more broadly

A Study of the Populations of X-ray Sources in the Small Magellanic Cloud with ASCA

The Advanced Satellite for Cosmology and Astrophysics (ASCA) has made multiple observations of the Small Magellanic Cloud (SMC). X-ray mosaic images in the soft (0.7--2.0 keV) and hard (2.0--7.0 keV) bands are separately constructed, and the latter provides the first hard X-ray view of the SMC. We extract 39 sources from the two-band images with a criterion of S/N>5, and conduct timing and spectral analyses for all of these sources. Coherent pulsations are detected from 12 X-ray sources; five of which are new discoveries. Most of the 12 X-ray pulsars are found to exhibit long-term flux variabilities, hence they are likely to be X-ray binary pulsars (XBPs). On the other hand, we classify four supernova remnants (SNRs) as thermal SNRs, because their spectra exhibit emission lines from highly ionized atoms. We find that XBPs and thermal SNRs in the SMC can be clearly separated by their hardness ratio (the ratio of the count rate between the hard and soft bands). Using this empirical grouping, we find many XBP candidates in the SMC, although no pulsations have yet been detected from these sources. Possible implications on the star-formation history and evolution of the SMC are presented by a comparison of the source populations in the SMC and our Galaxy.Comment: 11 pages, 39 Figures, to be published in ApJ Supplement. Tables (body and figures also) are available at http://www-cr.scphys.kyoto-u.ac.jp/member/jun/job