21 research outputs found
A Case Of Intermediate Toxic Epidermal Necrolysis (Lyell Syndrome) Induced By Hydroxychloroquine Sulfate: A Report
Malaria is a parasite disease that is endemic in tropical country as Niger (West Africa). Hydroxychloroquine sulfate (HCQ) is a synthetic antimalarial drug that is very often used to treat connective tissue diseases such as, scleroderma, systemic or discoid lupus erythematosus, rheumatoid arthritis. This drug may induce numerous cutaneous adverse reactions as well as the other anti-malarial drugs. We report on a case of intermediate Lyell syndrome that occurred in the first week of treatment of malaria attack with a young woman, aged 19, following the administration of hydroxychloroquine sulfate
Occlusion intestinale aigue rĂ©vĂ©lant un lymphome T digestif associĂ© Ă la maladie coeliaque, Ă propos dâun cas
Le lymphome T intestinal associĂ© Ă une entĂ©ropathie ou Enteropathy associated T-cell lymphoma (EATL), est une complication rare de la maladie coeliaque (MC). Nous rapportons lâobservation dâun lymphome T associĂ©e Ă une MC rĂ©vĂ©lĂ© par une occlusion intestinale aigue. Une patiente maghrĂ©bine de 38 ans, aux antĂ©cĂ©dents de stĂ©rilitĂ© et de douleurs abdominales chroniques, Ă©tait admise en urgence pour occlusion intestinale aigue. Lâintervention chirurgicale retrouvait une tumeur au dĂ©pend du grĂȘle avec des adĂ©nopathies mĂ©sentĂ©riques. Lâhistologie et lâimmunohistochimie de la piĂšce opĂ©ratoire objectivait un lymphome T digestif CD3+ et le bilan immunologique de la maladie coeliaque Ă©tait positif. Le diagnostic dâEATL Ă©tait ainsi retenu. La patiente Ă©tait mise sous chimiothĂ©rapie (CHOEP) et rĂ©gime sans gluten avec une rĂ©ponse complĂšte au traitement. LâEATL est une complication rare de la MC qui peut ĂȘtre rĂ©vĂ©lĂ©e par une occlusion intestinale. Son pronostic peut ĂȘtre amĂ©liorĂ© par une prise en charge prĂ©coce associant chirurgie et chimiothĂ©rapie. Sa prĂ©vention passe par un diagnostic prĂ©coce de la MC et un rĂ©gime sans gluten.Pan African Medical Journal 2016; 2
Campylobacter fetus Bacteremia Revealed by Cellulitis without Gastrointestinal Symptoms in the Context of Acquired Hypogammaglobulinemia: A Report of Three Cases
Campylobacter fetus bacteremia is rare and occurs mainly in patients with immunosuppression. This infection, which often involves secondary localizations has already been reported in some primary humoral immune deficiencies. We describe three cases of severe infection due to C. fetus with cellulitis at presentation, but without any gastrointestinal symptoms, occurring in patients with acquired hypogammaglobulinemia
Troponine Ultra-sensible: Quelles Indications et Comment InterprĂ©ter les RĂ©sultats en GĂ©riatrie Un cas d'ĂlĂ©vation de la Troponine chez une OctogĂ©naire
La troponine T ultra-sensible (us), marqueur biologique spĂ©cifique du cĆur, peut ĂȘtre Ă©levĂ©e dans des conditions pathologiques autres que le syndrome coronarien aigu. Ces autres causes peuvent ou non ĂȘtre directement liĂ©es aux maladies cardiaques. Nous rapportons le cas d'une patiente de 85 ans prĂ©sentant de multiples Ă©vĂ©nements cardiovasculaires qui prĂ©sentait une Ă©lĂ©vation de la troponine T us Ă 1088 pg/ml, probablement due Ă de multiples Ă©tiologies.
The ultra-sensitive troponin T (us), a specific biological marker of the heart, may be elevated in pathological conditions other than acute coronary syndrome. These other causes may or may not be directly related to heart disease. We report the case of an 85-year-old female patient with multiple cardiovascular events who presented an elevation of us troponin T to 1088 pg / ml, probably due to multiple etiologies
Troponine Ultra-sensible: Quelles Indications et Comment InterprĂ©ter les RĂ©sultats en GĂ©riatrie Un cas d'ĂlĂ©vation de la Troponine chez une OctogĂ©naire
La troponine T ultra-sensible (us), marqueur biologique spĂ©cifique du cĆur, peut ĂȘtre Ă©levĂ©e dans des conditions pathologiques autres que le syndrome coronarien aigu. Ces autres causes peuvent ou non ĂȘtre directement liĂ©es aux maladies cardiaques. Nous rapportons le cas d'une patiente de 85 ans prĂ©sentant de multiples Ă©vĂ©nements cardiovasculaires qui prĂ©sentait une Ă©lĂ©vation de la troponine T us Ă 1088 pg/ml, probablement due Ă de multiples Ă©tiologies.
The ultra-sensitive troponin T (us), a specific biological marker of the heart, may be elevated in pathological conditions other than acute coronary syndrome. These other causes may or may not be directly related to heart disease. We report the case of an 85-year-old female patient with multiple cardiovascular events who presented an elevation of us troponin T to 1088 pg / ml, probably due to multiple etiologies
Epidémies de Choléra en Afrique Sub-Saharienne: Revue documentaire de 2010 à 2016
Introduction: Cholera remains a major public health problem in many parts of the world and particularly in sub-Saharan African countries. The objective of this study is to review data on cholera epidemiology, risk, microbiological and disease control factors in sub-Saharan Africa from 2010 to 2016. Material and method: A literature review on cholera epidemics in sub-Saharan Africa from 2010 to 2016 was conducted using electronic databases from countries that have experienced epidemics. Annual cholera data for countries with outbreaks from 2010 to 2016 have been reported. Results: From 2010 through 2016, 35 of the 54 African countries have experienced cholera epidemics. An overall of 1268 outbreaks have been reported, of which 13.04% were recorded in Nigeria and 4.35% in Burundi. The number of cases reported was 801022 and 13232 deaths (overall CFR =1.65%). Vibrio cholerae O1 and O139 are the main etiological agents. The main risk factors are heavy rains, floods, contamination of water sources and lack ofsanitation. Conclusion: In addition to the suffering of patients, cholera outbreaks cause panic, disrupt economic and social structures and hinder the development of affected communities. Mobilization of the water, sanitation and hygiene sectors is essential to ensure the benefits of patient care and cholera vaccination.Introduction : Le cholĂ©ra demeure un problĂšme majeur de SantĂ© Publique dans de nombreuses parties du monde et en particulier dans les pays dâAfrique subsaharienne. Lâobjectif de cette Ă©tude de faire une revue des donnĂ©essur les Ă©pidĂ©mies de cholĂ©ra, les facteurs de risques, microbiologiques et de lutte contre la maladie en Afrique sub-saharienne de 2010 Ă 2016. Materiels et mĂ©thode: Une revue de la littĂ©rature sur les Ă©pidĂ©mies de cholĂ©ra en Afrique sub-saharienne de 2010 Ă 2016 a Ă©tĂ© conduite dans des banques de donnĂ©es ou bases de donnĂ©es et bibiothĂšques Ă©lectroniques des pays ayant connu des Ă©pidĂ©mies. Les donnĂ©es annuelles de cholĂ©ra dans les pays ayant connu des Ă©pidĂ©mies de 2010 Ă 2016 ont Ă©tĂ© rapportĂ©es. RĂ©sultats : Entre 2010 et 2016, 35 des 54 pays d'Afrique ont connu des Ă©pidĂ©mies de cholĂ©ra. 1268 Ă©pisodes Ă©pidĂ©miques ont Ă©tĂ© rapportĂ©s dont 13,04% au Nigeria et 4,35% au Burundi. Le nombre de cas notifiĂ©s Ă©tait de 801022 dont 13232 dĂ©cĂšs (lĂ©talitĂ© globale =1,65%). Le Vibrio cholerae O1 et O139 sont les principaux agents Ă©tiologiques Ă©pidĂ©miogĂšnes. Les principaux facteurs de risques sont les pluies abondantes, les inondations, la contamination des sources dâeau et le manque dâassainissement. Conclusion : En dehors des souffrances Ă©prouvĂ©es par les malades, les flambĂ©es de cholĂ©ra provoquent la panique, dĂ©sorganisent les structures Ă©conomiques et sociales et freinent le dĂ©veloppement des communautĂ©s touchĂ©es. Cependant, la mobilisation des secteurs de lâeau, de lâassainissement et de lâhygiĂšne ainsi que le rensforcement des systemes de surveillance et riposte surtout au niveau transfrontalier sont des etapes essentielles pour la lutte contre les epidemies de cholera en Afrique subsaharienne
Polyarthrite RhumatoĂŻde au Niger : Etats des Lieux
Objectif : Faire lâĂ©tat des lieux sur les aspects Ă©pidĂ©miologiques, cliniques, paracliniques et thĂ©rapeutiques de la polyarthrite rhumatoĂŻde au Niger. MĂ©thodes : Cette revue des donnĂ©es de la littĂ©rature sur la polyarthrite rhumatoĂŻde au Niger a Ă©tĂ© rĂ©alisĂ©e en utilisant les bases de donnĂ©es MEDLINE (via PUBMED) et de google scholar. Les critĂšres dâinclusion comprenaient des Ă©tudes publiĂ©es chez des adultes de plus de 18 ans ayant reçu un diagnostic de polyarthrite rhumatoĂŻde. Lâextraction des donnĂ©es a Ă©tĂ© rĂ©alisĂ©e grĂące Ă un formulaires prĂ©Ă©tablis. RĂ©sultats : La recherche dans la littĂ©rature a identifiĂ© 5 articles. Finalement, quatre articles ont Ă©tĂ© inclus pour la revue. La frĂ©quence de la polyarthrite rhumatoĂŻde a Ă©tĂ© rapportĂ©e dans trois Ă©tudes, celle-ci variait de 1,24% Ă 3,7%. Le genre fĂ©minin reprĂ©sentait 79 (79,79%) des patients. LâĂąge moyen globale Ă©tait de 43,41 ans. Le dĂ©lai moyen avant le diagnostic Ă©tait de 53,2 mois. La polyarthrite rhumatoĂŻde a Ă©tĂ© diagnostiquĂ© en utilisant les critĂšres ACR 1987 et les critĂšres ACR/EULAR 2010. Tous les patients avaient consultĂ© pour une polyarthrite. Le coup de vent cubital Ă©tait retrouvĂ© chez 27 (27,27%) patients. Les nodules rhumatoĂŻdes ont Ă©tĂ© retrouvĂ© chez 12 (12,12%) patients. Les facteurs rhumatoĂŻdes Ă©taient positifs chez 56 (56,56%) patients. Les anticorps anti peptides cycliques citrullinĂ©s Ă©taient positif chez 7 (7,07%) patients. Le mĂ©thotrexate Ă©tait le traitement de fond chez 67 (67,67%) patients et lâhydroxychloroquine chez 43 (43,43%) patients. Conclusion : Le diagnostic de la polyarthrite est tardif au Niger. La crĂ©ation dâun registre national des patients ayant une polyarthrite rhumatoĂŻde permettra un meilleur suivi des patients.
Objective: To review the epidemiologic, clinical, paraclinical and therapeutic aspects of rheumatoid arthritis in Niger. Methods: This review of literature on rheumatoid arthritis in Niger was conducted using MEDLINE (via PUBMED) and google scholar databases. Inclusion criteria included studies published in adults over 18 years of age with a diagnosis of rheumatoid arthritis. Data extraction was done using a pre-designed form. Results: The literature search identified 5 articles. Four articles were finally included in the review. The frequency of rheumatoid arthritis was reported in three studies and ranged from 1.24% to 3.7%. Females accounted for 79 (79.79%) of the patients. The mean age was 43.41 years. The mean time to diagnosis was 53.2 months. Rheumatoid arthritis was diagnosed according to ACR 1987 and ACR/EULAR 2010 criteria. All patients had a history of polyarthritis. Ulnar involvement was found in 27 (27.27%) patients. Rheumatoid nodules were found in 12 (12.12%) patients. Rheumatoid factors were positive in 56 (56.56%) patients. Anti-cyclic citrullinated peptide antibodies were positive in 7 (7.07%) patients. Methotrexate was the background treatment in 67 (67.67%) patients and hydroxychloroquine in 43 (43.43%) patients. Conclusion: Polyarthritis is diagnosed late in Niger. The creation of a national registry of rheumatoid arthritis patients will allow better follow-up of patients
Polyarthrite RhumatoĂŻde au Niger : Ătats des Lieux
Objectif : faire une revue des donnĂ©es de la littĂ©rature sur les aspects Ă©pidĂ©miologiques, cliniques, paracliniques et thĂ©rapeutiques de la polyarthrite rhumatoĂŻde au Niger. MĂ©thodes : Cette revue des donnĂ©es de la littĂ©rature sur la polyarthrite rhumatoĂŻde au Niger a Ă©tĂ© rĂ©alisĂ©e en utilisant les bases de donnĂ©es MEDLINE (via PUBMED) et de Google Scholar. Les critĂšres dâinclusion comprenaient des Ă©tudes publiĂ©es chez des adultes de plus de 18 ans ayant reçu un diagnostic de polyarthrite rhumatoĂŻde. Lâextraction des donnĂ©es a Ă©tĂ© rĂ©alisĂ©e grĂące Ă un formulaire prĂ©Ă©tabli. RĂ©sultats : La recherche dans la littĂ©rature a identifiĂ© 5 articles. Finalement, quatre articles ont Ă©tĂ© inclus pour la revue. La frĂ©quence de la polyarthrite rhumatoĂŻde a Ă©tĂ© rapportĂ©e dans trois Ă©tudes, celle-ci variait de 1,24% Ă 3,7%. Le genre fĂ©minin reprĂ©sentait 79 (79,79%) des patients. LâĂąge moyen globale Ă©tait de 43,41 ans. Le dĂ©lai moyen avant le diagnostic Ă©tait de 53,2 mois. La polyarthrite rhumatoĂŻde a Ă©tĂ© diagnostiquĂ© en utilisant les critĂšres ACR 1987 et les critĂšres ACR/EULAR 2010. Tous les patients avaient consultĂ© pour une polyarthrite. Le coup de vent cubital Ă©tait retrouvĂ© chez 27 (27,27%) patients. Les nodules rhumatoĂŻdes ont Ă©tĂ© retrouvĂ© chez 12 (12,12%) patients. Les facteurs rhumatoĂŻdes Ă©taient positifs chez 56 (56,56%) patients. Les anticorps anti peptides cycliques citrullinĂ©s Ă©taient positif chez 7 (7,07%) patients. Le mĂ©thotrexate Ă©tait le traitement de fond chez 67 (67,67%) patients et lâhydroxychloroquine chez 43 (43,43%) patients. Conclusion : Le diagnostic de la polyarthrite est tardif au Niger. La crĂ©ation dâun registre national des patients ayant une polyarthrite rhumatoĂŻde permettra un meilleur suivi des patients.
Objective: To review the epidemiologic, clinical, paraclinical and therapeutic aspects of rheumatoid arthritis in Niger. Methods: This review of literature on rheumatoid arthritis in Niger was conducted using MEDLINE (via PUBMED) and Google Scholar databases. Inclusion criteria included studies published in adults over 18 years of age with a diagnosis of rheumatoid arthritis. Data extraction was done using a pre-designed form. Results: The literature search identified 5 articles. Four articles were finally included in the review. The frequency of rheumatoid arthritis was reported in three studies and ranged from 1.24% to 3.7%. Females accounted for 79 (79.79%) of the patients. The mean age was 43.41 years. The mean time to diagnosis was 53.2 months. Rheumatoid arthritis was diagnosed according to ACR 1987 and ACR/EULAR 2010 criteria. All patients had a history of polyarthritis. Ulnar gale was found in 27 (27.27%) patients. Rheumatoid nodules were found in 12 (12.12%) patients. Rheumatoid factors were positive in 56 (56.56%) patients. Anti-cyclic citrullinated peptide antibodies were positive in 7 (7.07%) patients. Methotrexate was the background treatment in 67 (67.67%) patients and hydroxychloroquine in 43 (43.43%) patients. Conclusion: Polyarthritis is diagnosed late in Niger. The creation of a national registry of rheumatoid arthritis patients will allow better follow-up of patients
DĂ©nutrition Chez Les Patients CancĂ©reux Ă LâhĂŽpital National De Niamey (Niger)
Introduction : La dĂ©nutrition est un problĂšme frĂ©quemment rencontrĂ© chez les patients suivis pour pathologie cancĂ©reuse. Elle est d'origine multifactorielle et constitue un problĂšme important compliquant la prise en charge de ces patients. MĂ©thodologie : Il sâagissait dâune Ă©tude prospective et descriptive qui a Ă©tĂ© menĂ©e du 1 juillet au 30 Septembre auprĂšs de patients cancĂ©reux hospitalisĂ©s dans le service dâOncohĂ©matologie de lâHĂŽpital National de Niamey. Le diagnostic de la dĂ©nutrition Ă©tait posĂ© sur la base de lâIMC, lâalbuminĂ©mie et ou de la perte de poids. RĂ©sultats : La prĂ©valence de la dĂ©nutrition Ă©tait estimĂ©e Ă 66,70%. Tous avaient rĂ©pondu aux critĂšres de lâIMC, 54, 38% avaient une hypoalbuminĂ©mie et 82,40% avaient perdu du poids. Les tranches dâĂąge entre 0 et 15 ans et supĂ©rieure Ă 60 ans Ă©taient les plus touchĂ©es avec respectivement 76,19% et 75%. Les cancers Ă haut risque de dĂ©nutrition Ă©taient reprĂ©sentĂ©s par les tumeurs de la langue, de lâĆsophage et les tumeurs pulmonaires. Cette dĂ©nutrition Ă©tait d'origine multifactorielle, d'oĂč l'importance de dĂ©terminer les diffĂ©rents facteurs de risque tels que : la nature de la tumeur, la durĂ©e d'hospitalisation, les facteurs cliniques (diarrhĂ©e, vomissement, anorexie, et douleur). Parmi les patients qui Ă©taient dĂ©nutris sous chimiothĂ©rapie, 84,61% Ă©taient dĂ©nutris aprĂšs la troisiĂšme (3) cure. Seul lâĂąge Ă©tait associĂ© significativement avec la dĂ©nutrition (p<0,05). Sur la prise en charge nutritionnelle, six (6) patients seulement avaient bĂ©nĂ©ficiĂ© dâune alimentation entĂ©rale soit 5,9%. Aucun patient dĂ©nutri nâavait bĂ©nĂ©ficiĂ© dâune alimentation parentĂ©rale.
Introduction: Undernutrition is a problem frequently encountered in patients followed for cancer pathology. It is of multifactorial origin and constitutes an important problem complicating the management of these patients. Methodology: This was a prospective and descriptive study which was conducted from July 1 to September 30 with cancer patients hospitalized in the Onco-Hematology department of Niamey National Hospital. The diagnosis of undernutrition was made on the basis of BMI, albuminemia and weight loss. Results: The prevalence of undernutrition was estimated at 66.70%. All had met the BMI criteria, 54, 38% had hypo albuminemia and 82.40% had lost weight. The age groups between 0 and 15 and over 60 were the most affected with 76.19% and 75% respectively. Cancers at high risk of undernutrition were represented by tumors of the tongue, esophagus and lung tumors. This undernutrition was of multifactorial origin, hence the importance of determining the various risk factors such as: the nature of the tumor, the duration of hospitalization, clinical factors (diarrhea, vomiting, anorexia, and pain). Of the patients who were malnourished under chemotherapy, 84.61% were malnourished after the third (3) course of treatment. Only age was significantly associated with undernutrition (p <0.05). In terms of nutritional management, only six (6) patients had benefited from enteral nutrition, ie 5.9%. No malnourished patient had received parenteral nutrition
Anaplasma ovis infects sheep in Niger
International audienceAnaplasmosis due to Anaplasma ovis (A ovis) is an infection spread in small ruminants mostly in the tropical and subtropical region. This neglected disease which often induces a subclinical infection can be severe in case of co-infection with other pathogens. In the Republic of Niger, small ruminant breeding contributes for a large extent to the national economy; however, little is known about pathogens that infect sheep in this region. In the present study, 33 sheep blood samples were collected near the village of Madama in the north of the country. Molecular analysis for the investigation of the presence of Anaplasmataceae species infection was conducted targeting three genes, the 23S rRNA, 16S rRNA and the rpoB genes. Results showed that 23/33 (69.7%) of the sheep were infected by A. ovis. This result is the first molecular description of A. ovis in Niger