54 research outputs found

    PIN31 Cost-Effectiveness Analysis of Antifungal Treatments Available in Colombia for the Treatment of Invasive Candidiasis

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    Perturbation-induced radiation by the Ablowitz-Ladik soliton

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    An efficient formalism is elaborated to analytically describe dynamics of the Ablowitz-Ladik soliton in the presence of perturbations. This formalism is based on using the Riemann-Hilbert problem and provides the means of calculating evolution of the discrete soliton parameters, as well as shape distortion and perturbation-induced radiation effects. As an example, soliton characteristics are calculated for linear damping and quintic perturbations.Comment: 13 pages, 4 figures, Phys. Rev. E (in press

    Post-tectonic landscape evolution in NE Iberia using staircase terraces: Combined effects of uplift and climate

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    © 2017 Elsevier B.V.River incision into bedrock resulting from the combined effects of tectonic uplift and climate governs long-term regional landscape evolution. We determined spatial and temporal patterns of post-orogenic stream incision from a sequence of well-preserved staircase terraces developed over the last 1 Ma in the Central Pyrenees and its southern foreland Ebro basin (NE Spain). Extensive remnants of ten vertically separated terraces (Qt1 to Qt10, from oldest to youngest) were mapped along 170 km of the Cinca River valley, transverse to the Pyrenean mountain belt. Multiple outcrops appear in the upper reach of the valley (Ainsa sector, 50 km from headwaters) as well as in the lower reach (Albalate sector, 125 km from headwaters). Fluvial incision into bedrock was calculated using (i) differentially corrected GPS measurements of the altitude of straths and (ii) numerical dating of alluvial sediments from the lower terraces (Qt5 to Qt9) by Optically Stimulated Luminescence, previously reported by Lewis et al. (2009), and supplemented with new dates for the upper terraces (Qt1, Qt2 and Qt3) based on paleomagnetism and supported by soil development. Considering altitude differences and the elapsed time between successive well preserved terrace couples (Qt3–Qt7, Qt7–Qt9 and Qt9-Active channel), mean bedrock incision rates ranged from 0.76 to 0.38 m ka− 1, at the upper reach of the valley (Ainsa section), and from 0.61 to 0.20 m ka− 1, at the lower reach (Albalate section). River incision along the valley produced vertically separated, near-parallel longitudinal terrace profiles evidencing a rapid near-uniform regional uplift as response to (i) the tectonic lithospheric thickening in NE Iberia and (ii) the erosional download rebound related to the Ebro basin exorheism. Moreover, a subtle upstream divergence of strath profiles may have been a consequence of an increase in uplift rate toward the head of the valley. Additionally, incision rates changed over time as indicate results from the lower reach (Albalate section); the maximum rate was 1.48 m ka− 1 between Qt7 (61 ka) and Qt8 (47 ka), and the minimum rate was 0.11 m ka− 1 between Qt3 (401 ka) and Qt5 (178 ka). The highest incision rates were produced after the Marine Isotope Stage 4 most likely in response to (i) an increased snowmelt discharge during the subsequent deglaciation related to the last maximum advance of glaciers in the southern Pyrenees, and (ii) a limited width of the valley after Qt7 formation, resulting from the deactivation of the westward river migration. Therefore, incision rates over the last 1 Ma in the Cinca River valley were basically controlled by near-uniform bedrock uplift, in the context of climate variability. The results reported in this study represent significant data on fluvial incision in NE Iberia, and provide an assessment of the regional post-tectonic landscape evolution

    An Eccentric Massive Jupiter Orbiting a Subgiant on a 9.5-day Period Discovered in the Transiting Exoplanet Survey Satellite Full Frame Images

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    We report the discovery of TOI-172 b from the Transiting Exoplanet Survey Satellite (TESS) mission, a massive hot Jupiter transiting a slightly evolved G star with a 9.48-day orbital period. This is the first planet to be confirmed from analysis of only the TESS full frame images, because the host star was not chosen as a two-minute cadence target. From a global analysis of the TESS photometry and follow-up observations carried out by the TESS Follow-up Observing Program Working Group, TOI-172 (TIC 29857954) is a slightly evolved star with an effective temperature of T eff = 5645 ± 50 K, a mass of M ∗ = 1.128-0.061 +0.065 M o, radius of R ∗ = 1.777-0.044 +0.047 R o, a surface gravity of log g ∗ = 3.993-0.028 +0.027, and an age of 7.4-1.5 +1.6. Its planetary companion (TOI-172 b) has a radius of R P = 0.965-0.029 +0.032 R J, a mass of M P = 5.42-0.20 +0.22 M J, and is on an eccentric orbit (e = 0.3806-0.0090 +0.0093 ). TOI-172 b is one of the few known massive giant planets on a highly eccentric short-period orbit. Future study of the atmosphere of this planet and its system architecture offer opportunities to understand the formation and evolution of similar systems

    The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

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    INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

    Highly-parallelized simulation of a pixelated LArTPC on a GPU

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    The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

    Evidence of pair production of longitudinally polarised vector bosons and study of CP properties in ZZ → 4ℓ events with the ATLAS detector at √s = 13 TeV

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    A study of the polarisation and CP properties in ZZ production is presented. The used data set corresponds to an integrated luminosity of 140 fb−1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The ZZ candidate events are reconstructed using two same-flavour opposite-charge electron or muon pairs. The production of two longitudinally polarised Z bosons is measured with a significance of 4.3 standard deviations, and its cross-section is measured in a fiducial phase space to be 2.45 ± 0.60 fb, consistent with the next-to-leading-order Standard Model prediction. The inclusive differential cross-section as a function of a CP-sensitive angular observable is also measured. The results are used to constrain anomalous CP-odd neutral triple gauge couplings
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