1,337 research outputs found
The case for formal theory
The article introduces this issue of "Academy of Management Review" which focuses on topics such as the performance differentials between diversified companies and new business enterprises, the prediction of business mortality that is based on the industry conditions at the time of the company's founding, and the free-rider problem
Isoform-specific dynamic translocation of PKC by Ī±1-adrenoceptor stimulation in live cells.
Protein kinase C (PKC) plays key roles in the regulation of signal transduction and cellular function in various cell types. At least ten PKC isoforms have been identified and intracellular localization and trafficking of these individual isoforms are important for regulation of enzyme activity and substrate specificity. PKC can be activated downstream of Gq-protein coupled receptor (GqPCR) signaling and translocate to various cellular compartments including plasma membrane (PM). Recent reports suggested that different types of GqPCRs would activate different PKC isoforms (classic, novel and atypical PKCs) with different trafficking patterns. However, the knowledge of isoform-specific activation of PKC by each GqPCR is limited. Ī±1-Adrenoceptor (Ī±1-AR) is one of the GqPCRs highly expressed in the cardiovascular system. In this study, we examined the isoform-specific dynamic translocation of PKC in living HEK293T cells by Ī±1-AR stimulation (Ī±1-ARS). Rat PKCĪ±, Ī²I, Ī²II, Ī“, Īµ and Ī¶ fused with GFP at C-term were co-transfected with human Ī±1A-AR into HEK293T cells. The isoform-specific dynamic translocation of PKC in living HEK293T cells by Ī±1-ARS using phenylephrine was measured by confocal microscopy. Before stimulation, GFP-PKCs were localized at cytosolic region. Ī±1-ARS strongly and rapidly translocated a classical PKC (cPKC), PKCĪ±, (\u3c30 \u3es) to PM, with PKCĪ± returning diffusively into the cytosol within 5 min. Ī±1-ARS rapidly translocated other cPKCs, PKCĪ²I and PKCĪ²II, to the PM (\u3c30 \u3es), with sustained membrane localization. One novel PKC (nPKC), PKCĪµ, but not another nPKC, PKCĪ“, was translocated by Ī±1-AR stimulation to the PM (\u3c30 \u3es) and its membrane localization was also sustained. Finally, Ī±1-AR stimulation did not cause a diacylglycerol-insensitive atypical PKC, PKCĪ¶ translocation. Our data suggest that PKCĪ±, Ī² and Īµ activation may underlie physiological and pathophysiological responses of Ī±1-AR signaling for the phosphorylation of membrane-associated substrates including ion-channel and transporter proteins in the cardiovascular system
Impurity Energy Level Within The Haldane Gap
An impurity bond in a periodic 1D antiferromagnetic, spin 1 chain with
exchange is considered. Using the numerical density matrix renormalization
group method, we find an impurity energy level in the Haldane gap,
corresponding to a bound state near the impurity bond. When the level
changes gradually from the edge of the Haldane gap to the ground state energy
as the deviation changes from 0 to 1. It seems that there is
no threshold. Yet, there is a threshold when . The impurity level
appears only when the deviation is greater than ,
which is near 0.3 in our calculation.Comment: Latex file,9 pages uuencoded compressed postscript including 4
figure
'Mindless markers of the nation': The routine flagging of nationhood across the visual environment
The visual environment has increasingly been used as a lens with which to understand wider processes of social and economic change with studies employing in-depth qualitative approaches to focus on, for example, gentrification or trans-national networks. This exploratory paper offers an alternative perspective by using a novel method, quantitative photo mapping, to examine the extent to which a particular socio-cultural marker, the nation, is āflaggedā across three contrasting sites in Britain. As a multi-national state with an increasingly diverse population, Britain offers a particularly fruitful case study, drawing in debates around devolution, European integration and Commonwealth migration. In contributing to wider debates around banal nationalism, the paper notes the extent to which nations are increasingly articulated through commerce, consumption and market exchange and the overall significance of everyday markers (signs, objects, infrastructure) in naturalising a national view of the world
Interplay Between Time-Temperature-Transformation and the Liquid-Liquid Phase Transition in Water
We study the TIP5P water model proposed by Mahoney and Jorgensen, which is
closer to real water than previously-proposed classical pairwise additive
potentials. We simulate the model in a wide range of deeply supercooled states
and find (i) the existence of a non-monotonic ``nose-shaped'' temperature of
maximum density line and a non-reentrant spinodal, (ii) the presence of a low
temperature phase transition, (iii) the free evolution of bulk water to ice,
and (iv) the time-temperature-transformation curves at different densities.Comment: RevTeX4, 4 pages, 4 eps figure
Transmission Properties of the oscillating delta-function potential
We derive an exact expression for the transmission amplitude of a particle
moving through a harmonically driven delta-function potential by using the
method of continued-fractions within the framework of Floquet theory. We prove
that the transmission through this potential as a function of the incident
energy presents at most two real zeros, that its poles occur at energies
(), and that the
poles and zeros in the transmission amplitude come in pairs with the distance
between the zeros and the poles (and their residue) decreasing with increasing
energy of the incident particle. We also show the existence of non-resonant
"bands" in the transmission amplitude as a function of the strength of the
potential and the driving frequency.Comment: 21 pages, 12 figures, 1 tabl
Does coevolution promote species richness in parasitic cuckoos?
Why some lineages have diversified into larger numbers of species than others is a fundamental but still relatively poorly understood aspect of the evolutionary process. Coevolution has been recognized as a potentially important engine of speciation, but has rarely been tested in a comparative framework. We use a comparative approach based on a complete phylogeny of all living cuckoos to test whether parasiteāhost coevolution is associated with patterns of cuckoo species richness. There are no clear differences between parental and parasitic cuckoos in the number of species per genus. However, a cladogenesis test shows that brood parasitism is associated with both significantly higher speciation and extinction rates. Furthermore, subspecies diversification rate estimates were over twice as high in parasitic cuckoos as in parental cuckoos. Among parasitic cuckoos, there is marked variation in the severity of the detrimental effects on host fitness; chicks of some cuckoo species are raised alongside the young of the host and others are more virulent, with the cuckoo chick ejecting or killing the eggs/young of the host. We show that cuckoos with a more virulent parasitic strategy have more recognized subspecies. In addition, cuckoo species with more recognized subspecies have more hosts. These results hold after controlling for confounding geographical effects such as range size and isolation in archipelagos. Although the power of our analyses is limited by the fact that brood parasitism evolved independently only three times in cuckoos, our results suggest that coevolutionary arms races with hosts have contributed to higher speciation and extinction rates in parasitic cuckoos
Low-Lying Excited States and Low-Temperature Properties of an Alternating Spin-1 / Spin-1/2 Chain : A DMRG study
We report spin wave and DMRG studies of the ground and low-lying excited
states of uniform and dimerized alternating spin chains. The DMRG procedure is
also employed to obtain low-temperature thermodynamic properties of the system.
The ground state of a 2N spin system with spin-1 and spin-1/2 alternating from
site to site and interacting via an antiferromagnetic exchange is found to be
ferrimagnetic with total spin from both DMRG and spin wave analysis.
Both the studies also show that there is a gapless excitation to a state with
spin and a gapped excitation to a state with spin .
Surprisingly, the correlation length in the ground state is found to be very
small from both the studies for this gapless system. For this very reason, we
show that the ground state can be described by a variational ``ansatz'' of the
product type. DMRG analysis shows that the chain is susceptible to a
conditional spin-Peierls' instability. The DMRG studies of magnetization,
magnetic susceptibility () and specific heat show strong magnetic-field
dependence. The product shows a minimum as a function of
temperature() at low-magnetic fields and the minimum vanishes at
high-magnetic fields. This low-field behaviour is in agreement with earlier
experimental observations. The specific heat shows a maximum as a function of
temperature and the height of the maximum increases sharply at high magnetic
fields. It is hoped that these studies will motivate experimental studies at
high-magnetic fields.Comment: 22 pages in latex; 16 eps figures available upon reques
Anterior capsule phimosis and capsular block syndrome in a patient with Steinert myotonic dystrophy: a case report
A 55-year-old man with myotonic dystrophy underwent phacoemulsification with IOL implantation in the right eye
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