Multi-Behavior Agent Model for Supply Chain Management

Recent economic and international threats to occidental industries have encouraged companies to rethink their planning systems. Due to consolidation, the development of integrated supply chains and the use of inter-organizational information systems have increased business interdependencies and the need for collaboration. Thus, agility and the ability to deal quickly with disturbances in supply chains are critical to maintain overall performance. In order to develop tools to increase the agility of the supply chain and to promote the collaborative management of such disturbances, agent-based technology takes advantage of the ability of agents to make autonomous decisions in a distributed network. This paper proposes a multi-behavior agent model using different decision making approaches in a context where planning decisions are supported by a distributed advanced planning system (d-APS). The implementation of this solution is realized through the FOR@C experimental agent-based platform, dedicated to the supply chain planning for the forest products industry

Issues in collaborative logistics

Collaborative logistics is becoming more important in today’s industry. This is driven by increased environ-mental concerns, improved efficiency through collaborative planning supporting resources sharing and new business models implementation. This paper presents a survey of contributions to the field of collaborative logistics. It first describes current opportunities in collaborative planning. It then discusses main issues related to building the coalition, sharing resources and benefits, as well as issues related to information and decisions technologies. Business cases are described and used to support the discussion around the main issues. Finally, questions are raised, opening new paths for researchers in the field

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis.

The repair of DNA double-strand breaks (DSBs) is essential to maintain genomic integrity. In higher eukaryotes, DNA DSBs are predominantly repaired by non-homologous end joining (NHEJ), but DNA ends can also be joined by an alternative error-prone mechanism termed microhomologymediated end joining (MMEJ). In MMEJ, the repair of DNA breaks is mediated by annealing at regions of microhomology and is always associated with deletions at the break site. In budding yeast, the Mre11/Rad5/Xrs2 complex has been demonstrated to play a role in both classical NHEJ and MMEJ, but the involvement of the analogous MRE11/RAD50/ NBS1 (MRN) complex in end joining in higher eukaryotes is less certain. Here we demonstrate that in Xenopus laevis egg extracts, the MRN complex is not required for classical DNA-PKdependent NHEJ. However, the XMRN complex is necessary for resection-based end joining of mismatched DNA ends. This XMRN-dependent end joining process is independent of the core NHEJ components Ku70 and DNA-PK, occurs with delayed kinetics relative to classical NHEJ and brings about repair at sites of microhomology. These data indicate a role for the X. laevis MRN complex in MMEJ