MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma

Background The high incidence and mortality of lung tumours is a major health problem. Therefore, the identification both of biomarkers predicting efficacy for therapies in use and of novel efficacious therapeutic agents is crucial to increase patient survival. MAP17 (PDZK1IP1) is a small membrane-bound protein whose upregulation is reported as a common feature in tumours from diverse histological origins. Furthermore, MAP17 is correlated with tumour progression. Go to: Methods We assessed the expression of MAP17 in preclinical models, including cell lines and patient-derived xenografts (PDXs), assessing its correlation with sensitivity to different standard-of-care drugs in lung adenocarcinoma, as well as novel drugs. At the clinical level, we subsequently correlated MAP17 expression in human tumours with patient response to these therapies. Go to: Results We show that MAP17 expression is induced during lung tumourigenesis, particularly in lung adenocarcinomas, and provide in vitro and in vivo evidence that MAP17 levels predict sensitivity to therapies currently under clinical use in adenocarcinoma tumours, including cisplatin, carboplatin and EGFR inhibitors. In addition, we show that MAP17 expression predicts proteasome inhibitor efficacy in this context and that bortezomib, an FDA-approved drug, may be a novel therapeutic approach for MAP17-overexpressing lung adenocarcinomas. Go to: Conclusions Our results indicate a potential prognostic role for MAP17 in lung tumours, with particular relevance in lung adenocarcinomas, and highlight the predictive pot0065ntial of this membrane-associated protein for platinum-based therapy and EGFR inhibitor efficacy. Furthermore, we propose bortezomib treatment as a novel and efficacious therapy for lung adenocarcinomas exhibiting high MAP17 expression

Immigrant women living homeless in Madrid (Spain).

Homeless people are one of the most obvious embodiments of the phenomenon of social exclusion, and homeless immigrants and homeless women are considered 2 particularly vulnerable groups. The objective of this article is to analyze the differences between women living homeless born in Spain (nonimmigrants) and those born abroad (immigrants). The study was carried out based on the data obtained from a sample of women living homeless in Madrid (Spain; N = 136). The information was collected using a structured interview. The results show major similarities between immigrant and nonimmigrant homeless women in terms of their basic sociodemographic characteristics (age, marital status, number of children), their state of health, satisfaction with their family and/or partner relationships, and feelings of loneliness or abandonment. Fewer immigrant women had their documentation in order, they received fewer financial benefits and their contact with their family of origin was more limited. However, the immigrant women became homeless at an older age and were subject to less chronic homelessness, their levels of consumption of alcohol and other psychoactive substances were lower, they had experienced fewer stressful life events, more of them had completed higher education, and more of them used mobile telephones and the Internet. (PsycInfo Database Record (c) 2020 APA, all rights reserved)Ministerio de Economía, Industria y Competitivida

Polarization in Media Discourses on Europeanization in Spain

Political and media polarization has had a detrimental impact on democratic principles and democratic processes on a global scale. In Europe, such polarization has eroded the trust in national and European institutions and has challenged the basic values that stand at the heart of the European integration project. The aim of this study is to analyze Spanish media discourses on Europeanization, with an attempt to identify key areas in which polarizing narratives related to Europeanization are more prevalent. To conduct our study, six national media outlets were selected based on four criteria: media format, ownership, ideology, and consumption. A final sample of 540 news items collected between July 2021 to March 2022 was selected for analysis. Using a qualitative methodological approach, the study was carried out in two stages. In the first phase, we conducted a content analysis to identify the main topics discussed in relation to the European Union and the actors represented in them. This led to the identification of polarizing narratives and discourses emerging in the context of the discussed topics. In the second phase, we used critical discourse analysis to analyze polarizing discourses

High-fidelity noncovalent synthesis of hydrogen-bonded macrocyclic assemblies

This is the accepted version of the following article: Angewandte Chemie International Edition 54.23 (2015): 6780-6784, which has been published in final form at http://dx.doi.org/10.1002/anie.201501321A hydrogen-bonded cyclic tetramer is assembled with remarkably high effective molarities from a properly designed dinucleoside monomer. This self-assembled species exhibits an impressive thermodynamic and kinetic stability and is formed with high fidelities within a broad concentration rangeFunding from MINECO (CTQ2011-23659) and the E.U. (ERC-Starting Grant 279548) is gratefully acknowledge

Responsabilidad civil sanitaria. Análisis jurisprudencial

Con este trabajo se pretende analizar la delimitación material de la responsabilidad civil sanitaria, centrando la atención en los principales temas de debate surgidos en este ámbito, en las problemáticas y diferencias existentes a nivel doctrinal. Como metodología seguida en este trabajo, me ha parecido imprescindible consultar diferentes libros y artículos académicos para tener un conocimiento más amplio sobre la responsabilidad civil sanitaria. Además, el trabajo va destinado al análisis jurisprudencial de sentencias de los últimos años (desde el año 2012 hasta la actualidad) que reflejan la mayoría de aspectos definidos teóricamente. Finalmente, de todo lo aprendido, expongo unas conclusiones en el último apartado

Reciclando conocimientos en TICs: herramientas online y offline para su utilización en la enseñanza virtual y en la coordinación docente

El profesorado de nuestra Facultad ha ido solicitando la realización de cursos formativos sobre las nuevas tecnologías y profundizar en las herramientas más habituales, sobre todo, con las posibilidades que ofrece el Campus Virtual. Con este proyecto se pretendieron cubrir fundamentalmente dos demandas: - Optimizar la utilización de las plataformas virtuales. - Conocer herramientas offline útiles para la docencia y la coordinación docente. En total, se han realizado 7 actividades manteniendo una estructura lógica de cronología y continuidad en las mismas. De la mayoría de ellas se han generado tutoriales como material de ayuda, que se han puesto a disposición del resto de profesores y PAS en un Seminario de Trabajo abierto creado en Moodle expresamente, denominado “PIMCD2014: Reciclando conocimientos…” (seminario-invest-97673-11)

Soil pH effects on the Toxicity of zinc oxide nanoparticles to soil bacterial communities.

The environmental levels of ZnO nanoparticles (nZnO) are increasing continually given the widespread and expanding applications of this material. Soil pH appears to be one of the key factors affecting the behavior and toxicity of metal nanoparticles in soi

Chronopotentiometric study of ceramic cation-exchange membranes based on zirconium phosphate in contact with nickel sulfate solutions

In this article, the innovative cation-exchange membranes obtained from ceramic materials are presented. Different microporous ceramic supports were obtained from an initial mixture of alumina and kaolin, to which a varying content of starch was added in order to obtain supports with different pore size distributions. The deposition of zirconium phosphate into the porous supports generates membranes with cation-exchange properties. The fabrication of ion-exchange membranes which could resist aggressive electrolytes such as strong oxidizing spent chromium plating baths or radioactive solutions would allow the application of electrodialysis for the decontamination and regeneration of these industrial effluents. The performance of the manufactured membranes was studied in nickel sulfate solutions by means of chronopotentiometry. An increase of the membrane voltage drop during chronopotentiometric measurements was observed in some membranes, which seems to be a consequence of concentration polarization phenomena resulting from the ionic transfer occurred through the membranes. Current voltage curves were obtained for the different ceramic membranes, allowing the calculation of their ohmic resistance. The ohmic resistance of the membranes increased when the open porosity (OP) of the samples was incremented up to a value of 50%. For values of OP higher than 50%, the resistance of the membranes decreased significantly with porosity.Martí Calatayud, MC.; García Gabaldón, M.; Pérez-Herranz, V.; Sales, S.; Mestre, S. (2013). Chronopotentiometric study of ceramic cation-exchange membranes based on zirconium phosphate in contact with nickel sulfate solutions. Desalination and Water Treatment. 51(1-3):597-605. doi:10.1080/19443994.2012.714629597605511-3L. Harttinger, Handbook of Effluent Treatment and Recycling for The Metal Finishing Industry, Finishing Publications Ltd.; ASM International, Stevenage 1994.Balagopal, S., Landro, T., Zecevic, S., Sutija, D., Elangovan, S., & Khandkar, A. (1999). Selective sodium removal from aqueous waste streams with NaSicon ceramics. Separation and Purification Technology, 15(3), 231-237. doi:10.1016/s1383-5866(98)00104-xHobbs, D. . (1999). Caustic recovery from alkaline nuclear waste by an electrochemical separation process. Separation and Purification Technology, 15(3), 239-253. doi:10.1016/s1383-5866(98)00105-1Dzyazko, Y. S., Mahmoud, A., Lapicque, F., & Belyakov, V. N. (2006). Cr(VI) transport through ceramic ion-exchange membranes for treatment of industrial wastewaters. Journal of Applied Electrochemistry, 37(2), 209-217. doi:10.1007/s10800-006-9243-7García-Gabaldón, M., Pérez-Herranz, V., Sánchez, E., & Mestre, S. (2006). Effect of porosity on the effective electrical conductivity of different ceramic membranes used as separators in eletrochemical reactors. Journal of Membrane Science, 280(1-2), 536-544. doi:10.1016/j.memsci.2006.02.007Linkov, V. ., & Belyakov, V. . (2001). Novel ceramic membranes for electrodialysis. Separation and Purification Technology, 25(1-3), 57-63. doi:10.1016/s1383-5866(01)00090-9Tripathi, B. P., & Shahi, V. K. (2007). SPEEK–zirconium hydrogen phosphate composite membranes with low methanol permeability prepared by electro-migration and in situ precipitation. Journal of Colloid and Interface Science, 316(2), 612-621. doi:10.1016/j.jcis.2007.08.038Clearfield, A., & Smith, G. D. (1969). Crystallography and structure of .alpha.-zirconium bis(monohydrogen orthophosphate) monohydrate. Inorganic Chemistry, 8(3), 431-436. doi:10.1021/ic50073a005Alberti, G., Bernasconi, M. G., Casciola, M., & Costantino, U. (1978). Ion exchange of some divalent and trivalent cations on the surface of zirconium acid phosphate micro-crystals. Journal of Chromatography A, 160(1), 109-115. doi:10.1016/s0021-9673(00)91786-2Yaroslavtsev, A. B. (2003). Ion DiffusionThrow Interface in Heterogeneous Solid Systems with the Modified Surface. Defect and Diffusion Forum, 216-217, 133-140. doi:10.4028/www.scientific.net/ddf.216-217.133Yaroslavtsev, A. B. (2009). Composite materials with ionic conductivity: from inorganic composites to hybrid membranes. Russian Chemical Reviews, 78(11), 1013-1029. doi:10.1070/rc2009v078n11abeh004066Yaroslavtsev, A. B., Nikonenko, V. V., & Zabolotsky, V. I. (2003). Ion transfer in ion-exchange and membrane materials. Russian Chemical Reviews, 72(5), 393-421. doi:10.1070/rc2003v072n05abeh000797Davis, M. E. (2002). Ordered porous materials for emerging applications. Nature, 417(6891), 813-821. doi:10.1038/nature00785Taky, M., Pourcelly, G., Lebon, F., & Gavach, C. (1992). Polarization phenomena at the interfaces between an electrolyte solution and an ion exchange membrane. Journal of Electroanalytical Chemistry, 336(1-2), 171-194. doi:10.1016/0022-0728(92)80270-eSistat, P., & Pourcelly, G. (1997). Chronopotentiometric response of an ion-exchange membrane in the underlimiting current-range. Transport phenomena within the diffusion layers. Journal of Membrane Science, 123(1), 121-131. doi:10.1016/s0376-7388(96)00210-4Pismenskaia, N., Sistat, P., Huguet, P., Nikonenko, V., & Pourcelly, G. (2004). Chronopotentiometry applied to the study of ion transfer through anion exchange membranes. Journal of Membrane Science, 228(1), 65-76. doi:10.1016/j.memsci.2003.09.012Martí-Calatayud, M. C., García-Gabaldón, M., Pérez-Herranz, V., & Ortega, E. (2011). Determination of transport properties of Ni(II) through a Nafion cation-exchange membrane in chromic acid solutions. Journal of Membrane Science, 379(1-2), 449-458. doi:10.1016/j.memsci.2011.06.014García-Gabaldón, M., Pérez-Herranz, V., & Ortega, E. (2011). Evaluation of two ion-exchange membranes for the transport of tin in the presence of hydrochloric acid. Journal of Membrane Science, 371(1-2), 65-74. doi:10.1016/j.memsci.2011.01.015GARCIAGABALDON, M., PEREZHERRANZ, V., SANCHEZ, E., & MESTRE, S. (2008). Effect of tin concentration on the electrical properties of ceramic membranes used as separators in electrochemical reactors. Journal of Membrane Science, 323(1), 213-220. doi:10.1016/j.memsci.2008.06.03