University students’ views regarding gender in STEM studies: Design and validation of an instrument

[EN] Diferences in the representation of diversity in higher education, emphasising the gender gap in some areas, are issues addressed from diferent research domains. Socially, gender roles have been constructed and are also related to professions. In this context, the Social Cognitive Career Theory explores the possible causes of segregation. This segregation is evident in Europe and Spain, as indicated by the European Institute for Gender Equality. This paper describes the design and validation process of an instrument to fnd out what opinions university students have about higher education studies in science, technology,engineering and mathematics (STEM), according to gender. After drafting the questionnaire, it was piloted in a non-experimental quantitative design in Spain. Subsequently, a validity and reli ability study was applied to validate the items and construct their dimensionality. The process was implemented using Reliability Analysis and Exploratory Factor Analysis. Also, the dimensionality consists of fve scales: Gender Ideology, Perception and Self-perception, Expectations about Science, Attitudes and Interests. Based on the results, it is concluded that the opinion about STEM studies is conditioned by personal elements, such as motivations, educational background and family and social infuences, such as people who judged their decision, were their references or studied STEM programs. Finally, it is essential to pay socio-educational attention to the modulating components of decisions about which higher education studies to pursue. Awareness of the factors involved in the decision helps the educational community to establish mechanisms to prevent horizontal gender segregation. The instrument designed, validated and presented in this study provides a glimpse of possible causes for the gender gap in STEM higher education.Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE

Multimedia Analysis of Spanish Female Role Models in Science, Technology, Engineering and Mathematics

Horizontal segregation in the higher education framework is a problem that goes up in the work environment. Women are assuming traditional gender roles due to phenomena such as the threat of stereotyping, which prevents them from opting for higher studies in science, technology, engineering and mathematics (STEM). This research work arises within the project W-STEM, “Building the Future of Latin America: Involving Women in STEM”. The research aims to investigate women’s academic and professional development in science, technology, engineering and mathematics (STEM) through their personal experience in making career-related decisions. The research was developed by applying a qualitative method. During the year 2020, video semi-structured interviews were conducted with twenty-one women professionals in the STEM field. Of the twenty-one participants, six are linked to science, eight to technology, fifteen to engineering and one to mathematics. Due to their research lines, some of them are located in more than one STEM area, for example, in technology and engineering. These women were interviewed about their choice of studies and training, their jobs, professional achievements, family and social environment and their perspective on the gender gap in STEM. They all agree on horizontal segregation and consider it necessary to motivate girls and young women to study what they like. Furthermore, they all show passion for their work

The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins

Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human DNA damage response (DDR) genes and select siRNAs causing DNA–RNA hybrid accumulation and a significant increase in hybrid‐dependent DNA breakage. We identify post‐replicative repair and DNA damage checkpoint factors, including those of the ATM/CHK2 and ATR/CHK1 pathways. Thus, spontaneous DNA–RNA hybrids are likely a major source of replication stress, but they can also accumulate and menace genome integrity as a consequence of unrepaired DSBs and post‐replicative ssDNA gaps in normal cells. We show that DNA–RNA hybrid accumulation correlates with increased DNA damage and chromatin compaction marks. Our results suggest that different mechanisms can lead to DNA–RNA hybrids with distinct consequences for replication and DNA dynamics at each cell cycle stage and support the conclusion that DNA–RNA hybrids are a common source of spontaneous DNA damage that remains unsolved under a deficient DDR.European Research Council (ERC2014AdG669898TARLOOP)Worldwide Cancer Research (WCR15-00098

Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy

P. 2991-3012Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis and hepatocellular carcinoma. NAFLD is characterized by the accumulation of lipids in the liver arising from multiple factors: increased fatty acid uptake, increased de novo lipogenesis, reduced fatty acid oxidation and very low density lipoproteins (VLDL) secretion. Most therapeutic approaches for this disease are often directed at reducing body mass index and improving insulin resistance through lifestyle modifications, bariatric surgery and pharmacological treatments. Nevertheless, there is increasing evidence that the use of natural compounds, as polyphenols, exert multiple benefits on the disorders associated with NAFLD. These molecules seem to be able to regulate the expression of genes mainly involved in de novo lipogenesis and fatty acid oxidation, which contributes to their lipid-lowering effect in the liver. Their antioxidant, anti-inflammatory, antifibrogenic and antilipogenic properties seem to confer on them a great potential as strategy for preventing NAFLD progression. In this review, we summarized the effects of these compounds, especially flavonoids, and their mechanisms of action, that have been reported in several studies carried out in in vitro and in vivo models of NAFL

Psychological and Educational Factors of Digital Competence Optimization Interventions Pre- and Post-COVID-19 Lockdown: A Systematic Review

[EN] The rapid development of the ever-changing information and communication society demands skills from its members that allow access to and adapt to the various situations that they may face. To achieve this, it is essential to acquire a set of key competencies throughout different stages of life, among which we find digital competence. This systematic review aims to analyse, through a series of focal points and indicators, the internationally published interventions in the last ten years aimed at improving digital literacy and the acquisition of this competence by students in early childhood education, primary education, and higher education, as well as professionals from various fields. The procedure followed for the selection of the interventions has been documented and graphically represented according to the PRISMA statement, with searches conducted across various databases and journals. In total, 26 studies were selected, covering the period before, during, and after the COVID-19 health lockdown, and the influence of the lockdown on the development of digital competence was examined. The obtained results show the evolution of the selected interventions in terms of general aspects, instructional and evaluative procedures, fidelity, and encountered limitations. The results demonstrate a growing concern for the development of digital competence, amplified by the needs arising during the COVID-19 lockdown and evidenced by an increase in interventions aimed at this goal. It also showcases the relationship between adequate acquisition and the nurturing of other sychoeducational variables like motivation or satisfaction.S

Technology development as a tool towards circularity: a research agenda

New technological development enables to implement circular economy (CE) practices. This phenomenon is taking particular interest for the Academy. The aim of this study is to analyse the cognitive and intellectual structure of the relationship between CE and technology. The proposed research questions seek to answer how the evolution of the number of publications per year, the main authors, journals, institutions and countries in this field, and the most relevant topics and papers in the research area are. It is used a bibliometric approach of co-word analysis of 996 articles published on Web of Science. In addition, it is proposed a research agenda after reviewing the most cited articles and points the research trend topics. There is a need to include topics associated with the social sphere, since most of the research is focused on environmental aspects and economic effects. In recent years, research has been polarised towards the blockchain, Big Data and biorefinery technologies. Although these technologies are in demand, it should not ignore other emerging technologies that could be key to circularity, such as those related to product redesign or changes in production infrastructures

Physical Activity and Mental Health in Undergraduate Students

[EN] Most research support positive relationships between physical activity and mental health. However, possible moderating variables of these relationships have also been identified, such as age, gender, level of physical activity, and the scope of physical activity. This study aimed to analyze the relationships between physical activity and mental health levels in undergraduate students, assessing whether these associations can change depending on the level of physical activity (low, medium, or high) and the setting (occupational, commuting, or leisure time physical activity) in which it was performed. A descriptive and cross-sectional study was conducted. The sample comprised 847 undergraduate students. Physical activity and mental health were measured by the Global Physical Activity Questionnaire (GPAQv2) and the General Health Questionnaire (GHQ-12). We found relationships between students’ physical activity level and their mental health status. The higher the total physical activity, the better their mental health scores. High levels of commuting and leisure time physical activity is also associated with better mental health, while only moderate levels of occupational physical activity are associated with better mental health status. Regarding the possible associations between physical activity and vulnerability to mental health problems, with the fully adjusted regression model, leisure time and occupational physical activity remain protective of a poor state of mental health. Leisure time physical activity, performed at a high level, and moderate occupational physical activity seems to be the best combination of physical activity to reduce students’ vulnerability to potential mental health problems.SIUniversidad Francisco de Vitori

De la opresión al bienestar. Explorando poder, opresión y bienestar entre inmigrantes marroquíes en España

Durante las últimas décadas, millones de personas han llegado a países de la Unión Europea para mejorar su calidad de vida y la de sus familiares. Las diferentes culturas, mercados y servicios que encuentran en Europa, fomentan en estos nuevos ciudadanos de la Unión Europea expectativas de satisfacción de sus necesidades, reconocimiento justo de sus aportaciones. Sin embargo, frecuentemente los inmigrantes se incorporan a un mercado laboral precario, que les obliga a asentarse en barrios sin acceso a servicios y recursos sociales, fomentando actitudes de rechazo en los vecinos nativos. La incorporación de los inmigrantes se realiza, por tanto, en condiciones asimétricas, que dificultan sus posibilidades para desarrollar su proyecto migratorio. En este contexto, la adaptación de la comunidad inmigrante se configura como uno de los principales desafíos para el presente y futuro de la Unión Europea

Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice

DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different mechanisms and optimal survival requires a tight control between them. Here we uncover protein deneddylation as a major controller of repair pathway choice. Neddylation inhibition changes the normal repair profile toward an increase on homologous recombination. Indeed, RNF111/UBE2M-mediated neddylation acts as an inhibitor of BRCA1 and CtIP-mediated DNA end resection, a key process in repair pathway choice. By controlling the length of ssDNA produced during DNA resection, protein neddylation not only affects the choice between NHEJ and homologous recombination but also controls the balance between different recombination subpathways. Thus, protein neddylation status has a great impact in the way cells respond to DNA breaks.España , Ministerio de Economía y Competitividad SAF2010-1487

Analysis of Hand Function, Upper Limb Disability, and Its Relationship with Peripheral Vascular Alterations in Raynaud’s Phenomenon

This study aimed to compare vascular involvement, hand functionality, and upper limb disability between Raynaud’s phenomenon participants and controls. Also, we analyzed the relationships between vascular impairment, mobility, and strength with disability in this Raynaud population. We conducted a case–control study with fifty-seven participants. We registered sociodemographic and clinical data; vascular variables (temperature, cold test, blood flow, and oxygen saturation); functional variables (pinch strength, range of motion), and disability (Shortened Disabilities of the Arm, Shoulder and Hand Questionnaire) (Q-DASH). Raynaud participants present more disability in all Q-DASH subscales, lower hands’ temperature pre and post cold test, decreased blood flow on radial artery, decreased ranges of motions at passive extension of index finger, and active flexion and extension of thumb than the healthy controls. The multivariate regression analysis showed that extension of the index finger, lateral pinch strength, and oxygen saturation were significantly associated with disability in RP, almost the 55% of the total variance on the upper limb, 27% at sports/arts, and 42% at work. Our findings suggest that RP has a disabling effect on the upper extremities and a practice of activities in people who suffer it. Also, disability in Raynaud seems to be more related with hand mobility and strength impairment than vascular injury