244 research outputs found
Possibilidade De Incorporação de proteÃnas do hospedeiro pelo trypanosoma cruzi (Investigação Experimental)
Oral transmission of Chagas disease: importance of Trypanosoma cruzi biodeme in the intragastric experimental infection
Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles, results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes was tested in mice subjected to infection by the digestive route (gavage). Swiss mice were infected either with the Peruvian strain (Biodeme Type I, Z2b) or the Colombian strain (Biodeme Type III, Z1, or T. cruzi I); for control, intraperitoneal inoculation was performed in a group of mice. The Colombian strain revealed a similar high infectivity and pathogenicity when either route of infection was used. However, the Peruvian strain showed contrasting levels of infectivity and pathogenicity, being high by intraperitoneal inoculation and low when the gastric route was used. The higher infectivity of the Colombian strain (Biodeme Type III) by gastric inoculation is in keeping with its role in the epidemic episodes of acute Chagas disease registered in the literature, since strains belonging to Biodeme III are most often found in sylvatic hosts.A ocorrência de microepidemias de infecção pelo Trypanosoma cruzi atribuidas à ingestão de alimentos contaminados com excreta de vetores ou de reservatórios vertebrados, em áreas rurais chamou a atenção para este tipo não vetorial de transmissão da doença de Chagas. Considerando que cepas de diferentes biodemas se distribuem diferentemente nos ciclos silvestre e domiciliar de transmissão, a ocorrência de microepidemias predominantes em áreas próximas aos ecótopos silvestres pode estar relacionada com a cepa do parasito, tendo-se em conta a predominância do Biodema Tipo III, Z1 nestas áreas. No presente estudo foi investigada a infectividade de cepas do T. cruzi de diferentes biodemas quando inoculadas por via digestiva. Foi feita inoculação por via intragástrica (VIG) em camundongos SuÃços com a cepa Peruana (Biodema Tipo I, Z2b) ou com a Colombiana (Biodema Tipo III, Z1, T. cruzi I). Para controle da infecção, camundongos foram também inoculados por via intraperitoneal (VIP). A cepa Colombiana mostrou alta infectividade e patogenicidade tanto por VIP como por VIG. A cepa Peruana apresentou alta infectividade e patogenicidade pela VIP e mostrou baixa infectividade pela VIG. A mais elevada infectividade pela VIG, da cepa Colombiana, cujo biodema Tipo III, Z1 é o mais freqüentemente encontrado nos hospedeiros silvestres, está de acordo com a ocorrência dos episódios epidêmicos registrados na literatura
Estudio Preliminar Sobre La Decoloración Del Residual LÃquido De La Producción De Papel Mediante Ozonización
Preliminarily, the relationship between Color Reduction (%RC), Total Suspended Solids concentration (SST), and as independent variable, the time of Ozone Oxidation Process, was evaluated with reference values of DQO of the black liquor adjusting its concentration from SST to 300 and 50mg/dm3. A batch reactor of 12,60dm3, an effective height of 3,2dm and an ozone generating device from SEFILTRA company (air flow of 2dm3/min, c(O3) of 9,50mg/dm3 with a O3(g) production 19mg/min) was used. The polynomic correlation was determined from 192 data sets with satisfactory adjustment level (R=0,92; p <0,001). Although, preliminarily, the DQO reduction (%RDQO) was not included in the polynomial relationship, it can be concluded that: a) The %RC and %RDQO is reduced when color and DQO increases from the ozonized sample at same time intervals; this reduction is greater when the SST levels of the ozonized sample increases. b) The %RC and %RDQO decrease when the SST level of the ozonized sample increases. c) Depending on the initial color, of the DQO and of the SST level of the sample, values from 10 to 53 %Rc were obtained after 10 min, and of 66 to 94 %Rc after 60 min
Reversibility of cardiac fibrosis in mice chronically infected with Trypanosoma cruzi, under specific chemotherapy
Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi
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