Effect of obesity on thiol/disulfide balance in patients with polycystic ovary syndrome

Aim: In this study, we aimed to investigate the hypothesis that thiol/disulfide balance is similar in patients with PCOS with and without obesity.Material and Methods: This was a prospective study. Seventy-eight patients with PCOS were included in the study. A diagnosis of PCOS was made according to the Rotterdam criteria. The patients were divided into two groups as obese [n = 41, body mass index (BMI) >= 30 kg/m2] and non-obese (n = 37, BMI >18.5 and <30 kg/m2).Results: Native thiol and total thiol values were significantly lower in the oxidative stress test in the non-obese group than in the obese group (p = 0.021 and p = 0.019, respectively). There was no statistically significant difference in other thiol-disulfide parameters between the groups. Luteinizing hormone (r =-0.293, p = 0.09), total thiol (r =-0.321, p = 0.04), native thiol (r =-0.330, p = 0.03) and disulfide (r =-0.272, p = 0.16) rates were found to be statistically significantly negatively correlated with BMI.Discussion: Obesity in PCOS affects thiol-disulfide hemostasis. There is a negative correlation between BMI and oxidative stress markers

Pain relief effects of aromatherapy with rose oil (Rosa damascena Mill.) inhalation in patients with primary dysmenorrhea: A randomized controlled clinical trial

Introduction: Pharmacological agents, such as non-steroidal anti-inflammatory drugs (NSAIDs), and non -pharmacological techniques, including acupuncture and aromatherapy, are commonly used for the manage-ment of abdominal pain in patients with primary dysmenorrhea. Essential rose oil obtained from Rosa Mill (RDM) is often used in aromatherapy for the treatment of many diseases. This study was aimed at using visual analog scale (VAS) pain scores and total analgesic consumption to evaluate the effects of adding RDM essential oil inhalation to the standard treatment (NSAID) of primary dysmenorrhea. Methods: In this prospective randomized controlled clinical trial, 86 patients were randomized into groups R and C. The patients in group C only used standard analgesics (50 mg diclofenac sodium enteric film tablets). In group R, patients used both standard analgesics and RDM inhalation aromatherapy. A 10-point VAS was used to determine the pain values of the patients and was recorded as pre-treatment (VAS-0) and post-treatment (VAS -60). The analgesic consumption by the patients was recorded for 24 h. Results: In both groups, there was a significant decrease in VAS scores after treatment. The VAS-60 scores in group R were significantly lower than those in group C (2 [1-4] vs. 5 [2-5], respectively; P = 0.013). Analgesic consumption in group R was significantly lower than in group C (50 [50-100] mg vs. 100 [50-100] mg, respectively; p = 0.003). Conclusion: Inhalational rose oil aromatherapy is a good self-treatment option for primary dysmenorrhea

İçmesuyu şebekelerindeki fiziksel kayıpları önlemeye yönelik Diyarbakır için örnek bir model geliştirilmesi

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Tatlı suların varlığını tehdit eden büyük faktörlerden biri küresel iklim değişikliği diğeri ise dünya nüfusunun hızla artmasıdır. Diğer taraftan, yeryüzüne sular mekânsal ve zamansal olarak homojen dağılmamaktadır. Bu yüzden tatlı su kaynakları gün geçtikçe daha yetersiz hale gelmektedir. Yeryüzüne inen tatlı su kaynaklarını artırmak veya dağılımını homojen hale getirmek doğal yollarla mümkün olmadığına göre insanlık ya tuzlu sulardan içilebilir su elde etmek gibi sentetik (yapay) yollarla su miktarını artırmak ya da eldeki suyu en verimli ve adil şekilde dağıtarak kullanmak zorundadır. Yapay yollarla içilebilir su elde etmek yüksek maliyetli bir teknoloji gerektirmektedir. Ancak gelişmemiş ve gelişmekte olan ülkeler henüz bu tür bir teknolojiye sahip değildir. Oysa su stresi veya kıtlığının yaşandığı birçok ülke gelişmemiş veya gelişmekte olan ülkeler sınıfındandır. Diğer taraftan suyun ticari bir meta haline gelmesi de suyun adil bir şekilde insanlar arasında dağıtımını güçleştirmektedir. Dolayısıyla tatlı su kaynaklarını her zaman yetecek kadar artırmak ve olanı adil bir şekilde dağıtmak mümkün görülmemektedir. Mevcut su kaynaklarını korumak ve en iyi şekilde yönetmek günümüzde tek çare olarak görülmektedir. Bunun en büyük avantajı her ülkenin her zaman bunu düşük teknoloji ve düşük bir maliyetle yapabilmesidir. Bu nedenle bu yaklaşımları öneren çalışmalara günümüzde çok ihtiyaç vardır. Bu duyarlılık ile bu çalışmada izole edilmiş şehir içi su dağıtım şebekesinde kayıp ve kaçakların tespiti ve bunların giderilmesi rapor edilmiştir. Bu çalışmada fiziki kayıpları minimuma indirmek için bilgi teknolojileri kullanılarak, fiziki kayıplar, kaçınılmaz fiziki kayıplara kadar indirilmiştir. Çalışma alanı olarak Diyarbakır şehir merkezi seçilmiş olup yapılan operasyonlardan sonra daha önce 44 olan izole edilmiş bölgedeki altyapı kaçak endeksi (AKE) katsayısı bire indirilmiştir. Anahtar kelimeler: Coğrafi bilgi sistemleri, abone bilgi sistemleri, SCADA, su kayıpları, gece akımı analizleri, ölçüm bölgesi.Main factors that are threatening the potable water quantity are global climate change and increase in the world population. On the other hand, water is not distributed equally in location and time dimensions. Potable water amount is getting decreased deficient day by day. Increasing the potable water amount by natural ways is not possible and distributing equally among the nations as well. Desalination of the sea water is a synthetic solution, but it is an expensive way and not all of the countries can use it. Countries feeling the stress of insufficient water or drought are mostly undeveloped ones. On the other hand, water is becoming a commercial property, which makes impossible of equal distribution. The optimum solution is to improve the efficiency of existing water usage, controlling the existing sources, decreasing the water losses. One of the advantage of this solution is it can be applied to any country/city. Furthermore, it is cheaper and does not need expensive technologies. There are limited published studies on the subject therefore, such studies are still needed. In this study determination of water losses and illegal usage in an isolated water distribution network is examined in details. The study area is Diyarbakir city center. The infrastructure leakage index (ILI) at the end of the operations is decreased to 1, which initially were 44. Keywords: Geographical information systems, costumer information system, SCADA, water losses, night flow analysis, DMA

Hepatitis B virus and hepatitis C virus seroprevalence in rural areas of the southwestern region of Turkey

SummaryObjectivesMost previous studies on the frequency of hepatitis B virus (HBV) and hepatitis C virus (HCV) have analyzed data obtained from blood donors and risk groups. Few studies have been conducted in the field in rural and urban areas of Turkey. The aim of this study was to determine the seroprevalence of HBV and HCV and to investigate the association with risk factors.MethodsBetween January 2006 and March 2007, 2852 people aged 18 years and over were chosen in three districts using simple random sampling, and blood samples were drawn from them. The card test technique, which is highly sensitive, was applied to blood samples for the qualitative assessment of hepatitis B surface antigen (HBsAg), anti-hepatitis B surface antigen antibodies (anti-HBs), and anti-hepatitis C virus antibodies (anti-HCV). The ELISA technique was then applied only to positive samples for confirmation. In addition, participants answered survey questions on risk factors for infection with HBV and HCV.ResultsOur results showed that 71 (2.5%) were HBsAg-positive, 462 (16.2%) were anti-HBs-positive, and 29 (1.0%) were anti-HCV-positive. Further survey results showed that seropositivity increased with some of the risk factors.ConclusionsStudies on seropositivity that depend on field analyses reflect the true population more accurately. We conclude that such field studies and public education activities for hepatitis B and C are essential

Metabolic syndrome in bipolar disorder: prevalence, demographics and clinical correlates in individuals with bipolar I, bipolar II, and healthy controls

Background: The metabolic syndrome is a growing global public health problem and highly prevalent in patiens with bipolar disorder. There are a few studies about relationship between metabolic syndrome and bipolar disorder subtypes. Objective: The aim of this study was to investigate the prevalence of metabolic syndrome (MS) and its individual components in subjects with bipolar I (BD I) and bipolar II (BD II) disorder compared with non-psychiatric controls, and to determine the variables affecting MS. Methods: A total of 210 individuals (mean age 42.5 ± 11.87, 58.1% female) of whom 70 had BD I, 70 BD II, and 70 controls, were included in this study. MS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), the adapted ATP III (ATP III-A) and the International Diabetes Federation (IDF) criteria. Results: Participants with BD I had a significantly higher prevalence of MS when compared to individuals BD II and non-psychiatric controls according to the NCEP-ATP III, ATP III-A, and IDF criteria (ps &lt; 0.01). In individuals with MS, increased waist circumference was the most common abnormality. Logistic regression analysis revealed that the presence of physical illness, age and number of cigarettes smoked significantly predicted the presence of MS. Discussion: This study showed that MS was more prevalent among BD I individuals compared to BD II and controls, and highlighted the importance of regular screening for MS in individuals with BD

A.Eye Drive: gaze-based semi-autonomous wheelchair interface

Existing wheelchair control interfaces, such as sip & puff or screen based gaze-controlled cursors, are challenging for the severely disabled to navigate safely and independently as users continuously need tointeract with an interface during navigation. This putsa significant cognitive load on users and prevents them from interacting with the environment in other forms during navigation. We have combined eyetracking/gaze-contingent intention decoding with computervision context-awarealgorithms and autonomous navigation drawn fromself-driving vehicles to allow paralysed users to drive by eye, simply by decoding natural gaze about where the user wants to go: A.Eye Drive. Our “Zero UI” driving platform allows users to look and interact visually with at an objector destination of interest in their visual scene, and the wheelchairautonomously takes the user to the intended destination, while continuously updating the computed path for static and dynamic obstacles. This intention decoding technology empowers the end-user by promising more independence through their own agency

Maternal and fetal outcomes of COVID-19, SARS, and MERS: a narrative review on the current knowledge

OBJECTIVE: Coronavirus infections, including SARS. MERS and COVID-19 have significant impact on global health as well as on pregnancies. The aim of this review was to enlighten and summarize the cumulative knowledge regarding the relationship between Coronavirus outbreaks and pregnancy. MATERIALS AND METHODS: Literature search was commenced in order to analyze the maternofetal effects of Coronavirus outbreaks. RESULTS: Fever and cough are the most common presenting symptoms of COVID-19 which mostly affects pregnant women in their 3rd trimester with a maternal mortality rate of 0-77% and fetal and neonatal mortality rates of 1.2%. Fetal demise is common in critically ill pregnant. Pregnancy seems as a worsening factor for SARS and MERS epidemics and both infections affect prominently 3rd trimester pregnancies, although abortion (57%) is a significant risk for cases of early pregnancy. Clinical course of COVID-19, SARS and MERS may be rapid and worse in pregnant women than non-pregnant individuals. Cesarean section is the choice of delivery in most reported women due to mostly obstetrical reasons, although vaginal delivery seems not a worsening factor for the disease.CONCLUSIONS: COVID-19, SARS and MERS have significant detrimental effect on pregnancy. Rapid intervention, treatment, and intensive care support are essential for infected pregnant. Timely delivery is important in order to avoid intrauterine fetal death