5 research outputs found
Genipin cross-linked carbon dots for antimicrobial, bioimaging and bacterial discrimination
Indocyanine Green Loaded Magnetic Carbon Nanoparticles for Near Infrared Fluorescence/Magnetic Resonance Dual-Modal Imaging and Photothermal Therapy of Tumor
Malignant
tumor incidences have been rapidly rising recently and
are becoming a serious threat to human health. Herein, a multifunctional
cancer targeted theranostic nanoplatform is developed by in situ growth
of iron oxide magnetic nanoparticles on carbon nanoparticles, and
then loaded with fluorescent dye indocyanine green (ICG@MCNPs). The
loading of ICG on the nanoplatform significantly improves its photostability,
and hence facilitates long-term near-infrared fluorescence (NIRF)
imaging and efficient photothermal therapy (PTT) of tumor. The in
vivo NIRF imaging reveals that ICG@MCNPs can be targeted to the tumor
site. Moreover, in vivo magnetic resonance imaging also confirmed
the efficient accumulation of ICG@MCNPs in the tumor site. Inspiringly,
the subsequent PTT of tumor-bearing mice is achieved, as evidenced
by the complete ablation of the tumor and the recovery of the physiological
indexes to normal levels. Benefitting from its low-cost, simple preparation,
and excellent dual-modal imaging and therapy, the ICG@MCNPs-based
theranostic nanoplatform holds great promise in tumor-targeted nanomedicine